The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
1dctA	[pdb]	0.460695 3.49125e-05	70^PRO 71^CYS 75^SER 109^GLU 153^ARG 155^ARG	2.1.1.37		DNA restriction-modification system DNA methylation	transferase activity methyltransferase activity DNA (cytosine-5-)-methyltransferase activity DNA binding
2qrvD	[pdb]	0.605656 8.92675e-05	705^PRO 706^CYS 710^SER 752^GLU 786^ARG 788^ARG	0.0.0.0	DNA methylation genetic imprinting spermatogenesis in utero embryonic development DNA methylation genetic imprinting	cytosol nucleus cytoplasm nuclear heterochromatin condensed nuclear chromosome nuclear matrix euchromatin cytoplasm nucleus	transcription repressor activity enzyme binding metal ion binding zinc ion binding enzyme activator activity protein binding DNA (cytosine-5-)-methyltransferase activity metal ion binding transferase activity zinc ion binding methyltransferase activity DNA binding protein binding
2jimA	[pdb]	1.07906 0.000159115	540^ARG 542^ARG 549^LEU 552^PRO 553^CYS 555^SER	1.7.99.4	4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding molybdenum ion binding oxidoreductase activity iron ion binding nitrate reductase activity binding electron carrier activity	oxidation reduction nitrate assimilation electron transport chain transport Mo-molybdopterin cofactor biosynthetic process	periplasmic space
1zejA	[pdb]	1.33412 0.000263588	81^ARG 84^GLU 90^PRO 92^CYS 93^SER 106^ARG	0.0.0.0		coenzyme binding oxidoreductase activity binding catalytic activity	metabolic process fatty acid metabolic process
2gjxA	[pdb]	1.43443 0.000440831	59^SER 102^PRO 104^CYS 107^LEU 247^ARG 249^ARG	3.2.1.52	hydrolase activity acting on glycosyl bonds hydrolase activity beta-N-acetylhexosaminidase activity protein heterodimerization activity cation binding catalytic activity protein binding hydrolase activity acting on glycosyl bonds hydrolase activity beta-N-acetylhexosaminidase activity protein heterodimerization activity protein homodimerization activity cation binding catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolyzing O-glycosyl compounds	lysosome membrane lysosome membrane acrosomal vesicle	metabolic process carbohydrate metabolic process neuromuscular process controlling balance neuromuscular process controlling posture myelination glycosaminoglycan metabolic process sexual reproduction lipid storage adult walking behavior locomotory behavior sensory perception of sound lysosome organization ganglioside catabolic process skeletal system development metabolic process carbohydrate metabolic process neuromuscular process neuromuscular process controlling balance oogenesis cellular protein metabolic process myelination regulation of cellular metabolic process glycosaminoglycan metabolic process sexual reproduction lipid storage oligosaccharide catabolic process phospholipid biosynthetic process male courtship behavior locomotory behavior sensory perception of sound penetration of zona pellucida single fertilization lysosome organization cellular calcium ion homeostasis ganglioside catabolic process glycosphingolipid metabolic process skeletal system development
2nxoD	[pdb]	1.47188 0.000552928	41^GLU 109^ARG 113^ARG 131^THR 132^CYS 133^PRO	0.0.0.0
2a4dA	[pdb]	1.47517 0.000579599	87^ARG 90^ARG 120^THR 145^CYS 151^GLU 154^PRO		cell differentiation regulation of transcription DNA-dependent ubiquitin-dependent protein catabolic process regulation of DNA repair protein polyubiquitination regulation of protein metabolic process post-translational protein modification positive regulation of NF-kappaB transcription factor activity positive regulation of I-kappaB kinase/NF-kappaB cascade modification-dependent protein catabolic process	nucleus ubiquitin conjugating enzyme complex cytoplasm	transcription activator activity small conjugating protein ligase activity protein binding
2hlwA	[pdb]	1.47789 0.000579677	36^ARG 39^ARG 69^THR 94^CYS 100^GLU 103^PRO		cell differentiation regulation of transcription DNA-dependent ubiquitin-dependent protein catabolic process regulation of DNA repair protein polyubiquitination regulation of protein metabolic process post-translational protein modification positive regulation of NF-kappaB transcription factor activity positive regulation of I-kappaB kinase/NF-kappaB cascade modification-dependent protein catabolic process	nucleus ubiquitin conjugating enzyme complex cytoplasm	transcription activator activity small conjugating protein ligase activity protein binding
1j7dA	[pdb]	1.48986 0.000638082	11^GLU 14^ARG 44^ASP 69^VAL 75^ILE 78^PRO		T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity response to DNA damage stimulus ubiquitin-dependent protein catabolic process DNA repair proteolysis regulation of DNA repair regulation of protein metabolic process protein ubiquitination regulation of histone ubiquitination positive regulation of ubiquitin-protein ligase activity positive regulation of histone modification postreplication repair DNA double-strand break processing double-strand break repair via homologous recombination histone ubiquitination positive regulation of DNA repair positive regulation of I-kappaB kinase/NF-kappaB cascade ubiquitin cycle protein modification process post-translational protein modification ubiquitin cycle ubiquitin-dependent protein catabolic process cell proliferation regulation of DNA repair protein polyubiquitination regulation of protein metabolic process post-translational protein modification DNA double-strand break processing protein ubiquitination modification-dependent protein catabolic process modification-dependent protein catabolic process	cytoplasm UBC13-MMS2 complex nucleus cytoplasm nucleus UBC13-MMS2 complex	ligase activity ubiquitin-protein ligase activity small conjugating protein ligase activity protein binding ubiquitin binding protein binding small conjugating protein ligase activity nucleotide binding ATP binding
1rrsA	[pdb]	1.51207 0.00073623	149^ARG 153^ARG 154^LEU 204^SER 208^CYS 209^PRO	0.0.0.0	hydrolase activity acting on glycosyl bonds hydrolase activity 4 iron 4 sulfur cluster binding DNA N-glycosylase activity endonuclease activity catalytic activity DNA binding	intracellular	metabolic process DNA repair base-excision repair
2pmzY	[pdb]	1.54021 0.000889542	4^PRO 7^GLY 9^CYS 42^ILE 46^LYS 49^LEU	2.7.7.6	nucleus nucleus RNA polymerase complex	transcription transcription transcription DNA-dependent transcription transcription transcription DNA-dependent transcription transcription DNA-dependent transcription transcription transcription DNA-dependent transcription regulation of transcription transcription DNA-dependent cellular metabolic process transcription transcription transcription DNA-dependent transcription DNA-dependent transcription	zinc ion binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity ribonucleoside binding DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity DNA binding metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity protein dimerization activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity RNA binding DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity protein dimerization activity DNA binding metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity catalytic activity nucleotide binding transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding metal ion binding nucleotidyltransferase activity DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity
2v65A	[pdb]	1.54221 0.000889628	157^ARG 159^ARG 274^LEU 290^PRO 291^CYS 299^THR	1.1.1.27	cytoplasm	oxidation reduction glycolysis cellular carbohydrate metabolic process anaerobic glycolysis metabolic process carbohydrate metabolic process	oxidoreductase activity L-lactate dehydrogenase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor binding catalytic activity
2o7dE	[pdb]	1.54464 0.000932703	238^ARG 240^ARG 242^GLU 301^SER 304^CYS 306^PRO	0.0.0.0		biosynthetic process	lyase activity histidine ammonia-lyase activity ammonia ligase activity catalytic activity
2jndA	[pdb]	1.54965 0.00093293	69^THR 81^GLU 83^PRO 84^CYS 101^ARG 112^ARG	0.0.0.0	G-protein coupled receptor activity receptor activity signal transducer activity corticotrophin-releasing factor receptor activity protein binding hormone activity transmembrane receptor activity	G-protein coupled receptor protein signaling pathway signal transduction negative regulation of angiogenesis cell surface receptor linked signal transduction	plasma membrane integral to membrane membrane
1ml0D	[pdb]	1.562 0.00102571	29^ARG 30^ARG 33^SER 36^CYS 37^PRO 39^GLU	0.0.0.0	anti-apoptosis inflammatory response chemotaxis G-protein signaling coupled to cyclic nucleotide second messenger cell adhesion protein amino acid phosphorylation viral genome replication organ morphogenesis JAK-STAT cascade G-protein coupled receptor protein signaling pathway cell surface receptor linked signal transduction signal transduction humoral immune response cellular calcium ion homeostasis immune response vascular endothelial growth factor receptor signaling pathway cytokine-mediated signaling pathway transforming growth factor beta receptor signaling pathway positive regulation of endothelial cell proliferation response to bacterium macrophage chemotaxis monocyte chemotaxis	extracellular region extracellular space cell soma cytoplasm	protein binding cytokine activity chemokine activity signal transducer activity receptor binding protein kinase activity protein binding CCR2 chemokine receptor binding G-protein-coupled receptor binding
1v6aA	[pdb]	1.56904 0.0010754	155^ARG 157^ARG 276^LEU 292^PRO 293^CYS 301^THR	1.1.1.27	cytoplasm	oxidation reduction glycolysis cellular carbohydrate metabolic process anaerobic glycolysis metabolic process carbohydrate metabolic process	oxidoreductase activity L-lactate dehydrogenase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor binding catalytic activity
3flvB	[pdb]	1.58621 0.00123222	46^PRO 47^CYS 49^LEU 51^ARG 60^ARG 68^SER	0.0.0.0	lipid binding binding acyl-CoA binding	membrane integral to membrane	transport
1pp9A	[pdb]	1.60427 0.00134814	46^ILE 92^PRO 161^HIS 231^LYS 233^ARG 234^LYS		electron transport chain transport respiratory electron transport chain mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport proteolysis electron transport chain transport proteolysis electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport oxidation reduction electron transport chain transport electron transport chain transport	metal ion binding iron ion binding oxidoreductase activity electron carrier activity oxidoreductase activity acting on diphenols and related substances as donors ubiquinol-cytochrome-c reductase activity ubiquinol-cytochrome-c reductase activity metal ion binding zinc ion binding metalloendopeptidase activity catalytic activity metal ion binding zinc ion binding metalloendopeptidase activity catalytic activity ubiquinol-cytochrome-c reductase activity metal ion binding iron ion binding heme binding electron carrier activity 2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding ubiquinol-cytochrome-c reductase activity electron carrier activity ubiquinol-cytochrome-c reductase activity	mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial envelope mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion
2hcyA	[pdb]	1.60794 0.00140945	150^PRO 153^CYS 157^THR 298^ARG 302^ARG 305^LEU	1.1.1.1	metal ion binding oxidoreductase activity zinc ion binding alcohol dehydrogenase (NAD) activity methylglyoxal reductase (NADH-dependent) activity binding catalytic activity protein binding	oxidation reduction ethanol biosynthetic process during fermentation NADH oxidation amino acid catabolic process to alcohol via Ehrlich pathway metabolic process	plasma membrane enriched fraction cytoplasm
2qtzA	[pdb]	1.61014 0.00140959	385^LEU 399^ARG 400^ARG 433^SER 434^CYS 436^PRO	1.16.1.8	NADP or NADPH binding FAD binding FMN binding [methionine synthase] reductase activity oxidoreductase activity electron carrier activity iron ion binding	cytosol cytoplasm mitochondrion	oxidation reduction methionine metabolic process methionine biosynthetic process cellular amino acid biosynthetic process
1guzC	[pdb]	1.61233 0.00140973	146^LEU 150^ARG 169^CYS 185^THR 207^ARG 248^PRO	1.1.1.37		oxidation reduction tricarboxylic acid cycle cellular carbohydrate metabolic process metabolic process malate metabolic process glycolysis carbohydrate metabolic process oxidation reduction tricarboxylic acid cycle cellular carbohydrate metabolic process metabolic process malate metabolic process glycolysis carbohydrate metabolic process oxidation reduction tricarboxylic acid cycle cellular carbohydrate metabolic process metabolic process malate metabolic process glycolysis carbohydrate metabolic process	oxidoreductase activity L-malate dehydrogenase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor binding catalytic activity oxidoreductase activity L-malate dehydrogenase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor binding catalytic activity oxidoreductase activity L-malate dehydrogenase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor binding catalytic activity
