The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
2zpiA	[pdb]	0.081111 2.39392e-05	53^ASP 120^THR 127^GLN 190^PHE 193^ASP 196^GLY	4.2.1.84	lyase activity nitrile hydratase activity transition metal ion binding catalytic activity metal ion binding lyase activity iron ion binding nitrile hydratase activity transition metal ion binding catalytic activity	photosynthesis nitrogen compound metabolic process nitrogen compound metabolic process	plastid
1v29A	[pdb]	0.496675 0.000105757	64^PRO 131^SER 138^SER 201^PHE 204^GLU 207^TRP	0.0.0.0		nitrogen compound metabolic process	transition metal ion binding nitrile hydratase activity catalytic activity
2dppA	[pdb]	0.513652 0.0001141	60^GLU 127^TYR 134^ARG 197^TYR 200^ARG 203^ALA	0.0.0.0	photosynthesis nitrogen compound metabolic process nitrogen compound metabolic process	plastid	transition metal ion binding nitrile hydratase activity catalytic activity transition metal ion binding nitrile hydratase activity catalytic activity
2dxbX	[pdb]	0.580678 0.000153174	61^PRO 139^LEU 146^TYR 209^VAL 212^ASP 215^ILE	3.5.5.8	hydrolase activity thiocyanate hydrolase activity catalytic activity cobalt ion binding metal ion binding hydrolase activity thiocyanate hydrolase activity transition metal ion binding catalytic activity hydrolase activity thiocyanate hydrolase activity catalytic activity	photosynthesis nitrogen compound metabolic process photosynthesis	plastid plastid
1gpmA	[pdb]	1.277 0.000251285	33^TYR 213^ILE 216^ASP 218^VAL 375^PRO 376^LEU	6.3.5.2	cytosol cytoplasm	glutamine metabolic process GMP biosynthetic process purine nucleotide biosynthetic process biosynthetic process tRNA processing	ligase activity ATP binding nucleotide binding GMP synthase (glutamine-hydrolyzing) activity tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity catalytic activity protein binding
2rdrA	[pdb]	1.31361 0.000267776	87^TYR 116^ILE 155^PRO 156^LEU 166^VAL 244^ASP	0.0.0.0
2tmkB	[pdb]	1.53074 0.000458032	10^ILE 26^TYR 93^ASP 96^VAL 126^PRO 128^LEU	2.7.4.9	nucleotide biosynthetic process DNA repair plasmid maintenance DNA-dependent DNA replication dTTP biosynthetic process dTDP biosynthetic process dUDP biosynthetic process	nucleus cytoplasm	transferase activity kinase activity ATP binding nucleotide binding thymidylate kinase activity uridylate kinase activity identical protein binding
3bv0A	[pdb]	1.53353 0.000458071	242^ASP 243^ILE 247^TYR 251^LEU 274^VAL 276^PRO	2.6.1.62		biotin biosynthetic process	transferase activity transaminase activity adenosylmethionine-8-amino-7-oxononanoate transaminase activity pyridoxal phosphate binding catalytic activity
2ah6B	[pdb]	1.54604 0.000486392	106^PRO 108^LEU 112^ILE 167^VAL 176^ASP 179^TYR	0.0.0.0		cob(I)yrinic acid a,c-diamide adenosyltransferase activity ATP binding	cobalamin biosynthetic process
2uv9C	[pdb]	1.56287 0.000518046	794^PRO 829^TYR 837^LEU 839^ILE 889^VAL 895^ASP			macromolecule biosynthetic process biosynthetic process metabolic process fatty acid biosynthetic process	transferase activity holo-[acyl-carrier-protein] synthase activity binding catalytic activity magnesium ion binding
1rtyB	[pdb]	1.59412 0.000593501	105^PRO 107^LEU 111^ILE 166^VAL 175^ASP 178^TYR	2.5.1.17	cob(I)yrinic acid a,c-diamide adenosyltransferase activity ATP binding nucleotide binding transferase activity	cobalamin biosynthetic process porphyrin biosynthetic process	cytoplasm
3bs8A	[pdb]	1.59783 0.000614997	228^ASP 229^ILE 233^TYR 237^LEU 259^VAL 261^PRO	5.4.3.8	cytoplasm	isomerase activity glutamate-1-semialdehyde 2,1-aminomutase activity pyridoxal phosphate binding transaminase activity catalytic activity	porphyrin biosynthetic process tetrapyrrole biosynthetic process
1ui7B	[pdb]	1.60508 0.000637731	107^VAL 136^PRO 137^LEU 144^TYR 152^ILE 180^ASP	1.4.3.21		metal ion binding oxidoreductase activity copper ion binding quinone binding amine oxidase activity	oxidation reduction amine metabolic process
1oriA	[pdb]	1.66182 0.000858048	185^ILE 187^ASP 222^VAL 224^PRO 227^LEU 262^TYR	0.0.0.0	nucleus protein complex	peptidyl-arginine methylation to asymmetrical-dimethyl arginine protein amino acid methylation peptidyl-arginine methylation peptidyl-arginine omega-N-methylation	transferase activity methyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity snoRNP binding S-adenosylmethionine-dependent methyltransferase activity protein methyltransferase activity protein-arginine omega-N monomethyltransferase activity histone-arginine N-methyltransferase activity [cytochrome c]-arginine N-methyltransferase activity protein binding
2vlcB	[pdb]	1.67342 0.000892012	232^TYR 238^ASP 241^ILE 503^VAL 546^PRO 547^LEU	0.0.0.0		hydrolase activity rRNA N-glycosylase activity	negative regulation of translation pathogenesis defense response
2nwuB	[pdb]	1.69182 0.00100341	65^ILE 67^ASP 72^TYR 126^LEU 128^PRO 134^VAL
2zxcA	[pdb]	1.69812 0.00104321	362^VAL 364^PRO 367^LEU 376^ILE 379^ASP 467^TYR	3.5.1.23	extracellular region	hydrolase activity ceramidase activity	lipid metabolic process
1ofvA	[pdb]	1.70114 0.00104333	13^VAL 125^TYR 143^ILE 144^ASP 149^PRO 151^LEU			electron transport chain response to stress transport	oxidoreductase activity FMN binding electron carrier activity
2iujA	[pdb]	1.70399 0.00104345	253^LEU 254^PRO 270^TYR 525^VAL 548^ASP 552^ILE	0.0.0.0		fatty acid biosynthetic process lipid biosynthetic process oxylipin biosynthetic process oxidation reduction	metal ion binding oxidoreductase activity acting on single donors with incorporation of molecular oxygen incorporation of two atoms of oxygen oxidoreductase activity iron ion binding lipoxygenase activity electron carrier activity
1poiB	[pdb]	1.70778 0.00108409	7^TYR 33^LEU 34^PRO 65^VAL 253^ASP 259^ILE	2.8.3.12	cytoplasm cytoplasm	metabolic process metabolic process	transferase activity glutaconate CoA-transferase activity CoA-transferase activity transferase activity glutaconate CoA-transferase activity CoA-transferase activity
2p4bB	[pdb]	1.71344 0.00112673	112^PRO 114^LEU 154^TYR 157^ILE 171^ASP 185^VAL				periplasmic space
2pmzR	[pdb]	1.71408 0.00112675	750^TYR 891^LEU 893^PRO 905^VAL 907^ASP 908^ILE	0.0.0.0	nucleus nucleus RNA polymerase complex	transcription transcription transcription DNA-dependent transcription transcription transcription DNA-dependent transcription transcription DNA-dependent transcription transcription transcription DNA-dependent transcription regulation of transcription transcription DNA-dependent cellular metabolic process transcription transcription transcription DNA-dependent transcription DNA-dependent transcription	zinc ion binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity ribonucleoside binding DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity DNA binding metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity protein dimerization activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity RNA binding DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity protein dimerization activity DNA binding metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity catalytic activity nucleotide binding transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding metal ion binding nucleotidyltransferase activity DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity
2z8wA	[pdb]	1.72268 0.00117152	118^HOH 119^HOH 301^VAL 303^PRO 397^TYR 431^LEU	0.0.0.0	membrane	pathogenesis	receptor activity
2e7jB	[pdb]	1.75909 0.0014277	99^ASP 128^TYR 130^ILE 156^PRO 163^LEU 182^VAL			transferase activity Sep-tRNA:Cys-tRNA synthase activity pyridoxal phosphate binding catalytic activity	translation
3dtyE	[pdb]	1.75917 0.00142771	116^PRO 117^LEU 121^VAL 360^TYR 363^ILE 364^ASP	0.0.0.0		metabolic process	oxidoreductase activity electron carrier activity binding catalytic activity
1ej6C	[pdb]	1.77328 0.00154638	1044^ASP 1045^ILE 1059^LEU 1061^PRO 1066^VAL 1144^TYR		mRNA processing mRNA capping mRNA processing mRNA capping	structural molecule activity structural molecule activity metal ion binding hydrolase activity zinc ion binding ATP binding structural molecule activity helicase activity nucleotide binding nucleotidyltransferase activity transferase activity methyltransferase activity ATP binding structural molecule activity catalytic activity nucleotide binding mRNA guanylyltransferase activity mRNA (guanine-N7-)-methyltransferase activity GTP binding	virion viral capsid viral nucleocapsid virion viral nucleocapsid virion viral capsid viral nucleocapsid intracellular virion viral capsid viral nucleocapsid viral capsid
2g3nB	[pdb]	1.77616 0.00154656	467^TYR 548^ASP 561^ILE 570^VAL 598^LEU 599^PRO	3.2.1.20	cytoplasm	hydrolase activity acting on glycosyl bonds hydrolase activity alpha-glucosidase activity hydrolase activity hydrolyzing O-glycosyl compounds	metabolic process carbohydrate metabolic process
2ivfB	[pdb]	1.77626 0.00154656	23^GLY 24^ALA 146^GLY 251^VAL 259^PRO 260^LEU	0.0.0.0	iron-sulfur cluster binding electron carrier activity metal ion binding molybdenum ion binding oxidoreductase activity binding heme binding	oxidation reduction oxidation reduction	periplasmic space
