The LabelHash Server
7mhtA motif
Motif residues: PRO80 CYS81 SER85 GLU119 ARG163 ARG165
Table of Top 100 matches
Click here for a compact table with the top 100 matches.The images below show the motif residues and the match residues superimposed. The carbon atoms are white in the motif and green in the match. Other atoms in the motif and match are colored by element. The C-alphas are shown as spheres, while the remaining motif and match atoms are shown in stick representation. The rest of the matching protein is shown in ribbon representation.
Downloads
- A zip file with PDB files for the top 100 matches and the motif itself.
- An XML file with all matches. You can open this file in Chimera with our ViewMatch plugin.
Top 20 matches
For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.1. 1dctA [pdb]
LRMSD: 0.460694640875p-value: 3.49125257344e-05
Matching residues: PRO70 CYS71 SER75 GLU109 ARG153 ARG155
EC class: 2.1.1.37
GO terms:
Molecular function: transferase activity, methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, DNA binding
Biological process: DNA restriction-modification system, DNA methylation
2. 2qrvD [pdb]
LRMSD: 0.605655908585p-value: 8.92675088835e-05
Matching residues: PRO705 CYS706 SER710 GLU752 ARG786 ARG788
EC class: 0.0.0.0
GO terms:
Molecular function: transcription repressor activity, enzyme binding, metal ion binding, zinc ion binding, enzyme activator activity, protein binding, DNA (cytosine-5-)-methyltransferase activity, metal ion binding, transferase activity, zinc ion binding, methyltransferase activity, DNA binding, protein binding
Biological process: DNA methylation, genetic imprinting, spermatogenesis, in utero embryonic development, DNA methylation, genetic imprinting
Cellular component: cytosol, nucleus, cytoplasm, nuclear heterochromatin, condensed nuclear chromosome, nuclear matrix, euchromatin, cytoplasm, nucleus
3. 2jimA [pdb]
LRMSD: 1.07905983925p-value: 0.000159114817507
Matching residues: ARG540 ARG542 LEU549 PRO552 CYS553 SER555
EC class: 1.7.99.4
GO terms:
Molecular function: 4 iron, 4 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, molybdenum ion binding, oxidoreductase activity, iron ion binding, nitrate reductase activity, binding, electron carrier activity
Biological process: oxidation reduction, nitrate assimilation, electron transport chain, transport, Mo-molybdopterin cofactor biosynthetic process
Cellular component: periplasmic space
4. 1zejA [pdb]
LRMSD: 1.33411955833p-value: 0.00026358795003
Matching residues: ARG81 GLU84 PRO90 CYS92 SER93 ARG106
EC class: 0.0.0.0
GO terms:
Molecular function: coenzyme binding, oxidoreductase activity, binding, catalytic activity
Biological process: metabolic process, fatty acid metabolic process
5. 2gjxA [pdb]
LRMSD: 1.43442749977p-value: 0.000440831296146
Matching residues: SER59 PRO102 CYS104 LEU107 ARG247 ARG249
EC class: 3.2.1.52
GO terms:
Molecular function: hydrolase activity, acting on glycosyl bonds, hydrolase activity, beta-N-acetylhexosaminidase activity, protein heterodimerization activity, cation binding, catalytic activity, protein binding, hydrolase activity, acting on glycosyl bonds, hydrolase activity, beta-N-acetylhexosaminidase activity, protein heterodimerization activity, protein homodimerization activity, cation binding, catalytic activity, hydrolase activity, hydrolyzing O-glycosyl compounds, hydrolase activity, hydrolyzing O-glycosyl compounds
Biological process: metabolic process, carbohydrate metabolic process, neuromuscular process controlling balance, neuromuscular process controlling posture, myelination, glycosaminoglycan metabolic process, sexual reproduction, lipid storage, adult walking behavior, locomotory behavior, sensory perception of sound, lysosome organization, ganglioside catabolic process, skeletal system development, metabolic process, carbohydrate metabolic process, neuromuscular process, neuromuscular process controlling balance, oogenesis, cellular protein metabolic process, myelination, regulation of cellular metabolic process, glycosaminoglycan metabolic process, sexual reproduction, lipid storage, oligosaccharide catabolic process, phospholipid biosynthetic process, male courtship behavior, locomotory behavior, sensory perception of sound, penetration of zona pellucida, single fertilization, lysosome organization, cellular calcium ion homeostasis, ganglioside catabolic process, glycosphingolipid metabolic process, skeletal system development
