The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
1a53A	[pdb]	0.110057 3.1335e-05	51^GLU 56^SER 57^PRO 89^PHE 91^GLY 112^PHE 159^GLU 180^ASN 211^SER 233^GLY	4.1.1.48		aromatic amino acid family biosynthetic process cellular amino acid biosynthetic process tryptophan biosynthetic process metabolic process tryptophan metabolic process	carboxy-lyase activity lyase activity indole-3-glycerol-phosphate synthase activity catalytic activity
1vc4B	[pdb]	0.245601 7.52012e-05	51^GLU 56^SER 57^PRO 91^PHE 93^GLY 114^PHE 160^GLU 181^ASN 215^SER 236^GLY	0.0.0.0		indole-3-glycerol-phosphate synthase activity catalytic activity	metabolic process
1i4nA	[pdb]	0.543744 0.000156693	47^GLU 52^SER 53^PRO 87^PHE 89^GLY 110^PHE 157^GLU 179^ASN 210^SER 231^GLY	4.1.1.48		aromatic amino acid family biosynthetic process cellular amino acid biosynthetic process tryptophan biosynthetic process metabolic process tryptophan metabolic process	carboxy-lyase activity lyase activity indole-3-glycerol-phosphate synthase activity catalytic activity
1j5tA	[pdb]	0.579199 0.000170908	25^GLU 30^SER 31^PRO 65^PHE 67^GLY 88^PHE 135^GLU 157^ASN 188^SER 209^GLY	4.1.1.48		aromatic amino acid family biosynthetic process cellular amino acid biosynthetic process tryptophan biosynthetic process metabolic process tryptophan metabolic process	carboxy-lyase activity lyase activity indole-3-glycerol-phosphate synthase activity catalytic activity
2gqfA	[pdb]	2.62241 0.000267738	195^SER 234^PHE 238^GLY 240^SER 242^PRO 249^ASN 255^GLU 330^PHE 336^GLU 337^GLY				electron carrier activity oxidoreductase activity
1egvL	[pdb]	2.71882 0.000328608	138^ALA 139^ILE 165^GLU 166^ARG 170^LYS 333^SER 334^ASN 363^GLY 379^GLU 384^PHE	0.0.0.0		lyase activity propanediol dehydratase activity lyase activity propanediol dehydratase activity lyase activity propanediol dehydratase activity cobalamin binding hydro-lyase activity catalytic activity	metabolic process
1m1oB	[pdb]	2.77014 0.000378683	20^GLY 22^PHE 26^PRO 118^SER 198^GLU 202^PHE 217^GLU 347^GLY 353^SER 359^ASN	2.3.1.9	cytoplasm	poly-hydroxybutyrate biosynthetic process metabolic process	transferase activity acyltransferase activity acetyl-CoA C-acetyltransferase activity catalytic activity
2hu0D	[pdb]	2.82991 0.000466779	104^ASN 105^SER 119^GLU 165^GLU 351^GLY 374^PHE 404^SER 441^GLY 446^PHE 459^PRO	0.0.0.0	hydrolase activity acting on glycosyl bonds hydrolase activity exo-alpha-sialidase activity	metabolic process carbohydrate metabolic process	virion membrane apical plasma membrane virion integral to membrane membrane plasma membrane
1jfrA	[pdb]	2.86672 0.000530441	6^GLU 8^GLY 13^ASN 15^SER 55^GLY 75^PRO 79^SER 82^PHE 230^PHE 238^GLU	0.0.0.0			hydrolase activity
2qm0A	[pdb]	2.88351 0.000559454	178^PHE 180^SER 182^PRO 216^GLY 217^SER 228^ASN 232^GLU 244^PHE 248^GLU 265^GLY	0.0.0.0
3b7eA	[pdb]	2.90544 0.000622638	104^ASN 119^GLU 165^GLU 363^GLY 374^PHE 404^SER 441^GLY 442^SER 446^PHE 459^PRO	3.2.1.18	metabolic process carbohydrate metabolic process	metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity calcium ion binding exo-alpha-sialidase activity	virion membrane apical plasma membrane virion integral to membrane membrane plasma membrane
2ivfA	[pdb]	2.95029 0.000736315	91^ASP 196^GLU 197^ARG 487^ASN 660^GLU 664^PRO 670^PHE 742^GLU 753^PHE 766^GLY	0.0.0.0	iron-sulfur cluster binding electron carrier activity metal ion binding molybdenum ion binding oxidoreductase activity binding heme binding	oxidation reduction oxidation reduction	periplasmic space
3fkjA	[pdb]	2.95453 0.000756911	2^SER 7^ASN 42^PHE 132^PRO 146^GLU 159^GLU 165^GLY 168^SER 290^GLY 293^PHE	0.0.0.0		carbohydrate metabolic process	isomerase activity sugar binding
2as0B	[pdb]	2.98628 0.000846526	35^PRO 52^GLY 53^PHE 105^GLU 111^GLY 127^SER 133^PHE 153^GLU 155^ASN 159^SER	0.0.0.0			RNA binding
2e3tA	[pdb]	2.99467 0.000870721	802^GLU 841^PRO 864^PHE 865^SER 868^GLY 871^GLU 898^GLY 907^SER 908^ASN 914^PHE	1.17.3.2, 1.17.1.4	2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding molybdenum ion binding oxidoreductase activity iron ion binding xanthine oxidase activity xanthine dehydrogenase activity catalytic activity FAD binding electron carrier activity	oxidation reduction lactation response to aluminum ion regulation of epithelial cell differentiation bone resorption	peroxisome cytosol
2jkrU	[pdb]	3.01305 0.000947199	180^SER 182^ASN 287^PHE 311^PHE 360^GLY 391^GLU 396^PRO 397^SER 426^GLY 432^GLU		cell adhesion immune response positive regulation of T cell activation positive regulation of calcium-mediated signaling positive regulation of peptidyl-tyrosine phosphorylation cell surface receptor linked signal transduction cytokine production protein amino acid N-linked glycosylation response to protein stimulus conjugation with cellular fusion regulation of T cell activation positive regulation of protein kinase activity positive regulation of interleukin-2 biosynthetic process T cell selection T cell differentiation transmembrane receptor protein tyrosine kinase signaling pathway immune response interspecies interaction between organisms initiation of viral infection enzyme linked receptor protein signaling pathway cell surface receptor linked signal transduction signal transduction cell adhesion positive regulation of T cell activation positive regulation of calcium-mediated signaling positive regulation of peptidyl-tyrosine phosphorylation cytokine production protein amino acid N-linked glycosylation response to protein stimulus vesicle-mediated transport intracellular protein transport transport vesicle-mediated transport protein transport intracellular protein transport transport vesicle-mediated transport protein transport intracellular protein transport endocytosis transport regulation of defense response to virus by virus vesicle-mediated transport protein transport intracellular protein transport	integral to membrane membrane external side of plasma membrane plasma membrane endoplasmic reticulum lumen cell surface membrane raft AP-2 adaptor complex T cell receptor complex plasma membrane integral to membrane membrane endoplasmic reticulum membrane early endosome external side of plasma membrane endoplasmic reticulum lumen endoplasmic reticulum membrane cell surface membrane raft plasma membrane membrane coated pit transport vesicle clathrin vesicle coat clathrin coat of coated pit clathrin adaptor complex plasma membrane membrane coated pit membrane coat membrane plasma membrane coated pit secretory granule membrane coat clathrin adaptor complex plasma membrane membrane coated pit cytosol clathrin adaptor complex membrane coat	protein binding extracellular matrix structural constituent protein homodimerization activity glycoprotein binding zinc ion binding protein kinase binding MHC class II protein binding coreceptor activity transmembrane receptor activity receptor activity protein binding lipid binding protein transporter activity protein binding protein transporter activity protein binding binding lipid binding protein binding protein transporter activity binding
2znhB	[pdb]	3.01478 0.000947245	79^SER 80^PRO 191^SER 192^ASN 195^GLU 221^PHE 326^GLU 328^GLY 422^PHE 424^GLY		blood coagulation	extracellular space extracellular region plasma membrane	peptidase inhibitor activity protease binding serine-type endopeptidase inhibitor activity protein binding heparin binding endopeptidase inhibitor activity
2gtaD	[pdb]	3.01829 0.000973558	12^GLU 22^GLU 23^GLY 25^PHE 26^SER 27^PRO 72^PHE 79^ASN 80^SER 110^GLY
1sb7A	[pdb]	3.02856 0.00100084	27^PHE 155^GLY 161^GLY 309^SER 311^ASN 319^GLU 325^PRO 328^SER 329^PHE 336^GLU			RNA modification tRNA processing tRNA pseudouridine synthesis pseudouridine synthesis	isomerase activity pseudouridine synthase activity RNA binding protein binding
2z2oD	[pdb]	3.05825 0.00111802	101^PRO 138^ASN 141^SER 144^SER 145^PHE 156^PHE 175^GLU 184^GLY 187^GLY 200^GLU			metal ion binding lyase activity magnesium ion binding carbon-oxygen lyase activity catalytic activity	response to antibiotic antibiotic catabolic process
1iwpA	[pdb]	3.0629 0.00114945	139^LYS 140^GLY 163^HOH 167^HOH 171^HOH 364^GLY 378^SER 379^ASN 383^GLU 385^PHE	0.0.0.0		lyase activity glycerol dehydratase activity lyase activity glycerol dehydratase activity cobalamin binding hydro-lyase activity catalytic activity lyase activity glycerol dehydratase activity	metabolic process
1hesA	[pdb]	3.08402 0.00124933	180^SER 182^ASN 287^PHE 311^PHE 360^GLY 391^GLU 396^PRO 397^SER 426^GLY 432^GLU	0.0.0.0	plasma membrane membrane coated pit secretory granule mitochondrion clathrin coat of coated pit clathrin adaptor complex plasma membrane membrane coated pit cytosol peroxisomal membrane clathrin coat of coated pit clathrin adaptor complex mitochondrion plasma membrane membrane coated pit transport vesicle clathrin vesicle coat clathrin coat of coated pit clathrin adaptor complex membrane integral to membrane platelet alpha granule membrane plasma membrane integral to plasma membrane soluble fraction membrane fraction extracellular space external side of plasma membrane	protein binding lipid binding protein binding lipid binding transporter activity protein binding lipid binding protein binding sugar binding binding lipopolysaccharide binding heparin binding sialic acid binding fucose binding glycosphingolipid binding oligosaccharide binding	vesicle-mediated transport intracellular protein transport transport regulation of defense response to virus by virus vesicle-mediated transport intracellular protein transport transport vesicle-mediated transport intracellular protein transport transport cell adhesion leukocyte adhesion positive regulation of platelet activation response to lipopolysaccharide defense response to Gram-negative bacterium
2jf7A	[pdb]	3.10542 0.00135611	49^PHE 52^GLY 54^SER 113^SER 155^PRO 206^ASN 207^GLU 339^PHE 416^GLU 461^GLY	0.0.0.0		carbohydrate metabolic process	cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1uzbB	[pdb]	3.10808 0.00135621	57^ASN 59^SER 123^GLU 185^PHE 317^PHE 319^GLY 350^SER 358^PRO 369^GLU 396^GLY	0.0.0.0		metabolic process proline biosynthetic process oxidation reduction	oxidoreductase activity 1-pyrroline-5-carboxylate dehydrogenase activity
