The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
3tliA	[pdb]	0.185617 2.69185e-05	120^MET 143^GLU 144^LEU 157^TYR 231^HIS	3.4.24.27	extracellular region	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity calcium ion binding metalloendopeptidase activity	proteolysis
1bqbA	[pdb]	0.234533 5.69677e-05	122^MET 145^GLU 146^ILE 159^TYR 228^HIS	3.4.24.29	extracellular region	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity calcium ion binding metalloendopeptidase activity	proteolysis
2bh2B	[pdb]	0.416726 0.000124924	117^SER 416^MET 423^LEU 424^GLU 428^LEU			4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding transferase activity methyltransferase activity iron ion binding RNA methyltransferase activity RNA binding S-adenosylmethionine-dependent methyltransferase activity	rRNA processing RNA processing
1u4gA	[pdb]	0.457674 0.000170466	120^MET 141^GLU 142^VAL 155^TYR 223^HIS	3.4.24.26	extracellular region	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity calcium ion binding metalloendopeptidase activity	proteolysis
3bjqH	[pdb]	0.468885 0.000178368	28^LEU 119^ALA 120^LEU 266^TYR 271^HIS	0.0.0.0
2pz9A	[pdb]	0.539236 0.000273495	89^LEU 95^LEU 175^ILE 176^ALA 205^LEU	0.0.0.0		DNA binding transcription factor activity	regulation of transcription DNA-dependent transcription regulation of transcription
2nn6B	[pdb]	0.545391 0.000283064	100^ARG 134^SER 189^LEU 195^VAL 196^ILE		exosome (RNase complex) nucleolus nucleus nucleolus cytoplasm nucleus exosome (RNase complex) cytoplasm nucleus exosome (RNase complex) cellular_component cytoplasm nucleus exosome (RNase complex) nucleolus nucleolus nucleolus nucleolus nucleolus exosome (RNase complex) nucleus cytoplasm nucleolus nucleus exosome (RNase complex) nuclear exosome (RNase complex) cytoplasm nucleus exosome (RNase complex) nucleolus cytoplasmic exosome (RNase complex) nuclear exosome (RNase complex) cytoplasm nucleus exosome (RNase complex) cytoplasm nucleus exosome (RNase complex)	protein binding RNA binding hydrolase activity exonuclease activity nuclease activity protein binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity RNA binding hydrolase activity exonuclease activity nuclease activity RNA binding 7S RNA binding 3'-5'-exoribonuclease activity protein binding molecular_function hydrolase activity exonuclease activity nuclease activity RNA binding 3'-5'-exoribonuclease activity identical protein binding protein binding protein binding RNA binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity RNA binding protein binding RNA binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity protein binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity RNA binding protein binding hydrolase activity exonuclease activity nuclease activity RNA binding 3'-5'-exoribonuclease activity	rRNA processing rRNA processing RNA processing rRNA processing biological_process rRNA processing RNA processing RNA catabolic process rRNA processing RNA processing rRNA processing RNA processing immune response rRNA processing RNA processing rRNA processing rRNA processing RNA processing
1x3fA	[pdb]	0.599663 0.000389716	13^LEU 35^SER 83^LEU 99^VAL 100^GLU			DNA binding single-stranded DNA binding	response to DNA damage stimulus DNA repair DNA replication
2rjqA	[pdb]	0.614952 0.000432498	301^LEU 310^HIS 314^ALA 315^VAL 481^LEU	0.0.0.0	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity integrin binding metalloendopeptidase activity	plasma membrane cytoplasm nucleus proteinaceous extracellular matrix extracellular region extracellular matrix	proteolysis
3cwbC	[pdb]	0.630462 0.000518551	282^LEU 293^LEU 294^ALA 302^LEU 364^LEU	0.0.0.0	oxidation reduction electron transport chain transport electron transport chain transport respiratory electron transport chain	oxidoreductase activity acting on diphenols and related substances as donors 2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity ubiquinol-cytochrome-c reductase activity electron carrier activity iron ion binding metal ion binding iron ion binding oxidoreductase activity electron carrier activity	respiratory chain membrane fraction respiratory chain mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion
1hdsD	[pdb]	0.643121 0.000555045	80^LEU 90^LEU 136^VAL 139^ALA 145^HIS		hemoglobin complex hemoglobin complex	metal ion binding iron ion binding oxygen transporter activity heme binding oxygen binding metal ion binding iron ion binding oxygen transporter activity heme binding oxygen binding	oxygen transport transport oxygen transport transport
3fi1A	[pdb]	0.649189 0.000595785	134^ILE 135^ALA 138^LEU 255^LEU 262^LEU		plasma membrane integral to membrane membrane	sodium ion binding antiporter activity sodium ion transmembrane transporter activity	sodium ion transport ion transport transport regulation of pH
1xbaA	[pdb]	0.651231 0.000641252	453^LEU 495^LEU 497^ALA 507^TYR 561^LEU	2.7.10.2	integrin binding protein kinase activity transferase activity kinase activity ATP binding protein tyrosine kinase activity nucleotide binding non-membrane spanning protein tyrosine kinase activity protein binding receptor signaling protein tyrosine kinase activity	intracellular membrane-bounded organelle cytoplasm nucleolus nucleus plasma membrane T cell receptor complex B cell receptor complex	neutrophil chemotaxis leukocyte adhesion integrin-mediated signaling pathway interspecies interaction between organisms cell proliferation organ morphogenesis protein amino acid phosphorylation protein complex assembly signal transduction B cell receptor signaling pathway positive regulation of calcium-mediated signaling positive regulation of peptidyl-tyrosine phosphorylation protein amino acid autophosphorylation positive regulation of alpha-beta T cell proliferation positive regulation of alpha-beta T cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of B cell differentiation positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process positive regulation of interleukin-3 biosynthetic process beta selection positive regulation of mast cell degranulation leukotriene biosynthetic process peptidyl-tyrosine phosphorylation activation of JUN kinase activity intracellular signaling cascade enzyme linked receptor protein signaling pathway cell surface receptor linked signal transduction serotonin secretion activation of MAPK activity
1ue1B	[pdb]	0.668817 0.000746476	13^LEU 35^SER 83^LEU 99^ILE 100^GLU			DNA binding single-stranded DNA binding	response to DNA damage stimulus DNA repair DNA replication
2o5vA	[pdb]	0.669381 0.000746508	123^LEU 200^LEU 253^LEU 281^ALA 285^LEU		ATP binding DNA binding nucleotide binding nucleoside-triphosphatase activity single-stranded DNA binding	SOS response response to DNA damage stimulus DNA repair DNA replication	cytoplasm chromosome
1s9cB	[pdb]	0.675719 0.000803476	106^LEU 110^ALA 111^VAL 126^MET 136^LEU	1.1.1.35, 4.2.1.107	fatty acid beta-oxidation oxidation reduction fatty acid metabolic process lipid metabolic process metabolic process very-long-chain fatty acid metabolic process Sertoli cell development	peroxisome peroxisomal matrix mitochondrion	protein binding isomerase activity lyase activity oxidoreductase activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity 3-hydroxyacyl-CoA dehydrogenase activity hydro-lyase activity sterol transporter activity sterol carrier activity estradiol 17-beta-dehydrogenase activity binding catalytic activity
1dtzA	[pdb]	0.679234 0.00086648	63^LEU 80^GLU 81^VAL 308^LEU 320^LEU		extracellular region	iron ion transport ion transport transport cellular iron ion homeostasis	metal ion binding hydrolase activity serine-type peptidase activity peptidase activity iron ion binding ferric iron binding
1vpvB	[pdb]	0.688879 0.000936516	95^LEU 120^LEU 121^ALA 163^TYR 236^HIS
3c7jB	[pdb]	0.699336 0.00109711	22^HIS 29^GLU 32^LEU 59^SER 70^LEU	0.0.0.0	DNA binding transcription factor activity DNA binding transcription factor activity	intracellular intracellular	regulation of transcription DNA-dependent transcription regulation of transcription regulation of transcription regulation of transcription DNA-dependent transcription
2arzA	[pdb]	0.701407 0.0010973	181^LEU 182^ALA 192^LEU 208^LEU 236^TRP	0.0.0.0			FMN binding
3dl8G	[pdb]	0.702515 0.0010974	58^LEU 283^LEU 375^LEU 379^ALA 380^LEU		P-P-bond-hydrolysis-driven protein transmembrane transporter activity P-P-bond-hydrolysis-driven protein transmembrane transporter activity metal ion binding zinc ion binding ATP binding nucleotide binding protein binding helicase activity nucleic acid binding	intracellular protein transmembrane transport protein transport transport protein secretion intracellular protein transmembrane transport protein transport transport intracellular protein transmembrane transport protein transport transport protein import intracellular protein transport protein targeting	plasma membrane integral to membrane membrane plasma membrane integral to membrane membrane plasma membrane cytoplasm membrane