Cellular component: lysosome, membrane, lysosome, membrane, acrosomal vesicle
6. 2nxoD [pdb]
LRMSD: 1.47187697887p-value: 0.000552927900571
Matching residues: GLU41 ARG109 ARG113 THR131 CYS132 PRO133
EC class: 0.0.0.0
GO terms:
7. 2a4dA [pdb]
LRMSD: 1.47516584396p-value: 0.000579599349294
Matching residues: ARG87 ARG90 THR120 CYS145 GLU151 PRO154
EC class: GO terms:
Molecular function: transcription activator activity, small conjugating protein ligase activity, protein binding
Biological process: cell differentiation, regulation of transcription, DNA-dependent, ubiquitin-dependent protein catabolic process, regulation of DNA repair, protein polyubiquitination, regulation of protein metabolic process, post-translational protein modification, positive regulation of NF-kappaB transcription factor activity, positive regulation of I-kappaB kinase/NF-kappaB cascade, modification-dependent protein catabolic process
Cellular component: nucleus, ubiquitin conjugating enzyme complex, cytoplasm
8. 2hlwA [pdb]
LRMSD: 1.47788763046p-value: 0.00057967659086
Matching residues: ARG36 ARG39 THR69 CYS94 GLU100 PRO103
EC class: GO terms:
Molecular function: transcription activator activity, small conjugating protein ligase activity, protein binding
Biological process: cell differentiation, regulation of transcription, DNA-dependent, ubiquitin-dependent protein catabolic process, regulation of DNA repair, protein polyubiquitination, regulation of protein metabolic process, post-translational protein modification, positive regulation of NF-kappaB transcription factor activity, positive regulation of I-kappaB kinase/NF-kappaB cascade, modification-dependent protein catabolic process
Cellular component: nucleus, ubiquitin conjugating enzyme complex, cytoplasm
9. 1j7dA [pdb]
LRMSD: 1.48986160755p-value: 0.000638081517536
Matching residues: ARG11 ARG14 THR44 CYS69 GLU75 PRO78
EC class: GO terms:
Molecular function: ligase activity, ubiquitin-protein ligase activity, small conjugating protein ligase activity, protein binding, ubiquitin binding, protein binding, small conjugating protein ligase activity, nucleotide binding, ATP binding
Biological process: T cell receptor signaling pathway, positive regulation of NF-kappaB transcription factor activity, response to DNA damage stimulus, ubiquitin-dependent protein catabolic process, DNA repair, proteolysis, regulation of DNA repair, regulation of protein metabolic process, protein ubiquitination, regulation of histone ubiquitination, positive regulation of ubiquitin-protein ligase activity, positive regulation of histone modification, postreplication repair, DNA double-strand break processing, double-strand break repair via homologous recombination, histone ubiquitination, positive regulation of DNA repair, positive regulation of I-kappaB kinase/NF-kappaB cascade, ubiquitin cycle, protein modification process, post-translational protein modification, ubiquitin cycle, ubiquitin-dependent protein catabolic process, cell proliferation, regulation of DNA repair, protein polyubiquitination, regulation of protein metabolic process, post-translational protein modification, DNA double-strand break processing, protein ubiquitination, modification-dependent protein catabolic process, modification-dependent protein catabolic process
Cellular component: cytoplasm, UBC13-MMS2 complex, nucleus, cytoplasm, nucleus, UBC13-MMS2 complex
10. 1rrsA [pdb]
LRMSD: 1.51206827164p-value: 0.000736229645554
Matching residues: ARG149 ARG153 LEU154 SER204 CYS208 PRO209
EC class: 0.0.0.0
GO terms:
Molecular function: hydrolase activity, acting on glycosyl bonds, hydrolase activity, 4 iron, 4 sulfur cluster binding, DNA N-glycosylase activity, endonuclease activity, catalytic activity, DNA binding
Biological process: metabolic process, DNA repair, base-excision repair
Cellular component: intracellular
11. 2pmzY [pdb]
LRMSD: 1.54020929337p-value: 0.000889541639481
Matching residues: PRO4 CYS7 THR9 ARG42 ARG46 LEU49
EC class: 2.7.7.6
GO terms:
