The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
1b76B	[pdb]	0.225119 2.54906e-05	188^GLU 239^GLU 241^GLU 311^ARG 359^GLU 361^SER	6.1.1.14	cytoplasm	ligase activity ATP binding aminoacyl-tRNA ligase activity nucleotide binding glycine-tRNA ligase activity	translation glycyl-tRNA aminoacylation tRNA aminoacylation for protein translation
1atiA	[pdb]	0.320169 6.38816e-05	188^GLU 239^GLU 241^GLU 311^ARG 359^GLU 361^SER	6.1.1.14	cytoplasm	ligase activity ATP binding aminoacyl-tRNA ligase activity nucleotide binding glycine-tRNA ligase activity	translation glycyl-tRNA aminoacylation tRNA aminoacylation for protein translation
2q5iA	[pdb]	0.846432 0.000139793	245^GLU 296^GLU 298^GLU 410^ARG 522^GLU 524^SER	6.1.1.14	cytoplasm soluble fraction secretory granule	ligase activity ATP binding aminoacyl-tRNA ligase activity nucleotide binding glycine-tRNA ligase activity protein binding	translation glycyl-tRNA aminoacylation tRNA aminoacylation for protein translation regulated secretory pathway cell death
3d6jA	[pdb]	0.865409 0.000154827	23^THR 50^LEU 72^GLU 74^SER 76^GLU 77^ALA	0.0.0.0		hydrolase activity phosphoglycolate phosphatase activity catalytic activity	metabolic process
2p62A	[pdb]	0.922542 0.000200598	12^THR 14^GLU 15^SER 20^LEU 153^GLU 205^SER	0.0.0.0
2px5A	[pdb]	1.03459 0.000320952	10^GLU 153^SER 155^GLU 157^GLU 158^GLU 184^LEU	2.7.7.48, 3.4.21.91	hydrolase activity nucleotidyltransferase activity transferase activity ATP binding structural molecule activity helicase activity RNA-directed RNA polymerase activity nucleotide binding ATP-dependent helicase activity serine-type endopeptidase activity catalytic activity double-stranded RNA binding RNA helicase activity RNA binding nucleic acid binding methyltransferase activity	membrane viral envelope viral capsid viral nucleocapsid virion integral to membrane virion part	transcription RNA-dependent viral genome replication viral infectious cycle RNA metabolic process viral reproduction methylation
2oy0B	[pdb]	1.04565 0.000331363	10^GLU 153^SER 155^GLU 157^GLU 158^GLU 184^LEU	2.7.7.48, 3.4.21.91	hydrolase activity ATP binding helicase activity nucleotide binding ATP-dependent helicase activity structural molecule activity serine-type endopeptidase activity RNA-directed RNA polymerase activity catalytic activity double-stranded RNA binding RNA helicase activity RNA binding nucleic acid binding hydrolase activity nucleotidyltransferase activity transferase activity ATP binding structural molecule activity helicase activity RNA-directed RNA polymerase activity nucleotide binding ATP-dependent helicase activity serine-type endopeptidase activity catalytic activity double-stranded RNA binding RNA helicase activity RNA binding nucleic acid binding methyltransferase activity methyltransferase activity	transcription RNA-dependent viral genome replication viral infectious cycle RNA metabolic process viral reproduction transcription RNA-dependent viral genome replication viral infectious cycle RNA metabolic process viral reproduction methylation methylation	viral envelope virion integral to membrane membrane virion part viral capsid membrane viral envelope viral capsid viral nucleocapsid virion integral to membrane virion part
2ag1D	[pdb]	1.04977 0.000341896	211^LEU 214^GLU 216^SER 218^THR 219^ALA 327^GLU	0.0.0.0			lyase activity thiamin pyrophosphate binding catalytic activity magnesium ion binding
2ovwD	[pdb]	1.05181 0.000341919	15^THR 122^LEU 126^GLU 128^SER 393^GLU 397^THR	3.2.1.4		cellulose catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process	hydrolase activity acting on glycosyl bonds hydrolase activity cellulase activity hydrolase activity hydrolyzing O-glycosyl compounds
1avhA	[pdb]	1.10426 0.000441135	27^ALA 33^THR 36^GLU 37^SER 42^LEU 72^GLU	0.0.0.0	calcium-dependent phospholipid binding calcium ion binding phospholipid binding phospholipase inhibitor activity protein binding eukaryotic cell surface binding	cytoplasm intracellular	signal transduction anti-apoptosis blood coagulation negative regulation of coagulation protein homooligomerization response to organic substance
3d85D	[pdb]	1.15435 0.000560822	107^LEU 131^THR 151^ALA 152^THR 166^GLU 168^SER		antigen binding protein binding cytokine activity antigen binding protein binding protein heterodimerization activity cytokine activity growth factor activity interleukin-12 receptor binding signal transducer activity cytokine receptor activity protein binding protein homodimerization activity interleukin-12 alpha subunit binding	extracellular region cytoplasm extracellular region extracellular space membrane fraction extracellular region interleukin-12 complex extracellular space extracellular region membrane	immune response tissue remodeling innate immune response response to virus immune response inflammatory response T cell proliferation natural killer cell activation during immune response immune response positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of lymphocyte proliferation positive regulation of cell adhesion cell migration positive regulation of natural killer cell activation positive regulation of interferon-gamma production interferon-gamma biosynthetic process T-helper cell differentiation response to UV-B positive regulation of interferon-gamma biosynthetic process T-helper 1 type immune response regulation of cytokine biosynthetic process positive regulation of activated T cell proliferation natural killer cell activation positive regulation of T cell proliferation sensory perception of pain cell surface receptor linked signal transduction negative regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell apoptosis cell cycle arrest
3eucA	[pdb]	1.162 0.000581842	284^GLU 348^SER 349^THR 351^GLU 352^GLU 357^LEU	2.6.1.9		cellular amino acid biosynthetic process histidine biosynthetic process biosynthetic process	transferase activity transaminase activity histidinol-phosphate transaminase activity pyridoxal phosphate binding transferase activity transferring nitrogenous groups catalytic activity
2qezC	[pdb]	1.19961 0.000750199	117^LEU 119^SER 120^GLU 126^THR 306^THR 309^ALA			cellular amino acid metabolic process	lyase activity ethanolamine ammonia-lyase activity
1ipjC	[pdb]	1.21232 0.000787415	161^THR 165^SER 166^GLU 168^GLU 169^GLU 174^LEU			nutrient reservoir activity	vacuole aleurone grain
1he1B	[pdb]	1.21932 0.000827457	121^ASP 122^ASP 124^ASP 125^THR 148^GLU 207^THR	0.0.0.0	GTP binding nucleotide binding GTP binding nucleotide binding protein binding GTPase activity GTP binding nucleotide binding GTP-dependent protein binding enzyme binding GTPase activity protein binding GTP binding protein binding GTPase activity nucleotide binding GTPase activator activity	melanosome plasma membrane membrane intracellular melanosome plasma membrane membrane intracellular melanosome plasma membrane membrane cytosol intracellular membrane fraction cytoplasm cytoplasmic membrane-bounded vesicle extrinsic to plasma membrane lamellipodium cell projection cytoplasm membrane fraction intracellular melanosome plasma membrane membrane cell projection lamellipodium extrinsic to plasma membrane cytoplasmic membrane-bounded vesicle membrane extracellular region	small GTPase mediated signal transduction small GTPase mediated signal transduction negative regulation of receptor-mediated endocytosis ruffle organization lamellipodium assembly actin filament polymerization positive regulation of Rho protein signal transduction response to wounding anatomical structure morphogenesis intracellular signaling cascade inflammatory response cell motion small GTPase mediated signal transduction localization within membrane regulation of hydrogen peroxide metabolic process regulation of respiratory burst endocytosis hyperosmotic response cytoskeleton organization cell adhesion axon guidance dendrite development cell migration cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration regulation of cell migration positive regulation of actin filament polymerization positive regulation of phosphoinositide 3-kinase activity positive regulation of lamellipodium assembly cell adhesion bone resorption dendrite development small GTPase mediated signal transduction cell adhesion cytoskeleton organization hyperosmotic response endocytosis actin cytoskeleton organization cell proliferation chemotaxis positive regulation of phosphoinositide 3-kinase activity positive regulation of actin filament polymerization regulation of cell migration lamellipodium assembly embryonic olfactory bulb interneuron precursor migration cerebral cortex radially oriented cell migration cell migration axon guidance pathogenesis
2flqB	[pdb]	1.22187 0.000870512	93^ALA 95^THR 97^GLU 98^GLU 103^LEU 128^GLU	0.0.0.0		nitric oxide biosynthetic process	nitric-oxide synthase activity
1nclA	[pdb]	1.22245 0.000870539	9^GLU 13^LEU 124^SER 126^SER 128^GLU 133^GLU	2.7.4.6	cytoplasm	metal ion binding transferase activity kinase activity ATP binding magnesium ion binding nucleotide binding nucleoside diphosphate kinase activity	nucleotide metabolic process CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process
3bywA	[pdb]	1.23168 0.000917312	98^ARG 113^SER 116^GLU 139^ALA 141^GLU 144^THR	0.0.0.0	integral to membrane	peptidoglycan biosynthetic process	transferase activity transferase activity transferring pentosyl groups
1zs6D	[pdb]	1.23576 0.000967434	22^GLU 26^LEU 137^SER 139^SER 141^GLU 146^GLU	2.7.4.6	cytosol	metal ion binding transferase activity kinase activity ATP binding magnesium ion binding nucleotide binding nucleoside diphosphate kinase activity	nucleotide metabolic process apoptosis induction of apoptosis CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process
3glaA	[pdb]	1.23612 0.000967453	86^SER 87^GLU 89^SER 90^THR 93^GLU 100^ARG	0.0.0.0			response to stress
1wclA	[pdb]	1.25556 0.00113174	358^THR 379^SER 380^THR 382^GLU 383^GLU 407^ARG		RNA binding sequence-specific DNA binding transcription regulator activity protein binding transcription factor activity nucleotide binding transcription factor activity RNA binding sequence-specific DNA binding transcription regulator activity protein binding nucleotide binding RNA binding sequence-specific DNA binding transcription regulator activity protein binding transcription factor activity nucleotide binding RNA binding sequence-specific DNA binding transcription regulator activity protein binding transcription factor activity nucleotide binding DNA binding DNA binding DNA binding DNA binding	intracellular intracellular intracellular intracellular	transcription antitermination regulation of transcription DNA-dependent transcription termination transcription regulation of transcription termination transcription antitermination response to stress regulation of transcription DNA-dependent transcription termination transcription regulation of transcription termination transcription antitermination regulation of transcription DNA-dependent transcription termination transcription regulation of transcription termination transcription antitermination regulation of transcription DNA-dependent transcription termination transcription regulation of transcription termination DNA repair regulation of transcription DNA repair regulation of transcription DNA repair regulation of transcription DNA repair regulation of transcription