3d0hE	[pdb]	1.77714 0.00154662	410^TYR 454^ASP 455^ILE 458^VAL 477^PRO 478^LEU		entry of virus into host cell interspecies interaction between organisms proteolysis virion attachment binding of host cell surface receptor regulation of vasoconstriction regulation of vasodilation regulation of systemic arterial blood pressure by renin-angiotensin angiotensin-mediated drinking behavior regulation of cell proliferation regulation of inflammatory response regulation of cytokine production transmission of virus pathogenesis interspecies interaction between organisms virion attachment binding of host cell surface receptor membrane fusion receptor biosynthetic process oxygen and reactive oxygen species metabolic process angiotensin catabolic process in blood proteolysis	intracellular membrane-bounded organelle nucleus extracellular region plasma membrane integral to membrane membrane cell surface extracellular space membrane raft viral envelope virion membrane ER-Golgi intermediate compartment membrane plasma membrane virion integral to membrane membrane plasma membrane integral to membrane membrane extracellular region	metallopeptidase activity peptidyl-dipeptidase activity carboxypeptidase activity metal ion binding chloride ion binding hydrolase activity zinc ion binding peptidase activity glycoprotein binding viral receptor activity structural molecule activity host cell surface receptor binding metal ion binding chloride ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity carboxypeptidase activity peptidyl-dipeptidase activity
1kmhB	[pdb]	1.79314 0.00173657	105^PRO 107^LEU 110^ILE 119^ASP 124^VAL 213^TYR	3.6.3.14	metal ion binding hydrolase activity hydrogen ion transmembrane transporter activity ATP binding nucleotide binding proton-transporting ATPase activity rotational mechanism hydrogen ion transporting ATP synthase activity rotational mechanism nucleoside-triphosphatase activity hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances hydrogen-exporting ATPase activity phosphorylative mechanism hydrogen ion transmembrane transporter activity ATP binding nucleotide binding proton-transporting ATPase activity rotational mechanism hydrogen ion transporting ATP synthase activity rotational mechanism hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances metal ion binding hydrolase activity	proton transport ion transport transport ATP biosynthetic process ATP metabolic process ATP synthesis coupled proton transport proton transport ion transport transport ATP biosynthetic process ATP metabolic process ATP synthesis coupled proton transport plasma membrane ATP synthesis coupled proton transport plasma membrane ATP synthesis coupled proton transport	proton-transporting ATP synthase complex catalytic core F(1) membrane thylakoid plastid chloroplast proton-transporting two-sector ATPase complex catalytic domain proton-transporting two-sector ATPase complex thylakoid plastid chloroplast proton-transporting ATP synthase complex catalytic core F(1) proton-transporting two-sector ATPase complex catalytic domain proton-transporting two-sector ATPase complex membrane
2pygB	[pdb]	1.79482 0.00173668	245^TYR 290^ILE 292^ASP 300^PRO 303^LEU 360^VAL	0.0.0.0	alginic acid biosynthetic process	extracellular region extracellular space	isomerase activity calcium ion binding
1ehxA	[pdb]	1.79596 0.00173676	35^ILE 43^TYR 71^ASP 74^VAL 79^PRO 81^LEU	0.0.0.0	carbohydrate binding	carbohydrate metabolic process polysaccharide catabolic process	peptidoglycan-based cell wall
2rh3A	[pdb]	1.81835 0.00194876	90^PRO 95^VAL 98^ILE 100^ASP 106^TYR 112^LEU
1b1yA	[pdb]	1.81915 0.00194882	119^ILE 138^ASP 141^PRO 142^LEU 149^VAL 210^TYR	3.2.1.2		hydrolase activity acting on glycosyl bonds hydrolase activity beta-amylase activity cation binding catalytic activity	metabolic process carbohydrate metabolic process polysaccharide catabolic process
1s58A	[pdb]	1.82031 0.0019489	46^ILE 49^ASP 184^TYR 461^LEU 462^PRO 479^VAL	0.0.0.0		structural molecule activity	viral capsid
1n7uA	[pdb]	1.82344 0.00202447	153^VAL 155^PRO 156^LEU 303^TYR 306^ASP 307^ILE				virion
3bdlA	[pdb]	1.82941 0.00202494	543^PRO 545^LEU 672^TYR 739^ILE 740^ASP 763^VAL		Golgi apparatus cytoplasm melanosome nucleus RNA-induced silencing complex	interspecies interaction between organisms regulation of transcription DNA-dependent transcription RNA interference regulation of transcription	transcription cofactor activity hydrolase activity acting on ester bonds nuclease activity nucleic acid binding protein binding
3bg5A	[pdb]	1.84488 0.00226829	557^VAL 738^LEU 767^PRO 783^TYR 792^ASP 793^ILE	0.0.0.0	cytoplasm	ligase activity biotin binding ATP binding pyruvate carboxylase activity catalytic activity	metabolic process gluconeogenesis
1tv3A	[pdb]	1.85054 0.00226878	113^VAL 124^PRO 147^TYR 154^ASP 156^ILE 364^LEU			methanogenesis	transferase activity methyltransferase activity
3c26A	[pdb]	1.85145 0.00235507	160^LEU 162^PRO 205^VAL 208^ASP 210^TYR 214^ILE	0.0.0.0		N-acetyltransferase activity	metabolic process
3bccF	[pdb]	1.852 0.00235512	38^GLY 42^ILE 47^ASN 90^LEU 92^PRO 97^VAL		electron transport chain transport electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c electron transport chain transport proteolysis electron transport chain transport proteolysis electron transport chain transport mitochondrial electron transport ubiquinol to cytochrome c mitochondrial electron transport ubiquinol to cytochrome c oxidation reduction electron transport chain transport electron transport chain transport respiratory electron transport chain electron transport chain transport	metal ion binding iron ion binding heme binding electron carrier activity ubiquinol-cytochrome-c reductase activity ubiquinol-cytochrome-c reductase activity metal ion binding zinc ion binding metalloendopeptidase activity catalytic activity metal ion binding zinc ion binding metalloendopeptidase activity catalytic activity ubiquinol-cytochrome-c reductase activity oxidoreductase activity acting on diphenols and related substances as donors 2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding ubiquinol-cytochrome-c reductase activity electron carrier activity metal ion binding iron ion binding oxidoreductase activity electron carrier activity ubiquinol-cytochrome-c reductase activity	mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial envelope respiratory chain respiratory chain membrane fraction respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain respiratory chain mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane integral to membrane membrane mitochondrial respiratory chain mitochondrion mitochondrial inner membrane membrane mitochondrial respiratory chain mitochondrion
2buaC	[pdb]	1.85489 0.00235538	202^VAL 235^LEU 238^TYR 254^ILE 257^PRO 709^ASP	3.4.14.5	hydrolase activity serine-type peptidase activity peptidase activity aminopeptidase activity serine-type endopeptidase activity	plasma membrane integral to membrane membrane extracellular region	proteolysis
1k30A	[pdb]	1.85589 0.00235546	72^ILE 75^ASP 76^VAL 95^TYR 175^PRO 176^LEU	2.3.1.15	chloroplast stroma plastid chloroplast	phospholipid biosynthetic process metabolic process	transferase activity acyltransferase activity glycerol-3-phosphate O-acyltransferase activity
1jylA	[pdb]	1.85807 0.00235566	27^PRO 30^LEU 39^ILE 58^VAL 105^ASP 109^TYR	0.0.0.0		biosynthetic process	nucleotidyltransferase activity
2wb7B	[pdb]	1.86079 0.00244354	155^ILE 157^ASP 383^LEU 398^VAL 419^PRO 661^TYR
2v9xI	[pdb]	1.86647 0.00253315	99^LEU 100^PRO 104^VAL 127^ILE 128^ASP 179^TYR	3.5.4.13		hydrolase activity dCTP deaminase activity protein binding	nucleotide metabolic process dUTP metabolic process dUTP biosynthetic process pyrimidine ribonucleotide biosynthetic process
1qgoA	[pdb]	1.86818 0.00253331	14^TYR 174^VAL 199^PRO 206^ASP 209^ILE 235^LEU	4.99.1.3		cobalamin biosynthetic process porphyrin biosynthetic process	metal ion binding lyase activity sirohydrochlorin cobaltochelatase activity
1kqgA	[pdb]	1.86844 0.00253333	259^PRO 272^LEU 275^HIS 891^HOH 959^HOH 960^HOH	1.2.1.2	electron carrier activity iron ion binding formate dehydrogenase activity metal ion binding iron ion binding formate dehydrogenase activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding molybdenum ion binding oxidoreductase activity selenium binding iron ion binding formate dehydrogenase activity binding metal ion binding iron ion binding formate dehydrogenase activity metal ion binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding iron ion binding electron carrier activity formate dehydrogenase activity	electron transport chain transport cellular respiration electron transport chain transport respiratory electron transport chain oxidation reduction cellular respiration electron transport chain transport cellular respiration respiratory electron transport chain cellular respiration respiratory electron transport chain electron transport chain transport cellular respiration	membrane plasma membrane integral to membrane membrane formate dehydrogenase complex periplasmic space cytoplasm plasma membrane integral to membrane membrane formate dehydrogenase complex plasma membrane integral to membrane membrane formate dehydrogenase complex plasma membrane integral to membrane membrane