2jcvB	[pdb]	1.62967 0.00160955	321^CYS 323^THR 365^PRO 372^LEU 376^ARG 381^ARG	1.1.1.267		metal ion binding oxidoreductase activity 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity binding catalytic activity	oxidation reduction isoprenoid biosynthetic process metabolic process terpenoid biosynthetic process
2o6xA	[pdb]	1.63285 0.00160978	217^GLU 250^SER 255^PRO 293^ARG 296^ARG 302^CYS	0.0.0.0	cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity cysteine-type endopeptidase activity hydrolase activity cysteine-type peptidase activity peptidase activity peptidase activity hydrolase activity	extracellular region	proteolysis proteolysis
2gh0B	[pdb]	1.64281 0.00175505	274^PRO 284^GLU 287^ARG 290^ARG 340^CYS 342^THR		nervous system development peripheral nervous system development signal transduction neuron development sympathetic nervous system development axon guidance neuron migration neuroblast proliferation signal transduction induction of positive chemotaxis peripheral nervous system development axon guidance	plasma membrane anchored to membrane membrane extrinsic to membrane external side of plasma membrane extracellular region extracellular space	receptor activity receptor binding axon guidance receptor activity protein binding growth factor activity receptor binding protein binding
3fhcA	[pdb]	1.65562 0.0019077	20^ARG 293^ASN 294^VAL 324^THR 342^LEU 348^ARG		intracellular protein transmembrane transport mRNA transport protein transport transport protein export from nucleus regulation of cell cycle protein import into nucleus mRNA export from nucleus intracellular protein transmembrane transport mRNA transport protein transport transport mRNA export from nucleus	nuclear pore nucleus cytosol nuclear membrane cytoplasm membrane nuclear pore nucleus	protein binding transporter activity nucleocytoplasmic transporter activity hydrolase activity ATP binding helicase activity RNA binding nucleotide binding ATP-dependent helicase activity nucleic acid binding protein binding
3b8iE	[pdb]	1.6603 0.00190808	17^LEU 21^ARG 25^THR 44^CYS 84^PRO 229^ARG	4.1.1.3		catalytic activity magnesium ion binding oxaloacetate decarboxylase activity lyase activity carboxy-lyase activity metal ion binding	oxaloacetate metabolic process pyruvate biosynthetic process
1v47B	[pdb]	1.6606 0.0019081	169^ARG 176^ARG 294^CYS 295^PRO 302^SER 335^GLU	0.0.0.0		nucleotidyltransferase activity transferase activity sulfate adenylyltransferase (ATP) activity protein binding nucleotidyltransferase activity transferase activity sulfate adenylyltransferase (ATP) activity protein binding	sulfate assimilation sulfate assimilation
2o0rB	[pdb]	1.66775 0.00198892	34^PRO 287^LEU 292^ARG 297^ARG 373^THR 375^CYS	0.0.0.0		biosynthetic process	transferase activity transaminase activity pyridoxal phosphate binding 1-aminocyclopropane-1-carboxylate synthase activity transferase activity transferring nitrogenous groups catalytic activity
1yujA	[pdb]	1.67147 0.00207251	35^THR 36^CYS 37^PRO 47^ARG 51^ARG 53^LEU		nucleus polytene chromosome euchromatin intracellular centromeric heterochromatin chromatin	protein binding DNA binding transcription activator activity protein heterodimerization activity metal ion binding zinc ion binding nucleic acid binding specific RNA polymerase II transcription factor activity	regulation of transcription protein oligomerization positive regulation of transcription DNA-dependent chromatin assembly cell division oogenesis cell differentiation chromatin modification multicellular organismal development mitosis cell cycle regulation of transcription DNA-dependent transcription syncytial blastoderm mitotic cell cycle cellular process dosage compensation imaginal disc-derived wing morphogenesis chromatin organization nuclear division
1f2rI	[pdb]	1.6766 0.00215935	20^PRO 21^CYS 24^ARG 29^ARG 49^LEU 83^THR		apoptosis positive regulation of apoptosis induction of apoptosis DNA fragmentation involved in apoptosis apoptosis DNA fragmentation involved in apoptosis apoptotic chromosome condensation	cytoplasm intracellular cytoplasm nucleus intracellular	protein binding hydrolase activity nuclease activity protein binding nicotinate phosphoribosyltransferase activity DNA binding enzyme binding
2f9wA	[pdb]	1.68294 0.00224955	127^THR 143^CYS 144^PRO 189^LEU 193^ARG 197^ARG	2.7.1.33	cytoplasm	metal ion binding potassium ion binding transferase activity kinase activity ATP binding nucleotide binding pantothenate kinase activity transcription activator activity	response to antibiotic coenzyme A biosynthetic process positive regulation of transcription
1sxjE	[pdb]	1.68486 0.00224973	37^ALA 155^SER 156^ASP 167^ILE 183^LYS 185^PHE		cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation chromatin silencing at telomere postreplication repair mismatch repair nucleotide-excision repair base-excision repair lagging strand elongation leading strand elongation meiotic mismatch repair regulation of DNA replication response to DNA damage stimulus DNA repair DNA replication chromatin silencing at silent mating-type cassette mitotic sister chromatid cohesion cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation cell cycle checkpoint cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation cell division cell cycle DNA replication mismatch repair DNA repair leading strand elongation mitotic cell cycle	nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex replication fork nucleus PCNA complex nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex nucleus DNA replication factor C complex intracellular	protein binding ATP binding DNA binding nucleotide binding ATPase activity DNA clamp loader activity nucleoside-triphosphatase activity DNA polymerase processivity factor activity DNA binding protein binding protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity
1si2A	[pdb]	1.69308 0.00234346	253^ARG 255^ARG 283^THR 323^LEU 325^CYS 338^PRO	0.0.0.0	RNA binding translation initiation factor activity nucleic acid binding protein binding	cytoplasmic mRNA processing body cytoplasm ribonucleoprotein complex eukaryotic translation initiation factor 2 complex	nuclear-transcribed mRNA catabolic process transcription regulation of translation gene silencing by miRNA negative regulation of translation regulation of transcription gene silencing by RNA translation regulation of translational initiation
1jofD	[pdb]	1.69715 0.00244025	315^SER 317^CYS 318^PRO 322^GLU 338^ARG 346^ARG	5.5.1.5			isomerase activity carboxy-cis,cis-muconate cyclase activity
1zrtR	[pdb]	1.70196 0.00244072	94^ARG 140^PRO 153^CYS 158^SER 173^ARG 175^LEU	1.10.2.2	electron transport chain transport respiratory electron transport chain electron transport chain transport oxidation reduction electron transport chain transport	metal ion binding iron ion binding oxidoreductase activity electron carrier activity iron-sulfur cluster binding oxidoreductase activity acting on diphenols and related substances as donors metal ion binding iron ion binding heme binding electron carrier activity 2 iron 2 sulfur cluster binding metal ion binding iron ion binding ubiquinol-cytochrome-c reductase activity oxidoreductase activity electron carrier activity	plasma membrane integral to membrane membrane mitochondrial respiratory chain respiratory chain respiratory chain plasma membrane integral to membrane membrane mitochondrial respiratory chain plasma membrane integral to membrane membrane
1s1hB	[pdb]	1.70313 0.00244084	21^ARG 26^HIS 40^GLN 148^VAL 160^ASP 161^VAL		SSU rRNA binding SSU rRNA binding structural constituent of ribosome mRNA binding protein binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome ribonucleoprotein binding rRNA binding GTP binding translation elongation factor activity RNA binding nucleotide binding GTPase activity protein binding structural constituent of ribosome structural constituent of ribosome metal ion binding zinc ion binding structural constituent of ribosome protein binding structural constituent of ribosome structural constituent of ribosome protein binding structural constituent of ribosome RNA binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome nucleic acid binding RNA binding DNA-(apurinic or apyrimidinic site) lyase activity structural constituent of ribosome protein binding fibroblast growth factor 3 binding rRNA binding structural constituent of ribosome RNA binding DNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome structural constituent of ribosome	nucleolus nucleolus nucleolus cytoplasm ribonucleoprotein complex ribosome nucleus small-subunit processome 90S preribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit intracellular cytoplasm ribosome cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular small ribosomal subunit ribosome intracellular cytoplasm ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribonucleoprotein complex ribosome nucleus small-subunit processome 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit mitochondrion intracellular cytoplasm ribonucleoprotein complex ribosome preribosome small subunit precursor 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome nucleus small-subunit processome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit intracellular	ribosome biogenesis rRNA processing translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) ribosomal small subunit assembly translation translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) ribosomal small subunit assembly translation translational elongation ribosome biogenesis translation rRNA export from nucleus translation translation regulation of translational fidelity maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation translation rRNA export from nucleus maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation ribosome biogenesis rRNA processing translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation rRNA export from nucleus endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation rRNA export from nucleus ribosome biogenesis rRNA processing positive regulation of translational fidelity rRNA export from nucleus translation translation rRNA export from nucleus endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA 5.8S rRNA LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) ribosomal small subunit assembly translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA)
1ohtA	[pdb]	1.70372 0.00253904	16^LEU 18^ARG 24^ARG 54^PRO 56^CYS 59^SER	3.5.1.28	extracellular region	peptidoglycan catabolic process defense response to Gram-positive bacterium innate immune response immune response peptidoglycan metabolic process	protein binding peptidoglycan binding metal ion binding hydrolase activity zinc ion binding N-acetylmuramoyl-L-alanine amidase activity amidase activity
1tzpA	[pdb]	1.71368 0.00264001	39^SER 74^LEU 175^ARG 213^ARG 216^CYS 217^PRO		metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity serine-type endopeptidase activity metalloendopeptidase activity metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity serine-type endopeptidase activity metalloendopeptidase activity	periplasmic space outer membrane-bounded periplasmic space periplasmic space outer membrane-bounded periplasmic space	proteolysis peptidoglycan metabolic process proteolysis peptidoglycan metabolic process
1kogC	[pdb]	1.7181 0.00274408	331^PRO 360^SER 361^CYS 365^GLU 375^ARG 520^ARG	6.1.1.3	cytoplasm	metal ion binding ligase activity zinc ion binding ATP binding aminoacyl-tRNA ligase activity RNA binding nucleotide binding threonine-tRNA ligase activity ligase activity forming aminoacyl-tRNA and related compounds protein binding	regulation of translation translation tRNA aminoacylation threonyl-tRNA aminoacylation tRNA aminoacylation for protein translation
2hayB	[pdb]	1.71828 0.0027441	17^THR 164^CYS 165^PRO 197^LEU 200^ARG 202^ARG	0.0.0.0		oxidation reduction	oxidoreductase activity
2id5A	[pdb]	1.71967 0.00274426	1^THR 3^CYS 4^PRO 14^ARG 17^LEU 35^ARG		negative regulation of oligodendrocyte differentiation protein kinase B signaling cascade central nervous system neuron development neuron projection development	plasma membrane integral to membrane membrane	protein binding epidermal growth factor receptor binding
1njfD	[pdb]	1.72069 0.00274437	62^LEU 64^CYS 66^THR 72^PRO 117^ARG 119^ARG	2.7.7.7	DNA polymerase III complex nucleus	DNA replication	nucleotidyltransferase activity transferase activity ATP binding DNA-directed DNA polymerase activity nucleotide binding nucleoside-triphosphatase activity DNA binding protein binding
3dtyE	[pdb]	1.7225 0.00274456	116^PRO 118^CYS 120^THR 368^GLU 371^ARG 375^ARG	0.0.0.0		metabolic process	oxidoreductase activity electron carrier activity binding catalytic activity
2yyeB	[pdb]	1.72385 0.00274471	98^SER 99^CYS 105^LEU 111^ARG 115^ARG 139^PRO	2.7.9.3			transferase activity kinase activity selenium binding ATP binding magnesium ion binding nucleotide binding selenide water dikinase activity catalytic activity
3b4wA	[pdb]	1.73006 0.00285279	229^THR 238^ARG 242^ARG 246^GLU 250^PRO 251^CYS	0.0.0.0		oxidation reduction metabolic process	oxidoreductase activity
3c0qA	[pdb]	1.73155 0.00285296	7^PRO 8^CYS 16^THR 40^ARG 44^ARG 46^LEU	0.0.0.0		endonuclease activity	nucleotide-excision repair
2zk9X	[pdb]	1.74168 0.00308078	22^SER 31^PRO 32^CYS 45^ARG 50^ARG 163^LEU	0.0.0.0
2oo6A	[pdb]	1.74459 0.00308113	122^SER 124^CYS 125^PRO 150^GLU 153^ARG 155^ARG	0.0.0.0		catalytic activity	metabolic process
