The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
1zviA	[pdb]	0.186666 0.000111301	415^CYS 567^VAL 587^TRP 588^TYR 592^GLU 597^ASP	1.14.13.39	aging regulation of heart contraction response to heat response to organic nitrogen response to organic cyclic substance response to vitamin E response to estrogen stimulus response to ethanol negative regulation of blood pressure negative regulation of heart contraction positive regulation of vasodilation negative regulation of insulin secretion regulation of sensory perception of pain oxidation reduction nitric oxide biosynthetic process arginine catabolic process response to hypoxia	enzyme binding protein homodimerization activity protein binding metal ion binding oxidoreductase activity calmodulin binding iron ion binding nitric-oxide synthase activity NADP or NADPH binding FAD binding heme binding FMN binding electron carrier activity cadmium ion binding amino acid binding	nucleus cytoplasm mitochondrial outer membrane cytosol dendrite nuclear membrane azurophil granule dendritic spine synapse cell projection membrane plasma membrane mitochondrion sarcolemma perinuclear region of cytoplasm photoreceptor inner segment
3e6nA	[pdb]	0.201589 0.000129253	194^CYS 346^VAL 366^TRP 367^TYR 371^GLU 376^ASP	1.14.13.39	cytosol perinuclear region of cytoplasm cortical cytoskeleton cytoplasm peroxisome nucleus	defense response to bacterium superoxide metabolic process inflammatory response oxidation reduction regulation of cell proliferation nitric oxide biosynthetic process response to hypoxia ovulation from ovarian follicle defense response to Gram-negative bacterium retinoic acid receptor signaling pathway regulation of blood pressure regulation of heart contraction protein kinase cascade G-protein signaling coupled to cGMP nucleotide second messenger signal transduction blood vessel remodeling endothelial cell proliferation arginine catabolic process	protein binding calmodulin binding metal ion binding oxidoreductase activity zinc ion binding iron ion binding nitric-oxide synthase activity protein homodimerization activity NADP or NADPH binding FAD binding heme binding FMN binding electron carrier activity cAMP-dependent protein kinase regulator activity tetrahydrobiopterin binding arginine binding
1d1xB	[pdb]	0.23573 0.000177126	186^CYS 338^VAL 358^TRP 359^TYR 363^GLU 368^ASN	1.14.13.39	Golgi apparatus membrane plasma membrane cytoskeleton cytoplasm caveola	metal ion binding oxidoreductase activity zinc ion binding calmodulin binding calcium ion binding iron ion binding nitric-oxide synthase activity NADP or NADPH binding FAD binding heme binding FMN binding electron carrier activity	mitochondrion organization arginine catabolic process oxidation reduction blood coagulation nitric oxide biosynthetic process positive regulation of guanylate cyclase activity anti-apoptosis angiogenesis ovulation from ovarian follicle blood vessel remodeling regulation of sodium ion transport negative regulation of muscle hyperplasia smooth muscle hyperplasia lung development lipopolysaccharide-mediated signaling pathway negative regulation of potassium ion transport positive regulation of angiogenesis regulation of blood vessel size negative regulation of hydrolase activity negative regulation of calcium ion transport
3ej8A	[pdb]	0.264228 0.000216297	200^CYS 352^VAL 372^TRP 373^TYR 377^GLU 382^ASP	1.14.13.39	defense response to bacterium superoxide metabolic process oxidation reduction nitric oxide biosynthetic process regulation of insulin secretion arginine catabolic process defense response to Gram-negative bacterium innate immune response in mucosa positive regulation of killing of cells of another organism regulation of cellular respiration positive regulation of leukocyte mediated cytotoxicity response to hypoxia endothelial cell proliferation blood vessel remodeling signal transduction G-protein signaling coupled to cGMP nucleotide second messenger protein kinase cascade regulation of heart contraction regulation of blood pressure regulation of cell proliferation retinoic acid receptor signaling pathway	nucleus cytoplasm cytosol intracellular peroxisome cortical cytoskeleton perinuclear region of cytoplasm	protein binding metal ion binding oxidoreductase activity zinc ion binding calmodulin binding calcium ion binding iron ion binding nitric-oxide synthase activity NADP or NADPH binding FAD binding heme binding FMN binding electron carrier activity tetrahydrobiopterin binding protein homodimerization activity arginine binding cAMP-dependent protein kinase regulator activity