1olmA	[pdb]	1.86865 0.00253335	103^ILE 154^ASP 158^LEU 191^VAL 195^PRO 260^TYR		cytoplasm nucleus intracellular cytosol	positive regulation of transcription DNA-dependent regulation of cholesterol biosynthetic process transport regulation of transcription DNA-dependent transcription positive regulation of cholesterol biosynthetic process regulation of transcription	transcription activator activity phospholipid binding vitamin E binding lipid binding transporter activity enzyme activator activity
1ovtA	[pdb]	1.86999 0.00253348	42^TYR 49^ILE 55^ASP 74^LEU 76^PRO 260^VAL		extracellular region	iron ion transport ion transport transport cellular iron ion homeostasis	metal ion binding iron ion binding ferric iron binding
1ixkA	[pdb]	1.87346 0.00262587	114^LEU 116^PRO 124^ASP 145^VAL 191^ILE 244^TYR	0.0.0.0		S-adenosylmethionine-dependent methyltransferase activity RNA binding methyltransferase activity	rRNA processing
3cxbA	[pdb]	1.87751 0.00262626	160^LEU 161^PRO 176^VAL 179^ASP 181^ILE 186^TYR			cytoplasm	pathogenesis
1iktA	[pdb]	1.87942 0.00262644	19^LEU 24^PRO 30^VAL 50^ILE 51^ASP 60^TYR	4.2.1.107, 1.1.1.35	isomerase activity lyase activity oxidoreductase activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity 3-hydroxyacyl-CoA dehydrogenase activity hydro-lyase activity sterol transporter activity sterol carrier activity estradiol 17-beta-dehydrogenase activity binding catalytic activity protein binding	oxidation reduction fatty acid metabolic process lipid metabolic process metabolic process very-long-chain fatty acid metabolic process Sertoli cell development fatty acid beta-oxidation	peroxisome peroxisomal matrix mitochondrion
3dwoX	[pdb]	1.87937 0.00262644	331^TYR 373^ILE 375^ASP 406^VAL 410^PRO 411^LEU	0.0.0.0
1fnnA	[pdb]	1.88014 0.00262651	77^TYR 132^ASP 138^PRO 141^LEU 163^ILE 170^VAL	0.0.0.0		cell division DNA replication	nucleoside-triphosphatase activity nucleotide binding ATP binding
3dmaA	[pdb]	1.8889 0.00282096	30^VAL 35^ASP 37^ILE 63^PRO 66^LEU 171^TYR	0.0.0.0			manganese ion binding hydrolase activity nucleic acid binding
3c9fA	[pdb]	1.89567 0.00292347	47^LEU 299^ILE 308^TYR 471^PRO 475^VAL 486^ASP	0.0.0.0			hydrolase activity
1k9tA	[pdb]	1.90427 0.00302975	176^VAL 180^PRO 479^TYR 541^ILE 542^ASP 549^LEU	3.2.1.14		cation binding chitinase activity hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity hydrolase activity acting on glycosyl bonds hydrolase activity chitinase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity hydrolase activity hydrolase activity acting on glycosyl bonds	chitin catabolic process carbohydrate metabolic process metabolic process chitin catabolic process carbohydrate metabolic process polysaccharide catabolic process metabolic process
2gbfA	[pdb]	1.90444 0.00302977	200^VAL 233^LEU 236^TYR 252^ILE 255^PRO 710^ASP	3.4.14.5	establishment of localization proteolysis regulation of T cell mediated immunity	hydrolase activity serine-type peptidase activity peptidase activity aminopeptidase activity protein homodimerization activity peptide binding dipeptidyl-peptidase activity collagen binding serine-type endopeptidase activity	integral to membrane membrane plasma membrane extracellular region cell surface Golgi apparatus endoplasmic reticulum soluble fraction membrane fraction
1xfjA	[pdb]	1.91168 0.00313967	167^ILE 172^TYR 206^LEU 207^PRO 225^VAL 228^ASP	0.0.0.0
3bwwA	[pdb]	1.9167 0.00314024	171^ASP 177^VAL 187^PRO 201^TYR 204^ILE 253^LEU	0.0.0.0
2e85A	[pdb]	1.92126 0.0032538	16^ASP 20^PRO 21^LEU 61^VAL 122^TYR 128^ILE	0.0.0.0			metal ion binding hydrolase activity nickel ion binding peptidase activity aspartic-type endopeptidase activity enzyme activator activity protein binding
1eg7B	[pdb]	1.93137 0.00337219	1060^ILE 1297^TYR 1326^ASP 1375^VAL 1430^LEU 1434^PRO	6.3.4.3		ligase activity ATP binding nucleotide binding formate-tetrahydrofolate ligase activity	one-carbon metabolic process folic acid and derivative biosynthetic process
1f07A	[pdb]	1.93671 0.0034944	43^TYR 77^ILE 81^ASP 90^LEU 142^VAL 147^PRO	1.5.99.11	cytoplasm	oxidation reduction methanogenesis one-carbon metabolic process	oxidoreductase activity coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
1ywmA	[pdb]	1.93854 0.00349463	107^TYR 134^ILE 140^LEU 141^PRO 143^VAL 150^ASP	0.0.0.0		cell wall extracellular region membrane cell surface	pathogenesis
3b8sB	[pdb]	1.93856 0.00349463	177^VAL 181^PRO 504^TYR 572^ILE 573^ASP 580^LEU	0.0.0.0	extracellular region	hydrolase activity hydrolase activity acting on glycosyl bonds cation binding carbohydrate binding chitinase activity hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity	metabolic process chitin catabolic process carbohydrate metabolic process
2rirA	[pdb]	1.93896 0.00349468	150^TYR 210^VAL 214^ASP 215^ILE 235^PRO 238^LEU			diaminopimelate biosynthetic process lysine biosynthetic process cellular amino acid biosynthetic process sporulation resulting in formation of a cellular spore metabolic process	oxidoreductase activity electron carrier activity binding catalytic activity
1vdwA	[pdb]	1.94018 0.00361864	85^PRO 86^LEU 103^VAL 175^ILE 196^TYR 201^ASP	0.0.0.0			inositol or phosphatidylinositol phosphatase activity
1uj5A	[pdb]	1.94151 0.00361881	28^LEU 36^TYR 57^PRO 85^ILE 86^ASP 111^VAL	5.3.1.6		isomerase activity ribose-5-phosphate isomerase activity	pentose-phosphate shunt non-oxidative branch
1i9yA	[pdb]	1.94188 0.00361886	558^VAL 586^PRO 587^LEU 589^ASP 590^ILE 635^TYR	3.1.3.36	cytoplasm cell division site cell tip cytosol barrier septum	lipid metabolic process transport protein transport inositol lipid-mediated signaling	magnesium ion binding inositol-polyphosphate 5-phosphatase activity hydrolase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol or phosphatidylinositol phosphatase activity
3bwcB	[pdb]	1.95216 0.0037464	90^LEU 94^PRO 170^TYR 203^ASP 205^ILE 261^VAL	0.0.0.0			transferase activity spermidine synthase activity catalytic activity
1gjiB	[pdb]	1.95539 0.00387796	64^LEU 75^PRO 77^ASP 88^TYR 106^ILE 109^VAL		DNA binding transcription factor activity protein homodimerization activity protein heterodimerization activity	nucleus cytoplasm	regulation of transcription regulation of transcription DNA-dependent DNA fragmentation involved in apoptosis
1pv9A	[pdb]	1.96176 0.00401517	249^VAL 254^PRO 262^ASP 296^ILE 299^TYR 304^LEU	3.4.13.9	cellular process proteolysis	cobalt ion binding metal ion binding dipeptidase activity hydrolase activity metallopeptidase activity peptidase activity metalloexopeptidase activity aminopeptidase activity	cytoplasm
1tkcB	[pdb]	1.96768 0.00401601	17^ILE 21^ASP 31^PRO 35^LEU 75^TYR 272^VAL	2.2.1.1		metal ion binding transferase activity calcium ion binding transketolase activity catalytic activity protein binding	pentose-phosphate shunt metabolic process
1xl9A	[pdb]	1.97712 0.00430689	186^TYR 190^ASP 194^LEU 195^PRO 204^ILE 239^VAL	0.0.0.0	cytoplasm	diaminopimelate biosynthetic process lysine biosynthetic process cellular amino acid biosynthetic process metabolic process	lyase activity dihydrodipicolinate synthase activity catalytic activity
1ihmC	[pdb]	1.97838 0.00430709	3323^LEU 3327^ASP 3343^TYR 3376^ILE 3387^VAL 3393^PRO	0.0.0.0		structural molecule activity	virion cytoplasm viral capsid host cell cytoplasm
2czvA	[pdb]	1.98536 0.00446192	7^THR 10^PRO 20^ALA 28^ASP 178^PRO 181^LEU	3.1.26.5		hydrolase activity ribonuclease P activity ribonuclease activity hydrolase activity ribonuclease P activity ribonuclease activity catalytic activity	tRNA processing tRNA 5'-leader removal tRNA processing tRNA 5'-leader removal
2q9oB	[pdb]	1.98654 0.00446211	132^TYR 161^LEU 162^PRO 250^ILE 274^ASP 276^VAL	1.10.3.2	cellulose catabolic process oxidation reduction lignin catabolic process	extraorganismal space	laccase activity copper ion binding metal ion binding oxidoreductase activity
1o0rA	[pdb]	1.99011 0.00462281	139^PRO 140^LEU 142^VAL 205^ILE 260^ASP 264^TYR	2.4.1.22, 2.4.1.38, 2.4.1.90	N-acetyllactosamine synthase activity UDP-galactosyltransferase activity lactose synthase activity beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity metal ion binding manganese ion binding transferase activity transferring glycosyl groups transferase activity cytoskeletal protein binding galactosyltransferase activity	glycocalyx brush border membrane desmosome basolateral plasma membrane external side of plasma membrane Golgi apparatus Golgi trans cisterna cell surface plasma membrane integral to membrane membrane extracellular region	oligosaccharide biosynthetic process carbohydrate metabolic process epithelial cell development acute inflammatory response lactose biosynthetic process galactose metabolic process protein amino acid terminal N-glycosylation cell adhesion binding of sperm to zona pellucida penetration of zona pellucida negative regulation of cell proliferation glycoprotein biosynthetic process extracellular matrix organization mammary gland development wound healing regulation of cell proliferation positive regulation of apoptosis development of secondary sexual characteristics branching morphogenesis of a tube leukocyte migration regulation of cell motion regulation of acrosome reaction positive regulation of epithelial cell proliferation involved in wound healing angiogenesis involved in wound healing positive regulation of apoptosis involved in mammary gland involution