2f1zB	[pdb]	1.75914 0.00332627	66^ARG 70^THR 89^PRO 90^CYS 93^ARG 95^LEU	3.1.2.15	modification-dependent protein catabolic process protein deubiquitination interspecies interaction between organisms ubiquitin-dependent protein catabolic process	nucleus cytoplasm	ubiquitin-specific protease activity protein C-terminus binding protein binding hydrolase activity cysteine-type peptidase activity peptidase activity ubiquitin thiolesterase activity cysteine-type endopeptidase activity
2p26A	[pdb]	1.76734 0.0035883	12^ARG 16^GLU 19^PRO 21^CYS 22^THR 426^ARG		plasma membrane cytoplasm integrin complex membrane integral to membrane membrane raft cell surface membrane fraction	protein kinase binding protein binding receptor activity binding cell adhesion molecule binding protein heterodimerization activity glycoprotein binding	regulation of peptidyl-tyrosine phosphorylation apoptosis inflammatory response cell-cell signaling regulation of cell shape neutrophil chemotaxis leukocyte adhesion integrin-mediated signaling pathway cell adhesion cell-matrix adhesion positive regulation of NF-kappaB transcription factor activity activated T cell proliferation positive regulation of angiogenesis positive regulation of nitric oxide biosynthetic process cellular extravasation endothelial cell migration natural killer cell activation leukocyte migration during inflammatory response
2f1yA	[pdb]	1.77385 0.00372422	66^ARG 70^THR 89^PRO 90^CYS 93^ARG 95^LEU	3.1.2.15	nucleus cytoplasm cytoplasm nucleolus nucleus nucleoplasm insoluble fraction cytosol intracellular	protein deubiquitination interspecies interaction between organisms ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of cell proliferation modification-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination during ubiquitin-dependent protein catabolic process protein complex assembly negative regulation of transcription from RNA polymerase II promoter protein ubiquitination regulation of protein catabolic process interspecies interaction between organisms ubiquitin-dependent protein catabolic process negative regulation of cell proliferation protein catabolic process traversing start control point of mitotic cell cycle	ubiquitin-specific protease activity protein C-terminus binding protein binding hydrolase activity cysteine-type peptidase activity peptidase activity ubiquitin thiolesterase activity cysteine-type endopeptidase activity protein binding ubiquitin-protein ligase activity p53 binding basal transcription repressor activity enzyme binding zinc ion binding metal ion binding ligase activity identical protein binding
3bn3B	[pdb]	1.78043 0.00372513	26^THR 28^CYS 29^PRO 32^GLU 71^ARG 75^ARG		activated T cell proliferation positive regulation of T cell proliferation positive regulation of cell-cell adhesion leukocyte adhesion heterophilic cell adhesion T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell cell adhesion cell-cell adhesion phagocytosis signal transduction inflammatory response cell adhesion integrin-mediated signaling pathway cell motion positive regulation of calcium-mediated signaling	cell adhesion molecule binding protein binding protein binding calcium ion binding receptor activity magnesium ion binding	external side of plasma membrane immunological synapse membrane integral to membrane integral to plasma membrane plasma membrane integrin complex membrane integral to membrane plasma membrane
2i9bD	[pdb]	1.78718 0.0038635	63^ILE 71^CYS 73^LEU 96^ILE 103^MET 110^HIS	3.4.21.73	extracellular region plasma membrane cell surface integral to membrane plasma membrane extracellular region anchored to membrane membrane extrinsic to membrane	fibrinolysis blood coagulation signal transduction chemotaxis proteolysis smooth muscle cell migration response to hypoxia skeletal muscle regeneration cell motion regulation of proteolysis blood coagulation chemotaxis attachment of GPI anchor to protein signal transduction	hydrolase activity serine-type peptidase activity peptidase activity serine-type endopeptidase activity catalytic activity enzyme binding protein binding U-plasminogen activator receptor activity receptor activity
2azpA	[pdb]	1.78886 0.00400593	132^ARG 235^PRO 236^CYS 238^THR 270^GLU 272^ARG	5.1.1.8			isomerase activity 4-hydroxyproline epimerase activity proline racemase activity
2jkcA	[pdb]	1.79388 0.00400667	141^LEU 147^PRO 148^CYS 150^SER 501^ARG 503^ARG	0.0.0.0
2gtlN	[pdb]	1.79696 0.00415421	81^PHE 97^ASP 100^LEU 102^THR 138^PHE 144^LEU	0.0.0.0	extracellular region hemoglobin complex extracellular region hemoglobin complex hemoglobin complex extracellular region hemoglobin complex extracellular region	oxygen transporter activity metal ion binding iron ion binding oxygen transporter activity heme binding oxygen binding metal ion binding iron ion binding oxygen transporter activity heme binding oxygen binding metal ion binding iron ion binding oxygen transporter activity heme binding oxygen binding heme binding oxygen binding iron ion binding	transport oxygen transport transport oxygen transport transport oxygen transport transport oxygen transport
3cj1A	[pdb]	1.80415 0.00430741	245^ARG 251^ARG 253^LEU 264^PRO 310^CYS 315^SER			hydrolase activity calcium ion binding magnesium ion binding	membrane integral to membrane
1rmdA	[pdb]	1.80618 0.00430773	47^ARG 52^ARG 54^LEU 61^CYS 63^SER 67^PRO		DNA recombination V(D)J recombination T cell differentiation in the thymus B cell differentiation death negative regulation of caspase activity negative regulation of thymocyte apoptosis	metal ion binding hydrolase activity zinc ion binding endonuclease activity nuclease activity DNA binding protein binding nucleic acid binding	nucleus intracellular
2j28Z	[pdb]	1.81068 0.00446569	34^LEU 37^CYS 38^SER 42^PRO 56^ARG 59^ARG		rRNA binding RNA binding structural constituent of ribosome protein binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding structural constituent of ribosome protein binding rRNA binding RNA binding nucleotide binding protein binding rRNA binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome structural constituent of ribosome rRNA binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome protein binding structural constituent of ribosome protein binding structural constituent of ribosome RNA binding tRNA binding structural constituent of ribosome structural constituent of ribosome rRNA binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding transferase activity structural constituent of ribosome protein binding structural constituent of ribosome GTP binding RNA binding nucleotide binding nucleoside-triphosphatase activity 7S RNA binding rRNA binding RNA binding structural constituent of ribosome protein binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding 5S rRNA binding structural constituent of ribosome protein binding metal ion binding rRNA binding zinc ion binding RNA binding structural constituent of ribosome	ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit ribonucleoprotein complex ribosome ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex signal recognition particle endoplasmic reticulum targeting signal recognition particle ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular	translation translation translation translation translation translation response to antibiotic translation translation translation translation translation translation ribosomal large subunit assembly translation translation translation response to antibiotic regulation of translation regulation of transcription DNA-dependent transcription termination transcription translation translation regulation of transcription translation translation translation translation response to antibiotic translation translation translation SRP-dependent cotranslational protein targeting to membrane translation translation translation translation translation
1gt8C	[pdb]	1.81198 0.00446591	74^ARG 78^ARG 80^LEU 86^PRO 140^CYS 149^SER	1.3.1.2	NADP or NADPH binding FAD binding protein homodimerization activity dihydropyrimidine dehydrogenase (NADP+) activity FMN binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding electron carrier activity binding dihydroorotate oxidase activity dihydroorotate dehydrogenase activity catalytic activity	cytoplasm	thymidine catabolic process uracil catabolic process oxidation reduction metabolic process UMP biosynthetic process 'de novo' pyrimidine base biosynthetic process
2oypA	[pdb]	1.81528 0.00446645	15^PRO 16^CYS 17^SER 47^ARG 90^ARG 103^GLU	0.0.0.0			receptor activity
1ym7A	[pdb]	1.81568 0.00462903	376^SER 379^CYS 390^PRO 407^LEU 431^ARG 436^ARG	2.7.11.15	membrane cytosol	phosphorylation peptidyl-threonine phosphorylation signal transduction protein amino acid phosphorylation regulation of signal transduction intracellular protein transport cardiac muscle contraction negative regulation of striated muscle contraction peptidyl-serine phosphorylation negative regulation of the force of heart contraction by chemical signal desensitization of G-protein coupled receptor protein signaling pathway muscarinic acetylcholine receptor signaling pathway heart development G-protein coupled receptor protein signaling pathway regulation of the force of heart contraction negative regulation of G-protein coupled receptor protein signaling pathway	transferase activity kinase activity ATP binding protein serine/threonine kinase activity nucleotide binding beta-adrenergic receptor kinase activity signal transducer activity G-protein coupled receptor kinase activity protein kinase activity protein binding
2c6fB	[pdb]	1.81638 0.00462915	230^ARG 245^ARG 252^LEU 468^THR 474^CYS 475^PRO	3.4.15.1	peptidyl-dipeptidase activity metallopeptidase activity metal ion binding hydrolase activity zinc ion binding peptidase activity carboxypeptidase activity bradykinin receptor binding drug binding chloride ion binding	plasma membrane integral to membrane membrane extracellular region extracellular space endosome membrane fraction external side of plasma membrane	regulation of vasoconstriction angiotensin catabolic process in blood regulation of systemic arterial blood pressure by renin-angiotensin proteolysis blood vessel remodeling kidney development hormone catabolic process mononuclear cell proliferation regulation of blood pressure regulation of vasodilation peptide catabolic process arachidonic acid secretion regulation of smooth muscle cell migration hemopoietic stem cell differentiation regulation of renal output by angiotensin
3bq9B	[pdb]	1.81709 0.00462927	179^THR 181^CYS 212^GLU 221^PRO 237^ARG 243^ARG	0.0.0.0
1d2vC	[pdb]	1.81772 0.00462938	231^PRO 232^CYS 241^SER 363^ARG 370^ARG 373^LEU	1.11.1.7	lysosome nucleus extracellular space	metal ion binding oxidoreductase activity calcium ion binding iron ion binding peroxidase activity chromatin binding heme binding	response to oxidative stress oxidation reduction hydrogen peroxide catabolic process defense response anti-apoptosis low-density lipoprotein particle remodeling
1dj3B	[pdb]	1.82377 0.00479835	120^ARG 124^LEU 153^PRO 154^CYS 160^THR 165^ARG	6.3.4.4	metal ion binding ligase activity GTP binding magnesium ion binding nucleotide binding adenylosuccinate synthase activity	plastid chloroplast	purine nucleotide biosynthetic process
2ja4A	[pdb]	1.8249 0.00479855	277^ARG 292^ARG 343^PRO 348^SER 350^CYS 353^LEU	0.0.0.0	external side of plasma membrane integral to plasma membrane membrane integral to membrane plasma membrane	induction of apoptosis by extracellular signals T cell costimulation cell recognition cell proliferation	transmembrane receptor activity protein binding receptor activity scavenger receptor activity
1ez0C	[pdb]	1.82613 0.00479877	49^LEU 54^ARG 59^ARG 161^SER 167^CYS 168^PRO	1.2.1.4		oxidation reduction metabolic process	oxidoreductase activity aldehyde dehydrogenase (NADP+) activity
1yvjA	[pdb]	1.82664 0.00479885	920^ARG 925^ARG 927^LEU 1022^THR 1066^CYS 1067^PRO	2.7.10.2	endomembrane system membrane cytoskeleton	enzyme linked receptor protein signaling pathway protein kinase cascade peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter protein amino acid phosphorylation	transferase activity kinase activity ATP binding protein tyrosine kinase activity nucleotide binding non-membrane spanning protein tyrosine kinase activity protein binding Janus kinase activity protein kinase activity
2rfiB	[pdb]	1.82792 0.00479908	1000^SER 1003^CYS 1004^PRO 1099^LEU 1101^ARG 1103^ARG	2.1.1.43	histone methylation chromatin modification	histone-lysine N-methyltransferase activity methyltransferase activity metal ion binding transferase activity zinc ion binding	nucleus
2uvcL	[pdb]	1.83251 0.00497342	160^ARG 264^THR 265^CYS 272^PRO 277^GLU 278^ARG	0.0.0.0	fatty acid synthase complex	metabolic process fatty acid biosynthetic process	transferase activity oxidoreductase activity fatty-acid synthase activity