1m9jB	[pdb]	0.265419 0.000216309	184^CYS 336^VAL 356^TRP 357^TYR 361^GLU 366^ASN	1.14.13.39	Golgi apparatus membrane plasma membrane cytoskeleton cytoplasm cytosol Golgi membrane apical part of cell nucleus caveola soluble fraction	oxidation reduction nitric oxide biosynthetic process negative regulation of calcium ion transport negative regulation of hydrolase activity negative regulation of smooth muscle cell proliferation negative regulation of potassium ion transport lung development learning signal transduction regulation of sodium ion transport ovulation from ovarian follicle angiogenesis mitochondrion organization positive regulation of guanylate cyclase activity anti-apoptosis positive regulation of angiogenesis arginine catabolic process endothelial cell migration regulation of systemic arterial blood pressure by endothelin response to fluid shear stress regulation of blood vessel size smooth muscle hyperplasia negative regulation of muscle hyperplasia negative regulation of cell proliferation blood vessel remodeling negative regulation of platelet activation regulation of blood pressure response to heat positive regulation of vasodilation lipopolysaccharide-mediated signaling pathway	protein binding metal ion binding oxidoreductase activity zinc ion binding calmodulin binding iron ion binding nitric-oxide synthase activity NADP or NADPH binding FAD binding heme binding FMN binding electron carrier activity actin monomer binding cadmium ion binding tetrahydrobiopterin binding arginine binding calcium ion binding
1zsoA	[pdb]	1.2631 0.000437108	11^GLU 91^ASN 117^VAL 135^TRP 145^CYS 149^TYR	0.0.0.0
2yxmA	[pdb]	1.28303 0.000446027	29^VAL 41^TRP 42^TYR 75^ASP 77^GLU 87^CYS		cell adhesion striated muscle contraction	protein binding actin binding structural constituent of muscle titin binding	striated muscle thick filament myofibril
1m80B	[pdb]	1.49812 0.000663965	104^TRP 127^CYS 242^VAL 336^TYR 341^GLU 344^ASP	2.7.3.3	arginine kinase activity transferase activity kinase activity ATP binding nucleotide binding transferase activity transferring phosphorus-containing groups catalytic activity	cytoplasm	phosphorylation
1bdgA	[pdb]	1.51149 0.000693902	261^TRP 264^PHE 269^GLU 271^ASP 297^VAL 392^CYS	2.7.1.1		glycolysis carbohydrate metabolic process	transferase activity kinase activity ATP binding nucleotide binding hexokinase activity phosphotransferase activity alcohol group as acceptor
1yb0A	[pdb]	1.53459 0.00074554	105^GLU 107^ASN 126^VAL 137^CYS 147^TRP 150^PHE	0.0.0.0		N-acetylmuramoyl-L-alanine amidase activity	peptidoglycan catabolic process
1gv4B	[pdb]	1.58041 0.000896952	425^GLU 440^CYS 458^VAL 467^ASN 475^TYR 476^TRP	0.0.0.0	apoptotic chromosome condensation neuron apoptosis oxidation reduction apoptosis apoptotic mitochondrial changes DNA fragmentation involved in apoptosis cell redox homeostasis	electron carrier activity oxidoreductase activity DNA binding electron-transferring-flavoprotein dehydrogenase activity FAD binding	mitochondrial intermembrane space nucleus mitochondrion cytosol microsome mitochondrial outer membrane cytoplasm soluble fraction
1m6iA	[pdb]	1.58202 0.000896994	426^GLU 441^CYS 459^VAL 468^ASN 476^TYR 477^TRP	0.0.0.0	mitochondrial intermembrane space nucleus mitochondrion cytoplasm microsome soluble fraction	oxidation reduction apoptosis DNA fragmentation involved in apoptosis DNA damage response signal transduction resulting in induction of apoptosis cell redox homeostasis apoptotic chromosome condensation	oxidoreductase activity DNA binding electron carrier activity FAD binding protein binding