3d3aA	[pdb]	0.703407 0.00118843	68^ALA 69^LEU 104^LEU 111^TYR 356^LEU	0.0.0.0	beta-galactosidase complex	cell adhesion carbohydrate metabolic process	hydrolase activity hydrolyzing O-glycosyl compounds cation binding beta-galactosidase activity catalytic activity
1tpzA	[pdb]	0.705293 0.00118862	62^LEU 284^LEU 285^GLU 309^LEU 316^TYR		GTP binding nucleotide binding hydrolase activity identical protein binding GDP binding GTPase activity hydrolase activity acting on acid anhydrides	cytokine-mediated signaling pathway	nuclear membrane endoplasmic reticulum membrane cytoplasm Golgi apparatus endoplasmic reticulum nucleus membrane
1i3cB	[pdb]	0.705981 0.00118869	14^VAL 15^GLU 71^LEU 118^LEU 127^LEU			two-component response regulator activity protein binding	two-component signal transduction system (phosphorelay) regulation of transcription DNA-dependent
1ekfB	[pdb]	0.707653 0.00118885	41^VAL 42^GLU 48^TRP 62^HIS 67^SER	2.6.1.42	branched chain family amino acid biosynthetic process cellular amino acid biosynthetic process branched chain family amino acid metabolic process metabolic process	mitochondrion cytoplasm	transferase activity transaminase activity branched-chain-amino-acid transaminase activity catalytic activity
3busA	[pdb]	0.712478 0.00128805	136^LEU 137^GLU 139^LEU 217^SER 224^LEU	0.0.0.0		metabolic process metabolic process	transferase activity methyltransferase activity transferase activity methyltransferase activity
1p9nB	[pdb]	0.716829 0.00139531	4^LEU 110^ILE 111^ALA 115^LEU 148^LEU			GTP binding nucleotide binding protein binding	Mo-molybdopterin cofactor biosynthetic process
2ch8D	[pdb]	0.717548 0.0013954	44^ILE 45^GLU 59^LEU 103^LEU 108^LEU	0.0.0.0
1i9yA	[pdb]	0.719586 0.00139563	648^LEU 682^VAL 683^ALA 732^HIS 820^TYR	3.1.3.36	cytoplasm cell division site cell tip cytosol barrier septum	lipid metabolic process transport protein transport inositol lipid-mediated signaling	magnesium ion binding inositol-polyphosphate 5-phosphatase activity hydrolase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol or phosphatidylinositol phosphatase activity
2c9kA	[pdb]	0.719942 0.00139567	308^ALA 309^LEU 326^LEU 592^TYR 630^LEU	0.0.0.0		receptor binding	sporulation resulting in formation of a cellular spore pathogenesis defense response
1i1rB	[pdb]	0.7215 0.00139585	74^LEU 75^ALA 109^LEU 120^LEU 124^HIS	0.0.0.0	extracellular region ciliary neurotrophic factor receptor complex plasma membrane extracellular region integral to membrane membrane external side of plasma membrane interleukin-6 receptor complex oncostatin-M receptor complex receptor complex	positive regulation of tyrosine phosphorylation of Stat3 protein immune response interleukin-27-mediated signaling pathway ciliary neurotrophic factor-mediated signaling pathway cytokine-mediated signaling pathway regulation of Notch signaling pathway positive regulation of cell proliferation signal transduction glycogen metabolic process leukemia inhibitory factor signaling pathway positive regulation of cardiac muscle hypertrophy positive regulation vascular endothelial growth factor production positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of T cell proliferation positive regulation of adaptive immune response response to cytokine stimulus positive regulation of anti-apoptosis positive regulation of osteoblast differentiation positive regulation of acute inflammatory response	protein homodimerization activity interleukin-6 receptor binding cytokine activity protein binding ciliary neurotrophic factor receptor binding receptor activity cytokine receptor activity protein binding interleukin-11 binding interleukin-11 receptor activity interleukin-6 receptor activity interleukin-27 receptor activity receptor binding interleukin-6 binding growth factor binding oncostatin-M receptor activity ciliary neurotrophic factor receptor activity leukemia inhibitory factor receptor activity
2cbzA	[pdb]	0.724952 0.00151152	740^VAL 743^ALA 795^LEU 801^HIS 816^MET		ATPase activity ATP binding nucleotide binding transporter activity ATPase activity coupled to transmembrane movement of substances nucleoside-triphosphatase activity hydrolase activity	membrane integral to membrane integral to plasma membrane membrane fraction plasma membrane	transport response to drug
2v5qB	[pdb]	0.728607 0.00151197	148^LEU 155^TYR 277^VAL 278^ALA 281^LEU	2.7.11.21	cell division mitosis cell cycle positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle cell proliferation protein amino acid phosphorylation	nucleus cytosol nucleoplasm centrosome	transferase activity kinase activity ATP binding protein serine/threonine kinase activity nucleotide binding protein kinase activity polo kinase kinase activity protein binding
2p4oA	[pdb]	0.728999 0.00151202	76^LEU 84^LEU 86^ALA 112^LEU 141^LEU	0.0.0.0
1fnzA	[pdb]	0.730278 0.00163628	24^ALA 25^LEU 32^LEU 44^SER 103^LEU				binding metal ion binding manganese ion binding sugar binding calcium ion binding
3c65A	[pdb]	0.733832 0.00163676	382^GLU 398^LEU 400^VAL 440^LEU 472^LEU		SOS response response to DNA damage stimulus DNA repair nucleotide-excision repair	cytoplasm excinuclease repair complex intracellular	nuclease activity sequence-specific DNA binding excinuclease ABC activity DNA binding
1x1cA	[pdb]	0.734263 0.00163682	27^MET 30^ALA 31^ILE 46^LEU 81^SER	0.0.0.0			transferase activity methyltransferase activity O-methyltransferase activity
1l7vB	[pdb]	0.736569 0.00177049	133^GLN 141^VAL 216^ARG 218^GLU 219^GLU	0.0.0.0	plasma membrane integral to membrane membrane plasma membrane membrane	transport cobalamin transport transport cobalamin transport	transporter activity cobalamin transporter activity hydrolase activity ATP binding nucleotide binding cobalamin-transporting ATPase activity nucleoside-triphosphatase activity ATPase activity
2uxdD	[pdb]	0.738568 0.00177077	19^MG 58^MG 60^MG 68^MG 202^LEU		rRNA binding RNA binding structural constituent of ribosome metal ion binding rRNA binding zinc ion binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome tRNA binding RNA binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding rRNA binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome metal ion binding rRNA binding zinc ion binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding tRNA binding structural constituent of ribosome structural constituent of ribosome rRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome tRNA binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding tRNA binding structural constituent of ribosome nucleic acid binding	ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome small ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular	translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation
1gkzA	[pdb]	0.739068 0.00177085	139^LEU 140^ALA 143^LEU 334^HIS 340^LEU	2.7.11.4	branched chain family amino acid catabolic process peptidyl-histidine phosphorylation phosphorylation signal transduction	mitochondrial matrix mitochondrion mitochondrial alpha-ketoglutarate dehydrogenase complex	transferase activity kinase activity [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity transferase activity transferring phosphorus-containing groups ATP binding protein histidine kinase activity two-component sensor activity protein serine/threonine kinase activity nucleotide binding
2pljA	[pdb]	0.74079 0.00177109	18^LEU 22^GLU 23^ILE 38^LEU 387^LEU	0.0.0.0		catalytic activity	polyamine biosynthetic process
1dpeA	[pdb]	0.749264 0.00191546	32^LEU 37^VAL 38^GLU 150^LEU 500^HIS		oligopeptide transporter activity transporter activity	periplasmic space	protein transport chemotaxis oligopeptide transport transport peptide transport
1v04A	[pdb]	0.749306 0.00191547	58^LEU 90^LEU 281^TRP 333^VAL 334^ALA	3.1.8.1, 3.1.1.2	extracellular region extracellular region extracellular region microsome extracellular space cytoskeleton cytoplasm extracellular region microsome extracellular space high-density lipoprotein particle spherical high-density lipoprotein particle extracellular space high-density lipoprotein particle high-density lipoprotein particle extracellular space microsome high-density lipoprotein particle	hydrolase activity lipid transporter activity arylesterase activity aryldialkylphosphatase activity arylesterase activity aryldialkylphosphatase activity antioxidant activity hydrolase activity lipid transporter activity hydrolase activity lipid transporter activity arylesterase activity aryldialkylphosphatase activity high-density lipoprotein binding arylesterase activity hydrolase activity lipid transporter activity aryldialkylphosphatase activity phospholipid binding protein homodimerization activity	response to organophosphorus response to toxin cholesterol metabolic process blood circulation lipid metabolic process response to external stimulus response to toxin lipid metabolic process positive regulation of cholesterol efflux aromatic compound catabolic process positive regulation of transporter activity carboxylic acid catabolic process organophosphate catabolic process phosphatidylcholine metabolic process positive regulation of binding negative regulation of plasma lipoprotein oxidation lipid metabolic process response to toxin