1oz3B	[pdb]	2.00297 0.00479183	244^LEU 255^TYR 289^ASP 290^ILE 292^PRO 334^VAL		chromatin modification regulation of transcription DNA-dependent transcription regulation of transcription regulation of mitosis negative regulation of transcription hemopoiesis regulation of megakaryocyte differentiation regulation of cell cycle	metal ion binding zinc ion binding DNA binding transcription factor activity protein binding chromatin binding transcription repressor activity nucleosome binding nucleosomal histone binding SAM domain binding methylated histone residue binding histone binding identical protein binding	nucleus chromatin condensed chromosome nucleoplasm nucleolus
3cxrA	[pdb]	2.0041 0.00479202	72^VAL 119^ILE 122^ASP 123^LEU 126^PRO 163^TYR	0.0.0.0		metabolic process oxidation reduction	oxidoreductase activity binding catalytic activity
1otvB	[pdb]	2.00787 0.00496651	58^PRO 59^LEU 61^ASP 64^ILE 78^VAL 128^TYR	1.3.3.11		oxidation reduction pyrroloquinoline quinone biosynthetic process	oxidoreductase activity pyrroloquinoline-quinone synthase activity
1hwgC	[pdb]	2.01167 0.0049672	144^VAL 152^ASP 153^ILE 178^TYR 233^LEU 234^PRO		extracellular region extracellular space plasma membrane integral to membrane membrane extracellular region extracellular space receptor complex cell surface integral to plasma membrane growth hormone receptor complex	glucose transport positive regulation of tyrosine phosphorylation of Stat3 protein response to estradiol stimulus positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphoinositide 3-kinase cascade positive regulation of receptor internalization positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of multicellular organism growth positive regulation of JAK-STAT cascade positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of activation of JAK2 kinase activity positive regulation of MAP kinase activity JAK-STAT cascade endocytosis creatinine metabolic process regulation of multicellular organism growth taurine metabolic process fatty acid metabolic process creatine metabolic process valine metabolic process isoleucine metabolic process oxaloacetate metabolic process succinate metabolic process 2-oxoglutarate metabolic process citrate metabolic process allantoin metabolic process activation of JAK2 kinase activity JAK-STAT cascade activation of MAPK activity positive regulation of multicellular organism growth insulin-like growth factor receptor signaling pathway cellular response to hormone stimulus positive regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of tyrosine phosphorylation of Stat3 protein multicellular organismal metabolic process growth hormone receptor signaling pathway growth hormone receptor signaling pathway	hormone activity growth hormone receptor binding protein binding growth factor activity prolactin receptor binding receptor activity cytokine receptor activity protein binding phosphate binding protein kinase binding peptide hormone binding ubiquitin binding proline-rich region binding protein homodimerization activity growth hormone activity
3bh6B	[pdb]	2.01382 0.00514867	53^LEU 54^PRO 57^VAL 74^ILE 76^ASP 151^TYR		plasma membrane membrane spindle nucleus Golgi membrane membrane Golgi apparatus intracellular	response to stimulus visual perception CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process cell division cell cycle small GTPase mediated signal transduction protein folding	unfolded protein binding ATP binding binding nucleoside diphosphate kinase activity metal ion binding GTP binding magnesium ion binding nucleotide binding
3ge6B	[pdb]	2.01381 0.00514867	22^TYR 151^VAL 158^ASP 161^PRO 187^LEU 189^ILE	0.0.0.0			oxidoreductase activity
1y89B	[pdb]	2.01513 0.00514891	68^ASP 81^TYR 102^ILE 103^LEU 108^PRO 162^VAL	0.0.0.0		6-phosphogluconolactonase activity	pentose-phosphate shunt carbohydrate metabolic process
3brkX	[pdb]	2.01642 0.00514915	276^TYR 281^ILE 282^ASP 286^VAL 288^PRO 290^LEU	2.7.7.27		glycogen biosynthetic process biosynthetic process	nucleotide binding ATP binding nucleotidyltransferase activity transferase activity glucose-1-phosphate adenylyltransferase activity
1w99A	[pdb]	2.01939 0.00533451	272^TYR 539^LEU 593^PRO 595^ASP 598^VAL 631^ILE	0.0.0.0		receptor binding	sporulation resulting in formation of a cellular spore pathogenesis defense response
2vcnA	[pdb]	2.02113 0.00533484	153^ASP 156^ILE 216^VAL 219^PRO 220^LEU 235^TYR	0.0.0.0		oxidation reduction response to oxidative stress	oxidoreductase activity peroxidase activity L-ascorbate peroxidase activity heme binding
1fgxA	[pdb]	2.02381 0.00533535	139^PRO 140^LEU 142^VAL 205^ILE 260^ASP 264^TYR	2.4.1.38, 2.4.1.90, 2.4.1.22	cytoskeletal protein binding galactosyltransferase activity N-acetyllactosamine synthase activity UDP-galactosyltransferase activity lactose synthase activity beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity metal ion binding manganese ion binding transferase activity transferring glycosyl groups transferase activity	epithelial cell development acute inflammatory response lactose biosynthetic process galactose metabolic process protein amino acid terminal N-glycosylation cell adhesion binding of sperm to zona pellucida penetration of zona pellucida negative regulation of cell proliferation glycoprotein biosynthetic process extracellular matrix organization mammary gland development wound healing regulation of cell proliferation positive regulation of apoptosis development of secondary sexual characteristics branching morphogenesis of a tube leukocyte migration regulation of cell motion regulation of acrosome reaction positive regulation of epithelial cell proliferation involved in wound healing angiogenesis involved in wound healing positive regulation of apoptosis involved in mammary gland involution oligosaccharide biosynthetic process carbohydrate metabolic process	glycocalyx brush border membrane desmosome basolateral plasma membrane external side of plasma membrane Golgi apparatus Golgi trans cisterna cell surface plasma membrane integral to membrane membrane extracellular region
1dk4A	[pdb]	2.02412 0.00533541	192^ASP 193^VAL 195^PRO 206^TYR 234^LEU 236^ILE	3.1.3.25			metal ion binding hydrolase activity magnesium ion binding inositol-1(or 4)-monophosphatase activity inositol or phosphatidylinositol phosphatase activity
1wraB	[pdb]	2.02443 0.00533547	100^VAL 104^ASP 106^ILE 123^LEU 127^PRO 132^TYR	0.0.0.0			hydrolase activity
2o5eA	[pdb]	2.02603 0.00533578	9^PRO 11^LEU 103^ASP 112^VAL 134^ILE 328^TYR	5.99.1.2	DNA unwinding during replication DNA topological change DNA metabolic process	chromosome	nucleotide binding ATP binding isomerase activity DNA topoisomerase activity DNA binding DNA topoisomerase type I activity nucleic acid binding protein binding
2b9vP	[pdb]	2.02855 0.00552496	518^LEU 521^PRO 524^VAL 549^ASP 564^TYR 612^ILE	0.0.0.0		hydrolase activity alpha-amino-acid esterase activity dipeptidyl-peptidase activity aminopeptidase activity	metabolic process proteolysis
13pkB	[pdb]	2.02872 0.005525	245^TYR 300^PRO 301^LEU 316^ASP 317^ILE 347^VAL	2.7.2.3	glycolysis	glycosome	transferase activity kinase activity ATP binding nucleotide binding phosphoglycerate kinase activity
3g85A	[pdb]	2.03109 0.00552547	163^VAL 277^ILE 284^TYR 296^ASP 329^PRO 330^LEU	0.0.0.0	DNA binding transcription factor activity	intracellular	regulation of transcription DNA-dependent transcription regulation of transcription
2plrA	[pdb]	2.033 0.00552584	60^PRO 61^LEU 102^ASP 104^VAL 109^ILE 116^TYR	2.7.4.9		nucleotide biosynthetic process dTDP biosynthetic process dTTP biosynthetic process	transferase activity kinase activity ATP binding nucleotide binding thymidylate kinase activity
2z1qA	[pdb]	2.03536 0.00572289	409^PRO 412^LEU 478^VAL 484^ASP 485^ILE 490^TYR	0.0.0.0		FAD binding oxidoreductase activity acting on the CH-CH group of donors oxidoreductase activity electron carrier activity acyl-CoA dehydrogenase activity	oxidation reduction metabolic process
1lrvA	[pdb]	2.03789 0.00572341	96^TYR 116^ILE 120^ASP 122^LEU 123^PRO 142^VAL	0.0.0.0			binding
2nxpE	[pdb]	2.04043 0.00572393	239^LEU 242^PRO 306^VAL 309^ILE 314^TYR 340^ASP		histone acetyltransferase activity protein dimerization activity protein binding transcription factor activity transcription regulator activity transcription initiation factor activity promoter binding	intracellular membrane-bounded organelle cytoskeleton cytoplasm nucleolus nucleus transcription factor TFIID complex nucleoplasm transcription factor TFTC complex	transcription chromatin modification transcription initiation from RNA polymerase II promoter regulation of transcription DNA-dependent RNA elongation from RNA polymerase II promoter regulation of transcription interspecies interaction between organisms