1tygA	[pdb]	1.25763 0.00113187	175^ALA 177^THR 179^GLU 180^GLU 186^ARG 200^GLU		catalytic activity	cytoplasm	thiamin biosynthetic process metabolic process sulfur metabolic process
2a8pA	[pdb]	1.26072 0.00113206	59^LEU 91^GLU 135^GLU 138^GLU 140^GLU 141^ALA			metal ion binding manganese ion binding hydrolase activity RNA binding magnesium ion binding	nucleoplasm nucleolus nucleus
1jz1M	[pdb]	1.26489 0.00119421	35^SER 41^GLU 314^GLU 322^LEU 324^GLU 326^GLU	3.2.1.23	beta-galactosidase complex	hydrolase activity acting on glycosyl bonds hydrolase activity beta-galactosidase activity cation binding carbohydrate binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity protein binding magnesium ion binding manganese ion binding sodium ion binding metal ion binding	metabolic process carbohydrate metabolic process
3ct9B	[pdb]	1.27118 0.00126086	76^THR 97^LEU 327^SER 329^THR 331^GLU 332^GLU	0.0.0.0		metal ion binding hydrolase activity zinc ion binding protein dimerization activity metallopeptidase activity	proteolysis
2uxpA	[pdb]	1.27453 0.0012611	77^SER 78^GLU 80^GLU 82^GLU 142^THR 151^ARG			DNA binding transcription regulator activity transcription factor activity	regulation of transcription DNA-dependent transcription regulation of transcription
3cinA	[pdb]	1.28163 0.0013324	91^SER 93^ARG 134^GLU 155^GLU 158^THR 159^ALA	0.0.0.0		binding inositol-3-phosphate synthase activity catalytic activity	phospholipid biosynthetic process metabolic process inositol biosynthetic process
2j7uA	[pdb]	1.28183 0.00133242	399^THR 424^ALA 426^GLU 428^GLU 429^GLU 433^LEU	2.1.1.56, 3.4.21.91, 2.7.7.48	hydrolase activity ATP binding helicase activity nucleotide binding ATP-dependent helicase activity structural molecule activity serine-type endopeptidase activity RNA-directed RNA polymerase activity catalytic activity double-stranded RNA binding RNA helicase activity RNA binding nucleic acid binding hydrolase activity nucleotidyltransferase activity transferase activity ATP binding structural molecule activity helicase activity RNA-directed RNA polymerase activity nucleotide binding mRNA (guanine-N7-)-methyltransferase activity ATP-dependent helicase activity serine-type endopeptidase activity catalytic activity double-stranded RNA binding RNA helicase activity RNA binding nucleic acid binding methyltransferase activity methyltransferase activity	transcription RNA-dependent viral genome replication viral infectious cycle RNA metabolic process viral reproduction transcription RNA-dependent viral genome replication viral infectious cycle RNA metabolic process viral reproduction methylation methylation	virion part viral envelope viral capsid virion integral to membrane membrane viral envelope viral capsid viral nucleocapsid virion integral to membrane virion part membrane
1ecqA	[pdb]	1.28798 0.00140845	212^ALA 214^GLU 216^GLU 218^GLU 234^LEU 244^GLU	4.2.1.40		glucarate catabolic process metabolic process glucarate catabolic process metabolic process	metal ion binding lyase activity magnesium ion binding glucarate dehydratase activity catalytic activity metal ion binding lyase activity magnesium ion binding glucarate dehydratase activity catalytic activity
1v5qA	[pdb]	1.2976 0.00157552	79^GLU 81^SER 82^THR 84^GLU 85^GLU 89^LEU		cytoplasmic vesicle endoplasmic reticulum postsynaptic membrane synapse cell junction membrane plasma membrane membrane raft	protein binding	protein localization
2vu5A	[pdb]	1.29997 0.00157573	2^GLU 6^LEU 117^SER 119^SER 121^GLU 126^GLU	0.0.0.0	cytoplasm	metal ion binding transferase activity kinase activity ATP binding magnesium ion binding nucleotide binding nucleoside diphosphate kinase activity	nucleotide metabolic process CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process
1aeiD	[pdb]	1.30049 0.00157578	25^ALA 31^THR 33^GLU 35^SER 40^LEU 66^GLU	0.0.0.0			calcium-dependent phospholipid binding calcium ion binding
2z00A	[pdb]	1.30781 0.0016676	203^GLU 205^GLU 208^ARG 235^SER 236^THR 241^GLU	0.0.0.0		pyrimidine nucleotide biosynthetic process	zinc ion binding metal ion binding hydrolase activity dihydroorotase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds in cyclic amides hydrolase activity acting on carbon-nitrogen (but not peptide) bonds
1d1xB	[pdb]	1.32022 0.00186818	130^ARG 154^GLU 156^GLU 158^GLU 160^ALA 164^THR	1.14.13.39	Golgi apparatus membrane plasma membrane cytoskeleton cytoplasm caveola	metal ion binding oxidoreductase activity zinc ion binding calmodulin binding calcium ion binding iron ion binding nitric-oxide synthase activity NADP or NADPH binding FAD binding heme binding FMN binding electron carrier activity	mitochondrion organization arginine catabolic process oxidation reduction blood coagulation nitric oxide biosynthetic process positive regulation of guanylate cyclase activity anti-apoptosis angiogenesis ovulation from ovarian follicle blood vessel remodeling regulation of sodium ion transport negative regulation of muscle hyperplasia smooth muscle hyperplasia lung development lipopolysaccharide-mediated signaling pathway negative regulation of potassium ion transport positive regulation of angiogenesis regulation of blood vessel size negative regulation of hydrolase activity negative regulation of calcium ion transport
1m9jB	[pdb]	1.32135 0.0018683	128^ARG 152^GLU 154^GLU 156^GLU 158^ALA 162^THR	1.14.13.39	Golgi apparatus membrane plasma membrane cytoskeleton cytoplasm cytosol Golgi membrane apical part of cell nucleus caveola soluble fraction	oxidation reduction nitric oxide biosynthetic process negative regulation of calcium ion transport negative regulation of hydrolase activity negative regulation of smooth muscle cell proliferation negative regulation of potassium ion transport lung development learning signal transduction regulation of sodium ion transport ovulation from ovarian follicle angiogenesis mitochondrion organization positive regulation of guanylate cyclase activity anti-apoptosis positive regulation of angiogenesis arginine catabolic process endothelial cell migration regulation of systemic arterial blood pressure by endothelin response to fluid shear stress regulation of blood vessel size smooth muscle hyperplasia negative regulation of muscle hyperplasia negative regulation of cell proliferation blood vessel remodeling negative regulation of platelet activation regulation of blood pressure response to heat positive regulation of vasodilation lipopolysaccharide-mediated signaling pathway	protein binding metal ion binding oxidoreductase activity zinc ion binding calmodulin binding iron ion binding nitric-oxide synthase activity NADP or NADPH binding FAD binding heme binding FMN binding electron carrier activity actin monomer binding cadmium ion binding tetrahydrobiopterin binding arginine binding calcium ion binding
1qr4A	[pdb]	1.32217 0.00186839	13^GLU 90^SER 114^ARG 159^SER 165^GLU 167^GLU		cell adhesion signal transduction	protein binding receptor binding	proteinaceous extracellular matrix extracellular region
2asxB	[pdb]	1.32576 0.00197739	290^THR 291^ALA 296^GLU 302^GLU 320^GLU 324^ARG	0.0.0.0	integral to membrane	signal transducer activity	signal transduction
2nn6A	[pdb]	1.33476 0.0020933	71^VAL 72^THR 73^CYS 76^SER 119^TYR 127^ILE		exosome (RNase complex) nucleolus nucleus nucleolus cytoplasm nucleus exosome (RNase complex) cytoplasm nucleus exosome (RNase complex) cellular_component cytoplasm nucleus exosome (RNase complex) nucleolus nucleolus nucleolus nucleolus nucleolus exosome (RNase complex) nucleus cytoplasm nucleolus nucleus exosome (RNase complex) nuclear exosome (RNase complex) cytoplasm nucleus exosome (RNase complex) nucleolus cytoplasmic exosome (RNase complex) nuclear exosome (RNase complex) cytoplasm nucleus exosome (RNase complex) cytoplasm nucleus exosome (RNase complex)	protein binding RNA binding hydrolase activity exonuclease activity nuclease activity protein binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity RNA binding hydrolase activity exonuclease activity nuclease activity RNA binding 7S RNA binding 3'-5'-exoribonuclease activity protein binding molecular_function hydrolase activity exonuclease activity nuclease activity RNA binding 3'-5'-exoribonuclease activity identical protein binding protein binding protein binding RNA binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity RNA binding protein binding RNA binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity protein binding 3'-5'-exoribonuclease activity hydrolase activity exonuclease activity nuclease activity RNA binding protein binding hydrolase activity exonuclease activity nuclease activity RNA binding 3'-5'-exoribonuclease activity	rRNA processing rRNA processing RNA processing rRNA processing biological_process rRNA processing RNA processing RNA catabolic process rRNA processing RNA processing rRNA processing RNA processing immune response rRNA processing RNA processing rRNA processing rRNA processing RNA processing
1xxoA	[pdb]	1.33538 0.00209337	67^ALA 68^SER 70^LEU 83^GLU 85^THR 133^THR	0.0.0.0			FMN binding
1vq0B	[pdb]	1.33763 0.00209365	242^LEU 256^GLU 273^SER 274^GLU 276^GLU 278^GLU		cytoplasm	protein folding	zinc ion binding unfolded protein binding
1clcA	[pdb]	1.33875 0.00221513	221^GLU 369^GLU 372^GLU 374^LEU 410^THR 414^SER	3.2.1.4		cellulose catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process cellulose catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process	hydrolase activity acting on glycosyl bonds hydrolase activity calcium ion binding cellulase activity hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity hydrolase activity acting on glycosyl bonds hydrolase activity calcium ion binding cellulase activity hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
3gbuB	[pdb]	1.34118 0.00221543	191^ALA 193^GLU 195^GLU 199^LEU 212^THR 215^THR			D-ribose metabolic process	transferase activity kinase activity ribokinase activity
1p1dA	[pdb]	1.34222 0.00221556	87^GLU 89^SER 90^THR 92^GLU 93^GLU 97^LEU		nervous system development	postsynaptic density cell soma endomembrane system endoplasmic reticulum membrane cytoplasm postsynaptic membrane synapse cell junction membrane plasma membrane endoplasmic reticulum	protein binding