1qf9A	[pdb]	1.62171 0.00103762	9^VAL 23^CYS 30^PHE 32^TRP 186^GLU 187^ASN	2.7.4.14		pyrimidine nucleotide biosynthetic process nucleobase nucleoside nucleotide and nucleic acid metabolic process	transferase activity kinase activity ATP binding nucleotide binding cytidylate kinase activity nucleobase nucleoside nucleotide kinase activity nucleotide kinase activity phosphotransferase activity phosphate group as acceptor
1arcA	[pdb]	1.62798 0.00106898	9^ASP 25^VAL 36^CYS 73^TRP 75^TYR 154^GLU	3.4.21.50	extracellular region	hydrolase activity serine-type peptidase activity peptidase activity serine-type endopeptidase activity catalytic activity	proteolysis
1j0tA	[pdb]	1.63252 0.00110167	20^VAL 27^CYS 49^TRP 50^PHE 60^GLU 61^ASP		extracellular region	hormone activity neuropeptide hormone activity	neuropeptide signaling pathway
2bo6B	[pdb]	1.63922 0.00113589	233^CYS 324^VAL 335^ASP 337^GLU 341^PHE 344^TRP	0.0.0.0
1yvjA	[pdb]	1.66418 0.00124819	946^VAL 993^TRP 994^TYR 997^GLU 1001^ASP 1077^CYS	2.7.10.2	endomembrane system membrane cytoskeleton	enzyme linked receptor protein signaling pathway protein kinase cascade peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter protein amino acid phosphorylation	transferase activity kinase activity ATP binding protein tyrosine kinase activity nucleotide binding non-membrane spanning protein tyrosine kinase activity protein binding Janus kinase activity protein kinase activity
1ia6A	[pdb]	1.70064 0.00146453	76^TRP 79^TYR 83^GLU 86^ASP 321^CYS 422^VAL	0.0.0.0		carbohydrate metabolic process polysaccharide catabolic process	hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
2iqfA	[pdb]	1.70243 0.00151296	89^GLU 117^TYR 124^TRP 300^ASN 356^VAL 361^CYS	1.11.1.6	cytoplasm	oxidation reduction response to oxidative stress oxidation reduction hydrogen peroxide catabolic process response to oxidative stress hydrogen peroxide catabolic process	oxidoreductase activity peroxidase activity catalase activity heme binding iron ion binding metal ion binding oxidoreductase activity iron ion binding peroxidase activity catalase activity heme binding metal ion binding
1bbpD	[pdb]	1.71369 0.00156408	30^VAL 35^ASN 38^GLU 45^TRP 60^TYR 175^CYS	0.0.0.0	extracellular region	pigment binding binding transporter activity	protein-chromophore linkage transport
1fg9D	[pdb]	1.71875 0.0016172	21^GLU 30^TYR 31^TRP 68^CYS 83^VAL 107^ASP		membrane integral to membrane integral to plasma membrane extracellular region extracellular space	receptor activity interferon-gamma receptor activity cytokine binding cytokine activity interferon-gamma receptor binding	response to virus signal transduction positive regulation of smooth muscle cell apoptosis cell cycle arrest protein import into nucleus translocation tyrosine phosphorylation of Stat1 protein positive regulation of interleukin-12 production response to virus regulation of cell growth cell surface receptor linked signal transduction cell motion immune response regulation of immune response positive regulation of interleukin-1 beta secretion positive regulation of isotype switching to IgG isotypes positive regulation of transcription DNA-dependent regulation of transcription positive regulation of interleukin-6 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interleukin-12 biosynthetic process positive regulation of chemokine biosynthetic process defense response to bacterium negative regulation of myelination endoplasmic reticulum unfolded protein response neutrophil chemotaxis antigen processing and presentation inflammatory cell apoptosis neutrophil apoptosis positive regulation of membrane protein ectodomain proteolysis positive regulation of killing of cells of another organism regulation of insulin secretion positive regulation of nitric oxide biosynthetic process negative regulation of smooth muscle cell proliferation positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity positive regulation of fructose 1,6-bisphosphate metabolic process positive regulation of peptidyl-serine phosphorylation of STAT protein regulation of growth positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1-monooxygenase activity