Molecular function: zinc ion binding, nucleotidyltransferase activity, transferase activity, DNA-directed RNA polymerase activity, ribonucleoside binding, DNA binding, nucleotidyltransferase activity, transferase activity, DNA-directed RNA polymerase activity, DNA binding, metal ion binding, nucleotidyltransferase activity, transferase activity, zinc ion binding, DNA-directed RNA polymerase activity, DNA binding, nucleotidyltransferase activity, transferase activity, DNA-directed RNA polymerase activity, DNA binding, nucleotidyltransferase activity, transferase activity, DNA-directed RNA polymerase activity, protein dimerization activity, DNA binding, nucleotidyltransferase activity, transferase activity, DNA-directed RNA polymerase activity, RNA binding, DNA binding, nucleotidyltransferase activity, transferase activity, DNA-directed RNA polymerase activity, protein dimerization activity, DNA binding, metal ion binding, nucleotidyltransferase activity, transferase activity, zinc ion binding, DNA-directed RNA polymerase activity, DNA binding, nucleotidyltransferase activity, transferase activity, DNA-directed RNA polymerase activity, catalytic activity, nucleotide binding, transferase activity, zinc ion binding, DNA-directed RNA polymerase activity, DNA binding, metal ion binding, nucleotidyltransferase activity, DNA-directed RNA polymerase activity, DNA binding, nucleotidyltransferase activity, transferase activity
Biological process: transcription, transcription, transcription, DNA-dependent, transcription, transcription, transcription, DNA-dependent, transcription, transcription, DNA-dependent, transcription, transcription, transcription, DNA-dependent, transcription, regulation of transcription, transcription, DNA-dependent, cellular metabolic process, transcription, transcription, transcription, DNA-dependent, transcription, DNA-dependent, transcription
Cellular component: nucleus, nucleus, RNA polymerase complex
12. 2v65A [pdb]
LRMSD: 1.54220950603p-value: 0.000889628194273
Matching residues: ARG157 ARG159 LEU274 PRO290 CYS291 THR299
EC class: 1.1.1.27
GO terms:
Molecular function: oxidoreductase activity, L-lactate dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, binding, catalytic activity
Biological process: oxidation reduction, glycolysis, cellular carbohydrate metabolic process, anaerobic glycolysis, metabolic process, carbohydrate metabolic process
Cellular component: cytoplasm
13. 2o7dE [pdb]
LRMSD: 1.54463636875p-value: 0.000932702794671
Matching residues: ARG238 ARG240 GLU242 SER301 CYS304 PRO306
EC class: 0.0.0.0
GO terms:
Molecular function: lyase activity, histidine ammonia-lyase activity, ammonia ligase activity, catalytic activity
Biological process: biosynthetic process
14. 2jndA [pdb]
LRMSD: 1.54965424538p-value: 0.000932930328418
Matching residues: THR69 GLU81 PRO83 CYS84 ARG101 ARG112
EC class: 0.0.0.0
GO terms:
Molecular function: G-protein coupled receptor activity, receptor activity, signal transducer activity, corticotrophin-releasing factor receptor activity, protein binding, hormone activity, transmembrane receptor activity
Biological process: G-protein coupled receptor protein signaling pathway, signal transduction, negative regulation of angiogenesis, cell surface receptor linked signal transduction
Cellular component: plasma membrane, integral to membrane, membrane
15. 1ml0D [pdb]
LRMSD: 1.56199860573p-value: 0.00102571013849
Matching residues: ARG29 ARG30 SER33 CYS36 PRO37 GLU39
EC class: 0.0.0.0
GO terms:
Molecular function: protein binding, cytokine activity, chemokine activity, signal transducer activity, receptor binding, protein kinase activity, protein binding, CCR2 chemokine receptor binding, G-protein-coupled receptor binding
Biological process: anti-apoptosis, inflammatory response, chemotaxis, G-protein signaling, coupled to cyclic nucleotide second messenger, cell adhesion, protein amino acid phosphorylation, viral genome replication, organ morphogenesis, JAK-STAT cascade, G-protein coupled receptor protein signaling pathway, cell surface receptor linked signal transduction, signal transduction, humoral immune response, cellular calcium ion homeostasis, immune response, vascular endothelial growth factor receptor signaling pathway, cytokine-mediated signaling pathway, transforming growth factor beta receptor signaling pathway, positive regulation of endothelial cell proliferation, response to bacterium, macrophage chemotaxis, monocyte chemotaxis
Cellular component: extracellular region, extracellular space, cell soma, cytoplasm
16. 1v6aA [pdb]
LRMSD: 1.56904065609p-value: 0.00107539969031
Matching residues: ARG155 ARG157 LEU276 PRO292 CYS293 THR301
EC class: 1.1.1.27
