<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Viacheslav Y. Fofanov</style></author><author><style face="normal" font="default" size="100%">Chen, B. Y.</style></author><author><style face="normal" font="default" size="100%">Bryant, Drew H</style></author><author><style face="normal" font="default" size="100%">Moll, Mark</style></author><author><style face="normal" font="default" size="100%">Olivier Lichtarge</style></author><author><style face="normal" font="default" size="100%">L. E. Kavraki</style></author><author><style face="normal" font="default" size="100%">Marek Kimmel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Statistical Model to Correct Systematic Bias Introduced by Algorithmic Thresholds in Protein Structural Comparison Algorithms</style></title><secondary-title><style face="normal" font="default" size="100%">IEEE Intl. Conf. on Bioinformatics and Biomedicine (BIBM)</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">functional annotation of proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">kavrakilab</style></keyword><keyword><style  face="normal" font="default" size="100%">protein function</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year></dates><pub-location><style face="normal" font="default" size="100%">Philadelphia, PA</style></pub-location><abstract><style face="normal" font="default" size="100%">The identiﬁcation of protein function is crucial to understanding cellular processes and selecting novel proteins as drug targets. However, experimental methods for determining protein function can be expensive and time-consuming. Protein partial structure comparison methods seek to guide and accelerate the process of function determination by matching characterized functional site representations, motifs, to substructures within uncharacterized proteins, matches. One common difﬁculty of all protein structural comparison techniques is the computational cost of obtaining a match. In an effort to maintain practical efﬁciency, some algorithms employ efﬁcient geometric threshold-based searches to eliminate biologically irrelevant matches. Thresholds reﬁne and accelerate the method by limiting the number of potential matches that need to be considered. However, because statistical models rely on the output of the geometric matching method to accurately measure statistical signiﬁcance, geometric thresholds can also artiﬁcially distort the basis of statistical models, making statistical scores dependant on geometric thresholds and potentially causing signiﬁcant reductions in accuracy of the functional annotation method. This paper proposes a point-weight based correction approach to quantify and model the dependence of statistical scores to account for the systematic bias introduced by heuristics. Using a benchmark dataset of 20 structural motifs, we show that the point-weight correction procedure accurately models the information lost during the geometric comparison phase, removing systematic bias and greatly reducing misclassification rates of functionally related proteins, while maintaining speciﬁcity. 
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