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

2zpiA

[pdb]

0.081111
2.39392e-05

53^ASP 120^THR 127^GLN 190^PHE 193^ASP 196^GLY

4.2.1.84

lyase activity
nitrile hydratase activity
transition metal ion binding
catalytic activity
metal ion binding
lyase activity
iron ion binding
nitrile hydratase activity
transition metal ion binding
catalytic activity

photosynthesis
nitrogen compound metabolic process
nitrogen compound metabolic process

plastid

1v29A

[pdb]

0.496675
0.000105757

64^PRO 131^SER 138^SER 201^PHE 204^GLU 207^TRP

0.0.0.0

nitrogen compound metabolic process

transition metal ion binding
nitrile hydratase activity
catalytic activity

2dppA

[pdb]

0.513652
0.0001141

60^GLU 127^TYR 134^ARG 197^TYR 200^ARG 203^ALA

0.0.0.0

photosynthesis
nitrogen compound metabolic process
nitrogen compound metabolic process

plastid

transition metal ion binding
nitrile hydratase activity
catalytic activity
transition metal ion binding
nitrile hydratase activity
catalytic activity

2dxbX

[pdb]

0.580678
0.000153174

61^PRO 139^LEU 146^TYR 209^VAL 212^ASP 215^ILE

3.5.5.8

hydrolase activity
thiocyanate hydrolase activity
catalytic activity
cobalt ion binding
metal ion binding
hydrolase activity
thiocyanate hydrolase activity
transition metal ion binding
catalytic activity
hydrolase activity
thiocyanate hydrolase activity
catalytic activity

photosynthesis
nitrogen compound metabolic process
photosynthesis

plastid
plastid

1gpmA

[pdb]

1.277
0.000251285

33^TYR 213^ILE 216^ASP 218^VAL 375^PRO 376^LEU

6.3.5.2

cytosol
cytoplasm

glutamine metabolic process
GMP biosynthetic process
purine nucleotide biosynthetic process
biosynthetic process
tRNA processing

ligase activity
ATP binding
nucleotide binding
GMP synthase (glutamine-hydrolyzing) activity
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
catalytic activity
protein binding

2rdrA

[pdb]

1.31361
0.000267776

87^TYR 116^ILE 155^PRO 156^LEU 166^VAL 244^ASP

0.0.0.0

2tmkB

[pdb]

1.53074
0.000458032

10^ILE 26^TYR 93^ASP 96^VAL 126^PRO 128^LEU

2.7.4.9

nucleotide biosynthetic process
DNA repair
plasmid maintenance
DNA-dependent DNA replication
dTTP biosynthetic process
dTDP biosynthetic process
dUDP biosynthetic process

nucleus
cytoplasm

transferase activity
kinase activity
ATP binding
nucleotide binding
thymidylate kinase activity
uridylate kinase activity
identical protein binding

3bv0A

[pdb]

1.53353
0.000458071

242^ASP 243^ILE 247^TYR 251^LEU 274^VAL 276^PRO

2.6.1.62

biotin biosynthetic process

transferase activity
transaminase activity
adenosylmethionine-8-amino-7-oxononanoate transaminase activity
pyridoxal phosphate binding
catalytic activity

2ah6B

[pdb]

1.54604
0.000486392

106^PRO 108^LEU 112^ILE 167^VAL 176^ASP 179^TYR

0.0.0.0

cob(I)yrinic acid a,c-diamide adenosyltransferase activity
ATP binding

cobalamin biosynthetic process

2uv9C

[pdb]

1.56287
0.000518046

794^PRO 829^TYR 837^LEU 839^ILE 889^VAL 895^ASP

macromolecule biosynthetic process
biosynthetic process
metabolic process
fatty acid biosynthetic process

transferase activity
holo-[acyl-carrier-protein] synthase activity
binding
catalytic activity
magnesium ion binding

1rtyB

[pdb]

1.59412
0.000593501

105^PRO 107^LEU 111^ILE 166^VAL 175^ASP 178^TYR

2.5.1.17

cob(I)yrinic acid a,c-diamide adenosyltransferase activity
ATP binding
nucleotide binding
transferase activity

cobalamin biosynthetic process
porphyrin biosynthetic process

cytoplasm

3bs8A

[pdb]

1.59783
0.000614997

228^ASP 229^ILE 233^TYR 237^LEU 259^VAL 261^PRO

5.4.3.8

cytoplasm

isomerase activity
glutamate-1-semialdehyde 2,1-aminomutase activity
pyridoxal phosphate binding
transaminase activity
catalytic activity

porphyrin biosynthetic process
tetrapyrrole biosynthetic process

1ui7B

[pdb]

1.60508
0.000637731

107^VAL 136^PRO 137^LEU 144^TYR 152^ILE 180^ASP

1.4.3.21

metal ion binding
oxidoreductase activity
copper ion binding
quinone binding
amine oxidase activity

oxidation reduction
amine metabolic process

1oriA

[pdb]

1.66182
0.000858048

185^ILE 187^ASP 222^VAL 224^PRO 227^LEU 262^TYR

0.0.0.0

nucleus
protein complex

peptidyl-arginine methylation
to asymmetrical-dimethyl arginine
protein amino acid methylation
peptidyl-arginine methylation
peptidyl-arginine omega-N-methylation

transferase activity
methyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
snoRNP binding
S-adenosylmethionine-dependent methyltransferase activity
protein methyltransferase activity
protein-arginine omega-N monomethyltransferase activity
histone-arginine N-methyltransferase activity
[cytochrome c]-arginine N-methyltransferase activity
protein binding

2vlcB

[pdb]

1.67342
0.000892012

232^TYR 238^ASP 241^ILE 503^VAL 546^PRO 547^LEU

0.0.0.0

hydrolase activity
rRNA N-glycosylase activity

negative regulation of translation
pathogenesis
defense response

2nwuB

[pdb]

1.69182
0.00100341

65^ILE 67^ASP 72^TYR 126^LEU 128^PRO 134^VAL

2zxcA

[pdb]

1.69812
0.00104321

362^VAL 364^PRO 367^LEU 376^ILE 379^ASP 467^TYR

3.5.1.23

extracellular region

hydrolase activity
ceramidase activity

lipid metabolic process

1ofvA

[pdb]

1.70114
0.00104333

13^VAL 125^TYR 143^ILE 144^ASP 149^PRO 151^LEU

electron transport chain
response to stress
transport

oxidoreductase activity
FMN binding
electron carrier activity

2iujA

[pdb]

1.70399
0.00104345

253^LEU 254^PRO 270^TYR 525^VAL 548^ASP 552^ILE

0.0.0.0

fatty acid biosynthetic process
lipid biosynthetic process
oxylipin biosynthetic process
oxidation reduction

metal ion binding
oxidoreductase activity
acting on single donors with incorporation of molecular oxygen
incorporation of two atoms of oxygen
oxidoreductase activity
iron ion binding
lipoxygenase activity
electron carrier activity

1poiB

[pdb]

1.70778
0.00108409

7^TYR 33^LEU 34^PRO 65^VAL 253^ASP 259^ILE

2.8.3.12

cytoplasm
cytoplasm

metabolic process
metabolic process

transferase activity
glutaconate CoA-transferase activity
CoA-transferase activity
transferase activity
glutaconate CoA-transferase activity
CoA-transferase activity

2p4bB

[pdb]

1.71344
0.00112673

112^PRO 114^LEU 154^TYR 157^ILE 171^ASP 185^VAL

periplasmic space

2pmzR

[pdb]

1.71408
0.00112675

750^TYR 891^LEU 893^PRO 905^VAL 907^ASP 908^ILE

0.0.0.0

nucleus
nucleus
RNA polymerase complex

transcription
transcription
transcription
DNA-dependent
transcription
transcription
transcription
DNA-dependent
transcription
transcription
DNA-dependent
transcription
transcription
transcription
DNA-dependent
transcription
regulation of transcription
transcription
DNA-dependent
cellular metabolic process
transcription
transcription
transcription
DNA-dependent
transcription
DNA-dependent
transcription

zinc ion binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
ribonucleoside binding
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
DNA binding
metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
RNA binding
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
catalytic activity
nucleotide binding
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
metal ion binding
nucleotidyltransferase activity
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity

2z8wA

[pdb]

1.72268
0.00117152

118^HOH 119^HOH 301^VAL 303^PRO 397^TYR 431^LEU

0.0.0.0

membrane

pathogenesis

receptor activity

2e7jB

[pdb]

1.75909
0.0014277

99^ASP 128^TYR 130^ILE 156^PRO 163^LEU 182^VAL

transferase activity
Sep-tRNA:Cys-tRNA synthase activity
pyridoxal phosphate binding
catalytic activity

translation

3dtyE

[pdb]

1.75917
0.00142771

116^PRO 117^LEU 121^VAL 360^TYR 363^ILE 364^ASP

0.0.0.0

metabolic process

oxidoreductase activity
electron carrier activity
binding
catalytic activity

1ej6C

[pdb]

1.77328
0.00154638

1044^ASP 1045^ILE 1059^LEU 1061^PRO 1066^VAL 1144^TYR

mRNA processing
mRNA capping
mRNA processing
mRNA capping

structural molecule activity
structural molecule activity
metal ion binding
hydrolase activity
zinc ion binding
ATP binding
structural molecule activity
helicase activity
nucleotide binding
nucleotidyltransferase activity
transferase activity
methyltransferase activity
ATP binding
structural molecule activity
catalytic activity
nucleotide binding
mRNA guanylyltransferase activity
mRNA (guanine-N7-)-methyltransferase activity
GTP binding

virion
viral capsid
viral nucleocapsid
virion
viral nucleocapsid
virion
viral capsid
viral nucleocapsid
intracellular
virion
viral capsid
viral nucleocapsid
viral capsid

2g3nB

[pdb]

1.77616
0.00154656

467^TYR 548^ASP 561^ILE 570^VAL 598^LEU 599^PRO

3.2.1.20

cytoplasm

hydrolase activity
acting on glycosyl bonds
hydrolase activity
alpha-glucosidase activity
hydrolase activity
hydrolyzing O-glycosyl compounds

metabolic process
carbohydrate metabolic process

2ivfB

[pdb]

1.77626
0.00154656

23^GLY 24^ALA 146^GLY 251^VAL 259^PRO 260^LEU

0.0.0.0

iron-sulfur cluster binding
electron carrier activity
metal ion binding
molybdenum ion binding
oxidoreductase activity
binding
heme binding

oxidation reduction
oxidation reduction

periplasmic space

3d0hE

[pdb]