1tmf2	[pdb]	1.8356 0.00497398	100^ARG 101^ASN 106^ARG 215^GLY 254^PRO 260^ARG	0.0.0.0	RNA-protein covalent cross-linking transcription RNA-dependent viral genome replication proteolysis transcription RNA-protein covalent cross-linking transcription RNA-dependent viral genome replication proteolysis transcription	cytoplasm cytoplasmic vesicle viral capsid virion membrane icosahedral viral capsid cytoplasm cytoplasmic vesicle viral capsid virion membrane icosahedral viral capsid host cell cytoplasm host cell cytoplasm	hydrolase activity nucleotidyltransferase activity transferase activity cysteine-type peptidase activity peptidase activity ATP binding structural molecule activity helicase activity RNA-directed RNA polymerase activity RNA binding nucleotide binding nucleoside-triphosphatase activity cysteine-type endopeptidase activity catalytic activity RNA helicase activity hydrolase activity nucleotidyltransferase activity transferase activity cysteine-type peptidase activity peptidase activity ATP binding structural molecule activity helicase activity RNA-directed RNA polymerase activity RNA binding nucleotide binding nucleoside-triphosphatase activity cysteine-type endopeptidase activity catalytic activity RNA helicase activity
1uscA	[pdb]	1.83665 0.00515342	27^ARG 35^CYS 36^PRO 60^THR 69^ARG 111^LEU	0.0.0.0			oxidoreductase activity FMN binding electron carrier activity
3c4mA	[pdb]	1.8371 0.00515351	107^PRO 108^CYS 125^HOH 146^ARG 147^ARG 153^SER		cell surface receptor linked signal transduction bone resorption aging activation of adenylate cyclase activity by G-protein signaling pathway carbohydrate transport transport maltose transport positive regulation of signal transduction positive regulation of transcription from RNA polymerase II promoter G-protein coupled receptor protein signaling pathway signal transduction G-protein signaling coupled to cyclic nucleotide second messenger skeletal system development cell maturation bone mineralization negative regulation of cell proliferation positive regulation of cell proliferation elevation of cytosolic calcium ion concentration activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger cellular calcium ion homeostasis osteoblast development chondrocyte differentiation ossification bone resorption cellular calcium ion homeostasis induction of apoptosis by hormones cAMP metabolic process cell-cell signaling G-protein coupled receptor protein signaling pathway skeletal system development positive regulation of cAMP biosynthetic process regulation of gene expression Rho protein signal transduction activation of adenylate cyclase activity by G-protein signaling pathway	intracellular periplasmic space plasma membrane integral to membrane membrane integral to plasma membrane cytoplasm brush border membrane basolateral plasma membrane nucleus extracellular region extracellular space	sugar:hydrogen symporter activity maltose transmembrane transporter activity transporter activity G-protein coupled receptor activity receptor activity signal transducer activity parathyroid hormone receptor activity transmembrane receptor activity hormone activity parathyroid hormone receptor binding
3eofA	[pdb]	1.8377 0.00515362	77^CYS 81^ARG 82^ARG 109^THR 148^GLU 152^PRO	0.0.0.0			oxidoreductase activity
1szlA	[pdb]	1.83927 0.00515391	440^SER 466^ARG 468^ARG 470^LEU 479^PRO 480^CYS		cell adhesion	protein binding	proteinaceous extracellular matrix extracellular region
2is6A	[pdb]	1.8451 0.00533716	284^ARG 291^SER 317^PRO 605^ARG 610^LEU 640^CYS		SOS response response to DNA damage stimulus DNA repair DNA replication DNA unwinding during replication	cytoplasm	hydrolase activity ATP binding helicase activity DNA binding nucleotide binding ATP-dependent DNA helicase activity protein binding
1ixkA	[pdb]	1.84708 0.00533753	106^SER 196^PRO 197^CYS 249^LEU 295^ARG 296^ARG	0.0.0.0		S-adenosylmethionine-dependent methyltransferase activity RNA binding methyltransferase activity	rRNA processing
1m22A	[pdb]	1.84902 0.00533789	84^ARG 86^ARG 167^LEU 198^SER 200^CYS 230^PRO	0.0.0.0			carbon-nitrogen ligase activity with glutamine as amido-N-donor
1up7F	[pdb]	1.85083 0.00552342	150^ARG 318^ARG 332^LEU 335^PRO 336^CYS 345^THR	3.2.1.86		metabolic process carbohydrate metabolic process	metal ion binding manganese ion binding hydrolase activity acting on glycosyl bonds hydrolase activity 6-phospho-beta-glucosidase activity binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1p59A	[pdb]	1.8524 0.00552372	144^ARG 148^ARG 193^SER 196^CYS 197^PRO 207^GLU	0.0.0.0
3binA	[pdb]	1.85258 0.00552375	209^LEU 210^ARG 219^PRO 220^CYS 224^THR 254^ARG		biological_process cortical actin cytoskeleton organization positive regulation of cytokine secretion susceptibility to natural killer cell mediated cytotoxicity detection of stimulus activated T cell proliferation positive regulation of natural killer cell mediated cytotoxicity cell recognition T cell mediated cytotoxicity heterophilic cell adhesion homophilic cell adhesion negative regulation of cell cycle cell differentiation multicellular organismal development cell adhesion cell cycle immune response apoptosis spermatogenesis	cytoskeletal protein binding binding structural molecule activity actin binding protein binding receptor binding protein binding PDZ domain binding protein C-terminus binding protein homodimerization activity	cytoskeleton cytoplasm cell-cell junction plasma membrane extrinsic to membrane plasma membrane basolateral plasma membrane cell-cell junction integral to membrane membrane
1sddB	[pdb]	1.85422 0.00552407	1542^ARG 1608^ARG 1677^PRO 1707^LEU 1710^CYS 1714^THR		blood coagulation cell adhesion	extracellular region	metal ion binding calcium ion binding copper ion binding oxidoreductase activity
2ix5C	[pdb]	1.8548 0.00552418	43^PRO 44^CYS 46^SER 63^ARG 67^ARG 71^GLU	1.3.3.6	acyl-CoA oxidase activity oxidoreductase activity FAD binding oxidoreductase activity acting on the CH-CH group of donors electron carrier activity acyl-CoA dehydrogenase activity	peroxisome glyoxysome	short-chain fatty acid metabolic process embryonic development ending in seed dormancy fatty acid beta-oxidation oxidation reduction fatty acid metabolic process lipid metabolic process metabolic process
1beaA	[pdb]	1.85532 0.00552428	18^PRO 20^CYS 25^THR 60^LEU 88^ARG 92^ARG			extracellular region	peptidase inhibitor activity serine-type endopeptidase inhibitor activity endopeptidase inhibitor activity
1ib9A	[pdb]	1.85944 0.00571631	1^SER 8^CYS 9^PRO 12^LEU 17^ARG 28^ARG			extracellular region	peptidase inhibitor activity serine-type endopeptidase inhibitor activity endopeptidase inhibitor activity
1vi5B	[pdb]	1.86065 0.00571656	54^ARG 56^ARG 123^PRO 144^CYS 155^LEU 159^THR		ribonucleoprotein complex ribosome small ribosomal subunit intracellular	structural constituent of ribosome	translation
1s3gA	[pdb]	1.86093 0.00571661	127^ARG 135^THR 139^LEU 144^PRO 150^CYS 160^ARG	2.7.4.3	cytoplasm	metal ion binding transferase activity kinase activity zinc ion binding ATP binding nucleotide binding adenylate kinase activity nucleobase nucleoside nucleotide kinase activity nucleotide kinase activity phosphotransferase activity phosphate group as acceptor	nucleotide biosynthetic process nucleobase nucleoside nucleotide and nucleic acid metabolic process
1ej6C	[pdb]	1.86389 0.0057172	643^CYS 645^PRO 680^THR 838^LEU 840^ARG 842^ARG		mRNA processing mRNA capping mRNA processing mRNA capping	structural molecule activity structural molecule activity metal ion binding hydrolase activity zinc ion binding ATP binding structural molecule activity helicase activity nucleotide binding nucleotidyltransferase activity transferase activity methyltransferase activity ATP binding structural molecule activity catalytic activity nucleotide binding mRNA guanylyltransferase activity mRNA (guanine-N7-)-methyltransferase activity GTP binding	virion viral capsid viral nucleocapsid virion viral nucleocapsid virion viral capsid viral nucleocapsid intracellular virion viral capsid viral nucleocapsid viral capsid
1q4kB	[pdb]	1.86389 0.0057172	378^LEU 529^SER 544^CYS 545^PRO 579^ARG 584^ARG	2.7.11.21	cell division mitosis cell cycle positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle cell proliferation protein amino acid phosphorylation	nucleus cytosol nucleoplasm centrosome	transferase activity kinase activity ATP binding protein serine/threonine kinase activity nucleotide binding protein kinase activity polo kinase kinase activity protein binding
1k78A	[pdb]	1.86627 0.00591512	38^ARG 40^ARG 44^LEU 51^PRO 52^CYS 55^SER		nucleus transcription factor complex nucleus	positive regulation of erythrocyte differentiation positive regulation of transcription regulation of transcription DNA-dependent transcription positive regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter cell differentiation nervous system development spermatogenesis multicellular organismal development regulation of transcription DNA-dependent transcription organ morphogenesis humoral immune response transcription from RNA polymerase II promoter regulation of transcription regulation of transcription	protein binding transcription factor activity DNA binding sequence-specific DNA binding DNA binding
1uf2B	[pdb]	1.86865 0.0059156	206^ALA 211^VAL 213^ALA 240^THR 244^THR 246^ALA		RNA binding structural molecule activity host cell surface receptor binding structural molecule activity	viral envelope fusion with host membrane	virion viral nucleocapsid viral capsid virion viral envelope virion viral nucleocapsid
2ftxA	[pdb]	1.87492 0.00612071	148^ARG 160^LEU 167^SER 169^GLY 172^LEU 186^ASP		cell division mitosis cell cycle chromosome segregation microtubule nucleation cell division mitosis cell cycle chromosome segregation microtubule nucleation	nucleus condensed chromosome kinetochore Ndc80 complex condensed nuclear chromosome centromeric region condensed nuclear chromosome kinetochore nucleus condensed chromosome kinetochore Ndc80 complex condensed nuclear chromosome centromeric region condensed nuclear chromosome kinetochore	structural constituent of cytoskeleton protein binding structural constituent of cytoskeleton identical protein binding protein binding
1bnlC	[pdb]	1.87756 0.00612127	20^SER 24^ARG 136^GLU 139^ARG 143^PRO 165^CYS		Golgi apparatus cytoplasm nucleus proteinaceous extracellular matrix extracellular region collagen extracellular matrix	cell adhesion negative regulation of cell proliferation visual perception organ morphogenesis	metal ion binding zinc ion binding protein binding extracellular matrix structural constituent structural molecule activity
6paxA	[pdb]	1.88575 0.00655041	23^ARG 25^ARG 29^LEU 36^PRO 37^CYS 40^SER		DNA binding transcription factor activity sequence-specific DNA binding transcription regulator activity protein binding	cell differentiation multicellular organismal development regulation of transcription DNA-dependent transcription visual perception eye development central nervous system development organ morphogenesis regulation of transcription	nucleus
2p3sA	[pdb]	1.88664 0.00655061	127^ARG 135^THR 139^LEU 144^PRO 150^CYS 160^ARG	2.7.4.3	cytoplasm	metal ion binding transferase activity kinase activity zinc ion binding ATP binding nucleotide binding adenylate kinase activity nucleobase nucleoside nucleotide kinase activity nucleotide kinase activity phosphotransferase activity phosphate group as acceptor	nucleotide biosynthetic process nucleobase nucleoside nucleotide and nucleic acid metabolic process
3ehtA	[pdb]	1.89063 0.00655151	44^CYS 47^SER 59^PRO 66^ARG 85^ARG 86^GLU		G-protein coupled receptor activity receptor activity signal transducer activity corticotrophin-releasing factor receptor activity transmembrane receptor activity hormone activity neuropeptide hormone activity receptor binding sugar:hydrogen symporter activity maltose transmembrane transporter activity transporter activity	G-protein coupled receptor protein signaling pathway signal transduction activation of adenylate cyclase activity parturition female pregnancy G-protein signaling coupled to cAMP nucleotide second messenger immune response cell surface receptor linked signal transduction behavior response to stress positive regulation of circadian sleep/wake cycle wakefulness negative regulation of circadian sleep/wake cycle REM sleep positive regulation of cortisol secretion learning or memory parturition female pregnancy synaptic transmission signal transduction adrenal gland development lung development inflammatory response glucocorticoid biosynthetic process carbohydrate transport transport maltose transport	plasma membrane integral to membrane membrane integral to plasma membrane extracellular region soluble fraction periplasmic space
2fr1A	[pdb]	1.89277 0.00677584	1473^THR 1518^ARG 1520^ARG 1563^GLU 1566^CYS 1567^PRO	2.3.1.94		antibiotic biosynthetic process biosynthetic process metabolic process	transferase activity acyltransferase activity catalytic activity erythronolide synthase activity cofactor binding phosphopantetheine binding oxidoreductase activity binding acyl carrier activity
1ps9A	[pdb]	1.89348 0.00677601	463^SER 628^PRO 649^CYS 655^LEU 659^ARG 666^ARG	1.3.1.34		4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding 2,4-dienoyl-CoA reductase (NADPH) activity FAD binding FMN binding catalytic activity electron carrier activity	oxidation reduction metabolic process
2rdlA	[pdb]	1.89346 0.006776	137^ARG 161^ARG 163^LEU 165^PRO 182^CYS 226^SER	0.0.0.0		proteolysis	serine-type endopeptidase activity catalytic activity peptidase activity serine-type peptidase activity hydrolase activity