1tvpA	[pdb]	3.11469 0.00139407	21^PHE 24^PRO 25^SER 235^ASN 238^GLU 246^PHE 280^SER 281^GLY 286^GLU 293^GLY	0.0.0.0	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity cellulase activity cation binding carbohydrate binding calcium ion binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity	metabolic process cell adhesion carbohydrate metabolic process
1zcjA	[pdb]	3.14316 0.00155849	274^GLU 278^ASN 281^SER 433^PHE 446^PRO 447^SER 477^GLY 478^PHE 636^GLU 637^GLY	1.1.1.35, 4.2.1.17, 5.3.3.8	fatty acid beta-oxidation oxidation reduction fatty acid metabolic process lipid metabolic process metabolic process	isomerase activity lyase activity oxidoreductase activity catalytic activity enoyl-CoA hydratase activity dodecenoyl-CoA delta-isomerase activity 3-hydroxyacyl-CoA dehydrogenase activity coenzyme binding binding	mitochondrion peroxisome
2qh5B	[pdb]	3.15947 0.00164714	90^ASN 109^PRO 135^PHE 139^PHE 140^GLY 151^GLY 166^GLU 186^SER 199^GLU 243^SER	0.0.0.0		isomerase activity nucleotidyltransferase activity	lipopolysaccharide biosynthetic process biosynthetic process polysaccharide metabolic process
1wgzC	[pdb]	3.16141 0.00169311	206^PRO 267^PHE 313^GLU 314^ASN 319^SER 321^GLY 324^GLU 338^GLY 341^SER 345^PHE	0.0.0.0		carboxypeptidase activity metallocarboxypeptidase activity	proteolysis
1kv9A	[pdb]	3.17582 0.00179047	173^GLU 249^GLY 255^ASN 293^SER 375^PRO 376^SER 378^PHE 409^GLU 425^PHE 524^GLY	0.0.0.0	heme binding oxidoreductase activity acting on CH-OH group of donors electron carrier activity calcium ion binding iron ion binding	outer membrane-bounded periplasmic space membrane	oxidation reduction
3dzuD	[pdb]	3.19053 0.001895	245^SER 246^PRO 247^PHE 258^GLY 332^SER 335^ASN 343^GLU 344^GLY 352^PHE 365^GLU		cardiac muscle cell proliferation retinoic acid receptor signaling pathway positive regulation of transcription fat cell differentiation innate immune response regulation of blood pressure interspecies interaction between organisms regulation of transcription DNA-dependent transcription vitamin metabolic process positive regulation of transcription from RNA polymerase II promoter ventricular cardiac muscle cell differentiation ventricular cardiac muscle morphogenesis response to retinoic acid cholesterol metabolic process negative regulation of specific transcription from RNA polymerase II promoter heart development regulation of transcription negative regulation of cytokine production negative regulation of cell proliferation positive regulation of specific transcription from RNA polymerase II promoter negative regulation of specific transcription from RNA polymerase II promoter negative regulation of foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride brown fat cell differentiation regulation of transcription DNA-dependent transcription regulation of transcription signal transduction positive regulation of transcription from RNA polymerase II promoter steroid hormone receptor signaling pathway negative regulation of transcription from RNA polymerase II promoter white fat cell differentiation regulation of transcription DNA-dependent transcription response to nutrient lipid metabolic process positive regulation of fat cell differentiation placenta development positive regulation of transcription from RNA polymerase II promoter negative regulation of transcription DNA-dependent regulation of fat cell differentiation regulation of transcription cell fate commitment response to lipid epithelial cell differentiation long-chain fatty acid transport cell maturation response to low density lipoprotein stimulus low-density lipoprotein receptor biosynthetic process lipoprotein transport signal transduction monocyte differentiation negative regulation of transcription from RNA polymerase II promoter lipid homeostasis glucose homeostasis cellular response to insulin stimulus	nucleus nucleus cytoplasm nucleus cytosol	prostaglandin receptor activity protein binding metal ion binding zinc ion binding receptor activity DNA binding transcription coactivator activity retinoid-X receptor activity transcription factor activity sequence-specific DNA binding steroid binding ligand-dependent nuclear receptor activity steroid hormone receptor activity ligand-regulated transcription factor activity retinoic acid receptor activity vitamin D response element binding transcription regulator activity vitamin D receptor binding ligand-dependent nuclear receptor transcription coactivator activity transcription coactivator activity nuclear hormone receptor binding transcription regulator activity signal transducer activity protein binding thyroid hormone receptor coactivator activity transcription repressor activity receptor binding protein binding metal ion binding zinc ion binding receptor activity DNA binding sequence-specific DNA binding ligand-dependent nuclear receptor activity steroid hormone receptor activity transcription factor activity arachidonic acid binding transcription repressor activity transcription activator activity retinoid X receptor binding protein heterodimerization activity transcription activator binding drug binding
2dvkA	[pdb]	3.19118 0.00189504	29^ASN 36^SER 91^PRO 108^GLU 114^GLY 115^PHE 119^GLY 135^SER 177^PHE 182^GLU
1ebdB	[pdb]	3.19182 0.00189507	85^PHE 90^GLU 166^PHE 171^ASN 176^PRO 178^SER 190^GLU 192^GLY 198^PHE 199^GLY	1.8.1.4	cytoplasm	oxidation reduction glycolysis cell redox homeostasis glycolysis metabolic process	oxidoreductase activity dihydrolipoyl dehydrogenase activity FAD binding electron carrier activity lipoic acid binding transferase activity acyltransferase activity dihydrolipoyllysine-residue acetyltransferase activity protein binding
1wpxA	[pdb]	3.19272 0.00189512	51^ASN 58^SER 63^PHE 68^PRO 69^SER 72^GLY 100^GLY 145^GLU 296^GLU 401^PHE	3.4.16.5	cytoplasm fungal-type vacuole membrane fungal-type vacuole lumen vacuole endoplasmic reticulum cytoplasm fungal-type vacuole lumen fungal-type vacuole	regulation of proteolysis phytochelatin biosynthetic process vacuolar protein catabolic process proteolysis	serine-type endopeptidase inhibitor activity endopeptidase inhibitor activity peptidase inhibitor activity hydrolase activity peptidase activity carboxypeptidase activity glutathione gamma-glutamylcysteinyltransferase activity serine-type carboxypeptidase activity protein binding
2zk6A	[pdb]	3.19321 0.00189515	245^SER 246^PRO 247^PHE 258^GLY 332^SER 335^ASN 343^GLU 344^GLY 352^PHE 365^GLU		cytosol nucleus	regulation of transcription DNA-dependent transcription response to nutrient lipid metabolic process positive regulation of fat cell differentiation placenta development positive regulation of transcription from RNA polymerase II promoter negative regulation of transcription DNA-dependent regulation of fat cell differentiation regulation of transcription cell fate commitment response to lipid epithelial cell differentiation long-chain fatty acid transport cell maturation response to low density lipoprotein stimulus low-density lipoprotein receptor biosynthetic process lipoprotein transport signal transduction monocyte differentiation negative regulation of transcription from RNA polymerase II promoter lipid homeostasis glucose homeostasis cellular response to insulin stimulus positive regulation of transcription fat cell differentiation innate immune response regulation of blood pressure negative regulation of cytokine production negative regulation of cell proliferation positive regulation of specific transcription from RNA polymerase II promoter negative regulation of specific transcription from RNA polymerase II promoter negative regulation of foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride brown fat cell differentiation white fat cell differentiation	zinc ion binding receptor activity DNA binding sequence-specific DNA binding ligand-dependent nuclear receptor activity steroid hormone receptor activity transcription factor activity arachidonic acid binding transcription repressor activity transcription activator activity retinoid X receptor binding protein heterodimerization activity transcription activator binding drug binding prostaglandin receptor activity protein binding metal ion binding
1w1tB	[pdb]	3.2183 0.00212715	9^GLY 12^PHE 14^PRO 50^SER 55^ASN 59^GLU 96^GLY 106^SER 136^PHE 144^GLU	0.0.0.0	extracellular region	hydrolase activity hydrolase activity acting on glycosyl bonds cation binding carbohydrate binding chitinase activity hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity	metabolic process chitin catabolic process carbohydrate metabolic process
1rf8A	[pdb]	3.22678 0.00218889	103^GLU 112^GLY 163^PHE 170^GLU 179^GLY 196^PHE 201^SER 203^ASN 209^PRO 210^SER		cytoplasm eukaryotic translation initiation factor 4F complex stress granule ribosome mitochondrion eukaryotic translation initiation factor 4F complex stress granule ribosome cytoplasm nucleus	regulation of translation translation ribosome biogenesis stress granule assembly translational initiation RNA metabolic process regulation of translation translation regulation of cell cycle translational initiation nuclear-transcribed mRNA catabolic process nonsense-mediated decay	translation initiation factor activity RNA binding protein binding binding translation initiation factor activity RNA binding protein binding phosphatidylinositol 3-phosphate binding
3ei1A	[pdb]	3.22947 0.00218906	924^GLY 929^SER 951^PRO 955^SER 958^GLU 970^ASN 975^PHE 996^GLY 998^PHE 1002^GLU		cell cycle checkpoint interspecies interaction between organisms response to DNA damage stimulus ubiquitin-dependent protein catabolic process DNA repair nucleotide-excision repair DNA damage removal nucleotide-excision repair response to DNA damage stimulus ubiquitin-dependent protein catabolic process DNA repair modification-dependent protein catabolic process protein ubiquitination during ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process	cytoplasm nucleus nucleoplasm nucleus	protein binding DNA binding damaged DNA binding nucleic acid binding DNA binding protein binding
1nf0A	[pdb]	3.23729 0.00225313	6^PHE 34^GLU 178^PRO 211^SER 214^GLY 229^PHE 232^GLY 239^GLU 246^SER 248^ASN	5.3.1.1	isomerase activity triose-phosphate isomerase activity catalytic activity	lipid biosynthetic process fatty acid biosynthetic process pentose-phosphate shunt glycolysis gluconeogenesis metabolic process	plasma membrane enriched fraction mitochondrion cytoplasm