2ceiA	[pdb]	1.34231 0.00221557	27^GLU 30^ALA 31^SER 56^LEU 62^GLU 107^GLU	1.16.3.1	intracellular ferritin complex	metal ion binding oxidoreductase activity iron ion binding ferroxidase activity transition metal ion binding ferric iron binding binding protein binding	negative regulation of cell proliferation immune response oxidation reduction cellular iron ion homeostasis cell proliferation intracellular sequestering of iron ion iron ion transport
2f8sA	[pdb]	1.34543 0.00221596	397^ALA 399^THR 401^GLU 402^GLU 407^LEU 425^GLU	0.0.0.0			nucleic acid binding
2hypA	[pdb]	1.3498 0.0023412	149^LEU 154^GLU 155^GLU 157^ALA 158^THR 198^THR	0.0.0.0			hydrolase activity
1vpkA	[pdb]	1.35291 0.00246976	126^THR 160^GLU 188^GLU 189^ALA 190^SER 192^LEU	0.0.0.0	DNA replication	cytoplasm	nucleotidyltransferase activity transferase activity DNA-directed DNA polymerase activity 3'-5' exonuclease activity DNA binding
3dulB	[pdb]	1.35426 0.00246994	37^LEU 88^THR 91^ALA 92^SER 93^GLU 116^THR	0.0.0.0			transferase activity methyltransferase activity O-methyltransferase activity
2ieeA	[pdb]	1.35463 0.00246999	35^SER 47^THR 50^GLU 52^GLU 69^GLU 211^LEU		plasma membrane membrane outer membrane-bounded periplasmic space	transport	transporter activity
1urpA	[pdb]	1.35836 0.0024705	9^SER 37^LEU 39^SER 46^GLU 66^THR 87^THR		carbohydrate transport chemotaxis transport	periplasmic space membrane	sugar:hydrogen symporter activity
3d1lB	[pdb]	1.3624 0.00260629	20^THR 39^ARG 41^GLU 42^GLU 46^GLU 48^ALA	0.0.0.0		binding catalytic activity	metabolic process
2fugC	[pdb]	1.36359 0.00260646	308^GLN 320^SER 321^MET 323^ALA 324^VAL 329^LYS	1.6.99.5	NADH dehydrogenase (ubiquinone) activity quinone binding oxidoreductase activity NADH dehydrogenase (quinone) activity oxidoreductase activity acting on NADH or NADPH 4 iron 4 sulfur cluster binding iron-sulfur cluster binding quinone binding metal ion binding oxidoreductase activity iron ion binding NADH dehydrogenase (quinone) activity oxidoreductase activity acting on NADH or NADPH NADH dehydrogenase (ubiquinone) activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding quinone binding metal ion binding oxidoreductase activity iron ion binding NADH dehydrogenase (quinone) activity NAD or NADH binding oxidoreductase activity acting on NADH or NADPH FMN binding NADH dehydrogenase (ubiquinone) activity 2 iron 2 sulfur cluster binding iron-sulfur cluster binding quinone binding metal ion binding oxidoreductase activity iron ion binding NADH dehydrogenase (quinone) activity NAD or NADH binding electron carrier activity 4 iron 4 sulfur cluster binding 2 iron 2 sulfur cluster binding iron-sulfur cluster binding quinone binding metal ion binding oxidoreductase activity iron ion binding NADH dehydrogenase (quinone) activity molybdenum ion binding oxidoreductase activity acting on NADH or NADPH electron carrier activity NADH dehydrogenase (ubiquinone) activity binding quinone binding oxidoreductase activity NADH dehydrogenase (quinone) activity iron ion binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding quinone binding metal ion binding oxidoreductase activity NADH dehydrogenase (quinone) activity oxidoreductase activity acting on NADH or NADPH electron carrier activity quinone binding oxidoreductase activity NADH dehydrogenase (quinone) activity NAD or NADH binding oxidoreductase activity acting on NADH or NADPH electron carrier activity	oxidation reduction transport photosynthesis light reaction oxidation reduction photosynthesis light reaction oxidation reduction oxidation reduction oxidation reduction ATP synthesis coupled electron transport oxidation reduction oxidation reduction photosynthesis light reaction oxidation reduction transport photosynthesis light reaction	plasma membrane membrane plasma membrane membrane plasma membrane membrane plasma membrane membrane plasma membrane membrane plasma membrane membrane plasma membrane membrane plasma membrane membrane
1v19A	[pdb]	1.3654 0.00260673	9^GLU 58^GLU 86^THR 108^SER 111^SER 113^LEU	0.0.0.0		D-ribose metabolic process D-ribose metabolic process	kinase activity ribokinase activity kinase activity ribokinase activity transferase activity
1mzhB	[pdb]	1.36805 0.00274975	1169^THR 1170^SER 1175^GLU 1207^GLU 1210^GLU 1213^ARG	4.1.2.4	cytoplasm	deoxyribonucleotide catabolic process metabolic process carbohydrate catabolic process	lyase activity deoxyribose-phosphate aldolase activity catalytic activity
1rtrA	[pdb]	1.3696 0.00274999	182^LEU 204^GLU 207^SER 265^ALA 268^GLU 278^THR	0.0.0.0		isoprenoid biosynthetic process	transferase activity
1v93A	[pdb]	1.37236 0.0027504	18^GLU 34^THR 36^GLU 37^GLU 42^ARG 277^SER	0.0.0.0		oxidation reduction methionine metabolic process	oxidoreductase activity methylenetetrahydrofolate reductase (NADPH) activity
2opwA	[pdb]	1.37298 0.0027505	54^SER 55^THR 57^GLU 58^GLU 62^ARG 88^GLU			metal ion binding oxidoreductase activity acting on single donors with incorporation of molecular oxygen incorporation of two atoms of oxygen oxidoreductase activity iron ion binding	oxidation reduction
2htmA	[pdb]	1.37372 0.00290103	73^HOH 75^HOH 77^HOH 78^HOH 84^HOH 98^GLU		catalytic activity	cytoplasm	thiamin biosynthetic process metabolic process sulfur metabolic process
3dorB	[pdb]	1.3756 0.00290132	171^THR 172^ALA 174^GLU 175^GLU 180^ARG 521^THR			proteolysis	serine-type peptidase activity
2hmvA	[pdb]	1.37708 0.00290156	57^ALA 58^THR 60^GLU 62^GLU 64^LEU 89^THR		plasma membrane membrane	potassium ion binding cation transmembrane transporter activity binding catalytic activity	transport ion transport metabolic process potassium ion transport
2e8gA	[pdb]	1.37729 0.0029016	23^THR 92^LEU 101^GLU 104^GLU 105^GLU 108^ALA	0.0.0.0			tRNA binding
2z6mK	[pdb]	1.37841 0.00290177	27^GLU 30^ALA 31^SER 56^LEU 62^GLU 107^GLU	1.16.3.1	intracellular ferritin complex	metal ion binding oxidoreductase activity iron ion binding ferroxidase activity transition metal ion binding ferric iron binding binding protein binding	negative regulation of cell proliferation immune response oxidation reduction cellular iron ion homeostasis cell proliferation intracellular sequestering of iron ion iron ion transport
2j6eB	[pdb]	1.38192 0.00306095	380^GLU 382^GLU 393^THR 424^SER 426^SER 441^LEU		antigen binding protein binding	immune response	membrane fraction extracellular region
1keeE	[pdb]	1.38472 0.00306143	217^THR 233^PRO 235^GLY 253^THR 255^ILE 265^VAL	6.3.5.5	cellular amino acid biosynthetic process glutamine metabolic process arginine biosynthetic process pyrimidine nucleotide biosynthetic process biosynthetic process nitrogen compound metabolic process cellular amino acid biosynthetic process glutamine metabolic process arginine biosynthetic process pyrimidine nucleotide biosynthetic process biosynthetic process nitrogen compound metabolic process cellular amino acid biosynthetic process arginine biosynthetic process pyrimidine nucleotide biosynthetic process metabolic process nitrogen compound metabolic process	cytosol	ligase activity carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase activity catalytic activity ATP binding ligase activity carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase activity catalytic activity protein binding ATP binding metal ion binding manganese ion binding ligase activity ATP binding nucleotide binding carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase activity catalytic activity protein binding nucleotide binding nucleotide binding
1vdxA	[pdb]	1.38603 0.00306165	43^LEU 56^GLU 106^GLU 108^GLU 110^GLU 112^ALA		2'-5'-RNA ligase activity catalytic activity	RNA metabolic process	intracellular
2yv5A	[pdb]	1.38622 0.00306168	179^SER 183^SER 185^LEU 188^GLU 189^GLU 223^THR				metal ion binding hydrolase activity zinc ion binding GTP binding nucleotide binding GTPase activity metal ion binding hydrolase activity zinc ion binding GTP binding nucleotide binding GTPase activity
1wa3C	[pdb]	1.39024 0.00322967	16^LEU 20^SER 22^GLU 23^GLU 26^GLU 50^THR	0.0.0.0		catalytic activity	metabolic process
3buuA	[pdb]	1.39229 0.00323004	62^THR 126^THR 199^LEU 222^GLU 229^GLU 231^SER	0.0.0.0
1p3wA	[pdb]	1.39298 0.00323016	309^GLU 313^LEU 334^GLU 347^GLU 349^ALA 351^SER	2.8.1.7	cytoplasm	tRNA processing metabolic process cysteine metabolic process	transferase activity cysteine desulfurase activity pyridoxal phosphate binding catalytic activity protein binding
3bcvB	[pdb]	1.39433 0.00340692	8^SER 83^ALA 84^THR 86^GLU 177^LEU 184^GLU	0.0.0.0			transferase activity
1htaA	[pdb]	1.39488 0.00340703	32^LEU 37^GLU 38^GLU 40^ALA 42^GLU 61^GLU			DNA binding sequence-specific DNA binding	intracellular
1z3iX	[pdb]	1.39674 0.00340738	618^THR 622^GLU 623^GLU 658^LEU 663^GLU 667^SER	0.0.0.0			DNA-dependent ATPase activity ATP binding helicase activity DNA binding nucleic acid binding
1c0lA	[pdb]	1.40395 0.00359511	1066^ARG 1071^GLU 1072^GLU 1074^THR 1341^SER 1346^GLU	1.4.3.3	oxidation reduction metabolic process	oxidoreductase activity D-amino-acid oxidase activity binding catalytic activity	peroxisome
1o8rA	[pdb]	1.40452 0.00359522	13^GLU 36^ALA 70^LEU 74^GLU 75^GLU 78^GLU		extracellular region	hormone activity guanylate cyclase activator activity enzyme activator activity	signal transduction
3bksA	[pdb]	1.40628 0.00359557	43^SER 46^LEU 55^GLU 57^GLU 59^ALA 63^THR	0.0.0.0
1i6bA	[pdb]	1.40838 0.00379282	354^GLU 375^SER 376^THR 378^GLU 379^GLU 383^LEU		cytoplasm extracellular region	iron ion transport ion transport transport cellular iron ion homeostasis	metal ion binding hydrolase activity serine-type peptidase activity peptidase activity iron ion binding ferric iron binding
2dfaA	[pdb]	1.40995 0.00379315	124^THR 144^LEU 150^GLU 151^GLU 152^GLU 153^ALA
1xesA	[pdb]	1.41148 0.00379347	108^LEU 134^SER 135^THR 137^THR 194^SER 195^GLU		cytoplasm	response to stress biosynthetic process metabolic process	transferase activity acyltransferase activity transferase activity transferring acyl groups other than amino-acyl groups catalytic activity
2qk1A	[pdb]	1.41175 0.00379352	520^THR 527^ALA 550^ARG 554^GLU 555^GLU 556^THR		microtubule binding structural constituent of cytoskeleton binding protein binding identical protein binding	mitotic spindle organization in nucleus microtubule nucleation	spindle microtubule nucleus cell cortex spindle microtubule spindle pole body condensed nuclear chromosome kinetochore kinetochore
2ch1D	[pdb]	1.41258 0.0037937	90^LEU 108^ALA 110^GLU 112^SER 113^GLU 121^THR	0.0.0.0		metabolic process	pyridoxal phosphate binding catalytic activity
1o12B	[pdb]	1.41607 0.00400243	153^ALA 155^GLU 157^GLU 159^SER 161^LEU 183^GLU	0.0.0.0		N-acetylglucosamine metabolic process	N-acetylglucosamine-6-phosphate deacetylase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds hydrolase activity