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

1dctA

[pdb]

0.460695
3.49125e-05

70^PRO 71^CYS 75^SER 109^GLU 153^ARG 155^ARG

2.1.1.37

DNA restriction-modification system
DNA methylation

transferase activity
methyltransferase activity
DNA (cytosine-5-)-methyltransferase activity
DNA binding

2qrvD

[pdb]

0.605656
8.92675e-05

705^PRO 706^CYS 710^SER 752^GLU 786^ARG 788^ARG

0.0.0.0

DNA methylation
genetic imprinting
spermatogenesis
in utero embryonic development
DNA methylation
genetic imprinting

cytosol
nucleus
cytoplasm
nuclear heterochromatin
condensed nuclear chromosome
nuclear matrix
euchromatin
cytoplasm
nucleus

transcription repressor activity
enzyme binding
metal ion binding
zinc ion binding
enzyme activator activity
protein binding
DNA (cytosine-5-)-methyltransferase activity
metal ion binding
transferase activity
zinc ion binding
methyltransferase activity
DNA binding
protein binding

2jimA

[pdb]

1.07906
0.000159115

540^ARG 542^ARG 549^LEU 552^PRO 553^CYS 555^SER

1.7.99.4

4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
molybdenum ion binding
oxidoreductase activity
iron ion binding
nitrate reductase activity
binding
electron carrier activity

oxidation reduction
nitrate assimilation
electron transport chain
transport
Mo-molybdopterin cofactor biosynthetic process

periplasmic space

1zejA

[pdb]

1.33412
0.000263588

81^ARG 84^GLU 90^PRO 92^CYS 93^SER 106^ARG

0.0.0.0

coenzyme binding
oxidoreductase activity
binding
catalytic activity

metabolic process
fatty acid metabolic process

2gjxA

[pdb]

1.43443
0.000440831

59^SER 102^PRO 104^CYS 107^LEU 247^ARG 249^ARG

3.2.1.52

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
cation binding
catalytic activity
protein binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
protein homodimerization activity
cation binding
catalytic activity
hydrolase activity
hydrolyzing O-glycosyl compounds
hydrolase activity
hydrolyzing O-glycosyl compounds

lysosome
membrane
lysosome
membrane
acrosomal vesicle

metabolic process
carbohydrate metabolic process
neuromuscular process controlling balance
neuromuscular process controlling posture
myelination
glycosaminoglycan metabolic process
sexual reproduction
lipid storage
adult walking behavior
locomotory behavior
sensory perception of sound
lysosome organization
ganglioside catabolic process
skeletal system development
metabolic process
carbohydrate metabolic process
neuromuscular process
neuromuscular process controlling balance
oogenesis
cellular protein metabolic process
myelination
regulation of cellular metabolic process
glycosaminoglycan metabolic process
sexual reproduction
lipid storage
oligosaccharide catabolic process
phospholipid biosynthetic process
male courtship behavior
locomotory behavior
sensory perception of sound
penetration of zona pellucida
single fertilization
lysosome organization
cellular calcium ion homeostasis
ganglioside catabolic process
glycosphingolipid metabolic process
skeletal system development

2nxoD

[pdb]

1.47188
0.000552928

41^GLU 109^ARG 113^ARG 131^THR 132^CYS 133^PRO

0.0.0.0

2a4dA

[pdb]

1.47517
0.000579599

87^ARG 90^ARG 120^THR 145^CYS 151^GLU 154^PRO

cell differentiation
regulation of transcription
DNA-dependent
ubiquitin-dependent protein catabolic process
regulation of DNA repair
protein polyubiquitination
regulation of protein metabolic process
post-translational protein modification
positive regulation of NF-kappaB transcription factor activity
positive regulation of I-kappaB kinase/NF-kappaB cascade
modification-dependent protein catabolic process

nucleus
ubiquitin conjugating enzyme complex
cytoplasm

transcription activator activity
small conjugating protein ligase activity
protein binding

2hlwA

[pdb]

1.47789
0.000579677

36^ARG 39^ARG 69^THR 94^CYS 100^GLU 103^PRO

cell differentiation
regulation of transcription
DNA-dependent
ubiquitin-dependent protein catabolic process
regulation of DNA repair
protein polyubiquitination
regulation of protein metabolic process
post-translational protein modification
positive regulation of NF-kappaB transcription factor activity
positive regulation of I-kappaB kinase/NF-kappaB cascade
modification-dependent protein catabolic process

nucleus
ubiquitin conjugating enzyme complex
cytoplasm

transcription activator activity
small conjugating protein ligase activity
protein binding

1j7dA

[pdb]

1.48986
0.000638082

11^GLU 14^ARG 44^ASP 69^VAL 75^ILE 78^PRO

T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
response to DNA damage stimulus
ubiquitin-dependent protein catabolic process
DNA repair
proteolysis
regulation of DNA repair
regulation of protein metabolic process
protein ubiquitination
regulation of histone ubiquitination
positive regulation of ubiquitin-protein ligase activity
positive regulation of histone modification
postreplication repair
DNA double-strand break processing
double-strand break repair via homologous recombination
histone ubiquitination
positive regulation of DNA repair
positive regulation of I-kappaB kinase/NF-kappaB cascade
ubiquitin cycle
protein modification process
post-translational protein modification
ubiquitin cycle
ubiquitin-dependent protein catabolic process
cell proliferation
regulation of DNA repair
protein polyubiquitination
regulation of protein metabolic process
post-translational protein modification
DNA double-strand break processing
protein ubiquitination
modification-dependent protein catabolic process
modification-dependent protein catabolic process

cytoplasm
UBC13-MMS2 complex
nucleus
cytoplasm
nucleus
UBC13-MMS2 complex

ligase activity
ubiquitin-protein ligase activity
small conjugating protein ligase activity
protein binding
ubiquitin binding
protein binding
small conjugating protein ligase activity
nucleotide binding
ATP binding

1rrsA

[pdb]

1.51207
0.00073623

149^ARG 153^ARG 154^LEU 204^SER 208^CYS 209^PRO

0.0.0.0

hydrolase activity
acting on glycosyl bonds
hydrolase activity
4 iron
4 sulfur cluster binding
DNA N-glycosylase activity
endonuclease activity
catalytic activity
DNA binding

intracellular

metabolic process
DNA repair
base-excision repair

2pmzY

[pdb]

1.54021
0.000889542

4^PRO 7^GLY 9^CYS 42^ILE 46^LYS 49^LEU

2.7.7.6

nucleus
nucleus
RNA polymerase complex

transcription
transcription
transcription
DNA-dependent
transcription
transcription
transcription
DNA-dependent
transcription
transcription
DNA-dependent
transcription
transcription
transcription
DNA-dependent
transcription
regulation of transcription
transcription
DNA-dependent
cellular metabolic process
transcription
transcription
transcription
DNA-dependent
transcription
DNA-dependent
transcription

zinc ion binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
ribonucleoside binding
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
DNA binding
metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
RNA binding
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
catalytic activity
nucleotide binding
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
metal ion binding
nucleotidyltransferase activity
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity

2v65A

[pdb]

1.54221
0.000889628

157^ARG 159^ARG 274^LEU 290^PRO 291^CYS 299^THR

1.1.1.27

cytoplasm

oxidation reduction
glycolysis
cellular carbohydrate metabolic process
anaerobic glycolysis
metabolic process
carbohydrate metabolic process

oxidoreductase activity
L-lactate dehydrogenase activity
oxidoreductase activity
acting on the CH-OH group of donors
NAD or NADP as acceptor
binding
catalytic activity

2o7dE

[pdb]

1.54464
0.000932703

238^ARG 240^ARG 242^GLU 301^SER 304^CYS 306^PRO

0.0.0.0

biosynthetic process

lyase activity
histidine ammonia-lyase activity
ammonia ligase activity
catalytic activity

2jndA

[pdb]

1.54965
0.00093293

69^THR 81^GLU 83^PRO 84^CYS 101^ARG 112^ARG

0.0.0.0

G-protein coupled receptor activity
receptor activity
signal transducer activity
corticotrophin-releasing factor receptor activity
protein binding
hormone activity
transmembrane receptor activity

G-protein coupled receptor protein signaling pathway
signal transduction
negative regulation of angiogenesis
cell surface receptor linked signal transduction

plasma membrane
integral to membrane
membrane

1ml0D

[pdb]

1.562
0.00102571

29^ARG 30^ARG 33^SER 36^CYS 37^PRO 39^GLU

0.0.0.0

anti-apoptosis
inflammatory response
chemotaxis
G-protein signaling
coupled to cyclic nucleotide second messenger
cell adhesion
protein amino acid phosphorylation
viral genome replication
organ morphogenesis
JAK-STAT cascade
G-protein coupled receptor protein signaling pathway
cell surface receptor linked signal transduction
signal transduction
humoral immune response
cellular calcium ion homeostasis
immune response
vascular endothelial growth factor receptor signaling pathway
cytokine-mediated signaling pathway
transforming growth factor beta receptor signaling pathway
positive regulation of endothelial cell proliferation
response to bacterium
macrophage chemotaxis
monocyte chemotaxis

extracellular region
extracellular space
cell soma
cytoplasm

protein binding
cytokine activity
chemokine activity
signal transducer activity
receptor binding
protein kinase activity
protein binding
CCR2 chemokine receptor binding
G-protein-coupled receptor binding

1v6aA

[pdb]

1.56904
0.0010754

155^ARG 157^ARG 276^LEU 292^PRO 293^CYS 301^THR

1.1.1.27

cytoplasm

oxidation reduction
glycolysis
cellular carbohydrate metabolic process
anaerobic glycolysis
metabolic process
carbohydrate metabolic process

oxidoreductase activity
L-lactate dehydrogenase activity
oxidoreductase activity
acting on the CH-OH group of donors
NAD or NADP as acceptor
binding
catalytic activity

3flvB

[pdb]

1.58621
0.00123222

46^PRO 47^CYS 49^LEU 51^ARG 60^ARG 68^SER

0.0.0.0

lipid binding
binding
acyl-CoA binding

membrane
integral to membrane

transport

1pp9A

[pdb]

1.60427
0.00134814

46^ILE 92^PRO 161^HIS 231^LYS 233^ARG 234^LYS

electron transport chain
transport
respiratory electron transport chain
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
proteolysis
electron transport chain
transport
proteolysis
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
oxidation reduction
electron transport chain
transport
electron transport chain
transport

metal ion binding
iron ion binding
oxidoreductase activity
electron carrier activity
oxidoreductase activity
acting on diphenols and related substances as donors
ubiquinol-cytochrome-c reductase activity
ubiquinol-cytochrome-c reductase activity
metal ion binding
zinc ion binding
metalloendopeptidase activity
catalytic activity
metal ion binding
zinc ion binding
metalloendopeptidase activity
catalytic activity
ubiquinol-cytochrome-c reductase activity
metal ion binding
iron ion binding
heme binding
electron carrier activity
2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
ubiquinol-cytochrome-c reductase activity
electron carrier activity
ubiquinol-cytochrome-c reductase activity

mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial envelope
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion

2hcyA

[pdb]

1.60794
0.00140945

150^PRO 153^CYS 157^THR 298^ARG 302^ARG 305^LEU

1.1.1.1

metal ion binding
oxidoreductase activity
zinc ion binding
alcohol dehydrogenase (NAD) activity
methylglyoxal reductase (NADH-dependent) activity
binding
catalytic activity
protein binding

oxidation reduction
ethanol biosynthetic process during fermentation
NADH oxidation
amino acid catabolic process to alcohol via Ehrlich pathway
metabolic process

plasma membrane enriched fraction
cytoplasm

2qtzA

[pdb]

1.61014
0.00140959

385^LEU 399^ARG 400^ARG 433^SER 434^CYS 436^PRO

1.16.1.8

NADP or NADPH binding
FAD binding
FMN binding
[methionine synthase] reductase activity
oxidoreductase activity
electron carrier activity
iron ion binding

cytosol
cytoplasm
mitochondrion

oxidation reduction
methionine metabolic process
methionine biosynthetic process
cellular amino acid biosynthetic process