2r6hD	[pdb]	1.74073 0.00179206	283^TYR 313^TRP 377^ASP 379^GLU 383^CYS 392^VAL	0.0.0.0	2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding sodium ion binding oxidoreductase activity iron ion binding oxidoreductase activity acting on NADH or NADPH quinone or similar compound as acceptor electron carrier activity	oxidation reduction sodium ion transport ion transport transport	plasma membrane membrane integral to membrane Gram-negative-bacterium-type cell wall
1vkwA	[pdb]	1.74614 0.00185424	121^PHE 123^GLU 125^ASP 137^VAL 152^TRP 162^CYS	0.0.0.0			oxidoreductase activity
1nw7A	[pdb]	1.76935 0.00205441	57^ASP 64^CYS 93^GLU 161^TRP 162^PHE 236^VAL	2.1.1.72		DNA restriction-modification system methylation DNA methylation	transferase activity methyltransferase activity site-specific DNA-methyltransferase (adenine-specific) activity N-methyltransferase activity DNA binding nucleic acid binding
2ivfC	[pdb]	1.77873 0.0021274	118^TRP 119^TYR 125^ASN 126^GLU 162^VAL 165^CYS	0.0.0.0	iron-sulfur cluster binding electron carrier activity metal ion binding molybdenum ion binding oxidoreductase activity binding heme binding	oxidation reduction oxidation reduction	periplasmic space
1e8iA	[pdb]	1.78557 0.00220347	122^VAL 140^GLU 173^CYS 178^ASN 191^TYR 192^TRP	0.0.0.0		integral to membrane membrane integral to plasma membrane external side of plasma membrane	sugar binding transmembrane receptor activity binding calcium ion binding
2rgkC	[pdb]	1.79185 0.00228288	154^CYS 203^VAL 217^ASN 218^GLU 220^PHE 224^TRP			isomerase activity mannose-6-phosphate isomerase activity catalytic activity	mannose metabolic process
2ditA	[pdb]	1.7992 0.00236588	37^ASN 38^GLU 47^CYS 66^VAL 88^TRP 89^PHE		RNA binding RNA polymerase II transcription factor activity transcription elongation regulator activity nucleic acid binding nucleotide binding protein binding	nucleolus nucleus	regulation of transcription regulation of transcription DNA-dependent transcription viral genome replication regulation of transcription from RNA polymerase II promoter
2afaD	[pdb]	1.8057 0.00245244	156^CYS 205^VAL 219^ASN 220^GLU 222^PHE 226^TRP	0.0.0.0		isomerase activity mannose-6-phosphate isomerase activity catalytic activity	mannose metabolic process
1dnpB	[pdb]	1.81018 0.00254256	6^TRP 34^TYR 76^GLU 78^ASP 91^CYS 116^VAL	4.1.99.3		lyase activity DNA binding nucleotide binding deoxyribodipyrimidine photo-lyase activity DNA photolyase activity protein binding	protein-chromophore linkage response to DNA damage stimulus DNA repair
1umrB	[pdb]	1.81865 0.00263498	20^ASN 21^GLU 30^TRP 31^PHE 42^VAL 121^CYS	0.0.0.0		extracellular region extracellular region	sugar binding binding sugar binding binding
1d2fB	[pdb]	1.82256 0.00263534	147^TRP 148^PHE 169^CYS 178^VAL 182^ASP 183^GLU	4.4.1.8		lyase activity cystathionine beta-lyase activity pyridoxal phosphate binding transferase activity transferring nitrogenous groups catalytic activity	regulation of transcription DNA-dependent transcription biosynthetic process cellular amino acid biosynthetic process methionine biosynthetic process regulation of transcription
1zoxA	[pdb]	1.82267 0.00263536	9^GLU 22^CYS 62^VAL 88^TYR 89^TRP 106^ASN	0.0.0.0	immune response osteoclast differentiation	plasma membrane integral to membrane membrane	receptor activity protein binding
1vjzA	[pdb]	1.82531 0.00272921	8^TRP 82^CYS 182^ASN 194^VAL 259^GLU 289^PHE	0.0.0.0		carbohydrate metabolic process	cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
3ebgA	[pdb]	1.82673 0.00272935	512^TRP 513^PHE 566^GLU 579^VAL 617^CYS 680^ASN	0.0.0.0	aminopeptidase activity metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity	cytoplasm	proteolysis
1z72A	[pdb]	1.83215 0.00282747	68^CYS 143^VAL 180^TRP 183^PHE 187^GLU 189^ASN	0.0.0.0
2yu9J	[pdb]	1.83315 0.00282757	18^LYS 21^ILE 31^CYS 32^ALA 46^VAL 54^ARG		metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding magnesium ion binding protein binding ribonucleoside binding metal ion binding zinc ion binding DNA-directed RNA polymerase activity DNA binding protein binding protein binding protein binding protein binding metal ion binding zinc ion binding DNA-directed RNA polymerase activity DNA binding protein binding metal ion binding zinc ion binding DNA-directed RNA polymerase activity transcription regulator activity DNA binding nucleic acid binding protein binding DNA-directed RNA polymerase activity DNA