2hj9B	[pdb]	1.42043 0.0040034	182^VAL 184^GLY 186^SER 188^ASN 215^ALA 307^HOH		hydrolase activity transferase activity kinase activity phosphoprotein phosphatase activity protein histidine kinase activity transferase activity transferring phosphorus-containing groups ATP binding signal transducer activity two-component response regulator activity two-component sensor activity protein binding protein binding nucleotide binding	plasma membrane integral to membrane membrane periplasmic space	two-component signal transduction system (phosphorelay) peptidyl-histidine phosphorylation phosphorylation signal transduction regulation of transcription DNA-dependent
1f00I	[pdb]	1.42279 0.00422384	668^THR 670^ALA 679^THR 702^LEU 747^GLU 749^GLU		binding protein binding	cell outer membrane integral to membrane membrane plasma membrane cell surface	pathogenesis cell wall macromolecule catabolic process cell adhesion
1s1hK	[pdb]	1.42602 0.00422459	25^SER 53^PRO 55^GLY 59^LYS 85^ILE 89^MET		SSU rRNA binding SSU rRNA binding structural constituent of ribosome mRNA binding protein binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome ribonucleoprotein binding rRNA binding GTP binding translation elongation factor activity RNA binding nucleotide binding GTPase activity protein binding structural constituent of ribosome structural constituent of ribosome metal ion binding zinc ion binding structural constituent of ribosome protein binding structural constituent of ribosome structural constituent of ribosome protein binding structural constituent of ribosome RNA binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome nucleic acid binding RNA binding DNA-(apurinic or apyrimidinic site) lyase activity structural constituent of ribosome protein binding fibroblast growth factor 3 binding rRNA binding structural constituent of ribosome RNA binding DNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome structural constituent of ribosome	nucleolus nucleolus nucleolus cytoplasm ribonucleoprotein complex ribosome nucleus small-subunit processome 90S preribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit intracellular cytoplasm ribosome cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular small ribosomal subunit ribosome intracellular cytoplasm ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribonucleoprotein complex ribosome nucleus small-subunit processome 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome cytosolic small ribosomal subunit mitochondrion intracellular cytoplasm ribonucleoprotein complex ribosome preribosome small subunit precursor 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome nucleus small-subunit processome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit intracellular cytoplasm ribonucleoprotein complex ribosome 90S preribosome cytosolic small ribosomal subunit intracellular	ribosome biogenesis rRNA processing translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) ribosomal small subunit assembly translation translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) ribosomal small subunit assembly translation translational elongation ribosome biogenesis translation rRNA export from nucleus translation translation regulation of translational fidelity maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation translation rRNA export from nucleus maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation ribosome biogenesis rRNA processing translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation rRNA export from nucleus endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation rRNA export from nucleus ribosome biogenesis rRNA processing positive regulation of translational fidelity rRNA export from nucleus translation translation rRNA export from nucleus endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA 5.8S rRNA LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) ribosomal small subunit assembly translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA) translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA 5.8S rRNA LSU-rRNA)
3d4eA	[pdb]	1.42648 0.0042247	62^THR 120^ARG 163^SER 165^SER 169^GLU 170^GLU	0.0.0.0
1tuaA	[pdb]	1.42869 0.00422522	117^ARG 123^GLU 124^GLU 126^THR 149^ALA 170^GLU	0.0.0.0			RNA binding
2olcB	[pdb]	1.42951 0.00445802	147^THR 298^GLU 299^THR 301^SER 303^ALA 323^LEU	2.7.1.100		methionine biosynthetic process cellular amino acid biosynthetic process response to stress methionine biosynthetic process from S-adenosylmethionine	transferase activity kinase activity ATP binding nucleotide binding S-methyl-5-thioribose kinase activity
2r4fC	[pdb]	1.42967 0.00445806	559^GLU 565^SER 566^THR 850^GLU 852^SER 857^LEU	0.0.0.0	endoplasmic reticulum membrane peroxisomal membrane integral to membrane membrane endoplasmic reticulum peroxisome microsome	oxidation reduction sterol biosynthetic process lipid biosynthetic process cholesterol biosynthetic process steroid biosynthetic process germ cell migration gonad development coenzyme A metabolic process isoprenoid biosynthetic process negative regulation of MAP kinase activity embryonic development visual learning	oxidoreductase activity hydroxymethylglutaryl-CoA reductase (NADPH) activity coenzyme binding NADP or NADPH binding oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor protein homodimerization activity hydroxymethylglutaryl-CoA reductase activity
1vqkY	[pdb]	1.4309 0.00445837	194^GLU 218^GLU 220^GLU 222^GLU 224^ALA 227^ARG		rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome metal ion binding rRNA binding zinc ion binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome metal ion binding rRNA binding zinc ion binding RNA binding structural constituent of ribosome structural constituent of ribosome DNA binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding 5S rRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding metal ion binding rRNA binding zinc ion binding RNA binding structural constituent of ribosome metal ion binding rRNA binding zinc ion binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding sequence-specific DNA binding protein binding structural constituent of ribosome nucleotide binding rRNA binding RNA binding nucleotide binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding RNA binding tRNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome	ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome intracellular ribonucleoprotein complex ribosome large ribosomal subunit intracellular	translation translation translation translation ribosome biogenesis translation translation translation translation translation DNA repair translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation ribosome biogenesis translation translation translation
1x1oC	[pdb]	1.43099 0.00445839	184^GLU 204^ARG 207^GLU 208^GLU 211^GLU 212^ALA	0.0.0.0		nicotinate-nucleotide diphosphorylase (carboxylating) activity catalytic activity	pyridine nucleotide biosynthetic process NAD biosynthetic process metabolic process
1z6gA	[pdb]	1.43956 0.00470668	35^SER 37^SER 72^GLU 83^THR 87^GLU 99^LEU	0.0.0.0		purine nucleotide metabolic process	transferase activity kinase activity guanylate kinase activity
1hzhH	[pdb]	1.44133 0.00470715	405^GLU 407^GLU 421^THR 455^SER 457^SER 472^LEU		antigen binding protein binding	immune response	membrane fraction extracellular region
1tv3A	[pdb]	1.4429 0.00496803	39^LEU 268^ALA 272^GLU 273^GLU 274^THR 281^THR			methanogenesis	transferase activity methyltransferase activity
2fe8A	[pdb]	1.44297 0.00496805	124^LEU 182^ALA 204^GLU 239^GLU 241^SER 308^GLU		integral to membrane membrane cytoplasm viral replication complex integral to membrane membrane cytoplasm viral replication complex perinuclear region of cytoplasm perinuclear region of cytoplasm	metal ion binding hydrolase activity zinc ion binding cysteine-type peptidase activity peptidase activity RNA binding RNA-directed RNA polymerase activity catalytic activity metal ion binding hydrolase activity nucleotidyltransferase activity transferase activity zinc ion binding cysteine-type peptidase activity peptidase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity RNA-directed RNA polymerase activity RNA binding nucleotide binding exoribonuclease activity producing 5'-phosphomonoesters methyltransferase activity cysteine-type endopeptidase activity catalytic activity	viral protein processing viral genome replication viral reproduction proteolysis transcription RNA-dependent viral protein processing viral genome replication viral reproduction proteolysis transcription
2byvE	[pdb]	1.4455 0.00496873	62^GLU 65^GLU 84^LEU 129^THR 132^SER 134^GLU		cAMP binding guanyl-nucleotide exchange factor activity nucleotide binding cAMP-dependent protein kinase regulator activity protein binding	exocytosis insulin secretion cAMP-mediated signaling regulation of exocytosis calcium ion-dependent exocytosis regulation of small GTPase mediated signal transduction small GTPase mediated signal transduction intracellular signaling cascade signal transduction regulation of protein amino acid phosphorylation	membrane cytoplasm cytosol cAMP-dependent protein kinase complex intracellular
2z82A	[pdb]	1.44583 0.00496882	235^ALA 262^THR 264^GLU 265^SER 269^LEU 288^THR		intrinsic to membrane integral to membrane cell surface plasma membrane cytoplasmic vesicle membrane external side of plasma membrane	positive regulation of interleukin-6 production MyD88-dependent toll-like receptor signaling pathway cell surface pattern recognition receptor signaling pathway response to molecule of fungal origin innate immune response signal transduction immune response inflammatory response chloramphenicol transport positive regulation of tumor necrosis factor production	receptor activity protein binding protein binding transmembrane receptor activity Gram-positive bacterial binding peptidoglycan binding receptor activity
1xc5A	[pdb]	1.44841 0.00496951	433^SER 434^GLU 436^GLU 438^GLU 458^LEU 473^THR		nucleolus nucleus	protein binding Notch binding DNA binding transcription corepressor activity	regulation of transcription DNA-dependent transcription regulation of transcription negative regulation of specific transcription from RNA polymerase II promoter
2rcbA	[pdb]	1.44831 0.00496949	143^LEU 176^GLU 177^SER 178^SER 180^GLU 201^THR		calcium ion binding ion channel activity magnesium ion binding neurotransmitter binding neurotransmitter receptor activity glycine binding cation channel activity extracellular-glutamate-gated ion channel activity receptor activity ionotropic glutamate receptor activity	ion transport transport ionotropic glutamate receptor signaling pathway	plasma membrane postsynaptic membrane synapse cell junction integral to membrane membrane N-methyl-D-aspartate selective glutamate receptor complex
2cwdC	[pdb]	1.45041 0.00523796	57^ARG 63^GLU 64^GLU 65^GLU 67^ALA 140^GLU	0.0.0.0		protein amino acid dephosphorylation	protein tyrosine phosphatase activity
2edvA	[pdb]	1.45094 0.00523811	29^GLU 30^SER 34^THR 65^LEU 66^SER 68^GLU			cytoplasm cytosol plasma membrane membrane cytoskeleton	protein binding