1.77714
0.00154662

410^TYR 454^ASP 455^ILE 458^VAL 477^PRO 478^LEU

entry of virus into host cell
interspecies interaction between organisms
proteolysis
virion attachment
binding of host cell surface receptor
regulation of vasoconstriction
regulation of vasodilation
regulation of systemic arterial blood pressure by renin-angiotensin
angiotensin-mediated drinking behavior
regulation of cell proliferation
regulation of inflammatory response
regulation of cytokine production
transmission of virus
pathogenesis
interspecies interaction between organisms
virion attachment
binding of host cell surface receptor
membrane fusion
receptor biosynthetic process
oxygen and reactive oxygen species metabolic process
angiotensin catabolic process in blood
proteolysis

intracellular membrane-bounded organelle
nucleus
extracellular region
plasma membrane
integral to membrane
membrane
cell surface
extracellular space
membrane raft
viral envelope
virion membrane
ER-Golgi intermediate compartment membrane
plasma membrane
virion
integral to membrane
membrane
plasma membrane
integral to membrane
membrane
extracellular region

metallopeptidase activity
peptidyl-dipeptidase activity
carboxypeptidase activity
metal ion binding
chloride ion binding
hydrolase activity
zinc ion binding
peptidase activity
glycoprotein binding
viral receptor activity
structural molecule activity
host cell surface receptor binding
metal ion binding
chloride ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
carboxypeptidase activity
peptidyl-dipeptidase activity

1kmhB

[pdb]

1.79314
0.00173657

105^PRO 107^LEU 110^ILE 119^ASP 124^VAL 213^TYR

3.6.3.14

metal ion binding
hydrolase activity
hydrogen ion transmembrane transporter activity
ATP binding
nucleotide binding
proton-transporting ATPase activity
rotational mechanism
hydrogen ion transporting ATP synthase activity
rotational mechanism
nucleoside-triphosphatase activity
hydrolase activity
acting on acid anhydrides
catalyzing transmembrane movement of substances
hydrogen-exporting ATPase activity
phosphorylative mechanism
hydrogen ion transmembrane transporter activity
ATP binding
nucleotide binding
proton-transporting ATPase activity
rotational mechanism
hydrogen ion transporting ATP synthase activity
rotational mechanism
hydrolase activity
acting on acid anhydrides
catalyzing transmembrane movement of substances
metal ion binding
hydrolase activity

proton transport
ion transport
transport
ATP biosynthetic process
ATP metabolic process
ATP synthesis coupled proton transport
proton transport
ion transport
transport
ATP biosynthetic process
ATP metabolic process
ATP synthesis coupled proton transport
plasma membrane ATP synthesis coupled proton transport
plasma membrane ATP synthesis coupled proton transport

proton-transporting ATP synthase complex
catalytic core F(1)
membrane
thylakoid
plastid
chloroplast
proton-transporting two-sector ATPase complex
catalytic domain
proton-transporting two-sector ATPase complex
thylakoid
plastid
chloroplast
proton-transporting ATP synthase complex
catalytic core F(1)
proton-transporting two-sector ATPase complex
catalytic domain
proton-transporting two-sector ATPase complex
membrane

2pygB

[pdb]

1.79482
0.00173668

245^TYR 290^ILE 292^ASP 300^PRO 303^LEU 360^VAL

0.0.0.0

alginic acid biosynthetic process

extracellular region
extracellular space

isomerase activity
calcium ion binding

1ehxA

[pdb]

1.79596
0.00173676

35^ILE 43^TYR 71^ASP 74^VAL 79^PRO 81^LEU

0.0.0.0

carbohydrate binding

carbohydrate metabolic process
polysaccharide catabolic process

peptidoglycan-based cell wall

2rh3A

[pdb]

1.81835
0.00194876

90^PRO 95^VAL 98^ILE 100^ASP 106^TYR 112^LEU

1b1yA

[pdb]

1.81915
0.00194882

119^ILE 138^ASP 141^PRO 142^LEU 149^VAL 210^TYR

3.2.1.2

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-amylase activity
cation binding
catalytic activity

metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

1s58A

[pdb]

1.82031
0.0019489

46^ILE 49^ASP 184^TYR 461^LEU 462^PRO 479^VAL

0.0.0.0

structural molecule activity

viral capsid

1n7uA

[pdb]

1.82344
0.00202447

153^VAL 155^PRO 156^LEU 303^TYR 306^ASP 307^ILE

virion

3bdlA

[pdb]

1.82941
0.00202494

543^PRO 545^LEU 672^TYR 739^ILE 740^ASP 763^VAL

Golgi apparatus
cytoplasm
melanosome
nucleus
RNA-induced silencing complex

interspecies interaction between organisms
regulation of transcription
DNA-dependent
transcription
RNA interference
regulation of transcription

transcription cofactor activity
hydrolase activity
acting on ester bonds
nuclease activity
nucleic acid binding
protein binding

3bg5A

[pdb]

1.84488
0.00226829

557^VAL 738^LEU 767^PRO 783^TYR 792^ASP 793^ILE

0.0.0.0

cytoplasm

ligase activity
biotin binding
ATP binding
pyruvate carboxylase activity
catalytic activity

metabolic process
gluconeogenesis

1tv3A

[pdb]

1.85054
0.00226878

113^VAL 124^PRO 147^TYR 154^ASP 156^ILE 364^LEU

methanogenesis

transferase activity
methyltransferase activity

3c26A

[pdb]

1.85145
0.00235507

160^LEU 162^PRO 205^VAL 208^ASP 210^TYR 214^ILE

0.0.0.0

N-acetyltransferase activity

metabolic process

3bccF

[pdb]

1.852
0.00235512

38^GLY 42^ILE 47^ASN 90^LEU 92^PRO 97^VAL

electron transport chain
transport
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
electron transport chain
transport
proteolysis
electron transport chain
transport
proteolysis
electron transport chain
transport
mitochondrial electron transport
ubiquinol to cytochrome c
mitochondrial electron transport
ubiquinol to cytochrome c
oxidation reduction
electron transport chain
transport
electron transport chain
transport
respiratory electron transport chain
electron transport chain
transport

metal ion binding
iron ion binding
heme binding
electron carrier activity
ubiquinol-cytochrome-c reductase activity
ubiquinol-cytochrome-c reductase activity
metal ion binding
zinc ion binding
metalloendopeptidase activity
catalytic activity
metal ion binding
zinc ion binding
metalloendopeptidase activity
catalytic activity
ubiquinol-cytochrome-c reductase activity
oxidoreductase activity
acting on diphenols and related substances as donors
2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
ubiquinol-cytochrome-c reductase activity
electron carrier activity
metal ion binding
iron ion binding
oxidoreductase activity
electron carrier activity
ubiquinol-cytochrome-c reductase activity

mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial envelope
respiratory chain
respiratory chain
membrane fraction
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
respiratory chain
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
integral to membrane
membrane
mitochondrial respiratory chain
mitochondrion
mitochondrial inner membrane
membrane
mitochondrial respiratory chain
mitochondrion

2buaC

[pdb]

1.85489
0.00235538

202^VAL 235^LEU 238^TYR 254^ILE 257^PRO 709^ASP

3.4.14.5

hydrolase activity
serine-type peptidase activity
peptidase activity
aminopeptidase activity
serine-type endopeptidase activity

plasma membrane
integral to membrane
membrane
extracellular region

proteolysis

1k30A

[pdb]

1.85589
0.00235546

72^ILE 75^ASP 76^VAL 95^TYR 175^PRO 176^LEU

2.3.1.15

chloroplast stroma
plastid
chloroplast

phospholipid biosynthetic process
metabolic process

transferase activity
acyltransferase activity
glycerol-3-phosphate O-acyltransferase activity

1jylA

[pdb]

1.85807
0.00235566

27^PRO 30^LEU 39^ILE 58^VAL 105^ASP 109^TYR

0.0.0.0

biosynthetic process

nucleotidyltransferase activity

2wb7B

[pdb]

1.86079
0.00244354

155^ILE 157^ASP 383^LEU 398^VAL 419^PRO 661^TYR

2v9xI

[pdb]

1.86647
0.00253315

99^LEU 100^PRO 104^VAL 127^ILE 128^ASP 179^TYR

3.5.4.13

hydrolase activity
dCTP deaminase activity
protein binding

nucleotide metabolic process
dUTP metabolic process
dUTP biosynthetic process
pyrimidine ribonucleotide biosynthetic process

1qgoA

[pdb]

1.86818
0.00253331

14^TYR 174^VAL 199^PRO 206^ASP 209^ILE 235^LEU

4.99.1.3

cobalamin biosynthetic process
porphyrin biosynthetic process

metal ion binding
lyase activity
sirohydrochlorin cobaltochelatase activity

1kqgA

[pdb]

1.86844
0.00253333

259^PRO 272^LEU 275^HIS 891^HOH 959^HOH 960^HOH

1.2.1.2

electron carrier activity
iron ion binding
formate dehydrogenase activity
metal ion binding
iron ion binding
formate dehydrogenase activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
molybdenum ion binding
oxidoreductase activity
selenium binding
iron ion binding
formate dehydrogenase activity
binding
metal ion binding
iron ion binding
formate dehydrogenase activity
metal ion binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
iron ion binding
electron carrier activity
formate dehydrogenase activity

electron transport chain
transport
cellular respiration
electron transport chain
transport
respiratory electron transport chain
oxidation reduction
cellular respiration
electron transport chain
transport
cellular respiration
respiratory electron transport chain
cellular respiration
respiratory electron transport chain
electron transport chain
transport
cellular respiration

membrane
plasma membrane
integral to membrane
membrane
formate dehydrogenase complex
periplasmic space
cytoplasm
plasma membrane
integral to membrane
membrane
formate dehydrogenase complex
plasma membrane
integral to membrane
membrane
formate dehydrogenase complex
plasma membrane
integral to membrane
membrane

1olmA

[pdb]

1.86865
0.00253335

103^ILE 154^ASP 158^LEU 191^VAL 195^PRO 260^TYR

cytoplasm
nucleus
intracellular
cytosol

positive regulation of transcription
DNA-dependent
regulation of cholesterol biosynthetic process
transport
regulation of transcription
DNA-dependent
transcription
positive regulation of cholesterol biosynthetic process
regulation of transcription

transcription activator activity
phospholipid binding
vitamin E binding
lipid binding
transporter activity
enzyme activator activity

1ovtA

[pdb]