1iqcD	[pdb]	0.749534 0.0019155	167^LEU 171^GLU 172^LEU 233^LEU 251^LEU	1.11.1.5	metal ion binding oxidoreductase activity iron ion binding peroxidase activity cytochrome-c peroxidase activity heme binding electron carrier activity	oxidation reduction electron transport chain transport	periplasmic space
2ct9B	[pdb]	0.752321 0.00206922	38^LEU 58^ALA 59^ILE 62^LEU 201^LEU	0.0.0.0	cytoplasm cytosol	metal ion binding calcium ion binding	transcytosis calcium-mediated signaling calcium ion-dependent exocytosis
1vs3A	[pdb]	0.753893 0.00206948	58^LEU 110^TYR 115^LEU 128^ALA 129^LEU	5.4.99.12		RNA binding isomerase activity pseudouridine synthase activity	RNA modification tRNA processing pseudouridine synthesis tRNA pseudouridine synthesis
3c4nA	[pdb]	0.757098 0.00223392	191^LEU 196^GLU 197^LEU 207^LEU 239^LEU	0.0.0.0			oxidoreductase activity
2jwxA	[pdb]	0.764784 0.00241025	20^LEU 21^ALA 23^MET 90^LEU 105^LEU	0.0.0.0	isomerase activity calcium ion binding peptidyl-prolyl cis-trans isomerase activity binding	mitochondrial membrane integral to membrane membrane mitochondrion integral to endoplasmic reticulum membrane mitochondrial envelope	regulation of gene expression dorsal/ventral neural tube patterning neural tube development regulation of BMP signaling pathway positive regulation of BMP signaling pathway multicellular organism growth interspecies interaction between organisms apoptosis protein folding intracellular signaling cascade camera-type eye development dorsal/ventral pattern formation smoothened signaling pathway cell fate specification
1tpyA	[pdb]	0.767074 0.00241068	34^SER 231^HIS 240^ALA 243^LEU 263^MET	0.0.0.0		lipid biosynthetic process	transferase activity methyltransferase activity cyclopropane-fatty-acyl-phospholipid synthase activity
1mioB	[pdb]	0.768398 0.00241093	29^MET 32^ALA 33^LEU 133^LEU 161^LEU	1.18.6.1	iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding nitrogenase activity iron-sulfur cluster binding metal ion binding molybdenum ion binding oxidoreductase activity iron ion binding nitrogenase activity nucleotide binding ATP binding nucleotide binding ATP binding	molybdenum-iron nitrogenase complex molybdenum-iron nitrogenase complex	oxidation reduction nitrogen fixation oxidation reduction nitrogen fixation
3etkA	[pdb]	0.769427 0.00241112	207^ILE 210^GLU 213^LEU 241^SER 271^LEU	0.0.0.0			endodeoxyribonuclease activity producing 5'-phosphomonoesters hydrolase activity acting on carbon-nitrogen (but not peptide) bonds
1itfA	[pdb]	0.770823 0.0025978	15^LEU 26^LEU 80^LEU 141^GLU 142^VAL		cytokine activity interferon-alpha/beta receptor binding cytokine receptor binding	extracellular region extracellular space	response to virus inflammatory response cell-cell signaling cell surface receptor linked signal transduction induction of apoptosis defense response
1s1mB	[pdb]	0.775554 0.00259874	453^LEU 478^LEU 497^LEU 502^GLU 510^VAL	6.3.4.2	cytosol	glutamine metabolic process pyrimidine nucleotide biosynthetic process	ligase activity CTP synthase activity catalytic activity nucleotide binding ATP binding
1ku2A	[pdb]	0.776143 0.00259886	100^LEU 109^LEU 202^LEU 205^ALA 212^SER	0.0.0.0		regulation of transcription regulation of transcription DNA-dependent transcription transcription initiation	sigma factor activity DNA binding transcription factor activity
1uf4A	[pdb]	0.776101 0.00259885	30^MET 195^TYR 244^LEU 267^GLU 268^VAL	3.5.1.77		hydrolase activity N-carbamoyl-D-amino acid hydrolase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds	nitrogen compound metabolic process
2vz9A	[pdb]	0.781281 0.00279816	454^LEU 457^ILE 458^ALA 570^LEU 803^LEU	0.0.0.0		cofactor binding phosphopantetheine binding hydrolase activity acting on ester bonds transferase activity oxidoreductase activity zinc ion binding binding catalytic activity acyl carrier activity	oxidation reduction biosynthetic process metabolic process
2ef0A	[pdb]	0.781662 0.00279824	12^LEU 130^SER 171^LEU 172^GLU 195^LEU	0.0.0.0	cellular amino acid metabolic process	ornithine carbamoyltransferase complex	transferase activity carboxyl- or carbamoyltransferase activity amino acid binding ornithine carbamoyltransferase activity
1t60F	[pdb]	0.782607 0.00279844	7^LEU 113^VAL 114^ALA 118^HIS 154^SER	0.0.0.0		basement membrane proteinaceous extracellular matrix extracellular region collagen collagen type IV basement membrane proteinaceous extracellular matrix extracellular region collagen	binding extracellular matrix structural constituent binding extracellular matrix structural constituent
2rkbB	[pdb]	0.783153 0.00300896	202^HIS 210^ALA 216^LEU 229^LEU 239^LEU		biological adhesion metabolic process cellular amino acid metabolic process	cellular_component	molecular_function lyase activity pyridoxal phosphate binding catalytic activity
1j3yD	[pdb]	0.788273 0.00301007	81^LEU 91^LEU 137^VAL 140^ALA 146^HIS		hemoglobin binding oxygen binding protein binding oxygen transporter activity metal ion binding iron ion binding heme binding protein binding metal ion binding iron ion binding oxygen transporter activity heme binding oxygen binding	hemoglobin complex hemoglobin complex cytosolic small ribosomal subunit	oxygen transport positive regulation of nitric oxide biosynthetic process nitric oxide transport regulation of blood vessel size regulation of blood pressure transport oxygen transport transport
1yt3A	[pdb]	0.791025 0.00322731	225^LEU 233^LEU 263^LEU 267^GLU 268^ILE	3.1.13.5	cytoplasm intracellular	nucleic acid binding protein binding hydrolase activity exonuclease activity nuclease activity ribonuclease D activity 3'-5' exonuclease activity ribonuclease activity	tRNA processing nucleobase nucleoside nucleotide and nucleic acid metabolic process
2vl0E	[pdb]	0.792034 0.00322754	219^TRP 228^SER 272^ILE 275^ALA 283^HIS		ion channel activity neurotransmitter receptor activity extracellular ligand-gated ion channel activity	ion transport transport	membrane integral to membrane postsynaptic membrane
2j8mA	[pdb]	0.792476 0.00322764	56^LEU 87^SER 111^ALA 116^LEU 165^LEU	0.0.0.0		N-acetyltransferase activity	metabolic process
1fnoA	[pdb]	0.794742 0.00322815	34^LEU 47^LEU 50^ILE 60^ALA 78^HIS	3.4.11.4	cytoplasm	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity aminopeptidase activity tripeptide aminopeptidase activity protein dimerization activity	peptide metabolic process proteolysis
2alrA	[pdb]	0.795406 0.0032283	7^LEU 146^LEU 176^SER 180^ALA 204^LEU	1.1.1.2	apical plasma membrane cytosol	electron carrier activity oxidoreductase activity alcohol dehydrogenase (NADP+) activity aldehyde reductase activity protein binding L-glucuronate reductase activity	oxidation reduction cellular aldehyde metabolic process glucose metabolic process aldehyde catabolic process D-glucuronate catabolic process L-ascorbic acid biosynthetic process
1pjcA	[pdb]	0.798831 0.00345214	135^ILE 136^ALA 173^LEU 239^LEU 300^MET	0.0.0.0		oxidation reduction metabolic process	oxidoreductase activity alanine dehydrogenase activity electron carrier activity binding catalytic activity
3efeF	[pdb]	0.798918 0.00345216	22^LEU 25^GLU 26^LEU 183^LEU 204^LEU	0.0.0.0
1v26A	[pdb]	0.799125 0.00345221	203^LEU 206^LEU 207^ALA 324^TYR 359^LEU	0.0.0.0		ligase activity catalytic activity	metabolic process
1vcgB	[pdb]	0.800755 0.0034526	57^LEU 120^LEU 206^LEU 208^ALA 209^VAL	0.0.0.0	cytoplasm cytoplasm	isomerase activity isopentenyl-diphosphate delta-isomerase activity oxidoreductase activity FMN binding catalytic activity isomerase activity oxidoreductase activity FMN binding isopentenyl-diphosphate delta-isomerase activity catalytic activity	isoprenoid biosynthetic process metabolic process isoprenoid biosynthetic process metabolic process
2ieeA	[pdb]	0.802136 0.00345293	31^LEU 46^LEU 76^LEU 87^ALA 212^VAL		plasma membrane membrane outer membrane-bounded periplasmic space	transport	transporter activity
1v3uA	[pdb]	0.803054 0.00345314	29^LEU 41^ALA 42^LEU 44^LEU 97^SER	1.3.1.74, 1.3.1.48	cytoplasm	oxidation reduction metabolic process	oxidoreductase activity 15-oxoprostaglandin 13-oxidase activity 2-alkenal reductase activity zinc ion binding binding catalytic activity
1vdhE	[pdb]	0.803713 0.00368927	12^LEU 13^GLU 83^LEU 114^LEU 193^LEU
2htdB	[pdb]	0.803927 0.00368932	4^LEU 9^LEU 24^LEU 69^VAL 70^ALA	0.0.0.0			FMN binding FMN binding
2vpzC	[pdb]	0.804069 0.00368936	16^THR 27^ALA 232^LEU 240^LEU 243^LEU	0.0.0.0		iron ion binding metal ion binding 4 iron 4 sulfur cluster binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding molybdenum ion binding oxidoreductase activity iron ion binding binding iron-sulfur cluster binding electron carrier activity	oxidation reduction