binding protein binding metal ion binding zinc ion binding DNA-directed RNA polymerase activity protein dimerization activity DNA binding DNA-directed RNA polymerase activity protein dimerization activity DNA binding DNA-directed RNA polymerase activity DNA binding metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity magnesium ion binding DNA binding DNA-directed RNA polymerase activity protein binding	nucleus mitochondrion DNA-directed RNA polymerase II core complex DNA-directed RNA polymerase III complex nucleus DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II core complex nucleoplasm nucleolus nucleolus nucleus DNA-directed RNA polymerase I complex DNA-directed RNA polymerase II core complex nucleoplasm nucleus DNA-directed RNA polymerase II core complex nucleus DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II core complex nucleoplasm nucleus DNA-directed RNA polymerase II core complex nucleoplasm nucleus DNA-directed RNA polymerase II core complex cytoplasm nucleus DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II core complex nucleoplasm RNA polymerase complex nucleus mitochondrion DNA-directed RNA polymerase II core complex nucleus DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II core complex nucleoplasm	transcription transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription RNA elongation from RNA polymerase II promoter transcription transcription from RNA polymerase II promoter regulation of transcription response to DNA damage stimulus transcription DNA repair response to drug transcription from RNA polymerase II promoter transcription-coupled nucleotide-excision repair regulation of transcription transcription transcription from RNA polymerase II promoter transcription transcription from RNA polymerase II promoter transcription transcription from RNA polymerase II promoter transcription transcription from RNA polymerase II promoter transcription DNA-dependent transcription transcription from RNA polymerase II promoter transcription transcription from RNA polymerase II promoter
2e6pA	[pdb]	1.83547 0.00282781	32^CYS 43^TRP 44^TYR 58^VAL 76^ASP 79^GLU		cardiac myofibril assembly cytoskeleton organization	cytoskeletal adaptor activity	perinuclear region of cytoplasm M band Z disc intercalated disc
1f97A	[pdb]	1.8367 0.00282794	49^CYS 61^TRP 63^PHE 86^VAL 103^ASN 105^GLU		interspecies interaction between organisms epithelial cell differentiation cell adhesion	plasma membrane cell junction integral to membrane membrane tight junction	protein binding
2qqkH	[pdb]	1.84034 0.00293002	2^ILE 22^THR 95^LEU 96^PRO 102^THR 103^LYS		cell differentiation nervous system development multicellular organismal development axon guidance cell adhesion immune response immune response	membrane integral to membrane plasma membrane membrane fraction extracellular region membrane fraction extracellular region	receptor activity vascular endothelial growth factor receptor activity antigen binding protein binding antigen binding protein binding
1mhzD	[pdb]	1.8459 0.00303659	187^VAL 196^ASP 199^GLU 211^CYS 275^PHE 276^TRP	1.14.13.25		oxidation reduction one-carbon metabolic process methane metabolic process oxidation reduction one-carbon metabolic process cellular aromatic compound metabolic process oxidation reduction one-carbon metabolic process cellular aromatic compound metabolic process	oxidoreductase activity monooxygenase activity methane monooxygenase activity monooxygenase activity metal ion binding oxidoreductase activity iron ion binding methane monooxygenase activity transition metal ion binding oxidoreductase activity monooxygenase activity methane monooxygenase activity transition metal ion binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen NADH or NADPH as one donor and incorporation of one atom of oxygen
2ywmD	[pdb]	1.8686 0.00338406	151^CYS 159^TRP 161^PHE 194^VAL 208^GLU 209^ASN	0.0.0.0
1jwoA	[pdb]	1.87838 0.00350959	122^TRP 123^PHE 148^GLU 155^ASP 159^CYS 193^VAL	2.7.10.2	cytoplasm nucleus	protein amino acid phosphorylation positive regulation of cell proliferation cell proliferation mesoderm development signal transduction	transferase activity kinase activity ATP binding protein tyrosine kinase activity nucleotide binding non-membrane spanning protein tyrosine kinase activity protein binding protein kinase activity