2d1gB	[pdb]	3.24083 0.00231938	43^GLU 46^SER 103^SER 105^ASN 107^GLU 168^PHE 169^GLY 172^PHE 349^GLY 413^PRO	0.0.0.0			hydrolase activity acting on ester bonds hydrolase activity acting on ester bonds
1tvcA	[pdb]	3.24752 0.00238842	12^PHE 46^GLU 48^GLY 50^PHE 65^SER 66^PRO 71^ASN 73^GLU 106^GLY 135^SER	1.14.13.25		2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding monooxygenase activity methane monooxygenase activity electron carrier activity	oxidation reduction electron transport chain transport one-carbon metabolic process
2w61A	[pdb]	3.24939 0.00238856	141^ASN 143^GLU 187^SER 385^PRO 415^PHE 434^GLY 435^GLU 437^GLY 439^PHE 440^SER		cell wall organization ascospore wall assembly	plasma membrane anchored to membrane membrane cytoplasm	transferase activity 1,3-beta-glucanosyltransferase activity
1z33A	[pdb]	3.25003 0.0023886	65^GLY 106^PHE 108^SER 112^ASN 113^SER 126^PRO 151^GLY 165^GLU 173^PHE 179^GLU	0.0.0.0
1djhA	[pdb]	3.25929 0.00253461	506^GLY 507^PHE 509^SER 523^PHE 534^GLU 536^GLY 566^GLU 569^ASN 611^PRO 617^SER	3.1.4.11	lipid catabolic process signal transduction response to hyperoxia response to calcium ion elevation of cytosolic calcium ion concentration during G-protein signaling coupled to IP3 second messenger (phospholipase C activating) response to peptide hormone stimulus response to prostaglandin F stimulus positive regulation of inositol trisphosphate biosynthetic process positive regulation of norepinephrine secretion response to organic nitrogen response to aluminum ion G-protein coupled receptor protein signaling pathway intracellular signaling cascade lipid metabolic process angiogenesis placenta development	metal ion binding hydrolase activity calcium ion binding signal transducer activity phosphoinositide phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phospholipid binding protein binding phospholipase C activity phosphoric diester hydrolase activity	mitochondrial membrane cytosol nucleus membrane fraction membrane raft
2a2mA	[pdb]	3.25965 0.00253464	14^PHE 17^PRO 30^SER 86^GLY 106^PHE 112^SER 165^GLU 198^GLY 204^ASN 207^GLU	0.0.0.0
2c0hA	[pdb]	3.26974 0.00261244	34^PHE 239^SER 241^ASN 288^GLU 291^PHE 303^PRO 307^GLY 308^GLU 332^SER 333^GLY	3.2.1.78	cellular_component	mannan catabolic process metabolic process carbohydrate metabolic process	mannan endo-1,4-beta-mannosidase activity hydrolase activity acting on glycosyl bonds hydrolase activity cation binding catalytic activity
1nphA	[pdb]	3.27606 0.00269301	556^PRO 558^SER 563^SER 564^ASN 567^PHE 587^GLU 607^GLU 608^GLY 613^GLY 614^PHE		actin filament capping actin filament polymerization actin filament severing barbed-end actin filament capping vesicle-mediated transport	calcium ion binding actin binding protein binding	cytosol extracellular region cytoskeleton cytoplasm lamellipodium
3bs8A	[pdb]	3.29495 0.00294611	3^SER 7^SER 36^PRO 38^PHE 42^GLY 52^GLY 54^GLU 389^ASN 390^GLU 393^PHE	5.4.3.8	cytoplasm	isomerase activity glutamate-1-semialdehyde 2,1-aminomutase activity pyridoxal phosphate binding transaminase activity catalytic activity	porphyrin biosynthetic process tetrapyrrole biosynthetic process
2wabA	[pdb]	3.299 0.00294648	31^GLY 51^GLY 66^PRO 67^PHE 68^SER 96^GLU 138^ASN 147^PHE 154^SER 307^GLU	0.0.0.0		cellulose catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process lipid metabolic process	hydrolase activity acting on glycosyl bonds hydrolase activity cellulase activity cation binding hydrolase activity acting on ester bonds hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1np2B	[pdb]	3.30189 0.00303676	31^SER 36^PHE 46^GLY 123^PRO 163^ASN 168^SER 172^GLY 177^GLU 338^GLU 391^PHE	0.0.0.0		hydrolase activity acting on glycosyl bonds hydrolase activity beta-glucosidase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity	metabolic process cellulose catabolic process carbohydrate metabolic process
1flgA	[pdb]	3.30578 0.00303713	179^GLU 239^SER 244^GLY 271^ASN 291^SER 311^PRO 317^PHE 410^GLY 440^GLU 455^PHE		metal ion binding oxidoreductase activity calcium ion binding oxidoreductase activity acting on CH-OH group of donors electron carrier activity	oxidation reduction	periplasmic space outer membrane-bounded periplasmic space membrane
1k3dA	[pdb]	3.30678 0.00303722	128^ASN 159^GLU 167^PHE 214^GLY 216^PHE 224^PRO 230^SER 267^GLY 282^GLU 349^SER	4.1.1.49	carboxy-lyase activity lyase activity ATP binding calcium ion binding catalytic activity nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm	gluconeogenesis
4ktqA	[pdb]	3.31126 0.00313122	306^PHE 308^GLY 309^PHE 315^GLU 347^GLU 370^GLY 373^PRO 409^SER 438^SER 565^ASN	2.7.7.7	nucleotidyltransferase activity transferase activity DNA-directed DNA polymerase activity DNA binding sequence-specific DNA binding 5'-3' exonuclease activity catalytic activity nucleic acid binding nucleoside binding	nucleus intracellular	response to DNA damage stimulus DNA repair DNA replication
1d8wC	[pdb]	3.31496 0.00313158	144^PHE 152^GLY 153^PHE 156^SER 197^GLY 208^PRO 234^GLU 243^GLU 249^SER 250^ASN	5.3.1.14	L-rhamnose isomerase activity metal ion binding manganese ion binding isomerase activity zinc ion binding	cytoplasm	rhamnose metabolic process
1iyxB	[pdb]	3.31747 0.00322909	151^GLY 158^SER 163^GLU 185^PHE 200^SER 205^GLY 207^PHE 209^PRO 214^ASN 219^GLU	4.2.1.11	cell surface cytoplasm extracellular region phosphopyruvate hydratase complex	glycolysis	metal ion binding lyase activity magnesium ion binding phosphopyruvate hydratase activity
1qo9A	[pdb]	3.31847 0.00322919	81^GLU 84^ASN 156^SER 237^GLU 240^GLY 272^SER 331^PRO 371^PHE 436^GLY 439^PHE	3.1.1.7	hydrolase activity carboxylesterase activity acetylcholinesterase activity cholinesterase activity protein homodimerization activity	neurotransmitter catabolic process acetylcholine catabolic process in synaptic cleft choline catabolic process phototaxis synaptic transmission acetylcholine catabolic process	plasma membrane synapse anchored to membrane cell junction membrane cytoplasm
1a7jA	[pdb]	3.32143 0.00322949	70^PHE 73^GLU 81^GLU 139^ASN 140^SER 146^GLY 153^GLY 197^PRO 199^PHE 200^SER	2.7.1.19		reductive pentose-phosphate cycle photosynthesis metabolic process carbohydrate metabolic process	transferase activity kinase activity ATP binding nucleotide binding phosphoribulokinase activity
1a0cA	[pdb]	3.34341 0.00354701	44^SER 95^PRO 97^PHE 99^PHE 180^GLY 182^GLU 231^GLU 265^ASN 293^SER 333^GLY	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cobalt ion binding metal ion binding isomerase activity xylose isomerase activity magnesium ion binding	cytoplasm
2gmhA	[pdb]	3.34622 0.00366055	180^GLY 211^PHE 346^PHE 355^SER 356^PRO 373^SER 374^GLY 379^GLU 401^GLU 405^ASN	1.5.5.1	electron carrier activity oxidoreductase activity oxidizing metal ions with flavin as acceptor ubiquinone binding FAD binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding electron-transferring-flavoprotein dehydrogenase activity	mitochondrial part membrane mitochondrion mitochondrial inner membrane integral to membrane	response to oxidative stress electron transport chain oxidation reduction transport
1a0dD	[pdb]	3.34928 0.00366091	22^PHE 38^GLU 43^SER 88^GLU 91^ASN 309^PRO 332^GLY 359^SER 360^PHE 363^GLY	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding manganese ion binding isomerase activity xylose isomerase activity magnesium ion binding
2piaA	[pdb]	3.35004 0.003661	27^GLU 42^GLY 61^ASN 86^PHE 104^GLU 128^SER 201^PRO 224^SER 225^PHE 275^GLY			2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding electron carrier activity	oxidation reduction electron transport chain transport
1tqyA	[pdb]	3.36036 0.00389507	19^ALA 74^LEU 76^LEU 85^ASP 149^GLY 172^ARG 175^ILE 178^GLY 247^ARG 355^ALA			antibiotic biosynthetic process biosynthetic process metabolic process antibiotic biosynthetic process biosynthetic process metabolic process	transferase activity acyltransferase activity catalytic activity transferase activity acyltransferase activity catalytic activity
1xcrB	[pdb]	3.37506 0.00414509	110^GLU 127^GLY 161^PHE 183^ASN 216^SER 246^PRO 265^GLU 270^PHE 271^SER 277^GLY	0.0.0.0		nucleus	protein binding metal ion binding hydrolase activity zinc ion binding hydrolase activity acting on ester bonds
1iipA	[pdb]	3.3757 0.00414518	46^GLU 47^ASN 65^PRO 87^PHE 88^SER 92^GLY 97^SER 100^GLY 101^GLU 132^PHE	5.2.1.8	cytoplasm	peptide binding isomerase activity peptidyl-prolyl cis-trans isomerase activity binding protein binding	protein folding
3cewD	[pdb]	3.37652 0.00414528	40^PRO 44^SER 48^ASN 50^GLU 59^GLY 60^PHE 65^GLY 66^GLU 87^SER 96^PHE	0.0.0.0
2o9pA	[pdb]	3.37804 0.00414548	35^SER 40^PHE 50^GLY 126^PRO 166^ASN 172^SER 175^GLY 180^GLU 356^GLU 408^PHE	3.2.1.21		cellulose catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process	hydrolase activity acting on glycosyl bonds hydrolase activity beta-glucosidase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1yqtA	[pdb]	3.37965 0.00427652	103^GLY 267^GLU 277^SER 291^GLY 293^PHE 294^SER 296^PRO 304^ASN 318^PHE 322^GLU	0.0.0.0			iron-sulfur cluster binding nucleoside-triphosphatase activity ATPase activity electron carrier activity ATP binding nucleotide binding
1zapA	[pdb]	3.38347 0.00427704	199^GLY 202^GLU 205^GLY 253^GLU 257^ASN 259^SER 264^PHE 273^SER 275^PRO 298^PHE	3.4.23.24	extracellular region	hydrolase activity peptidase activity aspartic-type endopeptidase activity	proteolysis
2dq3A	[pdb]	3.38453 0.00427718	106^PRO 207^GLY 233^GLU 298^GLU 330^SER 354^SER 355^ASN 359^PHE 378^PHE 384^GLY	6.1.1.11	cytoplasm	ligase activity ATP binding aminoacyl-tRNA ligase activity nucleotide binding serine-tRNA ligase activity	translation seryl-tRNA aminoacylation tRNA aminoacylation for protein translation selenocysteine biosynthetic process
2iyaB	[pdb]	3.38828 0.00441312	137^SER 138^PRO 221^PHE 234^PHE 236^GLY 332^GLY 333^SER 336^GLU 356^ASN 358^GLU	0.0.0.0		antibiotic metabolic process metabolic process	transferase activity transferring glycosyl groups transferase activity transferase activity transferring hexosyl groups