1k3uB	[pdb]	0.804184 0.00368939	48^LEU 96^LEU 117^VAL 120^ALA 152^MET	4.2.1.20		aromatic amino acid family biosynthetic process cellular amino acid biosynthetic process tryptophan biosynthetic process metabolic process tryptophan metabolic process aromatic amino acid family biosynthetic process cellular amino acid biosynthetic process tryptophan biosynthetic process metabolic process tryptophan metabolic process	lyase activity tryptophan synthase activity pyridoxal phosphate binding catalytic activity protein binding lyase activity catalytic activity tryptophan synthase activity protein binding
3ebgA	[pdb]	0.8041 0.00368936	1011^HIS 1022^ALA 1025^ILE 1045^LEU 1064^MET	0.0.0.0	aminopeptidase activity metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity	cytoplasm	proteolysis
2fl0B	[pdb]	0.804862 0.00368956	18^GLU 19^LEU 52^MET 91^LEU 98^LEU	0.0.0.0		cellular iron ion homeostasis iron ion transport	metal ion binding iron ion binding transition metal ion binding oxidoreductase activity ferric iron binding
1vixA	[pdb]	0.80533 0.00368967	34^LEU 47^LEU 50^VAL 60^ALA 78^HIS	3.4.11.4	cytoplasm	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity aminopeptidase activity tripeptide aminopeptidase activity protein dimerization activity	peptide metabolic process proteolysis
1l1eB	[pdb]	0.805596 0.00368974	34^SER 231^HIS 240^ALA 243^LEU 263^MET	0.0.0.0		lipid biosynthetic process	transferase activity cyclopropane-fatty-acyl-phospholipid synthase activity
1yspA	[pdb]	0.806269 0.00368991	27^LEU 34^TYR 123^ILE 124^ALA 159^LEU			DNA binding	regulation of transcription regulation of transcription DNA-dependent transcription
3d3lA	[pdb]	0.806514 0.00368997	281^LEU 296^LEU 297^ALA 325^SER 330^LEU	1.13.11.31	cytosol sarcolemma cytoplasm	fatty acid oxidation anti-apoptosis positive regulation of cell proliferation cell motion positive regulation of cell adhesion positive regulation of cell growth oxygen and reactive oxygen species metabolic process superoxide anion generation oxidation reduction leukotriene biosynthetic process leukotriene metabolic process	hepoxilin-epoxide hydrolase activity arachidonate 12-lipoxygenase activity metal ion binding oxidoreductase activity acting on single donors with incorporation of molecular oxygen incorporation of two atoms of oxygen oxidoreductase activity iron ion binding lipoxygenase activity protein binding
1q8iA	[pdb]	0.807467 0.00369021	154^SER 296^VAL 297^ALA 300^LEU 333^LEU	2.7.7.7		SOS response response to DNA damage stimulus DNA repair DNA replication nucleobase nucleoside nucleotide and nucleic acid metabolic process	nucleotidyltransferase activity transferase activity DNA-directed DNA polymerase activity DNA binding nucleic acid binding nucleotide binding protein binding
1l5jB	[pdb]	0.808298 0.00369042	5^TYR 17^ILE 18^ALA 48^LEU 196^LEU	4.2.1.3		4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding lyase activity iron ion binding aconitate hydratase activity protein binding	tricarboxylic acid cycle metabolic process
2pw9C	[pdb]	0.808545 0.00369048	123^LEU 196^TYR 201^LEU 210^ALA 212^ILE	0.0.0.0		cytoplasm formate dehydrogenase complex	formate dehydrogenase activity
1vrmA	[pdb]	0.809309 0.00369067	56^SER 76^LEU 189^LEU 192^ILE 193^ALA	0.0.0.0			thiamin biosynthetic process
1xupO	[pdb]	0.809704 0.00369077	106^SER 313^ALA 314^ILE 317^LEU 352^LEU	2.7.1.30		glycerol metabolic process glycerol-3-phosphate metabolic process carbohydrate metabolic process	transferase activity kinase activity ATP binding nucleotide binding glycerol kinase activity phosphotransferase activity alcohol group as acceptor
1htyA	[pdb]	0.809867 0.00394011	678^LEU 752^LEU 775^GLU 776^ILE 894^LEU	3.2.1.114	Golgi membrane integral to membrane membrane Golgi apparatus Golgi stack endoplasmic reticulum	metabolic process mannose metabolic process carbohydrate metabolic process	metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity zinc ion binding mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity cation binding carbohydrate binding mannosidase activity alpha-mannosidase activity catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
1zsvA	[pdb]	0.809881 0.00394011	29^LEU 41^ALA 42^LEU 44^LEU 97^SER	1.3.1.48, 1.3.1.74	2-alkenal reductase activity 15-oxoprostaglandin 13-oxidase activity oxidoreductase activity zinc ion binding binding catalytic activity alcohol dehydrogenase (NAD) activity	cytoplasm	oxidation reduction metabolic process leukotriene metabolic process
1w98B	[pdb]	0.810134 0.00394018	153^LEU 187^LEU 212^LEU 215^GLU 216^LEU	0.0.0.0	cell division mitosis cell cycle DNA replication positive regulation of cell proliferation G2/M transition of mitotic cell cycle traversing start control point of mitotic cell cycle regulation of DNA replication protein amino acid phosphorylation androgen receptor signaling pathway positive regulation of transcription DNA-dependent G1/S transition of mitotic cell cycle cell division cell cycle	cyclin-dependent protein kinase holoenzyme complex cytosol nucleoplasm nucleus cytoplasm nucleus cytosol nucleoplasm	histone kinase activity protein binding transferase activity kinase activity ATP binding protein serine/threonine kinase activity nucleotide binding cyclin-dependent protein kinase activity protein kinase activity identical protein binding androgen receptor binding transcription coactivator activity protein binding
2g9dA	[pdb]	0.81047 0.00394027	154^LEU 195^LEU 219^GLU 220^LEU 325^LEU	3.5.1.96		arginine metabolic process metabolic process arginine catabolic process to glutamate	metal ion binding hydrolase activity zinc ion binding succinylglutamate desuccinylase activity hydrolase activity acting on ester bonds
1r5mA	[pdb]	0.815519 0.0039416	151^LEU 197^TYR 200^LEU 534^ALA 535^ILE		chromatin modification negative regulation of meiosis positive regulation of stress-activated MAPK cascade histone deacetylation chromatin silencing at telomere	nucleus Set3 complex Rpd3L-Expanded complex	protein binding
1lnsA	[pdb]	0.818453 0.00420566	144^LEU 158^LEU 159^ALA 166^LEU 197^SER	3.4.14.11	cytoplasm	hydrolase activity serine-type peptidase activity peptidase activity aminopeptidase activity dipeptidyl-peptidase activity	proteolysis
2gq0B	[pdb]	0.819314 0.0042059	423^MET 455^ILE 456^GLU 460^LEU 482^SER		ATP binding nucleotide binding unfolded protein binding protein binding	cytosol plasma membrane cytoplasm membrane	response to stress protein folding
1yycA	[pdb]	0.819905 0.00420607	124^ALA 125^VAL 127^LEU 139^TYR 167^LEU			plasma membrane	response to desiccation
1qyiA	[pdb]	0.821208 0.00420643	328^LEU 354^LEU 359^ALA 369^LEU 376^LEU	0.0.0.0
3caaA	[pdb]	0.822957 0.00420692	66^LEU 68^ALA 73^LEU 330^SER 358^LEU		extracellular region nucleus intracellular	peptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding DNA binding chymotrypsin inhibitor activity endopeptidase inhibitor activity	regulation of lipid metabolic process inflammatory response acute-phase response
1sqvC	[pdb]	0.823263 0.004485	281^LEU 292^LEU 293^ALA 301^LEU 363^LEU	0.0.0.0	electron transport chain transport oxidation reduction electron transport chain transport electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport proteolysis electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport proteolysis electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport respiratory electron transport chain	mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial membrane respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial envelope mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion	ubiquinol-cytochrome-c reductase activity 2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding ubiquinol-cytochrome-c reductase activity electron carrier activity electron carrier activity ubiquinol-cytochrome-c reductase activity oxidoreductase activity acting on diphenols and related substances as donors metal ion binding zinc ion binding metalloendopeptidase activity catalytic activity ubiquinol-cytochrome-c reductase activity metal ion binding iron ion binding heme binding electron carrier activity ubiquinol-cytochrome-c reductase activity metal ion binding zinc ion binding metalloendopeptidase activity catalytic activity ubiquinol-cytochrome-c reductase activity metal ion binding iron ion binding oxidoreductase activity electron carrier activity
1ukpA	[pdb]	0.827094 0.00448613	293^ALA 294^ILE 339^LEU 461^LEU 464^SER	3.2.1.2		hydrolase activity acting on glycosyl bonds hydrolase activity beta-amylase activity cation binding catalytic activity	metabolic process carbohydrate metabolic process polysaccharide catabolic process
1t11B	[pdb]	0.827571 0.00448628	187^LEU 278^LEU 294^LEU 299^GLU 300^ILE			cell division cell cycle protein folding protein transport	isomerase activity peptidyl-prolyl cis-trans isomerase activity
1cs6A	[pdb]	0.828464 0.00448654	140^TYR 166^LEU 233^LEU 234^GLU 265^LEU	0.0.0.0	cell adhesion neuron adhesion	plasma membrane anchored to membrane membrane	protein binding cell adhesion molecule binding