2pa5A	[pdb]	1.87942 0.00350972	380^GLU 381^ASN 390^VAL 415^TYR 416^TRP 515^CYS	3.1.3.48	cytoplasm	hydrolase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity phosphatase activity protein binding	protein amino acid dephosphorylation dephosphorylation
1kirB	[pdb]	1.88225 0.00363921	2^VAL 22^GLY 98^ILE 100^SER 105^MET 106^ASN		defense response to bacterium cytolysis metabolic process cell wall macromolecule catabolic process	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity catalytic activity lysozyme activity
1qgc4	[pdb]	1.88739 0.0036399	220^VAL 240^CYS 318^GLU 319^ASP 325^PHE 328^TRP		cytoplasmic vesicle viral capsid virion membrane cytoplasm icosahedral viral capsid cytoplasm cytoplasmic vesicle viral capsid virion membrane cytoplasm cytoplasmic vesicle viral capsid virion membrane icosahedral viral capsid host cell cytoplasm host cell cytoplasm	hydrolase activity nucleotidyltransferase activity transferase activity cysteine-type peptidase activity peptidase activity ATP binding structural molecule activity helicase activity RNA-directed RNA polymerase activity RNA binding nucleotide binding cysteine-type endopeptidase activity catalytic activity RNA helicase activity hydrolase activity nucleotidyltransferase activity transferase activity cysteine-type peptidase activity peptidase activity structural molecule activity RNA-directed RNA polymerase activity RNA binding nucleotide binding cysteine-type endopeptidase activity catalytic activity hydrolase activity nucleotidyltransferase activity transferase activity cysteine-type peptidase activity peptidase activity structural molecule activity RNA-directed RNA polymerase activity RNA binding nucleotide binding cysteine-type endopeptidase activity	transcription RNA-dependent viral protein processing viral genome replication viral reproduction proteolysis transcription transcription RNA-dependent viral genome replication proteolysis transcription transcription RNA-dependent viral protein processing viral reproduction
1bvkE	[pdb]	1.89485 0.00377249	2^VAL 22^GLY 98^ILE 100^SER 105^MET 106^ASN		defense response to bacterium cytolysis metabolic process cell wall macromolecule catabolic process	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity catalytic activity lysozyme activity
1c5dH	[pdb]	1.89792 0.00390702	2^VAL 22^CYS 98^GLU 99^ASP 104^PHE 107^TRP				antigen binding antigen binding
2oo6A	[pdb]	1.90752 0.00404755	119^VAL 124^CYS 211^ASP 213^GLU 240^PHE 241^TRP	0.0.0.0		catalytic activity	metabolic process
2p0vA	[pdb]	1.9105 0.00404799	55^GLU 79^CYS 88^VAL 116^TRP 118^TYR 125^ASP	0.0.0.0			catalytic activity
1ukcA	[pdb]	1.91231 0.00419259	241^TRP 335^ASP 338^GLU 400^PHE 407^VAL 526^CYS	0.0.0.0			hydrolase activity
2preA	[pdb]	1.91352 0.00419277	116^GLU 117^ASN 129^VAL 168^TYR 169^TRP 196^CYS	0.0.0.0		hydrolase activity cysteine-type peptidase activity cysteine-type endopeptidase activity peptidase activity	proteolysis
1s2kA	[pdb]	1.91391 0.00419283	39^TRP 93^VAL 130^ASN 132^GLU 133^PHE 165^CYS	3.4.23.32		hydrolase activity peptidase activity aspartic-type endopeptidase activity	proteolysis
1eemA	[pdb]	1.9145 0.00419292	32^CYS 123^VAL 178^TRP 181^PHE 185^GLU 190^ASN	2.5.1.18	L-ascorbic acid biosynthetic process biological_process metabolic process	cytoplasm	glutathione transferase activity monodehydroascorbate reductase (NADH) activity transferase activity
1rrsA	[pdb]	1.9176 0.00419339	20^TRP 21^PHE 187^ASN 188^GLU 198^CYS 210^VAL	0.0.0.0	hydrolase activity acting on glycosyl bonds hydrolase activity 4 iron 4 sulfur cluster binding DNA N-glycosylase activity endonuclease activity catalytic activity DNA binding	intracellular	metabolic process DNA repair base-excision repair
2fo5D	[pdb]	1.9287 0.00449968	126^GLU 128^ASP 140^VAL 183^TYR 184^TRP 213^CYS	0.0.0.0		hydrolase activity peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activity	proteolysis