1guzC

[pdb]

1.61233
0.00140973

146^LEU 150^ARG 169^CYS 185^THR 207^ARG 248^PRO

1.1.1.37

oxidation reduction
tricarboxylic acid cycle
cellular carbohydrate metabolic process
metabolic process
malate metabolic process
glycolysis
carbohydrate metabolic process
oxidation reduction
tricarboxylic acid cycle
cellular carbohydrate metabolic process
metabolic process
malate metabolic process
glycolysis
carbohydrate metabolic process
oxidation reduction
tricarboxylic acid cycle
cellular carbohydrate metabolic process
metabolic process
malate metabolic process
glycolysis
carbohydrate metabolic process

oxidoreductase activity
L-malate dehydrogenase activity
oxidoreductase activity
acting on the CH-OH group of donors
NAD or NADP as acceptor
binding
catalytic activity
oxidoreductase activity
L-malate dehydrogenase activity
oxidoreductase activity
acting on the CH-OH group of donors
NAD or NADP as acceptor
binding
catalytic activity
oxidoreductase activity
L-malate dehydrogenase activity
oxidoreductase activity
acting on the CH-OH group of donors
NAD or NADP as acceptor
binding
catalytic activity

2jcvB

[pdb]

1.62967
0.00160955

321^CYS 323^THR 365^PRO 372^LEU 376^ARG 381^ARG

1.1.1.267

metal ion binding
oxidoreductase activity
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
binding
catalytic activity

oxidation reduction
isoprenoid biosynthetic process
metabolic process
terpenoid biosynthetic process

2o6xA

[pdb]

1.63285
0.00160978

217^GLU 250^SER 255^PRO 293^ARG 296^ARG 302^CYS

0.0.0.0

cysteine-type peptidase activity
cysteine-type endopeptidase activity
endopeptidase activity
cysteine-type endopeptidase activity
hydrolase activity
cysteine-type peptidase activity
peptidase activity
peptidase activity
hydrolase activity

extracellular region

proteolysis
proteolysis

2gh0B

[pdb]

1.64281
0.00175505

274^PRO 284^GLU 287^ARG 290^ARG 340^CYS 342^THR

nervous system development
peripheral nervous system development
signal transduction
neuron development
sympathetic nervous system development
axon guidance
neuron migration
neuroblast proliferation
signal transduction
induction of positive chemotaxis
peripheral nervous system development
axon guidance

plasma membrane
anchored to membrane
membrane
extrinsic to membrane
external side of plasma membrane
extracellular region
extracellular space

receptor activity
receptor binding
axon guidance receptor activity
protein binding
growth factor activity
receptor binding
protein binding

3fhcA

[pdb]

1.65562
0.0019077

20^ARG 293^ASN 294^VAL 324^THR 342^LEU 348^ARG

intracellular protein transmembrane transport
mRNA transport
protein transport
transport
protein export from nucleus
regulation of cell cycle
protein import into nucleus
mRNA export from nucleus
intracellular protein transmembrane transport
mRNA transport
protein transport
transport
mRNA export from nucleus

nuclear pore
nucleus
cytosol
nuclear membrane
cytoplasm
membrane
nuclear pore
nucleus

protein binding
transporter activity
nucleocytoplasmic transporter activity
hydrolase activity
ATP binding
helicase activity
RNA binding
nucleotide binding
ATP-dependent helicase activity
nucleic acid binding
protein binding

3b8iE

[pdb]

1.6603
0.00190808

17^LEU 21^ARG 25^THR 44^CYS 84^PRO 229^ARG

4.1.1.3

catalytic activity
magnesium ion binding
oxaloacetate decarboxylase activity
lyase activity
carboxy-lyase activity
metal ion binding

oxaloacetate metabolic process
pyruvate biosynthetic process

1v47B

[pdb]

1.6606
0.0019081

169^ARG 176^ARG 294^CYS 295^PRO 302^SER 335^GLU

0.0.0.0

nucleotidyltransferase activity
transferase activity
sulfate adenylyltransferase (ATP) activity
protein binding
nucleotidyltransferase activity
transferase activity
sulfate adenylyltransferase (ATP) activity
protein binding

sulfate assimilation
sulfate assimilation

2o0rB

[pdb]

1.66775
0.00198892

34^PRO 287^LEU 292^ARG 297^ARG 373^THR 375^CYS

0.0.0.0

biosynthetic process

transferase activity
transaminase activity
pyridoxal phosphate binding
1-aminocyclopropane-1-carboxylate synthase activity
transferase activity
transferring nitrogenous groups
catalytic activity

1yujA

[pdb]

1.67147
0.00207251

35^THR 36^CYS 37^PRO 47^ARG 51^ARG 53^LEU

nucleus
polytene chromosome
euchromatin
intracellular
centromeric heterochromatin
chromatin

protein binding
DNA binding
transcription activator activity
protein heterodimerization activity
metal ion binding
zinc ion binding
nucleic acid binding
specific RNA polymerase II transcription factor activity

regulation of transcription
protein oligomerization
positive regulation of transcription
DNA-dependent
chromatin assembly
cell division
oogenesis
cell differentiation
chromatin modification
multicellular organismal development
mitosis
cell cycle
regulation of transcription
DNA-dependent
transcription
syncytial blastoderm mitotic cell cycle
cellular process
dosage compensation
imaginal disc-derived wing morphogenesis
chromatin organization
nuclear division

1f2rI

[pdb]

1.6766
0.00215935

20^PRO 21^CYS 24^ARG 29^ARG 49^LEU 83^THR

apoptosis
positive regulation of apoptosis
induction of apoptosis
DNA fragmentation involved in apoptosis
apoptosis
DNA fragmentation involved in apoptosis
apoptotic chromosome condensation

cytoplasm
intracellular
cytoplasm
nucleus
intracellular

protein binding
hydrolase activity
nuclease activity
protein binding
nicotinate phosphoribosyltransferase activity
DNA binding
enzyme binding

2f9wA

[pdb]

1.68294
0.00224955

127^THR 143^CYS 144^PRO 189^LEU 193^ARG 197^ARG

2.7.1.33

cytoplasm

metal ion binding
potassium ion binding
transferase activity
kinase activity
ATP binding
nucleotide binding
pantothenate kinase activity
transcription activator activity

response to antibiotic
coenzyme A biosynthetic process
positive regulation of transcription

1sxjE

[pdb]

1.68486
0.00224973

37^ALA 155^SER 156^ASP 167^ILE 183^LYS 185^PHE

cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
chromatin silencing at telomere
postreplication repair
mismatch repair
nucleotide-excision repair
base-excision repair
lagging strand elongation
leading strand elongation
meiotic mismatch repair
regulation of DNA replication
response to DNA damage stimulus
DNA repair
DNA replication
chromatin silencing at silent mating-type cassette
mitotic sister chromatid cohesion
cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
cell cycle checkpoint
cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
cell division
cell cycle
DNA replication
mismatch repair
DNA repair
leading strand elongation
mitotic cell cycle

nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
replication fork
nucleus
PCNA complex
nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
nucleus
DNA replication factor C complex
intracellular

protein binding
ATP binding
DNA binding
nucleotide binding
ATPase activity
DNA clamp loader activity
nucleoside-triphosphatase activity
DNA polymerase processivity factor activity
DNA binding
protein binding
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity

1si2A

[pdb]

1.69308
0.00234346

253^ARG 255^ARG 283^THR 323^LEU 325^CYS 338^PRO

0.0.0.0

RNA binding
translation initiation factor activity
nucleic acid binding
protein binding

cytoplasmic mRNA processing body
cytoplasm
ribonucleoprotein complex
eukaryotic translation initiation factor 2 complex

nuclear-transcribed mRNA catabolic process
transcription
regulation of translation
gene silencing by miRNA
negative regulation of translation
regulation of transcription
gene silencing by RNA
translation
regulation of translational initiation

1jofD

[pdb]

1.69715
0.00244025

315^SER 317^CYS 318^PRO 322^GLU 338^ARG 346^ARG

5.5.1.5

isomerase activity
carboxy-cis,cis-muconate cyclase activity

1zrtR

[pdb]

1.70196
0.00244072

94^ARG 140^PRO 153^CYS 158^SER 173^ARG 175^LEU

1.10.2.2

electron transport chain
transport
respiratory electron transport chain
electron transport chain
transport
oxidation reduction
electron transport chain
transport

metal ion binding
iron ion binding
oxidoreductase activity
electron carrier activity
iron-sulfur cluster binding
oxidoreductase activity
acting on diphenols and related substances as donors
metal ion binding
iron ion binding
heme binding
electron carrier activity
2 iron
2 sulfur cluster binding
metal ion binding
iron ion binding
ubiquinol-cytochrome-c reductase activity
oxidoreductase activity
electron carrier activity

plasma membrane
integral to membrane
membrane
mitochondrial respiratory chain
respiratory chain
respiratory chain
plasma membrane
integral to membrane
membrane
mitochondrial respiratory chain
plasma membrane
integral to membrane
membrane

1s1hB

[pdb]

1.70313
0.00244084

21^ARG 26^HIS 40^GLN 148^VAL 160^ASP 161^VAL

SSU rRNA binding
SSU rRNA binding
structural constituent of ribosome
mRNA binding
protein binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
ribonucleoprotein binding
rRNA binding
GTP binding
translation elongation factor activity
RNA binding
nucleotide binding
GTPase activity
protein binding
structural constituent of ribosome
structural constituent of ribosome
metal ion binding
zinc ion binding
structural constituent of ribosome
protein binding
structural constituent of ribosome
structural constituent of ribosome
protein binding
structural constituent of ribosome
RNA binding
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
nucleic acid binding
RNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
structural constituent of ribosome
protein binding
fibroblast growth factor 3 binding
rRNA binding
structural constituent of ribosome
RNA binding
DNA binding
structural constituent of ribosome
rRNA binding
structural constituent of ribosome
structural constituent of ribosome

nucleolus
nucleolus
nucleolus
cytoplasm
ribonucleoprotein complex
ribosome
nucleus
small-subunit processome
90S preribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribosome
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
small ribosomal subunit
ribosome
intracellular
cytoplasm
ribonucleoprotein complex
cytosolic small ribosomal subunit
cytoplasm
ribonucleoprotein complex
ribosome
nucleus
small-subunit processome
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
mitochondrion
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
preribosome
small subunit precursor
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
nucleus
small-subunit processome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
intracellular

ribosome biogenesis
rRNA processing
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
ribosomal small subunit assembly
translation
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
ribosomal small subunit assembly
translation
translational elongation
ribosome biogenesis
translation
rRNA export from nucleus
translation
translation
regulation of translational fidelity
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
translation
rRNA export from nucleus
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
ribosome biogenesis
rRNA processing
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
rRNA export from nucleus
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
rRNA export from nucleus
ribosome biogenesis
rRNA processing
positive regulation of translational fidelity
rRNA export from nucleus
translation
translation
rRNA export from nucleus
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA
5.8S rRNA
LSU-rRNA)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
ribosomal small subunit assembly
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)

1ohtA

[pdb]

1.70372
0.00253904

16^LEU 18^ARG 24^ARG 54^PRO 56^CYS 59^SER

3.5.1.28

extracellular region

peptidoglycan catabolic process
defense response to Gram-positive bacterium
innate immune response
immune response
peptidoglycan metabolic process

protein binding
peptidoglycan binding
metal ion binding
hydrolase activity
zinc ion binding
N-acetylmuramoyl-L-alanine amidase activity
amidase activity

1tzpA

[pdb]

1.71368
0.00264001

39^SER 74^LEU 175^ARG 213^ARG 216^CYS 217^PRO

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
serine-type endopeptidase activity
metalloendopeptidase activity
metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
serine-type endopeptidase activity
metalloendopeptidase activity

periplasmic space
outer membrane-bounded periplasmic space
periplasmic space
outer membrane-bounded periplasmic space

proteolysis
peptidoglycan metabolic process
proteolysis
peptidoglycan metabolic process

1kogC

[pdb]

1.7181
0.00274408

331^PRO 360^SER 361^CYS 365^GLU 375^ARG 520^ARG

6.1.1.3

cytoplasm

metal ion binding
ligase activity
zinc ion binding
ATP binding
aminoacyl-tRNA ligase activity
RNA binding
nucleotide binding
threonine-tRNA ligase activity
ligase activity
forming aminoacyl-tRNA and related compounds
protein binding

regulation of translation
translation
tRNA aminoacylation
threonyl-tRNA aminoacylation
tRNA aminoacylation for protein translation