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

3tliA

[pdb]

0.185617
2.69185e-05

120^MET 143^GLU 144^LEU 157^TYR 231^HIS

3.4.24.27

extracellular region

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
calcium ion binding
metalloendopeptidase activity

proteolysis

1bqbA

[pdb]

0.234533
5.69677e-05

122^MET 145^GLU 146^ILE 159^TYR 228^HIS

3.4.24.29

extracellular region

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
calcium ion binding
metalloendopeptidase activity

proteolysis

2bh2B

[pdb]

0.416726
0.000124924

117^SER 416^MET 423^LEU 424^GLU 428^LEU

4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
transferase activity
methyltransferase activity
iron ion binding
RNA methyltransferase activity
RNA binding
S-adenosylmethionine-dependent methyltransferase activity

rRNA processing
RNA processing

1u4gA

[pdb]

0.457674
0.000170466

120^MET 141^GLU 142^VAL 155^TYR 223^HIS

3.4.24.26

extracellular region

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
calcium ion binding
metalloendopeptidase activity

proteolysis

3bjqH

[pdb]

0.468885
0.000178368

28^LEU 119^ALA 120^LEU 266^TYR 271^HIS

0.0.0.0

2pz9A

[pdb]

0.539236
0.000273495

89^LEU 95^LEU 175^ILE 176^ALA 205^LEU

0.0.0.0

DNA binding
transcription factor activity

regulation of transcription
DNA-dependent
transcription
regulation of transcription

2nn6B

[pdb]

0.545391
0.000283064

100^ARG 134^SER 189^LEU 195^VAL 196^ILE

exosome (RNase complex)
nucleolus
nucleus
nucleolus
cytoplasm
nucleus
exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)
cellular_component
cytoplasm
nucleus
exosome (RNase complex)
nucleolus
nucleolus
nucleolus
nucleolus
nucleolus
exosome (RNase complex)
nucleus
cytoplasm
nucleolus
nucleus
exosome (RNase complex)
nuclear exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)
nucleolus
cytoplasmic exosome (RNase complex)
nuclear exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)

protein binding
RNA binding
hydrolase activity
exonuclease activity
nuclease activity
protein binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
7S RNA binding
3'-5'-exoribonuclease activity
protein binding
molecular_function
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
3'-5'-exoribonuclease activity
identical protein binding
protein binding
protein binding
RNA binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
protein binding
RNA binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
protein binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
protein binding
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
3'-5'-exoribonuclease activity

rRNA processing
rRNA processing
RNA processing
rRNA processing
biological_process
rRNA processing
RNA processing
RNA catabolic process
rRNA processing
RNA processing
rRNA processing
RNA processing
immune response
rRNA processing
RNA processing
rRNA processing
rRNA processing
RNA processing

1x3fA

[pdb]

0.599663
0.000389716

13^LEU 35^SER 83^LEU 99^VAL 100^GLU

DNA binding
single-stranded DNA binding

response to DNA damage stimulus
DNA repair
DNA replication

2rjqA

[pdb]

0.614952
0.000432498

301^LEU 310^HIS 314^ALA 315^VAL 481^LEU

0.0.0.0

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
integrin binding
metalloendopeptidase activity

plasma membrane
cytoplasm
nucleus
proteinaceous extracellular matrix
extracellular region
extracellular matrix

proteolysis

3cwbC

[pdb]

0.630462
0.000518551

282^LEU 293^LEU 294^ALA 302^LEU 364^LEU

0.0.0.0

oxidation reduction
electron transport chain
transport
electron transport chain
transport
respiratory electron transport chain

oxidoreductase activity
acting on diphenols and related substances as donors
2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
ubiquinol-cytochrome-c reductase activity
electron carrier activity
iron ion binding
metal ion binding
iron ion binding
oxidoreductase activity
electron carrier activity

respiratory chain
membrane fraction
respiratory chain
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion

1hdsD

[pdb]

0.643121
0.000555045

80^LEU 90^LEU 136^VAL 139^ALA 145^HIS

hemoglobin complex
hemoglobin complex

metal ion binding
iron ion binding
oxygen transporter activity
heme binding
oxygen binding
metal ion binding
iron ion binding
oxygen transporter activity
heme binding
oxygen binding

oxygen transport
transport
oxygen transport
transport

3fi1A

[pdb]

0.649189
0.000595785

134^ILE 135^ALA 138^LEU 255^LEU 262^LEU

plasma membrane
integral to membrane
membrane

sodium ion binding
antiporter activity
sodium ion transmembrane transporter activity

sodium ion transport
ion transport
transport
regulation of pH

1xbaA

[pdb]

0.651231
0.000641252

453^LEU 495^LEU 497^ALA 507^TYR 561^LEU

2.7.10.2

integrin binding
protein kinase activity
transferase activity
kinase activity
ATP binding
protein tyrosine kinase activity
nucleotide binding
non-membrane spanning protein tyrosine kinase activity
protein binding
receptor signaling protein tyrosine kinase activity

intracellular membrane-bounded organelle
cytoplasm
nucleolus
nucleus
plasma membrane
T cell receptor complex
B cell receptor complex

neutrophil chemotaxis
leukocyte adhesion
integrin-mediated signaling pathway
interspecies interaction between organisms
cell proliferation
organ morphogenesis
protein amino acid phosphorylation
protein complex assembly
signal transduction
B cell receptor signaling pathway
positive regulation of calcium-mediated signaling
positive regulation of peptidyl-tyrosine phosphorylation
protein amino acid autophosphorylation
positive regulation of alpha-beta T cell proliferation
positive regulation of alpha-beta T cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of B cell differentiation
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of interleukin-3 biosynthetic process
beta selection
positive regulation of mast cell degranulation
leukotriene biosynthetic process
peptidyl-tyrosine phosphorylation
activation of JUN kinase activity
intracellular signaling cascade
enzyme linked receptor protein signaling pathway
cell surface receptor linked signal transduction
serotonin secretion
activation of MAPK activity

1ue1B

[pdb]

0.668817
0.000746476

13^LEU 35^SER 83^LEU 99^ILE 100^GLU

DNA binding
single-stranded DNA binding

response to DNA damage stimulus
DNA repair
DNA replication

2o5vA

[pdb]

0.669381
0.000746508

123^LEU 200^LEU 253^LEU 281^ALA 285^LEU

ATP binding
DNA binding
nucleotide binding
nucleoside-triphosphatase activity
single-stranded DNA binding

SOS response
response to DNA damage stimulus
DNA repair
DNA replication

cytoplasm
chromosome

1s9cB

[pdb]

0.675719
0.000803476

106^LEU 110^ALA 111^VAL 126^MET 136^LEU

1.1.1.35, 4.2.1.107

fatty acid beta-oxidation
oxidation reduction
fatty acid metabolic process
lipid metabolic process
metabolic process
very-long-chain fatty acid metabolic process
Sertoli cell development

peroxisome
peroxisomal matrix
mitochondrion

protein binding
isomerase activity
lyase activity
oxidoreductase activity
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
3-hydroxyacyl-CoA dehydrogenase activity
hydro-lyase activity
sterol transporter activity
sterol carrier activity
estradiol 17-beta-dehydrogenase activity
binding
catalytic activity

1dtzA

[pdb]

0.679234
0.00086648

63^LEU 80^GLU 81^VAL 308^LEU 320^LEU

extracellular region

iron ion transport
ion transport
transport
cellular iron ion homeostasis

metal ion binding
hydrolase activity
serine-type peptidase activity
peptidase activity
iron ion binding
ferric iron binding

1vpvB

[pdb]

0.688879
0.000936516

95^LEU 120^LEU 121^ALA 163^TYR 236^HIS

3c7jB

[pdb]

0.699336
0.00109711

22^HIS 29^GLU 32^LEU 59^SER 70^LEU

0.0.0.0

DNA binding
transcription factor activity
DNA binding
transcription factor activity

intracellular
intracellular

regulation of transcription
DNA-dependent
transcription
regulation of transcription
regulation of transcription
regulation of transcription
DNA-dependent
transcription

2arzA

[pdb]

0.701407
0.0010973

181^LEU 182^ALA 192^LEU 208^LEU 236^TRP

0.0.0.0

FMN binding

3dl8G

[pdb]

0.702515
0.0010974

58^LEU 283^LEU 375^LEU 379^ALA 380^LEU

P-P-bond-hydrolysis-driven protein transmembrane transporter activity
P-P-bond-hydrolysis-driven protein transmembrane transporter activity
metal ion binding
zinc ion binding
ATP binding
nucleotide binding
protein binding
helicase activity
nucleic acid binding

intracellular protein transmembrane transport
protein transport
transport
protein secretion
intracellular protein transmembrane transport
protein transport
transport
intracellular protein transmembrane transport
protein transport
transport
protein import
intracellular protein transport
protein targeting

plasma membrane
integral to membrane
membrane
plasma membrane
integral to membrane
membrane
plasma membrane
cytoplasm
membrane

3d3aA

[pdb]

0.703407
0.00118843

68^ALA 69^LEU 104^LEU 111^TYR 356^LEU

0.0.0.0

beta-galactosidase complex

cell adhesion
carbohydrate metabolic process

hydrolase activity
hydrolyzing O-glycosyl compounds
cation binding
beta-galactosidase activity
catalytic activity

1tpzA

[pdb]

0.705293
0.00118862

62^LEU 284^LEU 285^GLU 309^LEU 316^TYR

GTP binding
nucleotide binding
hydrolase activity
identical protein binding
GDP binding
GTPase activity
hydrolase activity
acting on acid anhydrides

cytokine-mediated signaling pathway

nuclear membrane
endoplasmic reticulum membrane
cytoplasm
Golgi apparatus
endoplasmic reticulum
nucleus
membrane

1i3cB

[pdb]

0.705981
0.00118869

14^VAL 15^GLU 71^LEU 118^LEU 127^LEU

two-component response regulator activity
protein binding

two-component signal transduction system (phosphorelay)
regulation of transcription
DNA-dependent

1ekfB

[pdb]

0.707653
0.00118885

41^VAL 42^GLU 48^TRP 62^HIS 67^SER

2.6.1.42

branched chain family amino acid biosynthetic process
cellular amino acid biosynthetic process
branched chain family amino acid metabolic process
metabolic process

mitochondrion
cytoplasm

transferase activity
transaminase activity
branched-chain-amino-acid transaminase activity
catalytic activity