1u4gA	[pdb]	3.38843 0.00441314	81^GLY 84^PHE 91^PHE 95^PRO 143^SER 167^SER 171^GLY 172^GLU 249^GLU 255^ASN	3.4.24.26	extracellular region	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity calcium ion binding metalloendopeptidase activity	proteolysis
3b2xA	[pdb]	3.38891 0.00441321	750^PHE 760^ASN 763^GLU 787^GLY 789^PHE 792^SER 794^PRO 803^SER 804^GLY 810^GLU	3.4.11.2	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity aminopeptidase activity	plasma membrane membrane	proteolysis
3bk7A	[pdb]	3.39118 0.00441353	107^GLY 271^GLU 281^SER 295^GLY 297^PHE 298^SER 300^PRO 305^ASN 309^GLU 322^PHE	0.0.0.0			ATP binding iron-sulfur cluster binding nucleoside-triphosphatase activity ATPase activity electron carrier activity nucleotide binding
2qfeA	[pdb]	3.39296 0.00441378	725^GLY 730^GLU 741^PHE 756^GLY 757^PHE 775^GLU 778^PRO 779^SER 802^ASN 803^SER	0.0.0.0	hydrolase activity cysteine-type peptidase activity peptidase activity calcium-dependent cysteine-type endopeptidase activity	nucleus intracellular	proteolysis
1ukcA	[pdb]	3.39514 0.00455418	131^GLU 132^ASN 208^GLY 215^SER 237^GLU 239^SER 242^PRO 342^PHE 396^GLY 400^PHE	0.0.0.0			hydrolase activity
2vhdA	[pdb]	3.39564 0.00455425	50^SER 52^ASN 80^SER 81^PRO 88^PHE 93^PHE 96^GLY 103^GLU 107^GLY 160^GLU	1.11.1.5	metal ion binding oxidoreductase activity iron ion binding peroxidase activity cytochrome-c peroxidase activity heme binding electron carrier activity	oxidation reduction electron transport chain transport	periplasmic space
1hcuB	[pdb]	3.40009 0.0045549	242^GLY 246^SER 303^PRO 305^SER 315^ASN 340^PHE 353^GLU 354^GLY 355^PHE 396^GLU	0.0.0.0		calcium ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	membrane
3ce9D	[pdb]	3.40262 0.00470011	37^SER 41^GLY 42^GLU 74^PHE 76^GLU 80^ASN 97^GLY 116^SER 126^PHE 147^PRO	0.0.0.0		oxidation reduction aromatic amino acid family biosynthetic process	oxidoreductase activity acting on CH-OH group of donors metal ion binding 3-dehydroquinate synthase activity
2vjxA	[pdb]	3.40609 0.00470063	530^SER 532^ASN 541^PRO 542^PHE 544^SER 555^GLU 558^PHE 624^GLY 628^GLY 630^GLU	0.0.0.0		carbohydrate metabolic process	cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1tkjA	[pdb]	3.40748 0.00470084	158^ASN 164^SER 165^PRO 168^GLY 179^GLU 186^PHE 198^GLU 199^GLY 203^SER 242^PHE	3.4.11.24	extracellular region	metal ion binding hydrolase activity zinc ion binding peptidase activity calcium ion binding aminopeptidase activity	proteolysis
2o8jB	[pdb]	3.40999 0.00485086	931^GLU 1061^GLY 1063^PHE 1106^ASN 1108^SER 1121^PRO 1139^PHE 1140^SER 1149^GLU 1151^GLY	2.1.1.43	cellular_component nucleus	organ growth synaptonemal complex assembly biological_process chromatin modification histone H3-K9 methylation fertilization spermatid development germ cell development pachytene negative regulation of transcription from RNA polymerase II promoter	protein binding metal ion binding transferase activity zinc ion binding methyltransferase activity histone-lysine N-methyltransferase activity
1sqjA	[pdb]	3.41173 0.00485113	84^GLY 94^PHE 98^GLU 104^PHE 109^SER 110^PRO 124^GLU 134^ASN 139^GLY 148^SER	0.0.0.0			hydrolase activity
2pxxA	[pdb]	3.415 0.0050037	38^PRO 42^PHE 43^GLY 45^PHE 59^GLU 66^GLY 70^SER 83^ASN 86^SER 129^GLU	3.4.24.71	cell-cell signaling peptide hormone processing heart development cardioblast differentiation brain development metabolic process proteolysis	cytoplasmic vesicle membrane Golgi membrane integral to membrane membrane Golgi apparatus	metalloendopeptidase activity metal ion binding hydrolase activity transferase activity zinc ion binding metallopeptidase activity peptidase activity methyltransferase activity catalytic activity
2uvfB	[pdb]	3.41887 0.0050043	229^GLY 239^GLU 243^SER 246^ASN 327^GLY 331^SER 352^PRO 354^PHE 361^GLU 385^PHE	0.0.0.0		carbohydrate metabolic process	polygalacturonase activity
1d6iB	[pdb]	3.42045 0.00500455	235^PRO 237^PHE 344^PHE 348^GLU 353^SER 356^ASN 363^GLU 364^GLY 368^GLY 386^SER	2.3.1.74		flavonoid biosynthetic process biosynthetic process metabolic process	transferase activity acyltransferase activity naringenin-chalcone synthase activity transferase activity transferring acyl groups other than amino-acyl groups catalytic activity
1kqgA	[pdb]	3.42382 0.00515962	171^TYR 172^MET 180^ILE 465^PRO 512^PHE 514^GLY 696^GLU 699^GLY 735^SER 742^SER	1.2.1.2	electron carrier activity iron ion binding formate dehydrogenase activity metal ion binding iron ion binding formate dehydrogenase activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding molybdenum ion binding oxidoreductase activity selenium binding iron ion binding formate dehydrogenase activity binding metal ion binding iron ion binding formate dehydrogenase activity metal ion binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding iron ion binding electron carrier activity formate dehydrogenase activity	electron transport chain transport cellular respiration electron transport chain transport respiratory electron transport chain oxidation reduction cellular respiration electron transport chain transport cellular respiration respiratory electron transport chain cellular respiration respiratory electron transport chain electron transport chain transport cellular respiration	membrane plasma membrane integral to membrane membrane formate dehydrogenase complex periplasmic space cytoplasm plasma membrane integral to membrane membrane formate dehydrogenase complex plasma membrane integral to membrane membrane formate dehydrogenase complex plasma membrane integral to membrane membrane
1o1zA	[pdb]	3.42466 0.00515975	97^GLU 121^SER 137^GLY 142^GLU 144^ASN 160^PRO 162^SER 170^PHE 190^PHE 209^GLY	0.0.0.0		glycerophosphodiester phosphodiesterase activity phosphoric diester hydrolase activity phospholipase C activity	intracellular signaling cascade lipid metabolic process glycerol metabolic process
1t6kA	[pdb]	3.42604 0.00515997	71^PHE 75^PRO 99^GLY 103^PHE 106^GLU 213^SER 216^GLY 263^GLU 265^SER 267^ASN			antibiotic biosynthetic process pathogenesis biosynthetic process	isomerase activity catalytic activity
2w91A	[pdb]	3.42818 0.00516032	246^GLU 532^SER 533^PHE 554^ASN 557^SER 563^PRO 582^PHE 696^GLY 742^GLU 756^GLY	0.0.0.0	cell adhesion	cell wall extracellular region membrane cell surface cytoplasm	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity hydrolase activity
1piiA	[pdb]	3.43148 0.00532029	58^SER 59^PRO 93^PHE 95^GLY 116^PHE 166^ASN 169^GLU 192^SER 214^GLU 216^GLY	4.1.1.48, 5.3.1.24		catalytic activity phosphoribosylanthranilate isomerase activity indole-3-glycerol-phosphate synthase activity isomerase activity carboxy-lyase activity lyase activity	tryptophan biosynthetic process aromatic amino acid family biosynthetic process cellular amino acid biosynthetic process metabolic process tryptophan metabolic process
2qc5A	[pdb]	3.43259 0.00532048	74^GLU 78^ASN 99^SER 119^GLY 133^GLU 141^SER 143^PRO 145^PHE 156^PHE 165^GLY	0.0.0.0		carbon-oxygen lyase activity catalytic activity magnesium ion binding	response to antibiotic antibiotic catabolic process
2vr0E	[pdb]	3.43356 0.00532064	75^LEU 78^LYS 79^LEU 81^PHE 82^LYS 94^THR 111^VAL 339^SER 428^GLU 429^ASN	0.0.0.0	iron ion binding calcium ion binding oxidoreductase activity metal ion binding	periplasmic space	transport electron transport chain oxidation reduction nitrogen compound metabolic process
1zv2A	[pdb]	3.4339 0.00532069	100^PRO 161^GLY 163^PHE 275^PHE 278^SER 284^SER 298^GLU 311^GLU 317^GLY 337^ASN	1.7.2.1	metal ion binding oxidoreductase activity copper ion binding nitrite reductase (NO-forming) activity	oxidation reduction nitrate assimilation nitrogen compound metabolic process	periplasmic space
2h4qA	[pdb]	3.43428 0.00532075	2^GLU 9^GLY 11^PHE 32^PRO 36^SER 60^PHE 92^GLU 93^ASN 96^SER 97^GLY		chromosome condensation chromatin modification mitotic chromosome condensation	nucleus chromosome	peptidase inhibitor activity endopeptidase inhibitor activity DNA binding serine-type endopeptidase inhibitor activity
3d7gA	[pdb]	3.43688 0.00548556	90^PHE 159^PRO 162^SER 256^GLY 350^ASN 351^GLU 383^PHE 384^GLY 425^GLU 554^SER	3.4.17.21	cytoplasm nucleus membrane plasma membrane integral to membrane integral to plasma membrane membrane fraction	peptidase activity metal ion binding dipeptidase activity hydrolase activity zinc ion binding metallopeptidase activity carboxypeptidase activity catalytic activity	proteolysis
1xipA	[pdb]	3.44277 0.00548656	29^SER 31^ASN 32^GLU 55^SER 87^PRO 91^PHE 275^PHE 338^GLY 371^GLU 372^GLY		intracellular protein transmembrane transport mRNA transport protein transport transport nuclear pore organization rRNA export from nucleus mRNA export from nucleus ribosome export from nucleus	nuclear membrane membrane nuclear pore nucleus	structural molecule activity protein binding
2b39B	[pdb]	3.44348 0.00565602	837^SER 845^GLU 933^GLU 1381^GLY 1409^GLY 1410^PHE 1411^SER 1412^PRO 1438^ASN 1490^PHE	0.0.0.0	extracellular region extracellular space	innate immune response complement activation classical pathway complement activation alternative pathway immune response inflammatory response complement activation positive regulation of type IIa hypersensitivity positive regulation of phagocytosis	protein binding endopeptidase inhibitor activity
2o1xD	[pdb]	3.44644 0.00565654	188^SER 190^ASN 329^GLY 343^PHE 351^GLU 352^GLY 358^PHE 359^SER 363^PRO 373^GLU	2.2.1.7		thiamin biosynthetic process isoprenoid biosynthetic process terpenoid biosynthetic process metabolic process	transferase activity 1-deoxy-D-xylulose-5-phosphate synthase activity catalytic activity
1nmlA	[pdb]	3.44689 0.00565662	50^SER 52^ASN 70^GLY 80^SER 81^PRO 88^PHE 93^PHE 107^GLY 114^GLU 160^GLU	0.0.0.0		oxidation reduction	peroxidase activity heme binding oxidoreductase activity electron carrier activity iron ion binding
2hpgA	[pdb]	3.44775 0.00565677	107^PHE 179^PRO 187^SER 190^SER 192^GLY 238^GLY 240^PHE 311^GLU 319^ASN 323^GLU	0.0.0.0		outer membrane-bounded periplasmic space	transport
2yzgA	[pdb]	3.45553 0.0058325	23^GLY 78^PHE 205^ASN 211^SER 287^PRO 289^PHE 293^SER 300^GLU 302^GLY 315^GLU	6.3.2.4	cytoplasm cell wall	metal ion binding manganese ion binding ligase activity ATP binding magnesium ion binding nucleotide binding D-alanine-D-alanine ligase activity catalytic activity	peptidoglycan biosynthetic process regulation of cell shape cell wall organization