2hayB

[pdb]

1.71828
0.0027441

17^THR 164^CYS 165^PRO 197^LEU 200^ARG 202^ARG

0.0.0.0

oxidation reduction

oxidoreductase activity

2id5A

[pdb]

1.71967
0.00274426

1^THR 3^CYS 4^PRO 14^ARG 17^LEU 35^ARG

negative regulation of oligodendrocyte differentiation
protein kinase B signaling cascade
central nervous system neuron development
neuron projection development

plasma membrane
integral to membrane
membrane

protein binding
epidermal growth factor receptor binding

1njfD

[pdb]

1.72069
0.00274437

62^LEU 64^CYS 66^THR 72^PRO 117^ARG 119^ARG

2.7.7.7

DNA polymerase III complex
nucleus

DNA replication

nucleotidyltransferase activity
transferase activity
ATP binding
DNA-directed DNA polymerase activity
nucleotide binding
nucleoside-triphosphatase activity
DNA binding
protein binding

3dtyE

[pdb]

1.7225
0.00274456

116^PRO 118^CYS 120^THR 368^GLU 371^ARG 375^ARG

0.0.0.0

metabolic process

oxidoreductase activity
electron carrier activity
binding
catalytic activity

2yyeB

[pdb]

1.72385
0.00274471

98^SER 99^CYS 105^LEU 111^ARG 115^ARG 139^PRO

2.7.9.3

transferase activity
kinase activity
selenium binding
ATP binding
magnesium ion binding
nucleotide binding
selenide
water dikinase activity
catalytic activity

3b4wA

[pdb]

1.73006
0.00285279

229^THR 238^ARG 242^ARG 246^GLU 250^PRO 251^CYS

0.0.0.0

oxidation reduction
metabolic process

oxidoreductase activity

3c0qA

[pdb]

1.73155
0.00285296

7^PRO 8^CYS 16^THR 40^ARG 44^ARG 46^LEU

0.0.0.0

endonuclease activity

nucleotide-excision repair

2zk9X

[pdb]

1.74168
0.00308078

22^SER 31^PRO 32^CYS 45^ARG 50^ARG 163^LEU

0.0.0.0

2oo6A

[pdb]

1.74459
0.00308113

122^SER 124^CYS 125^PRO 150^GLU 153^ARG 155^ARG

0.0.0.0

catalytic activity

metabolic process

2f1zB

[pdb]

1.75914
0.00332627

66^ARG 70^THR 89^PRO 90^CYS 93^ARG 95^LEU

3.1.2.15

modification-dependent protein catabolic process
protein deubiquitination
interspecies interaction between organisms
ubiquitin-dependent protein catabolic process

nucleus
cytoplasm

ubiquitin-specific protease activity
protein C-terminus binding
protein binding
hydrolase activity
cysteine-type peptidase activity
peptidase activity
ubiquitin thiolesterase activity
cysteine-type endopeptidase activity

2p26A

[pdb]

1.76734
0.0035883

12^ARG 16^GLU 19^PRO 21^CYS 22^THR 426^ARG

plasma membrane
cytoplasm
integrin complex
membrane
integral to membrane
membrane raft
cell surface
membrane fraction

protein kinase binding
protein binding
receptor activity
binding
cell adhesion molecule binding
protein heterodimerization activity
glycoprotein binding

regulation of peptidyl-tyrosine phosphorylation
apoptosis
inflammatory response
cell-cell signaling
regulation of cell shape
neutrophil chemotaxis
leukocyte adhesion
integrin-mediated signaling pathway
cell adhesion
cell-matrix adhesion
positive regulation of NF-kappaB transcription factor activity
activated T cell proliferation
positive regulation of angiogenesis
positive regulation of nitric oxide biosynthetic process
cellular extravasation
endothelial cell migration
natural killer cell activation
leukocyte migration during inflammatory response

2f1yA

[pdb]

1.77385
0.00372422

66^ARG 70^THR 89^PRO 90^CYS 93^ARG 95^LEU

3.1.2.15

nucleus
cytoplasm
cytoplasm
nucleolus
nucleus
nucleoplasm
insoluble fraction
cytosol
intracellular

protein deubiquitination
interspecies interaction between organisms
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
positive regulation of cell proliferation
modification-dependent protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein ubiquitination during ubiquitin-dependent protein catabolic process
protein complex assembly
negative regulation of transcription from RNA polymerase II promoter
protein ubiquitination
regulation of protein catabolic process
interspecies interaction between organisms
ubiquitin-dependent protein catabolic process
negative regulation of cell proliferation
protein catabolic process
traversing start control point of mitotic cell cycle

ubiquitin-specific protease activity
protein C-terminus binding
protein binding
hydrolase activity
cysteine-type peptidase activity
peptidase activity
ubiquitin thiolesterase activity
cysteine-type endopeptidase activity
protein binding
ubiquitin-protein ligase activity
p53 binding
basal transcription repressor activity
enzyme binding
zinc ion binding
metal ion binding
ligase activity
identical protein binding

3bn3B

[pdb]

1.78043
0.00372513

26^THR 28^CYS 29^PRO 32^GLU 71^ARG 75^ARG

activated T cell proliferation
positive regulation of T cell proliferation
positive regulation of cell-cell adhesion
leukocyte adhesion
heterophilic cell adhesion
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
cell adhesion
cell-cell adhesion
phagocytosis
signal transduction
inflammatory response
cell adhesion
integrin-mediated signaling pathway
cell motion
positive regulation of calcium-mediated signaling

cell adhesion molecule binding
protein binding
protein binding
calcium ion binding
receptor activity
magnesium ion binding

external side of plasma membrane
immunological synapse
membrane
integral to membrane
integral to plasma membrane
plasma membrane
integrin complex
membrane
integral to membrane
plasma membrane

2i9bD

[pdb]

1.78718
0.0038635

63^ILE 71^CYS 73^LEU 96^ILE 103^MET 110^HIS

3.4.21.73

extracellular region
plasma membrane
cell surface
integral to membrane
plasma membrane
extracellular region
anchored to membrane
membrane
extrinsic to membrane

fibrinolysis
blood coagulation
signal transduction
chemotaxis
proteolysis
smooth muscle cell migration
response to hypoxia
skeletal muscle regeneration
cell motion
regulation of proteolysis
blood coagulation
chemotaxis
attachment of GPI anchor to protein
signal transduction

hydrolase activity
serine-type peptidase activity
peptidase activity
serine-type endopeptidase activity
catalytic activity
enzyme binding
protein binding
U-plasminogen activator receptor activity
receptor activity

2azpA

[pdb]

1.78886
0.00400593

132^ARG 235^PRO 236^CYS 238^THR 270^GLU 272^ARG

5.1.1.8

isomerase activity
4-hydroxyproline epimerase activity
proline racemase activity

2jkcA

[pdb]

1.79388
0.00400667

141^LEU 147^PRO 148^CYS 150^SER 501^ARG 503^ARG

0.0.0.0

2gtlN

[pdb]

1.79696
0.00415421

81^PHE 97^ASP 100^LEU 102^THR 138^PHE 144^LEU

0.0.0.0

extracellular region
hemoglobin complex
extracellular region
hemoglobin complex
hemoglobin complex
extracellular region
hemoglobin complex
extracellular region

oxygen transporter activity
metal ion binding
iron ion binding
oxygen transporter activity
heme binding
oxygen binding
metal ion binding
iron ion binding
oxygen transporter activity
heme binding
oxygen binding
metal ion binding
iron ion binding
oxygen transporter activity
heme binding
oxygen binding
heme binding
oxygen binding
iron ion binding

transport
oxygen transport
transport
oxygen transport
transport
oxygen transport
transport
oxygen transport

3cj1A

[pdb]

1.80415
0.00430741

245^ARG 251^ARG 253^LEU 264^PRO 310^CYS 315^SER

hydrolase activity
calcium ion binding
magnesium ion binding

membrane
integral to membrane

1rmdA

[pdb]

1.80618
0.00430773

47^ARG 52^ARG 54^LEU 61^CYS 63^SER 67^PRO

DNA recombination
V(D)J recombination
T cell differentiation in the thymus
B cell differentiation
death
negative regulation of caspase activity
negative regulation of thymocyte apoptosis

metal ion binding
hydrolase activity
zinc ion binding
endonuclease activity
nuclease activity
DNA binding
protein binding
nucleic acid binding

nucleus
intracellular

2j28Z

[pdb]

1.81068
0.00446569

34^LEU 37^CYS 38^SER 42^PRO 56^ARG 59^ARG

rRNA binding
RNA binding
structural constituent of ribosome
protein binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
protein binding
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
protein binding
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
protein binding
structural constituent of ribosome
protein binding
rRNA binding
RNA binding
nucleotide binding
protein binding
rRNA binding
RNA binding
tRNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
structural constituent of ribosome
rRNA binding
RNA binding
tRNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
protein binding
rRNA binding
RNA binding
structural constituent of ribosome
protein binding
structural constituent of ribosome
protein binding
structural constituent of ribosome
RNA binding
tRNA binding
structural constituent of ribosome
structural constituent of ribosome
rRNA binding
RNA binding
tRNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
protein binding
rRNA binding
RNA binding
transferase activity
structural constituent of ribosome
protein binding
structural constituent of ribosome
GTP binding
RNA binding
nucleotide binding
nucleoside-triphosphatase activity
7S RNA binding
rRNA binding
RNA binding
structural constituent of ribosome
protein binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
5S rRNA binding
structural constituent of ribosome
protein binding
metal ion binding
rRNA binding
zinc ion binding
RNA binding
structural constituent of ribosome

ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
large ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
large ribosomal subunit
ribonucleoprotein complex
ribosome
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
large ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
large ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
large ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
signal recognition particle
endoplasmic reticulum targeting
signal recognition particle
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
large ribosomal subunit
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular
ribonucleoprotein complex
ribosome
intracellular

translation
translation
translation
translation
translation
translation
response to antibiotic
translation
translation
translation
translation
translation
translation
ribosomal large subunit assembly
translation
translation
translation
response to antibiotic
regulation of translation
regulation of transcription
DNA-dependent
transcription termination
transcription
translation
translation
regulation of transcription
translation
translation
translation
translation
response to antibiotic
translation
translation
translation
SRP-dependent cotranslational protein targeting to membrane
translation
translation
translation
translation
translation

1gt8C

[pdb]

1.81198
0.00446591

74^ARG 78^ARG 80^LEU 86^PRO 140^CYS 149^SER

1.3.1.2

NADP or NADPH binding
FAD binding
protein homodimerization activity
dihydropyrimidine dehydrogenase (NADP+) activity
FMN binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
electron carrier activity
binding
dihydroorotate oxidase activity
dihydroorotate dehydrogenase activity
catalytic activity

cytoplasm

thymidine catabolic process
uracil catabolic process
oxidation reduction
metabolic process
UMP biosynthetic process
'de novo' pyrimidine base biosynthetic process

2oypA

[pdb]

1.81528
0.00446645

15^PRO 16^CYS 17^SER 47^ARG 90^ARG 103^GLU

0.0.0.0

receptor activity

1ym7A

[pdb]

1.81568
0.00462903

376^SER 379^CYS 390^PRO 407^LEU 431^ARG 436^ARG

2.7.11.15

membrane
cytosol

phosphorylation
peptidyl-threonine phosphorylation
signal transduction
protein amino acid phosphorylation
regulation of signal transduction
intracellular protein transport
cardiac muscle contraction
negative regulation of striated muscle contraction
peptidyl-serine phosphorylation
negative regulation of the force of heart contraction by chemical signal
desensitization of G-protein coupled receptor protein signaling pathway
muscarinic acetylcholine receptor signaling pathway
heart development
G-protein coupled receptor protein signaling pathway
regulation of the force of heart contraction
negative regulation of G-protein coupled receptor protein signaling pathway

transferase activity
kinase activity
ATP binding
protein serine/threonine kinase activity
nucleotide binding
beta-adrenergic receptor kinase activity
signal transducer activity
G-protein coupled receptor kinase activity
protein kinase activity
protein binding

2c6fB

[pdb]