3busA

[pdb]

0.712478
0.00128805

136^LEU 137^GLU 139^LEU 217^SER 224^LEU

0.0.0.0

metabolic process
metabolic process

transferase activity
methyltransferase activity
transferase activity
methyltransferase activity

1p9nB

[pdb]

0.716829
0.00139531

4^LEU 110^ILE 111^ALA 115^LEU 148^LEU

GTP binding
nucleotide binding
protein binding

Mo-molybdopterin cofactor biosynthetic process

2ch8D

[pdb]

0.717548
0.0013954

44^ILE 45^GLU 59^LEU 103^LEU 108^LEU

0.0.0.0

1i9yA

[pdb]

0.719586
0.00139563

648^LEU 682^VAL 683^ALA 732^HIS 820^TYR

3.1.3.36

cytoplasm
cell division site
cell tip
cytosol
barrier septum

lipid metabolic process
transport
protein transport
inositol lipid-mediated signaling

magnesium ion binding
inositol-polyphosphate 5-phosphatase activity
hydrolase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol or phosphatidylinositol phosphatase activity

2c9kA

[pdb]

0.719942
0.00139567

308^ALA 309^LEU 326^LEU 592^TYR 630^LEU

0.0.0.0

receptor binding

sporulation resulting in formation of a cellular spore
pathogenesis
defense response

1i1rB

[pdb]

0.7215
0.00139585

74^LEU 75^ALA 109^LEU 120^LEU 124^HIS

0.0.0.0

extracellular region
ciliary neurotrophic factor receptor complex
plasma membrane
extracellular region
integral to membrane
membrane
external side of plasma membrane
interleukin-6 receptor complex
oncostatin-M receptor complex
receptor complex

positive regulation of tyrosine phosphorylation of Stat3 protein
immune response
interleukin-27-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
cytokine-mediated signaling pathway
regulation of Notch signaling pathway
positive regulation of cell proliferation
signal transduction
glycogen metabolic process
leukemia inhibitory factor signaling pathway
positive regulation of cardiac muscle hypertrophy
positive regulation vascular endothelial growth factor production
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of T cell proliferation
positive regulation of adaptive immune response
response to cytokine stimulus
positive regulation of anti-apoptosis
positive regulation of osteoblast differentiation
positive regulation of acute inflammatory response

protein homodimerization activity
interleukin-6 receptor binding
cytokine activity
protein binding
ciliary neurotrophic factor receptor binding
receptor activity
cytokine receptor activity
protein binding
interleukin-11 binding
interleukin-11 receptor activity
interleukin-6 receptor activity
interleukin-27 receptor activity
receptor binding
interleukin-6 binding
growth factor binding
oncostatin-M receptor activity
ciliary neurotrophic factor receptor activity
leukemia inhibitory factor receptor activity

2cbzA

[pdb]

0.724952
0.00151152

740^VAL 743^ALA 795^LEU 801^HIS 816^MET

ATPase activity
ATP binding
nucleotide binding
transporter activity
ATPase activity
coupled to transmembrane movement of substances
nucleoside-triphosphatase activity
hydrolase activity

membrane
integral to membrane
integral to plasma membrane
membrane fraction
plasma membrane

transport
response to drug

2v5qB

[pdb]

0.728607
0.00151197

148^LEU 155^TYR 277^VAL 278^ALA 281^LEU

2.7.11.21

cell division
mitosis
cell cycle
positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
cell proliferation
protein amino acid phosphorylation

nucleus
cytosol
nucleoplasm
centrosome

transferase activity
kinase activity
ATP binding
protein serine/threonine kinase activity
nucleotide binding
protein kinase activity
polo kinase kinase activity
protein binding

2p4oA

[pdb]

0.728999
0.00151202

76^LEU 84^LEU 86^ALA 112^LEU 141^LEU

0.0.0.0

1fnzA

[pdb]

0.730278
0.00163628

24^ALA 25^LEU 32^LEU 44^SER 103^LEU

binding
metal ion binding
manganese ion binding
sugar binding
calcium ion binding

3c65A

[pdb]

0.733832
0.00163676

382^GLU 398^LEU 400^VAL 440^LEU 472^LEU

SOS response
response to DNA damage stimulus
DNA repair
nucleotide-excision repair

cytoplasm
excinuclease repair complex
intracellular

nuclease activity
sequence-specific DNA binding
excinuclease ABC activity
DNA binding

1x1cA

[pdb]

0.734263
0.00163682

27^MET 30^ALA 31^ILE 46^LEU 81^SER

0.0.0.0

transferase activity
methyltransferase activity
O-methyltransferase activity

1l7vB

[pdb]

0.736569
0.00177049

133^GLN 141^VAL 216^ARG 218^GLU 219^GLU

0.0.0.0

plasma membrane
integral to membrane
membrane
plasma membrane
membrane

transport
cobalamin transport
transport
cobalamin transport

transporter activity
cobalamin transporter activity
hydrolase activity
ATP binding
nucleotide binding
cobalamin-transporting ATPase activity
nucleoside-triphosphatase activity
ATPase activity

2uxdD

[pdb]

0.738568
0.00177077

19^MG 58^MG 60^MG 68^MG 202^LEU

rRNA binding
RNA binding
structural constituent of ribosome
metal ion binding
rRNA binding
zinc ion binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
tRNA binding
RNA binding
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
rRNA binding
RNA binding
tRNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
metal ion binding
rRNA binding
zinc ion binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
tRNA binding
structural constituent of ribosome
structural constituent of ribosome
rRNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
tRNA binding
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
tRNA binding
structural constituent of ribosome
rRNA binding
RNA binding
tRNA binding
structural constituent of ribosome
nucleic acid binding

ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
intracellular

translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation
translation

1gkzA

[pdb]

0.739068
0.00177085

139^LEU 140^ALA 143^LEU 334^HIS 340^LEU

2.7.11.4

branched chain family amino acid catabolic process
peptidyl-histidine phosphorylation
phosphorylation
signal transduction

mitochondrial matrix
mitochondrion
mitochondrial alpha-ketoglutarate dehydrogenase complex

transferase activity
kinase activity
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
transferase activity
transferring phosphorus-containing groups
ATP binding
protein histidine kinase activity
two-component sensor activity
protein serine/threonine kinase activity
nucleotide binding

2pljA

[pdb]

0.74079
0.00177109

18^LEU 22^GLU 23^ILE 38^LEU 387^LEU

0.0.0.0

catalytic activity

polyamine biosynthetic process

1dpeA

[pdb]

0.749264
0.00191546

32^LEU 37^VAL 38^GLU 150^LEU 500^HIS

oligopeptide transporter activity
transporter activity

periplasmic space

protein transport
chemotaxis
oligopeptide transport
transport
peptide transport

1v04A

[pdb]

0.749306
0.00191547

58^LEU 90^LEU 281^TRP 333^VAL 334^ALA

3.1.8.1, 3.1.1.2

extracellular region
extracellular region
extracellular region
microsome
extracellular space
cytoskeleton
cytoplasm
extracellular region
microsome
extracellular space
high-density lipoprotein particle
spherical high-density lipoprotein particle
extracellular space
high-density lipoprotein particle
high-density lipoprotein particle
extracellular space
microsome
high-density lipoprotein particle

hydrolase activity
lipid transporter activity
arylesterase activity
aryldialkylphosphatase activity
arylesterase activity
aryldialkylphosphatase activity
antioxidant activity
hydrolase activity
lipid transporter activity
hydrolase activity
lipid transporter activity
arylesterase activity
aryldialkylphosphatase activity
high-density lipoprotein binding
arylesterase activity
hydrolase activity
lipid transporter activity
aryldialkylphosphatase activity
phospholipid binding
protein homodimerization activity

response to organophosphorus
response to toxin
cholesterol metabolic process
blood circulation
lipid metabolic process
response to external stimulus
response to toxin
lipid metabolic process
positive regulation of cholesterol efflux
aromatic compound catabolic process
positive regulation of transporter activity
carboxylic acid catabolic process
organophosphate catabolic process
phosphatidylcholine metabolic process
positive regulation of binding
negative regulation of plasma lipoprotein oxidation
lipid metabolic process
response to toxin

1iqcD

[pdb]

0.749534
0.0019155

167^LEU 171^GLU 172^LEU 233^LEU 251^LEU

1.11.1.5

metal ion binding
oxidoreductase activity
iron ion binding
peroxidase activity
cytochrome-c peroxidase activity
heme binding
electron carrier activity

oxidation reduction
electron transport chain
transport

periplasmic space

2ct9B

[pdb]

0.752321
0.00206922

38^LEU 58^ALA 59^ILE 62^LEU 201^LEU

0.0.0.0

cytoplasm
cytosol

metal ion binding
calcium ion binding

transcytosis
calcium-mediated signaling
calcium ion-dependent exocytosis

1vs3A

[pdb]

0.753893
0.00206948

58^LEU 110^TYR 115^LEU 128^ALA 129^LEU

5.4.99.12

RNA binding
isomerase activity
pseudouridine synthase activity

RNA modification
tRNA processing
pseudouridine synthesis
tRNA pseudouridine synthesis

3c4nA

[pdb]

0.757098
0.00223392

191^LEU 196^GLU 197^LEU 207^LEU 239^LEU

0.0.0.0

oxidoreductase activity

2jwxA

[pdb]