1.86999
0.00253348

42^TYR 49^ILE 55^ASP 74^LEU 76^PRO 260^VAL

extracellular region

iron ion transport
ion transport
transport
cellular iron ion homeostasis

metal ion binding
iron ion binding
ferric iron binding

1ixkA

[pdb]

1.87346
0.00262587

114^LEU 116^PRO 124^ASP 145^VAL 191^ILE 244^TYR

0.0.0.0

S-adenosylmethionine-dependent methyltransferase activity
RNA binding
methyltransferase activity

rRNA processing

3cxbA

[pdb]

1.87751
0.00262626

160^LEU 161^PRO 176^VAL 179^ASP 181^ILE 186^TYR

cytoplasm

pathogenesis

1iktA

[pdb]

1.87942
0.00262644

19^LEU 24^PRO 30^VAL 50^ILE 51^ASP 60^TYR

4.2.1.107, 1.1.1.35

isomerase activity
lyase activity
oxidoreductase activity
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
3-hydroxyacyl-CoA dehydrogenase activity
hydro-lyase activity
sterol transporter activity
sterol carrier activity
estradiol 17-beta-dehydrogenase activity
binding
catalytic activity
protein binding

oxidation reduction
fatty acid metabolic process
lipid metabolic process
metabolic process
very-long-chain fatty acid metabolic process
Sertoli cell development
fatty acid beta-oxidation

peroxisome
peroxisomal matrix
mitochondrion

3dwoX

[pdb]

1.87937
0.00262644

331^TYR 373^ILE 375^ASP 406^VAL 410^PRO 411^LEU

0.0.0.0

1fnnA

[pdb]

1.88014
0.00262651

77^TYR 132^ASP 138^PRO 141^LEU 163^ILE 170^VAL

0.0.0.0

cell division
DNA replication

nucleoside-triphosphatase activity
nucleotide binding
ATP binding

3dmaA

[pdb]

1.8889
0.00282096

30^VAL 35^ASP 37^ILE 63^PRO 66^LEU 171^TYR

0.0.0.0

manganese ion binding
hydrolase activity
nucleic acid binding

3c9fA

[pdb]

1.89567
0.00292347

47^LEU 299^ILE 308^TYR 471^PRO 475^VAL 486^ASP

0.0.0.0

hydrolase activity

1k9tA

[pdb]

1.90427
0.00302975

176^VAL 180^PRO 479^TYR 541^ILE 542^ASP 549^LEU

3.2.1.14

cation binding
chitinase activity
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity
hydrolase activity
acting on glycosyl bonds
hydrolase activity
chitinase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity
hydrolase activity
hydrolase activity
acting on glycosyl bonds

chitin catabolic process
carbohydrate metabolic process
metabolic process
chitin catabolic process
carbohydrate metabolic process
polysaccharide catabolic process
metabolic process

2gbfA

[pdb]

1.90444
0.00302977

200^VAL 233^LEU 236^TYR 252^ILE 255^PRO 710^ASP

3.4.14.5

establishment of localization
proteolysis
regulation of T cell mediated immunity

hydrolase activity
serine-type peptidase activity
peptidase activity
aminopeptidase activity
protein homodimerization activity
peptide binding
dipeptidyl-peptidase activity
collagen binding
serine-type endopeptidase activity

integral to membrane
membrane
plasma membrane
extracellular region
cell surface
Golgi apparatus
endoplasmic reticulum
soluble fraction
membrane fraction

1xfjA

[pdb]

1.91168
0.00313967

167^ILE 172^TYR 206^LEU 207^PRO 225^VAL 228^ASP

0.0.0.0

3bwwA

[pdb]

1.9167
0.00314024

171^ASP 177^VAL 187^PRO 201^TYR 204^ILE 253^LEU

0.0.0.0

2e85A

[pdb]

1.92126
0.0032538

16^ASP 20^PRO 21^LEU 61^VAL 122^TYR 128^ILE

0.0.0.0

metal ion binding
hydrolase activity
nickel ion binding
peptidase activity
aspartic-type endopeptidase activity
enzyme activator activity
protein binding

1eg7B

[pdb]

1.93137
0.00337219

1060^ILE 1297^TYR 1326^ASP 1375^VAL 1430^LEU 1434^PRO

6.3.4.3

ligase activity
ATP binding
nucleotide binding
formate-tetrahydrofolate ligase activity

one-carbon metabolic process
folic acid and derivative biosynthetic process

1f07A

[pdb]

1.93671
0.0034944

43^TYR 77^ILE 81^ASP 90^LEU 142^VAL 147^PRO

1.5.99.11

cytoplasm

oxidation reduction
methanogenesis
one-carbon metabolic process

oxidoreductase activity
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity

1ywmA

[pdb]

1.93854
0.00349463

107^TYR 134^ILE 140^LEU 141^PRO 143^VAL 150^ASP

0.0.0.0

cell wall
extracellular region
membrane
cell surface

pathogenesis

3b8sB

[pdb]

1.93856
0.00349463

177^VAL 181^PRO 504^TYR 572^ILE 573^ASP 580^LEU

0.0.0.0

extracellular region

hydrolase activity
hydrolase activity
acting on glycosyl bonds
cation binding
carbohydrate binding
chitinase activity
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

metabolic process
chitin catabolic process
carbohydrate metabolic process

2rirA

[pdb]

1.93896
0.00349468

150^TYR 210^VAL 214^ASP 215^ILE 235^PRO 238^LEU

diaminopimelate biosynthetic process
lysine biosynthetic process
cellular amino acid biosynthetic process
sporulation resulting in formation of a cellular spore
metabolic process

oxidoreductase activity
electron carrier activity
binding
catalytic activity

1vdwA

[pdb]

1.94018
0.00361864

85^PRO 86^LEU 103^VAL 175^ILE 196^TYR 201^ASP

0.0.0.0

inositol or phosphatidylinositol phosphatase activity

1uj5A

[pdb]

1.94151
0.00361881

28^LEU 36^TYR 57^PRO 85^ILE 86^ASP 111^VAL

5.3.1.6

isomerase activity
ribose-5-phosphate isomerase activity

pentose-phosphate shunt
non-oxidative branch

1i9yA

[pdb]

1.94188
0.00361886

558^VAL 586^PRO 587^LEU 589^ASP 590^ILE 635^TYR

3.1.3.36

cytoplasm
cell division site
cell tip
cytosol
barrier septum

lipid metabolic process
transport
protein transport
inositol lipid-mediated signaling

magnesium ion binding
inositol-polyphosphate 5-phosphatase activity
hydrolase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol or phosphatidylinositol phosphatase activity

3bwcB

[pdb]

1.95216
0.0037464

90^LEU 94^PRO 170^TYR 203^ASP 205^ILE 261^VAL

0.0.0.0

transferase activity
spermidine synthase activity
catalytic activity

1gjiB

[pdb]

1.95539
0.00387796

64^LEU 75^PRO 77^ASP 88^TYR 106^ILE 109^VAL

DNA binding
transcription factor activity
protein homodimerization activity
protein heterodimerization activity

nucleus
cytoplasm

regulation of transcription
regulation of transcription
DNA-dependent
DNA fragmentation involved in apoptosis

1pv9A

[pdb]

1.96176
0.00401517

249^VAL 254^PRO 262^ASP 296^ILE 299^TYR 304^LEU

3.4.13.9

cellular process
proteolysis

cobalt ion binding
metal ion binding
dipeptidase activity
hydrolase activity
metallopeptidase activity
peptidase activity
metalloexopeptidase activity
aminopeptidase activity

cytoplasm

1tkcB

[pdb]

1.96768
0.00401601

17^ILE 21^ASP 31^PRO 35^LEU 75^TYR 272^VAL

2.2.1.1

metal ion binding
transferase activity
calcium ion binding
transketolase activity
catalytic activity
protein binding

pentose-phosphate shunt
metabolic process

1xl9A

[pdb]

1.97712
0.00430689

186^TYR 190^ASP 194^LEU 195^PRO 204^ILE 239^VAL

0.0.0.0

cytoplasm

diaminopimelate biosynthetic process
lysine biosynthetic process
cellular amino acid biosynthetic process
metabolic process

lyase activity
dihydrodipicolinate synthase activity
catalytic activity

1ihmC

[pdb]

1.97838
0.00430709

3323^LEU 3327^ASP 3343^TYR 3376^ILE 3387^VAL 3393^PRO

0.0.0.0

structural molecule activity

virion
cytoplasm
viral capsid
host cell cytoplasm

2czvA

[pdb]

1.98536
0.00446192

7^THR 10^PRO 20^ALA 28^ASP 178^PRO 181^LEU

3.1.26.5

hydrolase activity
ribonuclease P activity
ribonuclease activity
hydrolase activity
ribonuclease P activity
ribonuclease activity
catalytic activity

tRNA processing
tRNA 5'-leader removal
tRNA processing
tRNA 5'-leader removal

2q9oB

[pdb]

1.98654
0.00446211

132^TYR 161^LEU 162^PRO 250^ILE 274^ASP 276^VAL

1.10.3.2

cellulose catabolic process
oxidation reduction
lignin catabolic process

extraorganismal space

laccase activity
copper ion binding
metal ion binding
oxidoreductase activity

1o0rA

[pdb]

1.99011
0.00462281

139^PRO 140^LEU 142^VAL 205^ILE 260^ASP 264^TYR

2.4.1.22, 2.4.1.38, 2.4.1.90

N-acetyllactosamine synthase activity
UDP-galactosyltransferase activity
lactose synthase activity
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
metal ion binding
manganese ion binding
transferase activity
transferring glycosyl groups
transferase activity
cytoskeletal protein binding
galactosyltransferase activity

glycocalyx
brush border membrane
desmosome
basolateral plasma membrane
external side of plasma membrane
Golgi apparatus
Golgi trans cisterna
cell surface
plasma membrane
integral to membrane
membrane
extracellular region

oligosaccharide biosynthetic process
carbohydrate metabolic process
epithelial cell development
acute inflammatory response
lactose biosynthetic process
galactose metabolic process
protein amino acid terminal N-glycosylation
cell adhesion
binding of sperm to zona pellucida
penetration of zona pellucida
negative regulation of cell proliferation
glycoprotein biosynthetic process
extracellular matrix organization
mammary gland development
wound healing
regulation of cell proliferation
positive regulation of apoptosis
development of secondary sexual characteristics
branching morphogenesis of a tube
leukocyte migration
regulation of cell motion
regulation of acrosome reaction
positive regulation of epithelial cell proliferation involved in wound healing
angiogenesis involved in wound healing
positive regulation of apoptosis involved in mammary gland involution