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

1a53A

[pdb]

0.110057
3.1335e-05

51^GLU 56^SER 57^PRO 89^PHE 91^GLY 112^PHE 159^GLU 180^ASN 211^SER 233^GLY

4.1.1.48

aromatic amino acid family biosynthetic process
cellular amino acid biosynthetic process
tryptophan biosynthetic process
metabolic process
tryptophan metabolic process

carboxy-lyase activity
lyase activity
indole-3-glycerol-phosphate synthase activity
catalytic activity

1vc4B

[pdb]

0.245601
7.52012e-05

51^GLU 56^SER 57^PRO 91^PHE 93^GLY 114^PHE 160^GLU 181^ASN 215^SER 236^GLY

0.0.0.0

indole-3-glycerol-phosphate synthase activity
catalytic activity

metabolic process

1i4nA

[pdb]

0.543744
0.000156693

47^GLU 52^SER 53^PRO 87^PHE 89^GLY 110^PHE 157^GLU 179^ASN 210^SER 231^GLY

4.1.1.48

aromatic amino acid family biosynthetic process
cellular amino acid biosynthetic process
tryptophan biosynthetic process
metabolic process
tryptophan metabolic process

carboxy-lyase activity
lyase activity
indole-3-glycerol-phosphate synthase activity
catalytic activity

1j5tA

[pdb]

0.579199
0.000170908

25^GLU 30^SER 31^PRO 65^PHE 67^GLY 88^PHE 135^GLU 157^ASN 188^SER 209^GLY

4.1.1.48

aromatic amino acid family biosynthetic process
cellular amino acid biosynthetic process
tryptophan biosynthetic process
metabolic process
tryptophan metabolic process

carboxy-lyase activity
lyase activity
indole-3-glycerol-phosphate synthase activity
catalytic activity

2gqfA

[pdb]

2.62241
0.000267738

195^SER 234^PHE 238^GLY 240^SER 242^PRO 249^ASN 255^GLU 330^PHE 336^GLU 337^GLY

electron carrier activity
oxidoreductase activity

1egvL

[pdb]

2.71882
0.000328608

138^ALA 139^ILE 165^GLU 166^ARG 170^LYS 333^SER 334^ASN 363^GLY 379^GLU 384^PHE

0.0.0.0

lyase activity
propanediol dehydratase activity
lyase activity
propanediol dehydratase activity
lyase activity
propanediol dehydratase activity
cobalamin binding
hydro-lyase activity
catalytic activity

metabolic process

1m1oB

[pdb]

2.77014
0.000378683

20^GLY 22^PHE 26^PRO 118^SER 198^GLU 202^PHE 217^GLU 347^GLY 353^SER 359^ASN

2.3.1.9

cytoplasm

poly-hydroxybutyrate biosynthetic process
metabolic process

transferase activity
acyltransferase activity
acetyl-CoA C-acetyltransferase activity
catalytic activity

2hu0D

[pdb]

2.82991
0.000466779

104^ASN 105^SER 119^GLU 165^GLU 351^GLY 374^PHE 404^SER 441^GLY 446^PHE 459^PRO

0.0.0.0

hydrolase activity
acting on glycosyl bonds
hydrolase activity
exo-alpha-sialidase activity

metabolic process
carbohydrate metabolic process

virion membrane
apical plasma membrane
virion
integral to membrane
membrane
plasma membrane

1jfrA

[pdb]

2.86672
0.000530441

6^GLU 8^GLY 13^ASN 15^SER 55^GLY 75^PRO 79^SER 82^PHE 230^PHE 238^GLU

0.0.0.0

hydrolase activity

2qm0A

[pdb]

2.88351
0.000559454

178^PHE 180^SER 182^PRO 216^GLY 217^SER 228^ASN 232^GLU 244^PHE 248^GLU 265^GLY

0.0.0.0

3b7eA

[pdb]

2.90544
0.000622638

104^ASN 119^GLU 165^GLU 363^GLY 374^PHE 404^SER 441^GLY 442^SER 446^PHE 459^PRO

3.2.1.18

metabolic process
carbohydrate metabolic process

metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
calcium ion binding
exo-alpha-sialidase activity

virion membrane
apical plasma membrane
virion
integral to membrane
membrane
plasma membrane

2ivfA

[pdb]

2.95029
0.000736315

91^ASP 196^GLU 197^ARG 487^ASN 660^GLU 664^PRO 670^PHE 742^GLU 753^PHE 766^GLY

0.0.0.0

iron-sulfur cluster binding
electron carrier activity
metal ion binding
molybdenum ion binding
oxidoreductase activity
binding
heme binding

oxidation reduction
oxidation reduction

periplasmic space

3fkjA

[pdb]

2.95453
0.000756911

2^SER 7^ASN 42^PHE 132^PRO 146^GLU 159^GLU 165^GLY 168^SER 290^GLY 293^PHE

0.0.0.0

carbohydrate metabolic process

isomerase activity
sugar binding

2as0B

[pdb]

2.98628
0.000846526

35^PRO 52^GLY 53^PHE 105^GLU 111^GLY 127^SER 133^PHE 153^GLU 155^ASN 159^SER

0.0.0.0

RNA binding

2e3tA

[pdb]

2.99467
0.000870721

802^GLU 841^PRO 864^PHE 865^SER 868^GLY 871^GLU 898^GLY 907^SER 908^ASN 914^PHE

1.17.3.2, 1.17.1.4

2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
molybdenum ion binding
oxidoreductase activity
iron ion binding
xanthine oxidase activity
xanthine dehydrogenase activity
catalytic activity
FAD binding
electron carrier activity

oxidation reduction
lactation
response to aluminum ion
regulation of epithelial cell differentiation
bone resorption

peroxisome
cytosol

2jkrU

[pdb]

3.01305
0.000947199

180^SER 182^ASN 287^PHE 311^PHE 360^GLY 391^GLU 396^PRO 397^SER 426^GLY 432^GLU

cell adhesion
immune response
positive regulation of T cell activation
positive regulation of calcium-mediated signaling
positive regulation of peptidyl-tyrosine phosphorylation
cell surface receptor linked signal transduction
cytokine production
protein amino acid N-linked glycosylation
response to protein stimulus
conjugation with cellular fusion
regulation of T cell activation
positive regulation of protein kinase activity
positive regulation of interleukin-2 biosynthetic process
T cell selection
T cell differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
immune response
interspecies interaction between organisms
initiation of viral infection
enzyme linked receptor protein signaling pathway
cell surface receptor linked signal transduction
signal transduction
cell adhesion
positive regulation of T cell activation
positive regulation of calcium-mediated signaling
positive regulation of peptidyl-tyrosine phosphorylation
cytokine production
protein amino acid N-linked glycosylation
response to protein stimulus
vesicle-mediated transport
intracellular protein transport
transport
vesicle-mediated transport
protein transport
intracellular protein transport
transport
vesicle-mediated transport
protein transport
intracellular protein transport
endocytosis
transport
regulation of defense response to virus by virus
vesicle-mediated transport
protein transport
intracellular protein transport

integral to membrane
membrane
external side of plasma membrane
plasma membrane
endoplasmic reticulum lumen
cell surface
membrane raft
AP-2 adaptor complex
T cell receptor complex
plasma membrane
integral to membrane
membrane
endoplasmic reticulum membrane
early endosome
external side of plasma membrane
endoplasmic reticulum lumen
endoplasmic reticulum membrane
cell surface
membrane raft
plasma membrane
membrane
coated pit
transport vesicle
clathrin vesicle coat
clathrin coat of coated pit
clathrin adaptor complex
plasma membrane
membrane
coated pit
membrane coat
membrane
plasma membrane
coated pit
secretory granule
membrane coat
clathrin adaptor complex
plasma membrane
membrane
coated pit
cytosol
clathrin adaptor complex
membrane coat

protein binding
extracellular matrix structural constituent
protein homodimerization activity
glycoprotein binding
zinc ion binding
protein kinase binding
MHC class II protein binding
coreceptor activity
transmembrane receptor activity
receptor activity
protein binding
lipid binding
protein transporter activity
protein binding
protein transporter activity
protein binding
binding
lipid binding
protein binding
protein transporter activity
binding

2znhB

[pdb]

3.01478
0.000947245

79^SER 80^PRO 191^SER 192^ASN 195^GLU 221^PHE 326^GLU 328^GLY 422^PHE 424^GLY

blood coagulation

extracellular space
extracellular region
plasma membrane

peptidase inhibitor activity
protease binding
serine-type endopeptidase inhibitor activity
protein binding
heparin binding
endopeptidase inhibitor activity

2gtaD

[pdb]

3.01829
0.000973558

12^GLU 22^GLU 23^GLY 25^PHE 26^SER 27^PRO 72^PHE 79^ASN 80^SER 110^GLY

1sb7A

[pdb]

3.02856
0.00100084

27^PHE 155^GLY 161^GLY 309^SER 311^ASN 319^GLU 325^PRO 328^SER 329^PHE 336^GLU

RNA modification
tRNA processing
tRNA pseudouridine synthesis
pseudouridine synthesis

isomerase activity
pseudouridine synthase activity
RNA binding
protein binding

2z2oD

[pdb]

3.05825
0.00111802

101^PRO 138^ASN 141^SER 144^SER 145^PHE 156^PHE 175^GLU 184^GLY 187^GLY 200^GLU

metal ion binding
lyase activity
magnesium ion binding
carbon-oxygen lyase activity
catalytic activity

response to antibiotic
antibiotic catabolic process

1iwpA

[pdb]

3.0629
0.00114945

139^LYS 140^GLY 163^HOH 167^HOH 171^HOH 364^GLY 378^SER 379^ASN 383^GLU 385^PHE

0.0.0.0

lyase activity
glycerol dehydratase activity
lyase activity
glycerol dehydratase activity
cobalamin binding
hydro-lyase activity
catalytic activity
lyase activity
glycerol dehydratase activity

metabolic process

1hesA

[pdb]

3.08402
0.00124933

180^SER 182^ASN 287^PHE 311^PHE 360^GLY 391^GLU 396^PRO 397^SER 426^GLY 432^GLU

0.0.0.0

plasma membrane
membrane
coated pit
secretory granule
mitochondrion
clathrin coat of coated pit
clathrin adaptor complex
plasma membrane
membrane
coated pit
cytosol
peroxisomal membrane
clathrin coat of coated pit
clathrin adaptor complex
mitochondrion
plasma membrane
membrane
coated pit
transport vesicle
clathrin vesicle coat
clathrin coat of coated pit
clathrin adaptor complex
membrane
integral to membrane
platelet alpha granule membrane
plasma membrane
integral to plasma membrane
soluble fraction
membrane fraction
extracellular space
external side of plasma membrane

protein binding
lipid binding
protein binding
lipid binding
transporter activity
protein binding
lipid binding
protein binding
sugar binding
binding
lipopolysaccharide binding
heparin binding
sialic acid binding
fucose binding
glycosphingolipid binding
oligosaccharide binding

vesicle-mediated transport
intracellular protein transport
transport
regulation of defense response to virus by virus
vesicle-mediated transport
intracellular protein transport
transport
vesicle-mediated transport
intracellular protein transport
transport
cell adhesion
leukocyte adhesion
positive regulation of platelet activation
response to lipopolysaccharide
defense response to Gram-negative bacterium

2jf7A

[pdb]

3.10542
0.00135611

49^PHE 52^GLY 54^SER 113^SER 155^PRO 206^ASN 207^GLU 339^PHE 416^GLU 461^GLY

0.0.0.0

carbohydrate metabolic process

cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1uzbB

[pdb]

3.10808
0.00135621

57^ASN 59^SER 123^GLU 185^PHE 317^PHE 319^GLY 350^SER 358^PRO 369^GLU 396^GLY

0.0.0.0

metabolic process
proline biosynthetic process
oxidation reduction

oxidoreductase activity
1-pyrroline-5-carboxylate dehydrogenase activity

1tvpA

[pdb]

3.11469
0.00139407

21^PHE 24^PRO 25^SER 235^ASN 238^GLU 246^PHE 280^SER 281^GLY 286^GLU 293^GLY

0.0.0.0

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
cellulase activity
cation binding
carbohydrate binding
calcium ion binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

metabolic process
cell adhesion
carbohydrate metabolic process

1zcjA

[pdb]