GO terms:
Molecular function: oxidoreductase activity, L-lactate dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, binding, catalytic activity
Biological process: oxidation reduction, glycolysis, cellular carbohydrate metabolic process, anaerobic glycolysis, metabolic process, carbohydrate metabolic process
Cellular component: cytoplasm
17. 3flvB [pdb]
LRMSD: 1.58620607853p-value: 0.00123222277034
Matching residues: PRO46 CYS47 LEU49 ARG51 ARG60 SER68
EC class: 0.0.0.0
GO terms:
Molecular function: lipid binding, binding, acyl-CoA binding
Biological process: transport
Cellular component: membrane, integral to membrane
18. 1pp9A [pdb]
LRMSD: 1.60426795483p-value: 0.00134813890327
Matching residues: ARG46 ARG92 THR161 LEU231 PRO233 CYS234
EC class: GO terms:
Molecular function: metal ion binding, iron ion binding, oxidoreductase activity, electron carrier activity, oxidoreductase activity, acting on diphenols and related substances as donors, ubiquinol-cytochrome-c reductase activity, ubiquinol-cytochrome-c reductase activity, metal ion binding, zinc ion binding, metalloendopeptidase activity, catalytic activity, metal ion binding, zinc ion binding, metalloendopeptidase activity, catalytic activity, ubiquinol-cytochrome-c reductase activity, metal ion binding, iron ion binding, heme binding, electron carrier activity, 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, iron ion binding, ubiquinol-cytochrome-c reductase activity, electron carrier activity, ubiquinol-cytochrome-c reductase activity
Biological process: electron transport chain, transport, respiratory electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, electron transport chain, transport, mitochondrial electron transport, ubiquinol to cytochrome c, electron transport chain, transport, mitochondrial electron transport, ubiquinol to cytochrome c, electron transport chain, transport, proteolysis, electron transport chain, transport, proteolysis, electron transport chain, transport, mitochondrial electron transport, ubiquinol to cytochrome c, electron transport chain, transport, oxidation reduction, electron transport chain, transport, electron transport chain, transport
Cellular component: mitochondrial inner membrane, integral to membrane, membrane, mitochondrial respiratory chain, mitochondrion, respiratory chain, respiratory chain, respiratory chain, respiratory chain, respiratory chain, respiratory chain, respiratory chain, respiratory chain, respiratory chain, mitochondrial inner membrane, membrane, mitochondrial respiratory chain, mitochondrion, mitochondrial inner membrane, membrane, mitochondrial respiratory chain, mitochondrion, mitochondrial inner membrane, membrane, mitochondrial respiratory chain, mitochondrion, mitochondrial inner membrane, membrane, mitochondrial respiratory chain, mitochondrion, mitochondrial inner membrane, membrane, mitochondrial respiratory chain, mitochondrion, mitochondrial envelope, mitochondrial inner membrane, integral to membrane, membrane, mitochondrial respiratory chain, mitochondrion, mitochondrial inner membrane, integral to membrane, membrane, mitochondrial respiratory chain, mitochondrion, mitochondrial inner membrane, membrane, mitochondrial respiratory chain, mitochondrion
19. 2hcyA [pdb]
LRMSD: 1.6079428196p-value: 0.00140945310704
Matching residues: PRO150 CYS153 THR157 ARG298 ARG302 LEU305
EC class: 1.1.1.1
GO terms:
Molecular function: metal ion binding, oxidoreductase activity, zinc ion binding, alcohol dehydrogenase (NAD) activity, methylglyoxal reductase (NADH-dependent) activity, binding, catalytic activity, protein binding
Biological process: oxidation reduction, ethanol biosynthetic process during fermentation, NADH oxidation, amino acid catabolic process to alcohol via Ehrlich pathway, metabolic process
Cellular component: plasma membrane enriched fraction, cytoplasm
20. 2qtzA [pdb]
LRMSD: 1.61013674736p-value: 0.00140959362034
Matching residues: LEU385 ARG399 ARG400 SER433 CYS434 PRO436
EC class: 1.16.1.8
GO terms:
Molecular function: NADP or NADPH binding, FAD binding, FMN binding, [methionine synthase] reductase activity, oxidoreductase activity, electron carrier activity, iron ion binding
Biological process: oxidation reduction, methionine metabolic process, methionine biosynthetic process, cellular amino acid biosynthetic process
Cellular component: cytosol, cytoplasm, mitochondrion