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

1b76B

[pdb]

0.225119
2.54906e-05

188^GLU 239^GLU 241^GLU 311^ARG 359^GLU 361^SER

6.1.1.14

cytoplasm

ligase activity
ATP binding
aminoacyl-tRNA ligase activity
nucleotide binding
glycine-tRNA ligase activity

translation
glycyl-tRNA aminoacylation
tRNA aminoacylation for protein translation

1atiA

[pdb]

0.320169
6.38816e-05

188^GLU 239^GLU 241^GLU 311^ARG 359^GLU 361^SER

6.1.1.14

cytoplasm

ligase activity
ATP binding
aminoacyl-tRNA ligase activity
nucleotide binding
glycine-tRNA ligase activity

translation
glycyl-tRNA aminoacylation
tRNA aminoacylation for protein translation

2q5iA

[pdb]

0.846432
0.000139793

245^GLU 296^GLU 298^GLU 410^ARG 522^GLU 524^SER

6.1.1.14

cytoplasm
soluble fraction
secretory granule

ligase activity
ATP binding
aminoacyl-tRNA ligase activity
nucleotide binding
glycine-tRNA ligase activity
protein binding

translation
glycyl-tRNA aminoacylation
tRNA aminoacylation for protein translation
regulated secretory pathway
cell death

3d6jA

[pdb]

0.865409
0.000154827

23^THR 50^LEU 72^GLU 74^SER 76^GLU 77^ALA

0.0.0.0

hydrolase activity
phosphoglycolate phosphatase activity
catalytic activity

metabolic process

2p62A

[pdb]

0.922542
0.000200598

12^THR 14^GLU 15^SER 20^LEU 153^GLU 205^SER

0.0.0.0

2px5A

[pdb]

1.03459
0.000320952

10^GLU 153^SER 155^GLU 157^GLU 158^GLU 184^LEU

2.7.7.48, 3.4.21.91

hydrolase activity
nucleotidyltransferase activity
transferase activity
ATP binding
structural molecule activity
helicase activity
RNA-directed RNA polymerase activity
nucleotide binding
ATP-dependent helicase activity
serine-type endopeptidase activity
catalytic activity
double-stranded RNA binding
RNA helicase activity
RNA binding
nucleic acid binding
methyltransferase activity

membrane
viral envelope
viral capsid
viral nucleocapsid
virion
integral to membrane
virion part

transcription
RNA-dependent
viral genome replication
viral infectious cycle
RNA metabolic process
viral reproduction
methylation

2oy0B

[pdb]

1.04565
0.000331363

10^GLU 153^SER 155^GLU 157^GLU 158^GLU 184^LEU

2.7.7.48, 3.4.21.91

hydrolase activity
ATP binding
helicase activity
nucleotide binding
ATP-dependent helicase activity
structural molecule activity
serine-type endopeptidase activity
RNA-directed RNA polymerase activity
catalytic activity
double-stranded RNA binding
RNA helicase activity
RNA binding
nucleic acid binding
hydrolase activity
nucleotidyltransferase activity
transferase activity
ATP binding
structural molecule activity
helicase activity
RNA-directed RNA polymerase activity
nucleotide binding
ATP-dependent helicase activity
serine-type endopeptidase activity
catalytic activity
double-stranded RNA binding
RNA helicase activity
RNA binding
nucleic acid binding
methyltransferase activity
methyltransferase activity

transcription
RNA-dependent
viral genome replication
viral infectious cycle
RNA metabolic process
viral reproduction
transcription
RNA-dependent
viral genome replication
viral infectious cycle
RNA metabolic process
viral reproduction
methylation
methylation

viral envelope
virion
integral to membrane
membrane
virion part
viral capsid
membrane
viral envelope
viral capsid
viral nucleocapsid
virion
integral to membrane
virion part

2ag1D

[pdb]

1.04977
0.000341896

211^LEU 214^GLU 216^SER 218^THR 219^ALA 327^GLU

0.0.0.0

lyase activity
thiamin pyrophosphate binding
catalytic activity
magnesium ion binding

2ovwD

[pdb]

1.05181
0.000341919

15^THR 122^LEU 126^GLU 128^SER 393^GLU 397^THR

3.2.1.4

cellulose catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

hydrolase activity
acting on glycosyl bonds
hydrolase activity
cellulase activity
hydrolase activity
hydrolyzing O-glycosyl compounds

1avhA

[pdb]

1.10426
0.000441135

27^ALA 33^THR 36^GLU 37^SER 42^LEU 72^GLU

0.0.0.0

calcium-dependent phospholipid binding
calcium ion binding
phospholipid binding
phospholipase inhibitor activity
protein binding
eukaryotic cell surface binding

cytoplasm
intracellular

signal transduction
anti-apoptosis
blood coagulation
negative regulation of coagulation
protein homooligomerization
response to organic substance

3d85D

[pdb]

1.15435
0.000560822

107^LEU 131^THR 151^ALA 152^THR 166^GLU 168^SER

antigen binding
protein binding
cytokine activity
antigen binding
protein binding
protein heterodimerization activity
cytokine activity
growth factor activity
interleukin-12 receptor binding
signal transducer activity
cytokine receptor activity
protein binding
protein homodimerization activity
interleukin-12 alpha subunit binding

extracellular region
cytoplasm
extracellular region
extracellular space
membrane fraction
extracellular region
interleukin-12 complex
extracellular space
extracellular region
membrane

immune response
tissue remodeling
innate immune response
response to virus
immune response
inflammatory response
T cell proliferation
natural killer cell activation during immune response
immune response
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of lymphocyte proliferation
positive regulation of cell adhesion
cell migration
positive regulation of natural killer cell activation
positive regulation of interferon-gamma production
interferon-gamma biosynthetic process
T-helper cell differentiation
response to UV-B
positive regulation of interferon-gamma biosynthetic process
T-helper 1 type immune response
regulation of cytokine biosynthetic process
positive regulation of activated T cell proliferation
natural killer cell activation
positive regulation of T cell proliferation
sensory perception of pain
cell surface receptor linked signal transduction
negative regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell apoptosis
cell cycle arrest

3eucA

[pdb]

1.162
0.000581842

284^GLU 348^SER 349^THR 351^GLU 352^GLU 357^LEU

2.6.1.9

cellular amino acid biosynthetic process
histidine biosynthetic process
biosynthetic process

transferase activity
transaminase activity
histidinol-phosphate transaminase activity
pyridoxal phosphate binding
transferase activity
transferring nitrogenous groups
catalytic activity

2qezC

[pdb]

1.19961
0.000750199

117^LEU 119^SER 120^GLU 126^THR 306^THR 309^ALA

cellular amino acid metabolic process

lyase activity
ethanolamine ammonia-lyase activity

1ipjC

[pdb]

1.21232
0.000787415

161^THR 165^SER 166^GLU 168^GLU 169^GLU 174^LEU

nutrient reservoir activity

vacuole
aleurone grain

1he1B

[pdb]