3.14316
0.00155849

274^GLU 278^ASN 281^SER 433^PHE 446^PRO 447^SER 477^GLY 478^PHE 636^GLU 637^GLY

1.1.1.35, 4.2.1.17, 5.3.3.8

fatty acid beta-oxidation
oxidation reduction
fatty acid metabolic process
lipid metabolic process
metabolic process

isomerase activity
lyase activity
oxidoreductase activity
catalytic activity
enoyl-CoA hydratase activity
dodecenoyl-CoA delta-isomerase activity
3-hydroxyacyl-CoA dehydrogenase activity
coenzyme binding
binding

mitochondrion
peroxisome

2qh5B

[pdb]

3.15947
0.00164714

90^ASN 109^PRO 135^PHE 139^PHE 140^GLY 151^GLY 166^GLU 186^SER 199^GLU 243^SER

0.0.0.0

isomerase activity
nucleotidyltransferase activity

lipopolysaccharide biosynthetic process
biosynthetic process
polysaccharide metabolic process

1wgzC

[pdb]

3.16141
0.00169311

206^PRO 267^PHE 313^GLU 314^ASN 319^SER 321^GLY 324^GLU 338^GLY 341^SER 345^PHE

0.0.0.0

carboxypeptidase activity
metallocarboxypeptidase activity

proteolysis

1kv9A

[pdb]

3.17582
0.00179047

173^GLU 249^GLY 255^ASN 293^SER 375^PRO 376^SER 378^PHE 409^GLU 425^PHE 524^GLY

0.0.0.0

heme binding
oxidoreductase activity
acting on CH-OH group of donors
electron carrier activity
calcium ion binding
iron ion binding

outer membrane-bounded periplasmic space
membrane

oxidation reduction

3dzuD

[pdb]

3.19053
0.001895

245^SER 246^PRO 247^PHE 258^GLY 332^SER 335^ASN 343^GLU 344^GLY 352^PHE 365^GLU

cardiac muscle cell proliferation
retinoic acid receptor signaling pathway
positive regulation of transcription
fat cell differentiation
innate immune response
regulation of blood pressure
interspecies interaction between organisms
regulation of transcription
DNA-dependent
transcription
vitamin metabolic process
positive regulation of transcription from RNA polymerase II promoter
ventricular cardiac muscle cell differentiation
ventricular cardiac muscle morphogenesis
response to retinoic acid
cholesterol metabolic process
negative regulation of specific transcription from RNA polymerase II promoter
heart development
regulation of transcription
negative regulation of cytokine production
negative regulation of cell proliferation
positive regulation of specific transcription from RNA polymerase II promoter
negative regulation of specific transcription from RNA polymerase II promoter
negative regulation of foam cell differentiation
negative regulation of receptor biosynthetic process
negative regulation of cholesterol storage
negative regulation of sequestering of triglyceride
brown fat cell differentiation
regulation of transcription
DNA-dependent
transcription
regulation of transcription
signal transduction
positive regulation of transcription from RNA polymerase II promoter
steroid hormone receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
white fat cell differentiation
regulation of transcription
DNA-dependent
transcription
response to nutrient
lipid metabolic process
positive regulation of fat cell differentiation
placenta development
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transcription
DNA-dependent
regulation of fat cell differentiation
regulation of transcription
cell fate commitment
response to lipid
epithelial cell differentiation
long-chain fatty acid transport
cell maturation
response to low density lipoprotein stimulus
low-density lipoprotein receptor biosynthetic process
lipoprotein transport
signal transduction
monocyte differentiation
negative regulation of transcription from RNA polymerase II promoter
lipid homeostasis
glucose homeostasis
cellular response to insulin stimulus

nucleus
nucleus
cytoplasm
nucleus
cytosol

prostaglandin receptor activity
protein binding
metal ion binding
zinc ion binding
receptor activity
DNA binding
transcription coactivator activity
retinoid-X receptor activity
transcription factor activity
sequence-specific DNA binding
steroid binding
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
ligand-regulated transcription factor activity
retinoic acid receptor activity
vitamin D response element binding
transcription regulator activity
vitamin D receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
transcription coactivator activity
nuclear hormone receptor binding
transcription regulator activity
signal transducer activity
protein binding
thyroid hormone receptor coactivator activity
transcription repressor activity
receptor binding
protein binding
metal ion binding
zinc ion binding
receptor activity
DNA binding
sequence-specific DNA binding
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
transcription factor activity
arachidonic acid binding
transcription repressor activity
transcription activator activity
retinoid X receptor binding
protein heterodimerization activity
transcription activator binding
drug binding

2dvkA

[pdb]

3.19118
0.00189504

29^ASN 36^SER 91^PRO 108^GLU 114^GLY 115^PHE 119^GLY 135^SER 177^PHE 182^GLU

1ebdB

[pdb]

3.19182
0.00189507

85^PHE 90^GLU 166^PHE 171^ASN 176^PRO 178^SER 190^GLU 192^GLY 198^PHE 199^GLY

1.8.1.4

cytoplasm

oxidation reduction
glycolysis
cell redox homeostasis
glycolysis
metabolic process

oxidoreductase activity
dihydrolipoyl dehydrogenase activity
FAD binding
electron carrier activity
lipoic acid binding
transferase activity
acyltransferase activity
dihydrolipoyllysine-residue acetyltransferase activity
protein binding

1wpxA

[pdb]

3.19272
0.00189512

51^ASN 58^SER 63^PHE 68^PRO 69^SER 72^GLY 100^GLY 145^GLU 296^GLU 401^PHE

3.4.16.5

cytoplasm
fungal-type vacuole membrane
fungal-type vacuole lumen
vacuole
endoplasmic reticulum
cytoplasm
fungal-type vacuole lumen
fungal-type vacuole

regulation of proteolysis
phytochelatin biosynthetic process
vacuolar protein catabolic process
proteolysis

serine-type endopeptidase inhibitor activity
endopeptidase inhibitor activity
peptidase inhibitor activity
hydrolase activity
peptidase activity
carboxypeptidase activity
glutathione gamma-glutamylcysteinyltransferase activity
serine-type carboxypeptidase activity
protein binding

2zk6A

[pdb]

3.19321
0.00189515

245^SER 246^PRO 247^PHE 258^GLY 332^SER 335^ASN 343^GLU 344^GLY 352^PHE 365^GLU

cytosol
nucleus

regulation of transcription
DNA-dependent
transcription
response to nutrient
lipid metabolic process
positive regulation of fat cell differentiation
placenta development
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transcription
DNA-dependent
regulation of fat cell differentiation
regulation of transcription
cell fate commitment
response to lipid
epithelial cell differentiation
long-chain fatty acid transport
cell maturation
response to low density lipoprotein stimulus
low-density lipoprotein receptor biosynthetic process
lipoprotein transport
signal transduction
monocyte differentiation
negative regulation of transcription from RNA polymerase II promoter
lipid homeostasis
glucose homeostasis
cellular response to insulin stimulus
positive regulation of transcription
fat cell differentiation
innate immune response
regulation of blood pressure
negative regulation of cytokine production
negative regulation of cell proliferation
positive regulation of specific transcription from RNA polymerase II promoter
negative regulation of specific transcription from RNA polymerase II promoter
negative regulation of foam cell differentiation
negative regulation of receptor biosynthetic process
negative regulation of cholesterol storage
negative regulation of sequestering of triglyceride
brown fat cell differentiation
white fat cell differentiation

zinc ion binding
receptor activity
DNA binding
sequence-specific DNA binding
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
transcription factor activity
arachidonic acid binding
transcription repressor activity
transcription activator activity
retinoid X receptor binding
protein heterodimerization activity
transcription activator binding
drug binding
prostaglandin receptor activity
protein binding
metal ion binding

1w1tB

[pdb]

3.2183
0.00212715

9^GLY 12^PHE 14^PRO 50^SER 55^ASN 59^GLU 96^GLY 106^SER 136^PHE 144^GLU

0.0.0.0

extracellular region

hydrolase activity
hydrolase activity
acting on glycosyl bonds
cation binding
carbohydrate binding
chitinase activity
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

metabolic process
chitin catabolic process
carbohydrate metabolic process

1rf8A

[pdb]

3.22678
0.00218889

103^GLU 112^GLY 163^PHE 170^GLU 179^GLY 196^PHE 201^SER 203^ASN 209^PRO 210^SER

cytoplasm
eukaryotic translation initiation factor 4F complex
stress granule
ribosome
mitochondrion
eukaryotic translation initiation factor 4F complex
stress granule
ribosome
cytoplasm
nucleus

regulation of translation
translation
ribosome biogenesis
stress granule assembly
translational initiation
RNA metabolic process
regulation of translation
translation
regulation of cell cycle
translational initiation
nuclear-transcribed mRNA catabolic process
nonsense-mediated decay

translation initiation factor activity
RNA binding
protein binding
binding
translation initiation factor activity
RNA binding
protein binding
phosphatidylinositol 3-phosphate binding

3ei1A

[pdb]

3.22947
0.00218906

924^GLY 929^SER 951^PRO 955^SER 958^GLU 970^ASN 975^PHE 996^GLY 998^PHE 1002^GLU

cell cycle checkpoint
interspecies interaction between organisms
response to DNA damage stimulus
ubiquitin-dependent protein catabolic process
DNA repair
nucleotide-excision repair
DNA damage removal
nucleotide-excision repair
response to DNA damage stimulus
ubiquitin-dependent protein catabolic process
DNA repair
modification-dependent protein catabolic process
protein ubiquitination during ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process

cytoplasm
nucleus
nucleoplasm
nucleus

protein binding
DNA binding
damaged DNA binding
nucleic acid binding
DNA binding
protein binding

1nf0A

[pdb]

3.23729
0.00225313

6^PHE 34^GLU 178^PRO 211^SER 214^GLY 229^PHE 232^GLY 239^GLU 246^SER 248^ASN

5.3.1.1

isomerase activity
triose-phosphate isomerase activity
catalytic activity

lipid biosynthetic process
fatty acid biosynthetic process
pentose-phosphate shunt
glycolysis
gluconeogenesis
metabolic process

plasma membrane enriched fraction
mitochondrion
cytoplasm

2d1gB

[pdb]

3.24083
0.00231938

43^GLU 46^SER 103^SER 105^ASN 107^GLU 168^PHE 169^GLY 172^PHE 349^GLY 413^PRO

0.0.0.0

hydrolase activity
acting on ester bonds
hydrolase activity
acting on ester bonds

1tvcA

[pdb]

3.24752
0.00238842

12^PHE 46^GLU 48^GLY 50^PHE 65^SER 66^PRO 71^ASN 73^GLU 106^GLY 135^SER

1.14.13.25

2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
monooxygenase activity
methane monooxygenase activity
electron carrier activity

oxidation reduction
electron transport chain
transport
one-carbon metabolic process

2w61A

[pdb]

3.24939
0.00238856

141^ASN 143^GLU 187^SER 385^PRO 415^PHE 434^GLY 435^GLU 437^GLY 439^PHE 440^SER

cell wall organization
ascospore wall assembly

plasma membrane
anchored to membrane
membrane
cytoplasm

transferase activity
1,3-beta-glucanosyltransferase activity

1z33A

[pdb]

3.25003
0.0023886

65^GLY 106^PHE 108^SER 112^ASN 113^SER 126^PRO 151^GLY 165^GLU 173^PHE 179^GLU

0.0.0.0

1djhA

[pdb]