1oz3B

[pdb]

2.00297
0.00479183

244^LEU 255^TYR 289^ASP 290^ILE 292^PRO 334^VAL

chromatin modification
regulation of transcription
DNA-dependent
transcription
regulation of transcription
regulation of mitosis
negative regulation of transcription
hemopoiesis
regulation of megakaryocyte differentiation
regulation of cell cycle

metal ion binding
zinc ion binding
DNA binding
transcription factor activity
protein binding
chromatin binding
transcription repressor activity
nucleosome binding
nucleosomal histone binding
SAM domain binding
methylated histone residue binding
histone binding
identical protein binding

nucleus
chromatin
condensed chromosome
nucleoplasm
nucleolus

3cxrA

[pdb]

2.0041
0.00479202

72^VAL 119^ILE 122^ASP 123^LEU 126^PRO 163^TYR

0.0.0.0

metabolic process
oxidation reduction

oxidoreductase activity
binding
catalytic activity

1otvB

[pdb]

2.00787
0.00496651

58^PRO 59^LEU 61^ASP 64^ILE 78^VAL 128^TYR

1.3.3.11

oxidation reduction
pyrroloquinoline quinone biosynthetic process

oxidoreductase activity
pyrroloquinoline-quinone synthase activity

1hwgC

[pdb]

2.01167
0.0049672

144^VAL 152^ASP 153^ILE 178^TYR 233^LEU 234^PRO

extracellular region
extracellular space
plasma membrane
integral to membrane
membrane
extracellular region
extracellular space
receptor complex
cell surface
integral to plasma membrane
growth hormone receptor complex

glucose transport
positive regulation of tyrosine phosphorylation of Stat3 protein
response to estradiol stimulus
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phosphoinositide 3-kinase cascade
positive regulation of receptor internalization
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of multicellular organism growth
positive regulation of JAK-STAT cascade
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of activation of JAK2 kinase activity
positive regulation of MAP kinase activity
JAK-STAT cascade
endocytosis
creatinine metabolic process
regulation of multicellular organism growth
taurine metabolic process
fatty acid metabolic process
creatine metabolic process
valine metabolic process
isoleucine metabolic process
oxaloacetate metabolic process
succinate metabolic process
2-oxoglutarate metabolic process
citrate metabolic process
allantoin metabolic process
activation of JAK2 kinase activity
JAK-STAT cascade
activation of MAPK activity
positive regulation of multicellular organism growth
insulin-like growth factor receptor signaling pathway
cellular response to hormone stimulus
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
multicellular organismal metabolic process
growth hormone receptor signaling pathway
growth hormone receptor signaling pathway

hormone activity
growth hormone receptor binding
protein binding
growth factor activity
prolactin receptor binding
receptor activity
cytokine receptor activity
protein binding
phosphate binding
protein kinase binding
peptide hormone binding
ubiquitin binding
proline-rich region binding
protein homodimerization activity
growth hormone activity

3bh6B

[pdb]

2.01382
0.00514867

53^LEU 54^PRO 57^VAL 74^ILE 76^ASP 151^TYR

plasma membrane
membrane
spindle
nucleus
Golgi membrane
membrane
Golgi apparatus
intracellular

response to stimulus
visual perception
CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process
cell division
cell cycle
small GTPase mediated signal transduction
protein folding

unfolded protein binding
ATP binding
binding
nucleoside diphosphate kinase activity
metal ion binding
GTP binding
magnesium ion binding
nucleotide binding

3ge6B

[pdb]

2.01381
0.00514867

22^TYR 151^VAL 158^ASP 161^PRO 187^LEU 189^ILE

0.0.0.0

oxidoreductase activity

1y89B

[pdb]

2.01513
0.00514891

68^ASP 81^TYR 102^ILE 103^LEU 108^PRO 162^VAL

0.0.0.0

6-phosphogluconolactonase activity

pentose-phosphate shunt
carbohydrate metabolic process

3brkX

[pdb]

2.01642
0.00514915

276^TYR 281^ILE 282^ASP 286^VAL 288^PRO 290^LEU

2.7.7.27

glycogen biosynthetic process
biosynthetic process

nucleotide binding
ATP binding
nucleotidyltransferase activity
transferase activity
glucose-1-phosphate adenylyltransferase activity

1w99A

[pdb]

2.01939
0.00533451

272^TYR 539^LEU 593^PRO 595^ASP 598^VAL 631^ILE

0.0.0.0

receptor binding

sporulation resulting in formation of a cellular spore
pathogenesis
defense response

2vcnA

[pdb]

2.02113
0.00533484

153^ASP 156^ILE 216^VAL 219^PRO 220^LEU 235^TYR

0.0.0.0

oxidation reduction
response to oxidative stress

oxidoreductase activity
peroxidase activity
L-ascorbate peroxidase activity
heme binding

1fgxA

[pdb]

2.02381
0.00533535

139^PRO 140^LEU 142^VAL 205^ILE 260^ASP 264^TYR

2.4.1.38, 2.4.1.90, 2.4.1.22

cytoskeletal protein binding
galactosyltransferase activity
N-acetyllactosamine synthase activity
UDP-galactosyltransferase activity
lactose synthase activity
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
metal ion binding
manganese ion binding
transferase activity
transferring glycosyl groups
transferase activity

epithelial cell development
acute inflammatory response
lactose biosynthetic process
galactose metabolic process
protein amino acid terminal N-glycosylation
cell adhesion
binding of sperm to zona pellucida
penetration of zona pellucida
negative regulation of cell proliferation
glycoprotein biosynthetic process
extracellular matrix organization
mammary gland development
wound healing
regulation of cell proliferation
positive regulation of apoptosis
development of secondary sexual characteristics
branching morphogenesis of a tube
leukocyte migration
regulation of cell motion
regulation of acrosome reaction
positive regulation of epithelial cell proliferation involved in wound healing
angiogenesis involved in wound healing
positive regulation of apoptosis involved in mammary gland involution
oligosaccharide biosynthetic process
carbohydrate metabolic process

glycocalyx
brush border membrane
desmosome
basolateral plasma membrane
external side of plasma membrane
Golgi apparatus
Golgi trans cisterna
cell surface
plasma membrane
integral to membrane
membrane
extracellular region

1dk4A

[pdb]

2.02412
0.00533541

192^ASP 193^VAL 195^PRO 206^TYR 234^LEU 236^ILE

3.1.3.25

metal ion binding
hydrolase activity
magnesium ion binding
inositol-1(or 4)-monophosphatase activity
inositol or phosphatidylinositol phosphatase activity

1wraB

[pdb]

2.02443
0.00533547

100^VAL 104^ASP 106^ILE 123^LEU 127^PRO 132^TYR

0.0.0.0

hydrolase activity

2o5eA

[pdb]

2.02603
0.00533578

9^PRO 11^LEU 103^ASP 112^VAL 134^ILE 328^TYR

5.99.1.2

DNA unwinding during replication
DNA topological change
DNA metabolic process

chromosome

nucleotide binding
ATP binding
isomerase activity
DNA topoisomerase activity
DNA binding
DNA topoisomerase type I activity
nucleic acid binding
protein binding

2b9vP

[pdb]

2.02855
0.00552496

518^LEU 521^PRO 524^VAL 549^ASP 564^TYR 612^ILE

0.0.0.0

hydrolase activity
alpha-amino-acid esterase activity
dipeptidyl-peptidase activity
aminopeptidase activity

metabolic process
proteolysis

13pkB

[pdb]

2.02872
0.005525

245^TYR 300^PRO 301^LEU 316^ASP 317^ILE 347^VAL

2.7.2.3

glycolysis

glycosome

transferase activity
kinase activity
ATP binding
nucleotide binding
phosphoglycerate kinase activity

3g85A

[pdb]

2.03109
0.00552547

163^VAL 277^ILE 284^TYR 296^ASP 329^PRO 330^LEU

0.0.0.0

DNA binding
transcription factor activity

intracellular

regulation of transcription
DNA-dependent
transcription
regulation of transcription

2plrA

[pdb]

2.033
0.00552584

60^PRO 61^LEU 102^ASP 104^VAL 109^ILE 116^TYR

2.7.4.9

nucleotide biosynthetic process
dTDP biosynthetic process
dTTP biosynthetic process

transferase activity
kinase activity
ATP binding
nucleotide binding
thymidylate kinase activity

2z1qA

[pdb]

2.03536
0.00572289

409^PRO 412^LEU 478^VAL 484^ASP 485^ILE 490^TYR

0.0.0.0

FAD binding
oxidoreductase activity
acting on the CH-CH group of donors
oxidoreductase activity
electron carrier activity
acyl-CoA dehydrogenase activity

oxidation reduction
metabolic process

1lrvA

[pdb]

2.03789
0.00572341

96^TYR 116^ILE 120^ASP 122^LEU 123^PRO 142^VAL

0.0.0.0

binding

2nxpE

[pdb]

2.04043
0.00572393

239^LEU 242^PRO 306^VAL 309^ILE 314^TYR 340^ASP

histone acetyltransferase activity
protein dimerization activity
protein binding
transcription factor activity
transcription regulator activity
transcription initiation factor activity
promoter binding

intracellular membrane-bounded organelle
cytoskeleton
cytoplasm
nucleolus
nucleus
transcription factor TFIID complex
nucleoplasm
transcription factor TFTC complex

transcription
chromatin modification
transcription initiation from RNA polymerase II promoter
regulation of transcription
DNA-dependent
RNA elongation from RNA polymerase II promoter
regulation of transcription
interspecies interaction between organisms