1.21932
0.000827457

121^ASP 122^ASP 124^ASP 125^THR 148^GLU 207^THR

0.0.0.0

GTP binding
nucleotide binding
GTP binding
nucleotide binding
protein binding
GTPase activity
GTP binding
nucleotide binding
GTP-dependent protein binding
enzyme binding
GTPase activity
protein binding
GTP binding
protein binding
GTPase activity
nucleotide binding
GTPase activator activity

melanosome
plasma membrane
membrane
intracellular
melanosome
plasma membrane
membrane
intracellular
melanosome
plasma membrane
membrane
cytosol
intracellular
membrane fraction
cytoplasm
cytoplasmic membrane-bounded vesicle
extrinsic to plasma membrane
lamellipodium
cell projection
cytoplasm
membrane fraction
intracellular
melanosome
plasma membrane
membrane
cell projection
lamellipodium
extrinsic to plasma membrane
cytoplasmic membrane-bounded vesicle
membrane
extracellular region

small GTPase mediated signal transduction
small GTPase mediated signal transduction
negative regulation of receptor-mediated endocytosis
ruffle organization
lamellipodium assembly
actin filament polymerization
positive regulation of Rho protein signal transduction
response to wounding
anatomical structure morphogenesis
intracellular signaling cascade
inflammatory response
cell motion
small GTPase mediated signal transduction
localization within membrane
regulation of hydrogen peroxide metabolic process
regulation of respiratory burst
endocytosis
hyperosmotic response
cytoskeleton organization
cell adhesion
axon guidance
dendrite development
cell migration
cerebral cortex radially oriented cell migration
embryonic olfactory bulb interneuron precursor migration
regulation of cell migration
positive regulation of actin filament polymerization
positive regulation of phosphoinositide 3-kinase activity
positive regulation of lamellipodium assembly
cell adhesion
bone resorption
dendrite development
small GTPase mediated signal transduction
cell adhesion
cytoskeleton organization
hyperosmotic response
endocytosis
actin cytoskeleton organization
cell proliferation
chemotaxis
positive regulation of phosphoinositide 3-kinase activity
positive regulation of actin filament polymerization
regulation of cell migration
lamellipodium assembly
embryonic olfactory bulb interneuron precursor migration
cerebral cortex radially oriented cell migration
cell migration
axon guidance
pathogenesis

2flqB

[pdb]

1.22187
0.000870512

93^ALA 95^THR 97^GLU 98^GLU 103^LEU 128^GLU

0.0.0.0

nitric oxide biosynthetic process

nitric-oxide synthase activity

1nclA

[pdb]

1.22245
0.000870539

9^GLU 13^LEU 124^SER 126^SER 128^GLU 133^GLU

2.7.4.6

cytoplasm

metal ion binding
transferase activity
kinase activity
ATP binding
magnesium ion binding
nucleotide binding
nucleoside diphosphate kinase activity

nucleotide metabolic process
CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process

3bywA

[pdb]

1.23168
0.000917312

98^ARG 113^SER 116^GLU 139^ALA 141^GLU 144^THR

0.0.0.0

integral to membrane

peptidoglycan biosynthetic process

transferase activity
transferase activity
transferring pentosyl groups

1zs6D

[pdb]

1.23576
0.000967434

22^GLU 26^LEU 137^SER 139^SER 141^GLU 146^GLU

2.7.4.6

cytosol

metal ion binding
transferase activity
kinase activity
ATP binding
magnesium ion binding
nucleotide binding
nucleoside diphosphate kinase activity

nucleotide metabolic process
apoptosis
induction of apoptosis
CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process

3glaA

[pdb]

1.23612
0.000967453

86^SER 87^GLU 89^SER 90^THR 93^GLU 100^ARG

0.0.0.0

response to stress

1wclA

[pdb]

1.25556
0.00113174

358^THR 379^SER 380^THR 382^GLU 383^GLU 407^ARG

RNA binding
sequence-specific DNA binding
transcription regulator activity
protein binding
transcription factor activity
nucleotide binding
transcription factor activity
RNA binding
sequence-specific DNA binding
transcription regulator activity
protein binding
nucleotide binding
RNA binding
sequence-specific DNA binding
transcription regulator activity
protein binding
transcription factor activity
nucleotide binding
RNA binding
sequence-specific DNA binding
transcription regulator activity
protein binding
transcription factor activity
nucleotide binding
DNA binding
DNA binding
DNA binding
DNA binding

intracellular
intracellular
intracellular
intracellular

transcription antitermination
regulation of transcription
DNA-dependent
transcription termination
transcription
regulation of transcription termination
transcription antitermination
response to stress
regulation of transcription
DNA-dependent
transcription termination
transcription
regulation of transcription termination
transcription antitermination
regulation of transcription
DNA-dependent
transcription termination
transcription
regulation of transcription termination
transcription antitermination
regulation of transcription
DNA-dependent
transcription termination
transcription
regulation of transcription termination
DNA repair
regulation of transcription
DNA repair
regulation of transcription
DNA repair
regulation of transcription
DNA repair
regulation of transcription

1tygA

[pdb]

1.25763
0.00113187

175^ALA 177^THR 179^GLU 180^GLU 186^ARG 200^GLU

catalytic activity

cytoplasm

thiamin biosynthetic process
metabolic process
sulfur metabolic process

2a8pA

[pdb]

1.26072
0.00113206

59^LEU 91^GLU 135^GLU 138^GLU 140^GLU 141^ALA

metal ion binding
manganese ion binding
hydrolase activity
RNA binding
magnesium ion binding

nucleoplasm
nucleolus
nucleus

1jz1M

[pdb]

1.26489
0.00119421

35^SER 41^GLU 314^GLU 322^LEU 324^GLU 326^GLU

3.2.1.23

beta-galactosidase complex

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-galactosidase activity
cation binding
carbohydrate binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity
protein binding
magnesium ion binding
manganese ion binding
sodium ion binding
metal ion binding

metabolic process
carbohydrate metabolic process

3ct9B

[pdb]

1.27118
0.00126086

76^THR 97^LEU 327^SER 329^THR 331^GLU 332^GLU

0.0.0.0

metal ion binding
hydrolase activity
zinc ion binding
protein dimerization activity
metallopeptidase activity

proteolysis

2uxpA

[pdb]

1.27453
0.0012611

77^SER 78^GLU 80^GLU 82^GLU 142^THR 151^ARG

DNA binding
transcription regulator activity
transcription factor activity

regulation of transcription
DNA-dependent
transcription
regulation of transcription

3cinA

[pdb]

1.28163
0.0013324

91^SER 93^ARG 134^GLU 155^GLU 158^THR 159^ALA

0.0.0.0

binding
inositol-3-phosphate synthase activity
catalytic activity

phospholipid biosynthetic process
metabolic process
inositol biosynthetic process

2j7uA

[pdb]

1.28183
0.00133242

399^THR 424^ALA 426^GLU 428^GLU 429^GLU 433^LEU

2.1.1.56, 3.4.21.91, 2.7.7.48

hydrolase activity
ATP binding
helicase activity
nucleotide binding
ATP-dependent helicase activity
structural molecule activity
serine-type endopeptidase activity
RNA-directed RNA polymerase activity
catalytic activity
double-stranded RNA binding
RNA helicase activity
RNA binding
nucleic acid binding
hydrolase activity
nucleotidyltransferase activity
transferase activity
ATP binding
structural molecule activity
helicase activity
RNA-directed RNA polymerase activity
nucleotide binding
mRNA (guanine-N7-)-methyltransferase activity
ATP-dependent helicase activity
serine-type endopeptidase activity
catalytic activity
double-stranded RNA binding
RNA helicase activity
RNA binding
nucleic acid binding
methyltransferase activity
methyltransferase activity

transcription
RNA-dependent
viral genome replication
viral infectious cycle
RNA metabolic process
viral reproduction
transcription
RNA-dependent
viral genome replication
viral infectious cycle
RNA metabolic process
viral reproduction
methylation
methylation

virion part
viral envelope
viral capsid
virion
integral to membrane
membrane
viral envelope
viral capsid
viral nucleocapsid
virion
integral to membrane
virion part
membrane

1ecqA

[pdb]

1.28798
0.00140845

212^ALA 214^GLU 216^GLU 218^GLU 234^LEU 244^GLU

4.2.1.40

glucarate catabolic process
metabolic process
glucarate catabolic process
metabolic process

metal ion binding
lyase activity
magnesium ion binding
glucarate dehydratase activity
catalytic activity
metal ion binding
lyase activity
magnesium ion binding
glucarate dehydratase activity
catalytic activity

1v5qA

[pdb]

1.2976
0.00157552

79^GLU 81^SER 82^THR 84^GLU 85^GLU 89^LEU

cytoplasmic vesicle
endoplasmic reticulum
postsynaptic membrane
synapse
cell junction
membrane
plasma membrane
membrane raft

protein binding

protein localization

2vu5A

[pdb]

1.29997
0.00157573

2^GLU 6^LEU 117^SER 119^SER 121^GLU 126^GLU

0.0.0.0

cytoplasm

metal ion binding
transferase activity
kinase activity
ATP binding
magnesium ion binding
nucleotide binding
nucleoside diphosphate kinase activity

nucleotide metabolic process
CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process

1aeiD

[pdb]

1.30049
0.00157578

25^ALA 31^THR 33^GLU 35^SER 40^LEU 66^GLU

0.0.0.0

calcium-dependent phospholipid binding
calcium ion binding

2z00A

[pdb]

1.30781
0.0016676

203^GLU 205^GLU 208^ARG 235^SER 236^THR 241^GLU

0.0.0.0

pyrimidine nucleotide biosynthetic process

zinc ion binding
metal ion binding
hydrolase activity
dihydroorotase activity
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds
in cyclic amides
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds

1d1xB

[pdb]

1.32022
0.00186818

130^ARG 154^GLU 156^GLU 158^GLU 160^ALA 164^THR

1.14.13.39

Golgi apparatus
membrane
plasma membrane
cytoskeleton
cytoplasm
caveola

metal ion binding
oxidoreductase activity
zinc ion binding
calmodulin binding
calcium ion binding
iron ion binding
nitric-oxide synthase activity
NADP or NADPH binding
FAD binding
heme binding
FMN binding
electron carrier activity

mitochondrion organization
arginine catabolic process
oxidation reduction
blood coagulation
nitric oxide biosynthetic process
positive regulation of guanylate cyclase activity
anti-apoptosis
angiogenesis
ovulation from ovarian follicle
blood vessel remodeling
regulation of sodium ion transport
negative regulation of muscle hyperplasia
smooth muscle hyperplasia
lung development
lipopolysaccharide-mediated signaling pathway
negative regulation of potassium ion transport
positive regulation of angiogenesis
regulation of blood vessel size
negative regulation of hydrolase activity
negative regulation of calcium ion transport

1m9jB

[pdb]