3.25929
0.00253461

506^GLY 507^PHE 509^SER 523^PHE 534^GLU 536^GLY 566^GLU 569^ASN 611^PRO 617^SER

3.1.4.11

lipid catabolic process
signal transduction
response to hyperoxia
response to calcium ion
elevation of cytosolic calcium ion concentration during G-protein signaling
coupled to IP3 second messenger (phospholipase C activating)
response to peptide hormone stimulus
response to prostaglandin F stimulus
positive regulation of inositol trisphosphate biosynthetic process
positive regulation of norepinephrine secretion
response to organic nitrogen
response to aluminum ion
G-protein coupled receptor protein signaling pathway
intracellular signaling cascade
lipid metabolic process
angiogenesis
placenta development

metal ion binding
hydrolase activity
calcium ion binding
signal transducer activity
phosphoinositide phospholipase C activity
phosphatidylinositol-4,5-bisphosphate binding
phospholipid binding
protein binding
phospholipase C activity
phosphoric diester hydrolase activity

mitochondrial membrane
cytosol
nucleus
membrane fraction
membrane raft

2a2mA

[pdb]

3.25965
0.00253464

14^PHE 17^PRO 30^SER 86^GLY 106^PHE 112^SER 165^GLU 198^GLY 204^ASN 207^GLU

0.0.0.0

2c0hA

[pdb]

3.26974
0.00261244

34^PHE 239^SER 241^ASN 288^GLU 291^PHE 303^PRO 307^GLY 308^GLU 332^SER 333^GLY

3.2.1.78

cellular_component

mannan catabolic process
metabolic process
carbohydrate metabolic process

mannan endo-1,4-beta-mannosidase activity
hydrolase activity
acting on glycosyl bonds
hydrolase activity
cation binding
catalytic activity

1nphA

[pdb]

3.27606
0.00269301

556^PRO 558^SER 563^SER 564^ASN 567^PHE 587^GLU 607^GLU 608^GLY 613^GLY 614^PHE

actin filament capping
actin filament polymerization
actin filament severing
barbed-end actin filament capping
vesicle-mediated transport

calcium ion binding
actin binding
protein binding

cytosol
extracellular region
cytoskeleton
cytoplasm
lamellipodium

3bs8A

[pdb]

3.29495
0.00294611

3^SER 7^SER 36^PRO 38^PHE 42^GLY 52^GLY 54^GLU 389^ASN 390^GLU 393^PHE

5.4.3.8

cytoplasm

isomerase activity
glutamate-1-semialdehyde 2,1-aminomutase activity
pyridoxal phosphate binding
transaminase activity
catalytic activity

porphyrin biosynthetic process
tetrapyrrole biosynthetic process

2wabA

[pdb]

3.299
0.00294648

31^GLY 51^GLY 66^PRO 67^PHE 68^SER 96^GLU 138^ASN 147^PHE 154^SER 307^GLU

0.0.0.0

cellulose catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process
lipid metabolic process

hydrolase activity
acting on glycosyl bonds
hydrolase activity
cellulase activity
cation binding
hydrolase activity
acting on ester bonds
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1np2B

[pdb]

3.30189
0.00303676

31^SER 36^PHE 46^GLY 123^PRO 163^ASN 168^SER 172^GLY 177^GLU 338^GLU 391^PHE

0.0.0.0

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-glucosidase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

metabolic process
cellulose catabolic process
carbohydrate metabolic process

1flgA

[pdb]

3.30578
0.00303713

179^GLU 239^SER 244^GLY 271^ASN 291^SER 311^PRO 317^PHE 410^GLY 440^GLU 455^PHE

metal ion binding
oxidoreductase activity
calcium ion binding
oxidoreductase activity
acting on CH-OH group of donors
electron carrier activity

oxidation reduction

periplasmic space
outer membrane-bounded periplasmic space
membrane

1k3dA

[pdb]

3.30678
0.00303722

128^ASN 159^GLU 167^PHE 214^GLY 216^PHE 224^PRO 230^SER 267^GLY 282^GLU 349^SER

4.1.1.49

carboxy-lyase activity
lyase activity
ATP binding
calcium ion binding
catalytic activity
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm

gluconeogenesis

4ktqA

[pdb]

3.31126
0.00313122

306^PHE 308^GLY 309^PHE 315^GLU 347^GLU 370^GLY 373^PRO 409^SER 438^SER 565^ASN

2.7.7.7

nucleotidyltransferase activity
transferase activity
DNA-directed DNA polymerase activity
DNA binding
sequence-specific DNA binding
5'-3' exonuclease activity
catalytic activity
nucleic acid binding
nucleoside binding

nucleus
intracellular

response to DNA damage stimulus
DNA repair
DNA replication

1d8wC

[pdb]

3.31496
0.00313158

144^PHE 152^GLY 153^PHE 156^SER 197^GLY 208^PRO 234^GLU 243^GLU 249^SER 250^ASN

5.3.1.14

L-rhamnose isomerase activity
metal ion binding
manganese ion binding
isomerase activity
zinc ion binding

cytoplasm

rhamnose metabolic process

1iyxB

[pdb]

3.31747
0.00322909

151^GLY 158^SER 163^GLU 185^PHE 200^SER 205^GLY 207^PHE 209^PRO 214^ASN 219^GLU

4.2.1.11

cell surface
cytoplasm
extracellular region
phosphopyruvate hydratase complex

glycolysis

metal ion binding
lyase activity
magnesium ion binding
phosphopyruvate hydratase activity

1qo9A

[pdb]

3.31847
0.00322919

81^GLU 84^ASN 156^SER 237^GLU 240^GLY 272^SER 331^PRO 371^PHE 436^GLY 439^PHE

3.1.1.7

hydrolase activity
carboxylesterase activity
acetylcholinesterase activity
cholinesterase activity
protein homodimerization activity

neurotransmitter catabolic process
acetylcholine catabolic process in synaptic cleft
choline catabolic process
phototaxis
synaptic transmission
acetylcholine catabolic process

plasma membrane
synapse
anchored to membrane
cell junction
membrane
cytoplasm

1a7jA

[pdb]

3.32143
0.00322949

70^PHE 73^GLU 81^GLU 139^ASN 140^SER 146^GLY 153^GLY 197^PRO 199^PHE 200^SER

2.7.1.19

reductive pentose-phosphate cycle
photosynthesis
metabolic process
carbohydrate metabolic process

transferase activity
kinase activity
ATP binding
nucleotide binding
phosphoribulokinase activity

1a0cA

[pdb]

3.34341
0.00354701

44^SER 95^PRO 97^PHE 99^PHE 180^GLY 182^GLU 231^GLU 265^ASN 293^SER 333^GLY

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cobalt ion binding
metal ion binding
isomerase activity
xylose isomerase activity
magnesium ion binding

cytoplasm

2gmhA

[pdb]

3.34622
0.00366055

180^GLY 211^PHE 346^PHE 355^SER 356^PRO 373^SER 374^GLY 379^GLU 401^GLU 405^ASN

1.5.5.1

electron carrier activity
oxidoreductase activity
oxidizing metal ions with flavin as acceptor
ubiquinone binding
FAD binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
electron-transferring-flavoprotein dehydrogenase activity

mitochondrial part
membrane
mitochondrion
mitochondrial inner membrane
integral to membrane

response to oxidative stress
electron transport chain
oxidation reduction
transport

1a0dD

[pdb]

3.34928
0.00366091

22^PHE 38^GLU 43^SER 88^GLU 91^ASN 309^PRO 332^GLY 359^SER 360^PHE 363^GLY

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
manganese ion binding
isomerase activity
xylose isomerase activity
magnesium ion binding

2piaA

[pdb]

3.35004
0.003661

27^GLU 42^GLY 61^ASN 86^PHE 104^GLU 128^SER 201^PRO 224^SER 225^PHE 275^GLY

2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
electron carrier activity

oxidation reduction
electron transport chain
transport

1tqyA

[pdb]

3.36036
0.00389507

19^ALA 74^LEU 76^LEU 85^ASP 149^GLY 172^ARG 175^ILE 178^GLY 247^ARG 355^ALA

antibiotic biosynthetic process
biosynthetic process
metabolic process
antibiotic biosynthetic process
biosynthetic process
metabolic process

transferase activity
acyltransferase activity
catalytic activity
transferase activity
acyltransferase activity
catalytic activity

1xcrB

[pdb]

3.37506
0.00414509

110^GLU 127^GLY 161^PHE 183^ASN 216^SER 246^PRO 265^GLU 270^PHE 271^SER 277^GLY

0.0.0.0

nucleus

protein binding
metal ion binding
hydrolase activity
zinc ion binding
hydrolase activity
acting on ester bonds

1iipA

[pdb]

3.3757
0.00414518

46^GLU 47^ASN 65^PRO 87^PHE 88^SER 92^GLY 97^SER 100^GLY 101^GLU 132^PHE

5.2.1.8

cytoplasm

peptide binding
isomerase activity
peptidyl-prolyl cis-trans isomerase activity
binding
protein binding

protein folding

3cewD

[pdb]

3.37652
0.00414528

40^PRO 44^SER 48^ASN 50^GLU 59^GLY 60^PHE 65^GLY 66^GLU 87^SER 96^PHE

0.0.0.0

2o9pA

[pdb]

3.37804
0.00414548

35^SER 40^PHE 50^GLY 126^PRO 166^ASN 172^SER 175^GLY 180^GLU 356^GLU 408^PHE

3.2.1.21

cellulose catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-glucosidase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1yqtA

[pdb]

3.37965
0.00427652

103^GLY 267^GLU 277^SER 291^GLY 293^PHE 294^SER 296^PRO 304^ASN 318^PHE 322^GLU

0.0.0.0

iron-sulfur cluster binding
nucleoside-triphosphatase activity
ATPase activity
electron carrier activity
ATP binding
nucleotide binding

1zapA

[pdb]

3.38347
0.00427704

199^GLY 202^GLU 205^GLY 253^GLU 257^ASN 259^SER 264^PHE 273^SER 275^PRO 298^PHE

3.4.23.24

extracellular region

hydrolase activity
peptidase activity
aspartic-type endopeptidase activity

proteolysis

2dq3A

[pdb]

3.38453
0.00427718

106^PRO 207^GLY 233^GLU 298^GLU 330^SER 354^SER 355^ASN 359^PHE 378^PHE 384^GLY

6.1.1.11

cytoplasm

ligase activity
ATP binding
aminoacyl-tRNA ligase activity
nucleotide binding
serine-tRNA ligase activity

translation
seryl-tRNA aminoacylation
tRNA aminoacylation for protein translation
selenocysteine biosynthetic process

2iyaB

[pdb]

3.38828
0.00441312

137^SER 138^PRO 221^PHE 234^PHE 236^GLY 332^GLY 333^SER 336^GLU 356^ASN 358^GLU

0.0.0.0

antibiotic metabolic process
metabolic process

transferase activity
transferring glycosyl groups
transferase activity
transferase activity
transferring hexosyl groups

1u4gA

[pdb]

3.38843
0.00441314

81^GLY 84^PHE 91^PHE 95^PRO 143^SER 167^SER 171^GLY 172^GLU 249^GLU 255^ASN

3.4.24.26

extracellular region

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
calcium ion binding
metalloendopeptidase activity

proteolysis

3b2xA

[pdb]

3.38891
0.00441321

750^PHE 760^ASN 763^GLU 787^GLY 789^PHE 792^SER 794^PRO 803^SER 804^GLY 810^GLU

3.4.11.2

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
aminopeptidase activity

plasma membrane
membrane

proteolysis

3bk7A

[pdb]

3.39118
0.00441353

107^GLY 271^GLU 281^SER 295^GLY 297^PHE 298^SER 300^PRO 305^ASN 309^GLU 322^PHE

0.0.0.0

ATP binding
iron-sulfur cluster binding
nucleoside-triphosphatase activity
ATPase activity
electron carrier activity
nucleotide binding

2qfeA

[pdb]