0.764784
0.00241025

20^LEU 21^ALA 23^MET 90^LEU 105^LEU

0.0.0.0

isomerase activity
calcium ion binding
peptidyl-prolyl cis-trans isomerase activity
binding

mitochondrial membrane
integral to membrane
membrane
mitochondrion
integral to endoplasmic reticulum membrane
mitochondrial envelope

regulation of gene expression
dorsal/ventral neural tube patterning
neural tube development
regulation of BMP signaling pathway
positive regulation of BMP signaling pathway
multicellular organism growth
interspecies interaction between organisms
apoptosis
protein folding
intracellular signaling cascade
camera-type eye development
dorsal/ventral pattern formation
smoothened signaling pathway
cell fate specification

1tpyA

[pdb]

0.767074
0.00241068

34^SER 231^HIS 240^ALA 243^LEU 263^MET

0.0.0.0

lipid biosynthetic process

transferase activity
methyltransferase activity
cyclopropane-fatty-acyl-phospholipid synthase activity

1mioB

[pdb]

0.768398
0.00241093

29^MET 32^ALA 33^LEU 133^LEU 161^LEU

1.18.6.1

iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
nitrogenase activity
iron-sulfur cluster binding
metal ion binding
molybdenum ion binding
oxidoreductase activity
iron ion binding
nitrogenase activity
nucleotide binding
ATP binding
nucleotide binding
ATP binding

molybdenum-iron nitrogenase complex
molybdenum-iron nitrogenase complex

oxidation reduction
nitrogen fixation
oxidation reduction
nitrogen fixation

3etkA

[pdb]

0.769427
0.00241112

207^ILE 210^GLU 213^LEU 241^SER 271^LEU

0.0.0.0

endodeoxyribonuclease activity
producing 5'-phosphomonoesters
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds

1itfA

[pdb]

0.770823
0.0025978

15^LEU 26^LEU 80^LEU 141^GLU 142^VAL

cytokine activity
interferon-alpha/beta receptor binding
cytokine receptor binding

extracellular region
extracellular space

response to virus
inflammatory response
cell-cell signaling
cell surface receptor linked signal transduction
induction of apoptosis
defense response

1s1mB

[pdb]

0.775554
0.00259874

453^LEU 478^LEU 497^LEU 502^GLU 510^VAL

6.3.4.2

cytosol

glutamine metabolic process
pyrimidine nucleotide biosynthetic process

ligase activity
CTP synthase activity
catalytic activity
nucleotide binding
ATP binding

1ku2A

[pdb]

0.776143
0.00259886

100^LEU 109^LEU 202^LEU 205^ALA 212^SER

0.0.0.0

regulation of transcription
regulation of transcription
DNA-dependent
transcription
transcription initiation

sigma factor activity
DNA binding
transcription factor activity

1uf4A

[pdb]

0.776101
0.00259885

30^MET 195^TYR 244^LEU 267^GLU 268^VAL

3.5.1.77

hydrolase activity
N-carbamoyl-D-amino acid hydrolase activity
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds

nitrogen compound metabolic process

2vz9A

[pdb]

0.781281
0.00279816

454^LEU 457^ILE 458^ALA 570^LEU 803^LEU

0.0.0.0

cofactor binding
phosphopantetheine binding
hydrolase activity
acting on ester bonds
transferase activity
oxidoreductase activity
zinc ion binding
binding
catalytic activity
acyl carrier activity

oxidation reduction
biosynthetic process
metabolic process

2ef0A

[pdb]

0.781662
0.00279824

12^LEU 130^SER 171^LEU 172^GLU 195^LEU

0.0.0.0

cellular amino acid metabolic process

ornithine carbamoyltransferase complex

transferase activity
carboxyl- or carbamoyltransferase activity
amino acid binding
ornithine carbamoyltransferase activity

1t60F

[pdb]

0.782607
0.00279844

7^LEU 113^VAL 114^ALA 118^HIS 154^SER

0.0.0.0

basement membrane
proteinaceous extracellular matrix
extracellular region
collagen
collagen type IV
basement membrane
proteinaceous extracellular matrix
extracellular region
collagen

binding
extracellular matrix structural constituent
binding
extracellular matrix structural constituent

2rkbB

[pdb]

0.783153
0.00300896

202^HIS 210^ALA 216^LEU 229^LEU 239^LEU

biological adhesion
metabolic process
cellular amino acid metabolic process

cellular_component

molecular_function
lyase activity
pyridoxal phosphate binding
catalytic activity

1j3yD

[pdb]

0.788273
0.00301007

81^LEU 91^LEU 137^VAL 140^ALA 146^HIS

hemoglobin binding
oxygen binding
protein binding
oxygen transporter activity
metal ion binding
iron ion binding
heme binding
protein binding
metal ion binding
iron ion binding
oxygen transporter activity
heme binding
oxygen binding

hemoglobin complex
hemoglobin complex
cytosolic small ribosomal subunit

oxygen transport
positive regulation of nitric oxide biosynthetic process
nitric oxide transport
regulation of blood vessel size
regulation of blood pressure
transport
oxygen transport
transport

1yt3A

[pdb]

0.791025
0.00322731

225^LEU 233^LEU 263^LEU 267^GLU 268^ILE

3.1.13.5

cytoplasm
intracellular

nucleic acid binding
protein binding
hydrolase activity
exonuclease activity
nuclease activity
ribonuclease D activity
3'-5' exonuclease activity
ribonuclease activity

tRNA processing
nucleobase
nucleoside
nucleotide and nucleic acid metabolic process

2vl0E

[pdb]

0.792034
0.00322754

219^TRP 228^SER 272^ILE 275^ALA 283^HIS

ion channel activity
neurotransmitter receptor activity
extracellular ligand-gated ion channel activity

ion transport
transport

membrane
integral to membrane
postsynaptic membrane

2j8mA

[pdb]

0.792476
0.00322764

56^LEU 87^SER 111^ALA 116^LEU 165^LEU

0.0.0.0

N-acetyltransferase activity

metabolic process

1fnoA

[pdb]

0.794742
0.00322815

34^LEU 47^LEU 50^ILE 60^ALA 78^HIS

3.4.11.4

cytoplasm

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
aminopeptidase activity
tripeptide aminopeptidase activity
protein dimerization activity

peptide metabolic process
proteolysis

2alrA

[pdb]

0.795406
0.0032283

7^LEU 146^LEU 176^SER 180^ALA 204^LEU

1.1.1.2

apical plasma membrane
cytosol

electron carrier activity
oxidoreductase activity
alcohol dehydrogenase (NADP+) activity
aldehyde reductase activity
protein binding
L-glucuronate reductase activity

oxidation reduction
cellular aldehyde metabolic process
glucose metabolic process
aldehyde catabolic process
D-glucuronate catabolic process
L-ascorbic acid biosynthetic process

1pjcA

[pdb]

0.798831
0.00345214

135^ILE 136^ALA 173^LEU 239^LEU 300^MET

0.0.0.0

oxidation reduction
metabolic process

oxidoreductase activity
alanine dehydrogenase activity
electron carrier activity
binding
catalytic activity

3efeF

[pdb]

0.798918
0.00345216

22^LEU 25^GLU 26^LEU 183^LEU 204^LEU

0.0.0.0

1v26A

[pdb]

0.799125
0.00345221

203^LEU 206^LEU 207^ALA 324^TYR 359^LEU

0.0.0.0

ligase activity
catalytic activity

metabolic process

1vcgB

[pdb]

0.800755
0.0034526

57^LEU 120^LEU 206^LEU 208^ALA 209^VAL

0.0.0.0

cytoplasm
cytoplasm

isomerase activity
isopentenyl-diphosphate delta-isomerase activity
oxidoreductase activity
FMN binding
catalytic activity
isomerase activity
oxidoreductase activity
FMN binding
isopentenyl-diphosphate delta-isomerase activity
catalytic activity

isoprenoid biosynthetic process
metabolic process
isoprenoid biosynthetic process
metabolic process

2ieeA

[pdb]

0.802136
0.00345293

31^LEU 46^LEU 76^LEU 87^ALA 212^VAL

plasma membrane
membrane
outer membrane-bounded periplasmic space

transport

transporter activity

1v3uA

[pdb]

0.803054
0.00345314

29^LEU 41^ALA 42^LEU 44^LEU 97^SER

1.3.1.74, 1.3.1.48

cytoplasm

oxidation reduction
metabolic process

oxidoreductase activity
15-oxoprostaglandin 13-oxidase activity
2-alkenal reductase activity
zinc ion binding
binding
catalytic activity

1vdhE

[pdb]

0.803713
0.00368927

12^LEU 13^GLU 83^LEU 114^LEU 193^LEU

2htdB

[pdb]

0.803927
0.00368932

4^LEU 9^LEU 24^LEU 69^VAL 70^ALA

0.0.0.0

FMN binding
FMN binding

2vpzC

[pdb]

0.804069
0.00368936

16^THR 27^ALA 232^LEU 240^LEU 243^LEU

0.0.0.0

iron ion binding
metal ion binding
4 iron
4 sulfur cluster binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
molybdenum ion binding
oxidoreductase activity
iron ion binding
binding
iron-sulfur cluster binding
electron carrier activity

oxidation reduction

1k3uB

[pdb]

0.804184
0.00368939

48^LEU 96^LEU 117^VAL 120^ALA 152^MET

4.2.1.20

aromatic amino acid family biosynthetic process
cellular amino acid biosynthetic process
tryptophan biosynthetic process
metabolic process
tryptophan metabolic process
aromatic amino acid family biosynthetic process
cellular amino acid biosynthetic process
tryptophan biosynthetic process
metabolic process
tryptophan metabolic process

lyase activity
tryptophan synthase activity
pyridoxal phosphate binding
catalytic activity
protein binding
lyase activity
catalytic activity
tryptophan synthase activity
protein binding