1.32135
0.0018683

128^ARG 152^GLU 154^GLU 156^GLU 158^ALA 162^THR

1.14.13.39

Golgi apparatus
membrane
plasma membrane
cytoskeleton
cytoplasm
cytosol
Golgi membrane
apical part of cell
nucleus
caveola
soluble fraction

oxidation reduction
nitric oxide biosynthetic process
negative regulation of calcium ion transport
negative regulation of hydrolase activity
negative regulation of smooth muscle cell proliferation
negative regulation of potassium ion transport
lung development
learning
signal transduction
regulation of sodium ion transport
ovulation from ovarian follicle
angiogenesis
mitochondrion organization
positive regulation of guanylate cyclase activity
anti-apoptosis
positive regulation of angiogenesis
arginine catabolic process
endothelial cell migration
regulation of systemic arterial blood pressure by endothelin
response to fluid shear stress
regulation of blood vessel size
smooth muscle hyperplasia
negative regulation of muscle hyperplasia
negative regulation of cell proliferation
blood vessel remodeling
negative regulation of platelet activation
regulation of blood pressure
response to heat
positive regulation of vasodilation
lipopolysaccharide-mediated signaling pathway

protein binding
metal ion binding
oxidoreductase activity
zinc ion binding
calmodulin binding
iron ion binding
nitric-oxide synthase activity
NADP or NADPH binding
FAD binding
heme binding
FMN binding
electron carrier activity
actin monomer binding
cadmium ion binding
tetrahydrobiopterin binding
arginine binding
calcium ion binding

1qr4A

[pdb]

1.32217
0.00186839

13^GLU 90^SER 114^ARG 159^SER 165^GLU 167^GLU

cell adhesion
signal transduction

protein binding
receptor binding

proteinaceous extracellular matrix
extracellular region

2asxB

[pdb]

1.32576
0.00197739

290^THR 291^ALA 296^GLU 302^GLU 320^GLU 324^ARG

0.0.0.0

integral to membrane

signal transducer activity

signal transduction

2nn6A

[pdb]

1.33476
0.0020933

71^VAL 72^THR 73^CYS 76^SER 119^TYR 127^ILE

exosome (RNase complex)
nucleolus
nucleus
nucleolus
cytoplasm
nucleus
exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)
cellular_component
cytoplasm
nucleus
exosome (RNase complex)
nucleolus
nucleolus
nucleolus
nucleolus
nucleolus
exosome (RNase complex)
nucleus
cytoplasm
nucleolus
nucleus
exosome (RNase complex)
nuclear exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)
nucleolus
cytoplasmic exosome (RNase complex)
nuclear exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)
cytoplasm
nucleus
exosome (RNase complex)

protein binding
RNA binding
hydrolase activity
exonuclease activity
nuclease activity
protein binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
7S RNA binding
3'-5'-exoribonuclease activity
protein binding
molecular_function
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
3'-5'-exoribonuclease activity
identical protein binding
protein binding
protein binding
RNA binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
protein binding
RNA binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
protein binding
3'-5'-exoribonuclease activity
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
protein binding
hydrolase activity
exonuclease activity
nuclease activity
RNA binding
3'-5'-exoribonuclease activity

rRNA processing
rRNA processing
RNA processing
rRNA processing
biological_process
rRNA processing
RNA processing
RNA catabolic process
rRNA processing
RNA processing
rRNA processing
RNA processing
immune response
rRNA processing
RNA processing
rRNA processing
rRNA processing
RNA processing

1xxoA

[pdb]

1.33538
0.00209337

67^ALA 68^SER 70^LEU 83^GLU 85^THR 133^THR

0.0.0.0

FMN binding

1vq0B

[pdb]

1.33763
0.00209365

242^LEU 256^GLU 273^SER 274^GLU 276^GLU 278^GLU

cytoplasm

protein folding

zinc ion binding
unfolded protein binding

1clcA

[pdb]

1.33875
0.00221513

221^GLU 369^GLU 372^GLU 374^LEU 410^THR 414^SER

3.2.1.4

cellulose catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process
cellulose catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

hydrolase activity
acting on glycosyl bonds
hydrolase activity
calcium ion binding
cellulase activity
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity
hydrolase activity
acting on glycosyl bonds
hydrolase activity
calcium ion binding
cellulase activity
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

3gbuB

[pdb]

1.34118
0.00221543

191^ALA 193^GLU 195^GLU 199^LEU 212^THR 215^THR

D-ribose metabolic process

transferase activity
kinase activity
ribokinase activity

1p1dA

[pdb]

1.34222
0.00221556

87^GLU 89^SER 90^THR 92^GLU 93^GLU 97^LEU

nervous system development

postsynaptic density
cell soma
endomembrane system
endoplasmic reticulum membrane
cytoplasm
postsynaptic membrane
synapse
cell junction
membrane
plasma membrane
endoplasmic reticulum

protein binding

2ceiA

[pdb]

1.34231
0.00221557

27^GLU 30^ALA 31^SER 56^LEU 62^GLU 107^GLU

1.16.3.1

intracellular ferritin complex

metal ion binding
oxidoreductase activity
iron ion binding
ferroxidase activity
transition metal ion binding
ferric iron binding
binding
protein binding

negative regulation of cell proliferation
immune response
oxidation reduction
cellular iron ion homeostasis
cell proliferation
intracellular sequestering of iron ion
iron ion transport

2f8sA

[pdb]

1.34543
0.00221596

397^ALA 399^THR 401^GLU 402^GLU 407^LEU 425^GLU

0.0.0.0

nucleic acid binding

2hypA

[pdb]

1.3498
0.0023412

149^LEU 154^GLU 155^GLU 157^ALA 158^THR 198^THR

0.0.0.0

hydrolase activity

1vpkA

[pdb]

1.35291
0.00246976

126^THR 160^GLU 188^GLU 189^ALA 190^SER 192^LEU

0.0.0.0

DNA replication

cytoplasm

nucleotidyltransferase activity
transferase activity
DNA-directed DNA polymerase activity
3'-5' exonuclease activity
DNA binding

3dulB

[pdb]

1.35426
0.00246994

37^LEU 88^THR 91^ALA 92^SER 93^GLU 116^THR

0.0.0.0

transferase activity
methyltransferase activity
O-methyltransferase activity

2ieeA

[pdb]

1.35463
0.00246999

35^SER 47^THR 50^GLU 52^GLU 69^GLU 211^LEU

plasma membrane
membrane
outer membrane-bounded periplasmic space

transport

transporter activity

1urpA

[pdb]

1.35836
0.0024705

9^SER 37^LEU 39^SER 46^GLU 66^THR 87^THR

carbohydrate transport
chemotaxis
transport

periplasmic space
membrane

sugar:hydrogen symporter activity

3d1lB

[pdb]

1.3624
0.00260629

20^THR 39^ARG 41^GLU 42^GLU 46^GLU 48^ALA

0.0.0.0

binding
catalytic activity

metabolic process

2fugC

[pdb]

1.36359
0.00260646

308^GLN 320^SER 321^MET 323^ALA 324^VAL 329^LYS

1.6.99.5

NADH dehydrogenase (ubiquinone) activity
quinone binding
oxidoreductase activity
NADH dehydrogenase (quinone) activity
oxidoreductase activity
acting on NADH or NADPH
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
quinone binding
metal ion binding
oxidoreductase activity
iron ion binding
NADH dehydrogenase (quinone) activity
oxidoreductase activity
acting on NADH or NADPH
NADH dehydrogenase (ubiquinone) activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
quinone binding
metal ion binding
oxidoreductase activity
iron ion binding
NADH dehydrogenase (quinone) activity
NAD or NADH binding
oxidoreductase activity
acting on NADH or NADPH
FMN binding
NADH dehydrogenase (ubiquinone) activity
2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
quinone binding
metal ion binding
oxidoreductase activity
iron ion binding
NADH dehydrogenase (quinone) activity
NAD or NADH binding
electron carrier activity
4 iron
4 sulfur cluster binding
2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
quinone binding
metal ion binding
oxidoreductase activity
iron ion binding
NADH dehydrogenase (quinone) activity
molybdenum ion binding
oxidoreductase activity
acting on NADH or NADPH
electron carrier activity
NADH dehydrogenase (ubiquinone) activity
binding
quinone binding
oxidoreductase activity
NADH dehydrogenase (quinone) activity
iron ion binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
quinone binding
metal ion binding
oxidoreductase activity
NADH dehydrogenase (quinone) activity
oxidoreductase activity
acting on NADH or NADPH
electron carrier activity
quinone binding
oxidoreductase activity
NADH dehydrogenase (quinone) activity
NAD or NADH binding
oxidoreductase activity
acting on NADH or NADPH
electron carrier activity

oxidation reduction
transport
photosynthesis
light reaction
oxidation reduction
photosynthesis
light reaction
oxidation reduction
oxidation reduction
oxidation reduction
ATP synthesis coupled electron transport
oxidation reduction
oxidation reduction
photosynthesis
light reaction
oxidation reduction
transport
photosynthesis
light reaction

plasma membrane
membrane
plasma membrane
membrane
plasma membrane
membrane
plasma membrane
membrane
plasma membrane
membrane
plasma membrane
membrane
plasma membrane
membrane
plasma membrane
membrane

1v19A

[pdb]

1.3654
0.00260673

9^GLU 58^GLU 86^THR 108^SER 111^SER 113^LEU

0.0.0.0

D-ribose metabolic process
D-ribose metabolic process

kinase activity
ribokinase activity
kinase activity
ribokinase activity
transferase activity

1mzhB

[pdb]

1.36805
0.00274975

1169^THR 1170^SER 1175^GLU 1207^GLU 1210^GLU 1213^ARG

4.1.2.4

cytoplasm

deoxyribonucleotide catabolic process
metabolic process
carbohydrate catabolic process

lyase activity
deoxyribose-phosphate aldolase activity
catalytic activity

1rtrA

[pdb]

1.3696
0.00274999

182^LEU 204^GLU 207^SER 265^ALA 268^GLU 278^THR

0.0.0.0

isoprenoid biosynthetic process

transferase activity

1v93A

[pdb]

1.37236
0.0027504

18^GLU 34^THR 36^GLU 37^GLU 42^ARG 277^SER

0.0.0.0

oxidation reduction
methionine metabolic process

oxidoreductase activity
methylenetetrahydrofolate reductase (NADPH) activity

2opwA

[pdb]

1.37298
0.0027505

54^SER 55^THR 57^GLU 58^GLU 62^ARG 88^GLU

metal ion binding
oxidoreductase activity
acting on single donors with incorporation of molecular oxygen
incorporation of two atoms of oxygen
oxidoreductase activity
iron ion binding

oxidation reduction

2htmA

[pdb]