3.39296
0.00441378

725^GLY 730^GLU 741^PHE 756^GLY 757^PHE 775^GLU 778^PRO 779^SER 802^ASN 803^SER

0.0.0.0

hydrolase activity
cysteine-type peptidase activity
peptidase activity
calcium-dependent cysteine-type endopeptidase activity

nucleus
intracellular

proteolysis

1ukcA

[pdb]

3.39514
0.00455418

131^GLU 132^ASN 208^GLY 215^SER 237^GLU 239^SER 242^PRO 342^PHE 396^GLY 400^PHE

0.0.0.0

hydrolase activity

2vhdA

[pdb]

3.39564
0.00455425

50^SER 52^ASN 80^SER 81^PRO 88^PHE 93^PHE 96^GLY 103^GLU 107^GLY 160^GLU

1.11.1.5

metal ion binding
oxidoreductase activity
iron ion binding
peroxidase activity
cytochrome-c peroxidase activity
heme binding
electron carrier activity

oxidation reduction
electron transport chain
transport

periplasmic space

1hcuB

[pdb]

3.40009
0.0045549

242^GLY 246^SER 303^PRO 305^SER 315^ASN 340^PHE 353^GLU 354^GLY 355^PHE 396^GLU

0.0.0.0

calcium ion binding
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

membrane

3ce9D

[pdb]

3.40262
0.00470011

37^SER 41^GLY 42^GLU 74^PHE 76^GLU 80^ASN 97^GLY 116^SER 126^PHE 147^PRO

0.0.0.0

oxidation reduction
aromatic amino acid family biosynthetic process

oxidoreductase activity
acting on CH-OH group of donors
metal ion binding
3-dehydroquinate synthase activity

2vjxA

[pdb]

3.40609
0.00470063

530^SER 532^ASN 541^PRO 542^PHE 544^SER 555^GLU 558^PHE 624^GLY 628^GLY 630^GLU

0.0.0.0

carbohydrate metabolic process

cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1tkjA

[pdb]

3.40748
0.00470084

158^ASN 164^SER 165^PRO 168^GLY 179^GLU 186^PHE 198^GLU 199^GLY 203^SER 242^PHE

3.4.11.24

extracellular region

metal ion binding
hydrolase activity
zinc ion binding
peptidase activity
calcium ion binding
aminopeptidase activity

proteolysis

2o8jB

[pdb]

3.40999
0.00485086

931^GLU 1061^GLY 1063^PHE 1106^ASN 1108^SER 1121^PRO 1139^PHE 1140^SER 1149^GLU 1151^GLY

2.1.1.43

cellular_component
nucleus

organ growth
synaptonemal complex assembly
biological_process
chromatin modification
histone H3-K9 methylation
fertilization
spermatid development
germ cell development
pachytene
negative regulation of transcription from RNA polymerase II promoter

protein binding
metal ion binding
transferase activity
zinc ion binding
methyltransferase activity
histone-lysine N-methyltransferase activity

1sqjA

[pdb]

3.41173
0.00485113

84^GLY 94^PHE 98^GLU 104^PHE 109^SER 110^PRO 124^GLU 134^ASN 139^GLY 148^SER

0.0.0.0

hydrolase activity

2pxxA

[pdb]

3.415
0.0050037

38^PRO 42^PHE 43^GLY 45^PHE 59^GLU 66^GLY 70^SER 83^ASN 86^SER 129^GLU

3.4.24.71

cell-cell signaling
peptide hormone processing
heart development
cardioblast differentiation
brain development
metabolic process
proteolysis

cytoplasmic vesicle membrane
Golgi membrane
integral to membrane
membrane
Golgi apparatus

metalloendopeptidase activity
metal ion binding
hydrolase activity
transferase activity
zinc ion binding
metallopeptidase activity
peptidase activity
methyltransferase activity
catalytic activity

2uvfB

[pdb]

3.41887
0.0050043

229^GLY 239^GLU 243^SER 246^ASN 327^GLY 331^SER 352^PRO 354^PHE 361^GLU 385^PHE

0.0.0.0

carbohydrate metabolic process

polygalacturonase activity

1d6iB

[pdb]

3.42045
0.00500455

235^PRO 237^PHE 344^PHE 348^GLU 353^SER 356^ASN 363^GLU 364^GLY 368^GLY 386^SER

2.3.1.74

flavonoid biosynthetic process
biosynthetic process
metabolic process

transferase activity
acyltransferase activity
naringenin-chalcone synthase activity
transferase activity
transferring acyl groups other than amino-acyl groups
catalytic activity

1kqgA

[pdb]

3.42382
0.00515962

171^TYR 172^MET 180^ILE 465^PRO 512^PHE 514^GLY 696^GLU 699^GLY 735^SER 742^SER

1.2.1.2

electron carrier activity
iron ion binding
formate dehydrogenase activity
metal ion binding
iron ion binding
formate dehydrogenase activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
molybdenum ion binding
oxidoreductase activity
selenium binding
iron ion binding
formate dehydrogenase activity
binding
metal ion binding
iron ion binding
formate dehydrogenase activity
metal ion binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
iron ion binding
electron carrier activity
formate dehydrogenase activity

electron transport chain
transport
cellular respiration
electron transport chain
transport
respiratory electron transport chain
oxidation reduction
cellular respiration
electron transport chain
transport
cellular respiration
respiratory electron transport chain
cellular respiration
respiratory electron transport chain
electron transport chain
transport
cellular respiration

membrane
plasma membrane
integral to membrane
membrane
formate dehydrogenase complex
periplasmic space
cytoplasm
plasma membrane
integral to membrane
membrane
formate dehydrogenase complex
plasma membrane
integral to membrane
membrane
formate dehydrogenase complex
plasma membrane
integral to membrane
membrane

1o1zA

[pdb]

3.42466
0.00515975

97^GLU 121^SER 137^GLY 142^GLU 144^ASN 160^PRO 162^SER 170^PHE 190^PHE 209^GLY

0.0.0.0

glycerophosphodiester phosphodiesterase activity
phosphoric diester hydrolase activity
phospholipase C activity

intracellular signaling cascade
lipid metabolic process
glycerol metabolic process

1t6kA

[pdb]

3.42604
0.00515997

71^PHE 75^PRO 99^GLY 103^PHE 106^GLU 213^SER 216^GLY 263^GLU 265^SER 267^ASN

antibiotic biosynthetic process
pathogenesis
biosynthetic process

isomerase activity
catalytic activity

2w91A

[pdb]

3.42818
0.00516032

246^GLU 532^SER 533^PHE 554^ASN 557^SER 563^PRO 582^PHE 696^GLY 742^GLU 756^GLY

0.0.0.0

cell adhesion

cell wall
extracellular region
membrane
cell surface
cytoplasm

mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
hydrolase activity

1piiA

[pdb]

3.43148
0.00532029

58^SER 59^PRO 93^PHE 95^GLY 116^PHE 166^ASN 169^GLU 192^SER 214^GLU 216^GLY

4.1.1.48, 5.3.1.24

catalytic activity
phosphoribosylanthranilate isomerase activity
indole-3-glycerol-phosphate synthase activity
isomerase activity
carboxy-lyase activity
lyase activity

tryptophan biosynthetic process
aromatic amino acid family biosynthetic process
cellular amino acid biosynthetic process
metabolic process
tryptophan metabolic process

2qc5A

[pdb]

3.43259
0.00532048

74^GLU 78^ASN 99^SER 119^GLY 133^GLU 141^SER 143^PRO 145^PHE 156^PHE 165^GLY

0.0.0.0

carbon-oxygen lyase activity
catalytic activity
magnesium ion binding

response to antibiotic
antibiotic catabolic process

2vr0E

[pdb]

3.43356
0.00532064

75^LEU 78^LYS 79^LEU 81^PHE 82^LYS 94^THR 111^VAL 339^SER 428^GLU 429^ASN

0.0.0.0

iron ion binding
calcium ion binding
oxidoreductase activity
metal ion binding

periplasmic space

transport
electron transport chain
oxidation reduction
nitrogen compound metabolic process

1zv2A

[pdb]

3.4339
0.00532069

100^PRO 161^GLY 163^PHE 275^PHE 278^SER 284^SER 298^GLU 311^GLU 317^GLY 337^ASN

1.7.2.1

metal ion binding
oxidoreductase activity
copper ion binding
nitrite reductase (NO-forming) activity

oxidation reduction
nitrate assimilation
nitrogen compound metabolic process

periplasmic space

2h4qA

[pdb]

3.43428
0.00532075

2^GLU 9^GLY 11^PHE 32^PRO 36^SER 60^PHE 92^GLU 93^ASN 96^SER 97^GLY

chromosome condensation
chromatin modification
mitotic chromosome condensation

nucleus
chromosome

peptidase inhibitor activity
endopeptidase inhibitor activity
DNA binding
serine-type endopeptidase inhibitor activity

3d7gA

[pdb]

3.43688
0.00548556

90^PHE 159^PRO 162^SER 256^GLY 350^ASN 351^GLU 383^PHE 384^GLY 425^GLU 554^SER

3.4.17.21

cytoplasm
nucleus
membrane
plasma membrane
integral to membrane
integral to plasma membrane
membrane fraction

peptidase activity
metal ion binding
dipeptidase activity
hydrolase activity
zinc ion binding
metallopeptidase activity
carboxypeptidase activity
catalytic activity

proteolysis

1xipA

[pdb]

3.44277
0.00548656

29^SER 31^ASN 32^GLU 55^SER 87^PRO 91^PHE 275^PHE 338^GLY 371^GLU 372^GLY

intracellular protein transmembrane transport
mRNA transport
protein transport
transport
nuclear pore organization
rRNA export from nucleus
mRNA export from nucleus
ribosome export from nucleus

nuclear membrane
membrane
nuclear pore
nucleus

structural molecule activity
protein binding

2b39B

[pdb]

3.44348
0.00565602

837^SER 845^GLU 933^GLU 1381^GLY 1409^GLY 1410^PHE 1411^SER 1412^PRO 1438^ASN 1490^PHE

0.0.0.0

extracellular region
extracellular space

innate immune response
complement activation
classical pathway
complement activation
alternative pathway
immune response
inflammatory response
complement activation
positive regulation of type IIa hypersensitivity
positive regulation of phagocytosis

protein binding
endopeptidase inhibitor activity

2o1xD

[pdb]

3.44644
0.00565654

188^SER 190^ASN 329^GLY 343^PHE 351^GLU 352^GLY 358^PHE 359^SER 363^PRO 373^GLU

2.2.1.7

thiamin biosynthetic process
isoprenoid biosynthetic process
terpenoid biosynthetic process
metabolic process

transferase activity
1-deoxy-D-xylulose-5-phosphate synthase activity
catalytic activity

1nmlA

[pdb]

3.44689
0.00565662

50^SER 52^ASN 70^GLY 80^SER 81^PRO 88^PHE 93^PHE 107^GLY 114^GLU 160^GLU

0.0.0.0

oxidation reduction

peroxidase activity
heme binding
oxidoreductase activity
electron carrier activity
iron ion binding

2hpgA

[pdb]

3.44775
0.00565677

107^PHE 179^PRO 187^SER 190^SER 192^GLY 238^GLY 240^PHE 311^GLU 319^ASN 323^GLU

0.0.0.0

outer membrane-bounded periplasmic space

transport

2yzgA

[pdb]

3.45553
0.0058325

23^GLY 78^PHE 205^ASN 211^SER 287^PRO 289^PHE 293^SER 300^GLU 302^GLY 315^GLU

6.3.2.4

cytoplasm
cell wall

metal ion binding
manganese ion binding
ligase activity
ATP binding
magnesium ion binding
nucleotide binding
D-alanine-D-alanine ligase activity
catalytic activity

peptidoglycan biosynthetic process
regulation of cell shape
cell wall organization