1.81638
0.00462915

230^ARG 245^ARG 252^LEU 468^THR 474^CYS 475^PRO

3.4.15.1

peptidyl-dipeptidase activity
metallopeptidase activity
metal ion binding
hydrolase activity
zinc ion binding
peptidase activity
carboxypeptidase activity
bradykinin receptor binding
drug binding
chloride ion binding

plasma membrane
integral to membrane
membrane
extracellular region
extracellular space
endosome
membrane fraction
external side of plasma membrane

regulation of vasoconstriction
angiotensin catabolic process in blood
regulation of systemic arterial blood pressure by renin-angiotensin
proteolysis
blood vessel remodeling
kidney development
hormone catabolic process
mononuclear cell proliferation
regulation of blood pressure
regulation of vasodilation
peptide catabolic process
arachidonic acid secretion
regulation of smooth muscle cell migration
hemopoietic stem cell differentiation
regulation of renal output by angiotensin

3bq9B

[pdb]

1.81709
0.00462927

179^THR 181^CYS 212^GLU 221^PRO 237^ARG 243^ARG

0.0.0.0

1d2vC

[pdb]

1.81772
0.00462938

231^PRO 232^CYS 241^SER 363^ARG 370^ARG 373^LEU

1.11.1.7

lysosome
nucleus
extracellular space

metal ion binding
oxidoreductase activity
calcium ion binding
iron ion binding
peroxidase activity
chromatin binding
heme binding

response to oxidative stress
oxidation reduction
hydrogen peroxide catabolic process
defense response
anti-apoptosis
low-density lipoprotein particle remodeling

1dj3B

[pdb]

1.82377
0.00479835

120^ARG 124^LEU 153^PRO 154^CYS 160^THR 165^ARG

6.3.4.4

metal ion binding
ligase activity
GTP binding
magnesium ion binding
nucleotide binding
adenylosuccinate synthase activity

plastid
chloroplast

purine nucleotide biosynthetic process

2ja4A

[pdb]

1.8249
0.00479855

277^ARG 292^ARG 343^PRO 348^SER 350^CYS 353^LEU

0.0.0.0

external side of plasma membrane
integral to plasma membrane
membrane
integral to membrane
plasma membrane

induction of apoptosis by extracellular signals
T cell costimulation
cell recognition
cell proliferation

transmembrane receptor activity
protein binding
receptor activity
scavenger receptor activity

1ez0C

[pdb]

1.82613
0.00479877

49^LEU 54^ARG 59^ARG 161^SER 167^CYS 168^PRO

1.2.1.4

oxidation reduction
metabolic process

oxidoreductase activity
aldehyde dehydrogenase (NADP+) activity

1yvjA

[pdb]

1.82664
0.00479885

920^ARG 925^ARG 927^LEU 1022^THR 1066^CYS 1067^PRO

2.7.10.2

endomembrane system
membrane
cytoskeleton

enzyme linked receptor protein signaling pathway
protein kinase cascade
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
protein amino acid phosphorylation

transferase activity
kinase activity
ATP binding
protein tyrosine kinase activity
nucleotide binding
non-membrane spanning protein tyrosine kinase activity
protein binding
Janus kinase activity
protein kinase activity

2rfiB

[pdb]

1.82792
0.00479908

1000^SER 1003^CYS 1004^PRO 1099^LEU 1101^ARG 1103^ARG

2.1.1.43

histone methylation
chromatin modification

histone-lysine N-methyltransferase activity
methyltransferase activity
metal ion binding
transferase activity
zinc ion binding

nucleus

2uvcL

[pdb]

1.83251
0.00497342

160^ARG 264^THR 265^CYS 272^PRO 277^GLU 278^ARG

0.0.0.0

fatty acid synthase complex

metabolic process
fatty acid biosynthetic process

transferase activity
oxidoreductase activity
fatty-acid synthase activity

1tmf2

[pdb]

1.8356
0.00497398

100^ARG 101^ASN 106^ARG 215^GLY 254^PRO 260^ARG

0.0.0.0

RNA-protein covalent cross-linking
transcription
RNA-dependent
viral genome replication
proteolysis
transcription
RNA-protein covalent cross-linking
transcription
RNA-dependent
viral genome replication
proteolysis
transcription

cytoplasm
cytoplasmic vesicle
viral capsid
virion
membrane
icosahedral viral capsid
cytoplasm
cytoplasmic vesicle
viral capsid
virion
membrane
icosahedral viral capsid
host cell cytoplasm
host cell cytoplasm

hydrolase activity
nucleotidyltransferase activity
transferase activity
cysteine-type peptidase activity
peptidase activity
ATP binding
structural molecule activity
helicase activity
RNA-directed RNA polymerase activity
RNA binding
nucleotide binding
nucleoside-triphosphatase activity
cysteine-type endopeptidase activity
catalytic activity
RNA helicase activity
hydrolase activity
nucleotidyltransferase activity
transferase activity
cysteine-type peptidase activity
peptidase activity
ATP binding
structural molecule activity
helicase activity
RNA-directed RNA polymerase activity
RNA binding
nucleotide binding
nucleoside-triphosphatase activity
cysteine-type endopeptidase activity
catalytic activity
RNA helicase activity

1uscA

[pdb]

1.83665
0.00515342

27^ARG 35^CYS 36^PRO 60^THR 69^ARG 111^LEU

0.0.0.0

oxidoreductase activity
FMN binding
electron carrier activity

3c4mA

[pdb]

1.8371
0.00515351

107^PRO 108^CYS 125^HOH 146^ARG 147^ARG 153^SER

cell surface receptor linked signal transduction
bone resorption
aging
activation of adenylate cyclase activity by G-protein signaling pathway
carbohydrate transport
transport
maltose transport
positive regulation of signal transduction
positive regulation of transcription from RNA polymerase II promoter
G-protein coupled receptor protein signaling pathway
signal transduction
G-protein signaling
coupled to cyclic nucleotide second messenger
skeletal system development
cell maturation
bone mineralization
negative regulation of cell proliferation
positive regulation of cell proliferation
elevation of cytosolic calcium ion concentration
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
cellular calcium ion homeostasis
osteoblast development
chondrocyte differentiation
ossification
bone resorption
cellular calcium ion homeostasis
induction of apoptosis by hormones
cAMP metabolic process
cell-cell signaling
G-protein coupled receptor protein signaling pathway
skeletal system development
positive regulation of cAMP biosynthetic process
regulation of gene expression
Rho protein signal transduction
activation of adenylate cyclase activity by G-protein signaling pathway

intracellular
periplasmic space
plasma membrane
integral to membrane
membrane
integral to plasma membrane
cytoplasm
brush border membrane
basolateral plasma membrane
nucleus
extracellular region
extracellular space

sugar:hydrogen symporter activity
maltose transmembrane transporter activity
transporter activity
G-protein coupled receptor activity
receptor activity
signal transducer activity
parathyroid hormone receptor activity
transmembrane receptor activity
hormone activity
parathyroid hormone receptor binding

3eofA

[pdb]

1.8377
0.00515362

77^CYS 81^ARG 82^ARG 109^THR 148^GLU 152^PRO

0.0.0.0

oxidoreductase activity

1szlA

[pdb]

1.83927
0.00515391

440^SER 466^ARG 468^ARG 470^LEU 479^PRO 480^CYS

cell adhesion

protein binding

proteinaceous extracellular matrix
extracellular region

2is6A

[pdb]

1.8451
0.00533716

284^ARG 291^SER 317^PRO 605^ARG 610^LEU 640^CYS

SOS response
response to DNA damage stimulus
DNA repair
DNA replication
DNA unwinding during replication

cytoplasm

hydrolase activity
ATP binding
helicase activity
DNA binding
nucleotide binding
ATP-dependent DNA helicase activity
protein binding

1ixkA

[pdb]

1.84708
0.00533753

106^SER 196^PRO 197^CYS 249^LEU 295^ARG 296^ARG

0.0.0.0

S-adenosylmethionine-dependent methyltransferase activity
RNA binding
methyltransferase activity

rRNA processing

1m22A

[pdb]

1.84902
0.00533789

84^ARG 86^ARG 167^LEU 198^SER 200^CYS 230^PRO

0.0.0.0

carbon-nitrogen ligase activity
with glutamine as amido-N-donor

1up7F

[pdb]

1.85083
0.00552342

150^ARG 318^ARG 332^LEU 335^PRO 336^CYS 345^THR

3.2.1.86

metabolic process
carbohydrate metabolic process

metal ion binding
manganese ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
6-phospho-beta-glucosidase activity
binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1p59A

[pdb]

1.8524
0.00552372

144^ARG 148^ARG 193^SER 196^CYS 197^PRO 207^GLU

0.0.0.0

3binA

[pdb]

1.85258
0.00552375

209^LEU 210^ARG 219^PRO 220^CYS 224^THR 254^ARG

biological_process
cortical actin cytoskeleton organization
positive regulation of cytokine secretion
susceptibility to natural killer cell mediated cytotoxicity
detection of stimulus
activated T cell proliferation
positive regulation of natural killer cell mediated cytotoxicity
cell recognition
T cell mediated cytotoxicity
heterophilic cell adhesion
homophilic cell adhesion
negative regulation of cell cycle
cell differentiation
multicellular organismal development
cell adhesion
cell cycle
immune response
apoptosis
spermatogenesis

cytoskeletal protein binding
binding
structural molecule activity
actin binding
protein binding
receptor binding
protein binding
PDZ domain binding
protein C-terminus binding
protein homodimerization activity

cytoskeleton
cytoplasm
cell-cell junction
plasma membrane
extrinsic to membrane
plasma membrane
basolateral plasma membrane
cell-cell junction
integral to membrane
membrane

1sddB

[pdb]

1.85422
0.00552407

1542^ARG 1608^ARG 1677^PRO 1707^LEU 1710^CYS 1714^THR

blood coagulation
cell adhesion

extracellular region

metal ion binding
calcium ion binding
copper ion binding
oxidoreductase activity

2ix5C

[pdb]

1.8548
0.00552418

43^PRO 44^CYS 46^SER 63^ARG 67^ARG 71^GLU

1.3.3.6

acyl-CoA oxidase activity
oxidoreductase activity
FAD binding
oxidoreductase activity
acting on the CH-CH group of donors
electron carrier activity
acyl-CoA dehydrogenase activity

peroxisome
glyoxysome

short-chain fatty acid metabolic process
embryonic development ending in seed dormancy
fatty acid beta-oxidation
oxidation reduction
fatty acid metabolic process
lipid metabolic process
metabolic process

1beaA

[pdb]

1.85532
0.00552428

18^PRO 20^CYS 25^THR 60^LEU 88^ARG 92^ARG

extracellular region

peptidase inhibitor activity
serine-type endopeptidase inhibitor activity
endopeptidase inhibitor activity

1ib9A

[pdb]

1.85944
0.00571631

1^SER 8^CYS 9^PRO 12^LEU 17^ARG 28^ARG

extracellular region

peptidase inhibitor activity
serine-type endopeptidase inhibitor activity
endopeptidase inhibitor activity

1vi5B

[pdb]

1.86065
0.00571656

54^ARG 56^ARG 123^PRO 144^CYS 155^LEU 159^THR

ribonucleoprotein complex
ribosome
small ribosomal subunit
intracellular

structural constituent of ribosome

translation

1s3gA

[pdb]

1.86093
0.00571661

127^ARG 135^THR 139^LEU 144^PRO 150^CYS 160^ARG

2.7.4.3

cytoplasm

metal ion binding
transferase activity
kinase activity
zinc ion binding
ATP binding
nucleotide binding
adenylate kinase activity
nucleobase
nucleoside
nucleotide kinase activity
nucleotide kinase activity
phosphotransferase activity
phosphate group as acceptor

nucleotide biosynthetic process
nucleobase
nucleoside
nucleotide and nucleic acid metabolic process

1ej6C

[pdb]

1.86389
0.0057172

643^CYS 645^PRO 680^THR 838^LEU 840^ARG 842^ARG

mRNA processing
mRNA capping
mRNA processing
mRNA capping

structural molecule activity
structural molecule activity
metal ion binding
hydrolase activity
zinc ion binding
ATP binding
structural molecule activity
helicase activity
nucleotide binding
nucleotidyltransferase activity
transferase activity
methyltransferase activity
ATP binding
structural molecule activity
catalytic activity
nucleotide binding
mRNA guanylyltransferase activity
mRNA (guanine-N7-)-methyltransferase activity
GTP binding

virion
viral capsid
viral nucleocapsid
virion
viral nucleocapsid
virion
viral capsid
viral nucleocapsid
intracellular
virion
viral capsid
viral nucleocapsid
viral capsid

1q4kB

[pdb]

1.86389
0.0057172

378^LEU 529^SER 544^CYS 545^PRO 579^ARG 584^ARG

2.7.11.21

cell division
mitosis
cell cycle
positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
cell proliferation
protein amino acid phosphorylation