1.37372
0.00290103

73^HOH 75^HOH 77^HOH 78^HOH 84^HOH 98^GLU

catalytic activity

cytoplasm

thiamin biosynthetic process
metabolic process
sulfur metabolic process

3dorB

[pdb]

1.3756
0.00290132

171^THR 172^ALA 174^GLU 175^GLU 180^ARG 521^THR

proteolysis

serine-type peptidase activity

2hmvA

[pdb]

1.37708
0.00290156

57^ALA 58^THR 60^GLU 62^GLU 64^LEU 89^THR

plasma membrane
membrane

potassium ion binding
cation transmembrane transporter activity
binding
catalytic activity

transport
ion transport
metabolic process
potassium ion transport

2e8gA

[pdb]

1.37729
0.0029016

23^THR 92^LEU 101^GLU 104^GLU 105^GLU 108^ALA

0.0.0.0

tRNA binding

2z6mK

[pdb]

1.37841
0.00290177

27^GLU 30^ALA 31^SER 56^LEU 62^GLU 107^GLU

1.16.3.1

intracellular ferritin complex

metal ion binding
oxidoreductase activity
iron ion binding
ferroxidase activity
transition metal ion binding
ferric iron binding
binding
protein binding

negative regulation of cell proliferation
immune response
oxidation reduction
cellular iron ion homeostasis
cell proliferation
intracellular sequestering of iron ion
iron ion transport

2j6eB

[pdb]

1.38192
0.00306095

380^GLU 382^GLU 393^THR 424^SER 426^SER 441^LEU

antigen binding
protein binding

immune response

membrane fraction
extracellular region

1keeE

[pdb]

1.38472
0.00306143

217^THR 233^PRO 235^GLY 253^THR 255^ILE 265^VAL

6.3.5.5

cellular amino acid biosynthetic process
glutamine metabolic process
arginine biosynthetic process
pyrimidine nucleotide biosynthetic process
biosynthetic process
nitrogen compound metabolic process
cellular amino acid biosynthetic process
glutamine metabolic process
arginine biosynthetic process
pyrimidine nucleotide biosynthetic process
biosynthetic process
nitrogen compound metabolic process
cellular amino acid biosynthetic process
arginine biosynthetic process
pyrimidine nucleotide biosynthetic process
metabolic process
nitrogen compound metabolic process

cytosol

ligase activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
carbamoyl-phosphate synthase activity
catalytic activity
ATP binding
ligase activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
carbamoyl-phosphate synthase activity
catalytic activity
protein binding
ATP binding
metal ion binding
manganese ion binding
ligase activity
ATP binding
nucleotide binding
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
carbamoyl-phosphate synthase activity
catalytic activity
protein binding
nucleotide binding
nucleotide binding

1vdxA

[pdb]

1.38603
0.00306165

43^LEU 56^GLU 106^GLU 108^GLU 110^GLU 112^ALA

2'-5'-RNA ligase activity
catalytic activity

RNA metabolic process

intracellular

2yv5A

[pdb]

1.38622
0.00306168

179^SER 183^SER 185^LEU 188^GLU 189^GLU 223^THR

metal ion binding
hydrolase activity
zinc ion binding
GTP binding
nucleotide binding
GTPase activity
metal ion binding
hydrolase activity
zinc ion binding
GTP binding
nucleotide binding
GTPase activity

1wa3C

[pdb]

1.39024
0.00322967

16^LEU 20^SER 22^GLU 23^GLU 26^GLU 50^THR

0.0.0.0

catalytic activity

metabolic process

3buuA

[pdb]

1.39229
0.00323004

62^THR 126^THR 199^LEU 222^GLU 229^GLU 231^SER

0.0.0.0

1p3wA

[pdb]

1.39298
0.00323016

309^GLU 313^LEU 334^GLU 347^GLU 349^ALA 351^SER

2.8.1.7

cytoplasm

tRNA processing
metabolic process
cysteine metabolic process

transferase activity
cysteine desulfurase activity
pyridoxal phosphate binding
catalytic activity
protein binding

3bcvB

[pdb]

1.39433
0.00340692

8^SER 83^ALA 84^THR 86^GLU 177^LEU 184^GLU

0.0.0.0

transferase activity

1htaA

[pdb]

1.39488
0.00340703

32^LEU 37^GLU 38^GLU 40^ALA 42^GLU 61^GLU

DNA binding
sequence-specific DNA binding

intracellular

1z3iX

[pdb]

1.39674
0.00340738

618^THR 622^GLU 623^GLU 658^LEU 663^GLU 667^SER

0.0.0.0

DNA-dependent ATPase activity
ATP binding
helicase activity
DNA binding
nucleic acid binding

1c0lA

[pdb]

1.40395
0.00359511

1066^ARG 1071^GLU 1072^GLU 1074^THR 1341^SER 1346^GLU

1.4.3.3

oxidation reduction
metabolic process

oxidoreductase activity
D-amino-acid oxidase activity
binding
catalytic activity

peroxisome

1o8rA

[pdb]

1.40452
0.00359522

13^GLU 36^ALA 70^LEU 74^GLU 75^GLU 78^GLU

extracellular region

hormone activity
guanylate cyclase activator activity
enzyme activator activity

signal transduction

3bksA

[pdb]

1.40628
0.00359557

43^SER 46^LEU 55^GLU 57^GLU 59^ALA 63^THR

0.0.0.0

1i6bA

[pdb]

1.40838
0.00379282

354^GLU 375^SER 376^THR 378^GLU 379^GLU 383^LEU

cytoplasm
extracellular region

iron ion transport
ion transport
transport
cellular iron ion homeostasis

metal ion binding
hydrolase activity
serine-type peptidase activity
peptidase activity
iron ion binding
ferric iron binding

2dfaA

[pdb]

1.40995
0.00379315

124^THR 144^LEU 150^GLU 151^GLU 152^GLU 153^ALA

1xesA

[pdb]

1.41148
0.00379347

108^LEU 134^SER 135^THR 137^THR 194^SER 195^GLU

cytoplasm

response to stress
biosynthetic process
metabolic process

transferase activity
acyltransferase activity
transferase activity
transferring acyl groups other than amino-acyl groups
catalytic activity

2qk1A

[pdb]

1.41175
0.00379352

520^THR 527^ALA 550^ARG 554^GLU 555^GLU 556^THR

microtubule binding
structural constituent of cytoskeleton
binding
protein binding
identical protein binding

mitotic spindle organization in nucleus
microtubule nucleation

spindle
microtubule
nucleus
cell cortex
spindle microtubule
spindle pole body
condensed nuclear chromosome kinetochore
kinetochore

2ch1D

[pdb]

1.41258
0.0037937

90^LEU 108^ALA 110^GLU 112^SER 113^GLU 121^THR

0.0.0.0

metabolic process

pyridoxal phosphate binding
catalytic activity

1o12B

[pdb]

1.41607
0.00400243

153^ALA 155^GLU 157^GLU 159^SER 161^LEU 183^GLU

0.0.0.0

N-acetylglucosamine metabolic process

N-acetylglucosamine-6-phosphate deacetylase activity
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity

2hj9B

[pdb]

1.42043
0.0040034

182^VAL 184^GLY 186^SER 188^ASN 215^ALA 307^HOH

hydrolase activity
transferase activity
kinase activity
phosphoprotein phosphatase activity
protein histidine kinase activity
transferase activity
transferring phosphorus-containing groups
ATP binding
signal transducer activity
two-component response regulator activity
two-component sensor activity
protein binding
protein binding
nucleotide binding

plasma membrane
integral to membrane
membrane
periplasmic space

two-component signal transduction system (phosphorelay)
peptidyl-histidine phosphorylation
phosphorylation
signal transduction
regulation of transcription
DNA-dependent

1f00I

[pdb]

1.42279
0.00422384

668^THR 670^ALA 679^THR 702^LEU 747^GLU 749^GLU

binding
protein binding

cell outer membrane
integral to membrane
membrane
plasma membrane
cell surface

pathogenesis
cell wall macromolecule catabolic process
cell adhesion

1s1hK

[pdb]

1.42602
0.00422459

25^SER 53^PRO 55^GLY 59^LYS 85^ILE 89^MET

SSU rRNA binding
SSU rRNA binding
structural constituent of ribosome
mRNA binding
protein binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
ribonucleoprotein binding
rRNA binding
GTP binding
translation elongation factor activity
RNA binding
nucleotide binding
GTPase activity
protein binding
structural constituent of ribosome
structural constituent of ribosome
metal ion binding
zinc ion binding
structural constituent of ribosome
protein binding
structural constituent of ribosome
structural constituent of ribosome
protein binding
structural constituent of ribosome
RNA binding
rRNA binding
RNA binding
structural constituent of ribosome
rRNA binding
RNA binding
structural constituent of ribosome
nucleic acid binding
RNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
structural constituent of ribosome
protein binding
fibroblast growth factor 3 binding
rRNA binding
structural constituent of ribosome
RNA binding
DNA binding
structural constituent of ribosome
rRNA binding
structural constituent of ribosome
structural constituent of ribosome

nucleolus
nucleolus
nucleolus
cytoplasm
ribonucleoprotein complex
ribosome
nucleus
small-subunit processome
90S preribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribosome
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
small ribosomal subunit
ribosome
intracellular
cytoplasm
ribonucleoprotein complex
cytosolic small ribosomal subunit
cytoplasm
ribonucleoprotein complex
ribosome
nucleus
small-subunit processome
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
cytosolic small ribosomal subunit
mitochondrion
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
preribosome
small subunit precursor
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
nucleus
small-subunit processome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
intracellular
cytoplasm
ribonucleoprotein complex
ribosome
90S preribosome
cytosolic small ribosomal subunit
intracellular

ribosome biogenesis
rRNA processing
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
ribosomal small subunit assembly
translation
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
ribosomal small subunit assembly
translation
translational elongation
ribosome biogenesis
translation
rRNA export from nucleus
translation
translation
regulation of translational fidelity
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
translation
rRNA export from nucleus
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
ribosome biogenesis
rRNA processing
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
rRNA export from nucleus
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
rRNA export from nucleus
ribosome biogenesis
rRNA processing
positive regulation of translational fidelity
rRNA export from nucleus
translation
translation
rRNA export from nucleus
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA
5.8S rRNA
LSU-rRNA)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
ribosomal small subunit assembly
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)
translation
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA
LSU-rRNA)