3ebgA

[pdb]

0.8041
0.00368936

1011^HIS 1022^ALA 1025^ILE 1045^LEU 1064^MET

0.0.0.0

aminopeptidase activity
metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity

cytoplasm

proteolysis

2fl0B

[pdb]

0.804862
0.00368956

18^GLU 19^LEU 52^MET 91^LEU 98^LEU

0.0.0.0

cellular iron ion homeostasis
iron ion transport

metal ion binding
iron ion binding
transition metal ion binding
oxidoreductase activity
ferric iron binding

1vixA

[pdb]

0.80533
0.00368967

34^LEU 47^LEU 50^VAL 60^ALA 78^HIS

3.4.11.4

cytoplasm

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
aminopeptidase activity
tripeptide aminopeptidase activity
protein dimerization activity

peptide metabolic process
proteolysis

1l1eB

[pdb]

0.805596
0.00368974

34^SER 231^HIS 240^ALA 243^LEU 263^MET

0.0.0.0

lipid biosynthetic process

transferase activity
cyclopropane-fatty-acyl-phospholipid synthase activity

1yspA

[pdb]

0.806269
0.00368991

27^LEU 34^TYR 123^ILE 124^ALA 159^LEU

DNA binding

regulation of transcription
regulation of transcription
DNA-dependent
transcription

3d3lA

[pdb]

0.806514
0.00368997

281^LEU 296^LEU 297^ALA 325^SER 330^LEU

1.13.11.31

cytosol
sarcolemma
cytoplasm

fatty acid oxidation
anti-apoptosis
positive regulation of cell proliferation
cell motion
positive regulation of cell adhesion
positive regulation of cell growth
oxygen and reactive oxygen species metabolic process
superoxide anion generation
oxidation reduction
leukotriene biosynthetic process
leukotriene metabolic process

hepoxilin-epoxide hydrolase activity
arachidonate 12-lipoxygenase activity
metal ion binding
oxidoreductase activity
acting on single donors with incorporation of molecular oxygen
incorporation of two atoms of oxygen
oxidoreductase activity
iron ion binding
lipoxygenase activity
protein binding

1q8iA

[pdb]

0.807467
0.00369021

154^SER 296^VAL 297^ALA 300^LEU 333^LEU

2.7.7.7

SOS response
response to DNA damage stimulus
DNA repair
DNA replication
nucleobase
nucleoside
nucleotide and nucleic acid metabolic process

nucleotidyltransferase activity
transferase activity
DNA-directed DNA polymerase activity
DNA binding
nucleic acid binding
nucleotide binding
protein binding

1l5jB

[pdb]

0.808298
0.00369042

5^TYR 17^ILE 18^ALA 48^LEU 196^LEU

4.2.1.3

4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
lyase activity
iron ion binding
aconitate hydratase activity
protein binding

tricarboxylic acid cycle
metabolic process

2pw9C

[pdb]

0.808545
0.00369048

123^LEU 196^TYR 201^LEU 210^ALA 212^ILE

0.0.0.0

cytoplasm
formate dehydrogenase complex

formate dehydrogenase activity

1vrmA

[pdb]

0.809309
0.00369067

56^SER 76^LEU 189^LEU 192^ILE 193^ALA

0.0.0.0

thiamin biosynthetic process

1xupO

[pdb]

0.809704
0.00369077

106^SER 313^ALA 314^ILE 317^LEU 352^LEU

2.7.1.30

glycerol metabolic process
glycerol-3-phosphate metabolic process
carbohydrate metabolic process

transferase activity
kinase activity
ATP binding
nucleotide binding
glycerol kinase activity
phosphotransferase activity
alcohol group as acceptor

1htyA

[pdb]

0.809867
0.00394011

678^LEU 752^LEU 775^GLU 776^ILE 894^LEU

3.2.1.114

Golgi membrane
integral to membrane
membrane
Golgi apparatus
Golgi stack
endoplasmic reticulum

metabolic process
mannose metabolic process
carbohydrate metabolic process

metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
zinc ion binding
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
cation binding
carbohydrate binding
mannosidase activity
alpha-mannosidase activity
catalytic activity
hydrolase activity
hydrolyzing O-glycosyl compounds

1zsvA

[pdb]

0.809881
0.00394011

29^LEU 41^ALA 42^LEU 44^LEU 97^SER

1.3.1.48, 1.3.1.74

2-alkenal reductase activity
15-oxoprostaglandin 13-oxidase activity
oxidoreductase activity
zinc ion binding
binding
catalytic activity
alcohol dehydrogenase (NAD) activity

cytoplasm

oxidation reduction
metabolic process
leukotriene metabolic process

1w98B

[pdb]

0.810134
0.00394018

153^LEU 187^LEU 212^LEU 215^GLU 216^LEU

0.0.0.0

cell division
mitosis
cell cycle
DNA replication
positive regulation of cell proliferation
G2/M transition of mitotic cell cycle
traversing start control point of mitotic cell cycle
regulation of DNA replication
protein amino acid phosphorylation
androgen receptor signaling pathway
positive regulation of transcription
DNA-dependent
G1/S transition of mitotic cell cycle
cell division
cell cycle

cyclin-dependent protein kinase holoenzyme complex
cytosol
nucleoplasm
nucleus
cytoplasm
nucleus
cytosol
nucleoplasm

histone kinase activity
protein binding
transferase activity
kinase activity
ATP binding
protein serine/threonine kinase activity
nucleotide binding
cyclin-dependent protein kinase activity
protein kinase activity
identical protein binding
androgen receptor binding
transcription coactivator activity
protein binding

2g9dA

[pdb]

0.81047
0.00394027

154^LEU 195^LEU 219^GLU 220^LEU 325^LEU

3.5.1.96

arginine metabolic process
metabolic process
arginine catabolic process to glutamate

metal ion binding
hydrolase activity
zinc ion binding
succinylglutamate desuccinylase activity
hydrolase activity
acting on ester bonds

1r5mA

[pdb]

0.815519
0.0039416

151^LEU 197^TYR 200^LEU 534^ALA 535^ILE

chromatin modification
negative regulation of meiosis
positive regulation of stress-activated MAPK cascade
histone deacetylation
chromatin silencing at telomere

nucleus
Set3 complex
Rpd3L-Expanded complex

protein binding

1lnsA

[pdb]

0.818453
0.00420566

144^LEU 158^LEU 159^ALA 166^LEU 197^SER

3.4.14.11

cytoplasm

hydrolase activity
serine-type peptidase activity
peptidase activity
aminopeptidase activity
dipeptidyl-peptidase activity

proteolysis

2gq0B

[pdb]

0.819314
0.0042059

423^MET 455^ILE 456^GLU 460^LEU 482^SER

ATP binding
nucleotide binding
unfolded protein binding
protein binding

cytosol
plasma membrane
cytoplasm
membrane

response to stress
protein folding

1yycA

[pdb]

0.819905
0.00420607

124^ALA 125^VAL 127^LEU 139^TYR 167^LEU

plasma membrane

response to desiccation

1qyiA

[pdb]

0.821208
0.00420643

328^LEU 354^LEU 359^ALA 369^LEU 376^LEU

0.0.0.0

3caaA

[pdb]

0.822957
0.00420692

66^LEU 68^ALA 73^LEU 330^SER 358^LEU

extracellular region
nucleus
intracellular

peptidase inhibitor activity
serine-type endopeptidase inhibitor activity
protein binding
DNA binding
chymotrypsin inhibitor activity
endopeptidase inhibitor activity

regulation of lipid metabolic process
inflammatory response
acute-phase response

1sqvC

[pdb]

0.823263
0.004485

281^LEU 292^LEU 293^ALA 301^LEU 363^LEU

0.0.0.0

electron transport chain
transport
oxidation reduction
electron transport chain
transport
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
proteolysis
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
proteolysis
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
respiratory electron transport chain

mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial membrane
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial envelope
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion

ubiquinol-cytochrome-c reductase activity
2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
ubiquinol-cytochrome-c reductase activity
electron carrier activity
electron carrier activity
ubiquinol-cytochrome-c reductase activity
oxidoreductase activity
acting on diphenols and related substances as donors
metal ion binding
zinc ion binding
metalloendopeptidase activity
catalytic activity
ubiquinol-cytochrome-c reductase activity
metal ion binding
iron ion binding
heme binding
electron carrier activity
ubiquinol-cytochrome-c reductase activity
metal ion binding
zinc ion binding
metalloendopeptidase activity
catalytic activity
ubiquinol-cytochrome-c reductase activity
metal ion binding
iron ion binding
oxidoreductase activity
electron carrier activity

1ukpA

[pdb]

0.827094
0.00448613

293^ALA 294^ILE 339^LEU 461^LEU 464^SER

3.2.1.2

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-amylase activity
cation binding
catalytic activity

metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

1t11B

[pdb]

0.827571
0.00448628

187^LEU 278^LEU 294^LEU 299^GLU 300^ILE

cell division
cell cycle
protein folding
protein transport

isomerase activity
peptidyl-prolyl cis-trans isomerase activity

1cs6A

[pdb]

0.828464
0.00448654

140^TYR 166^LEU 233^LEU 234^GLU 265^LEU

0.0.0.0

cell adhesion
neuron adhesion

plasma membrane
anchored to membrane
membrane

protein binding
cell adhesion molecule binding