2z64A	[pdb]	1.93282 0.00466077	555^GLU 576^ASN 582^CYS 587^PHE 590^TRP 617^VAL		extracellular region extracellular space lipopolysaccharide receptor complex membrane integral to membrane intrinsic to membrane perinuclear region of cytoplasm integral to plasma membrane	immune response inflammatory response detection of lipopolysaccharide activation of innate immune response positive regulation of platelet activation detection of lipopolysaccharide positive regulation of interleukin-6 production positive regulation of stress-activated MAPK cascade positive regulation of interferon-beta biosynthetic process defense response to Gram-negative bacterium positive regulation of ERK1 and ERK2 cascade positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway mast cell activation activation of NF-kappaB-inducing kinase activity macrophage activation positive regulation of interleukin-6 biosynthetic process positive regulation of interleukin-13 biosynthetic process positive regulation of interleukin-1 biosynthetic process innate immune response immune response inflammatory response positive regulation of JNK cascade positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of tumor necrosis factor production interferon-gamma production response to lipopolysaccharide response to bacterium production of nitric oxide during acute inflammatory response signal transduction positive regulation of interleukin-8 biosynthetic process positive regulation of tumor necrosis factor biosynthetic process	protein binding lipopolysaccharide receptor activity lipopolysaccharide receptor activity receptor activity protein binding transmembrane receptor activity
2dgaA	[pdb]	1.93716 0.0046615	186^TRP 187^PHE 191^GLU 262^ASP 326^CYS 403^VAL	0.0.0.0		hydrolase activity acting on glycosyl bonds hydrolase activity beta-glucosidase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity	metabolic process carbohydrate metabolic process
2ai0M	[pdb]	1.94036 0.00482803	25^SER 30^ARG 39^GLN 58^THR 94^TYR 101^TRP	0.0.0.0
1z8hB	[pdb]	1.9418 0.00482827	35^CYS 81^VAL 196^GLU 197^ASN 204^TRP 205^PHE	0.0.0.0		hydrolase activity acting on ester bonds hydrolase activity	lipid metabolic process
1dbiA	[pdb]	1.94355 0.00482858	137^CYS 145^GLU 149^ASN 159^VAL 176^TYR 200^TRP		extracellular region	metal ion binding hydrolase activity serine-type peptidase activity peptidase activity calcium ion binding serine-type endopeptidase activity	proteolysis
2cagA	[pdb]	1.9512 0.00500156	87^GLU 115^PHE 122^TRP 298^ASN 354^VAL 359^CYS	1.11.1.6	cytoplasm	metal ion binding oxidoreductase activity iron ion binding peroxidase activity catalase activity heme binding	oxidation reduction hydrogen peroxide catabolic process response to oxidative stress
1pg7X	[pdb]	1.95297 0.00500187	2^VAL 22^CYS 95^GLU 96^ASP 102^TYR 103^TRP				antigen binding
2q4aB	[pdb]	1.95457 0.00517952	156^TYR 157^GLU 161^ASP 247^TRP 282^VAL 293^CYS		metal ion binding oxidoreductase activity iron ion binding electron carrier activity	nucleus	oxidation reduction
1tuoA	[pdb]	1.95613 0.00517981	253^ASP 293^VAL 315^PHE 317^TRP 327^CYS 345^GLU	0.0.0.0		carbohydrate metabolic process	intramolecular transferase activity phosphotransferases
1k9aE	[pdb]	1.96164 0.005364	82^TRP 83^PHE 108^GLU 115^ASP 119^CYS 153^VAL	2.7.10.2	cell-cell junction plasma membrane cytoplasm membrane	negative regulation of cell proliferation protein amino acid phosphorylation	transferase activity kinase activity ATP binding protein tyrosine kinase activity nucleotide binding non-membrane spanning protein tyrosine kinase activity protein binding protein kinase activity
2eefA	[pdb]	1.9654 0.00536471	54^VAL 80^CYS 118^GLU 120^ASN 124^TYR 125^TRP				glycogen metabolic process carbohydrate metabolic process
2vtcB	[pdb]	1.97047 0.00555179	4^VAL 37^TRP 38^TYR 40^GLU 43^ASP 59^CYS	3.2.1.4	calcium ion binding cellulase activity hydrolase activity hydrolase activity acting on glycosyl bonds metal ion binding	extracellular region	polysaccharide catabolic process carbohydrate metabolic process metabolic process cellulose catabolic process
1bapA	[pdb]	1.97177 0.00555204	14^GLU 17^PHE 21^TRP 64^CYS 235^ASP 258^VAL	0.0.0.0	carbohydrate transport transport	periplasmic space	sugar:hydrogen symporter activity
2h00B	[pdb]	1.97579 0.00574192	53^GLU 54^ASP 143^PHE 207^TRP 210^CYS 233^VAL				transferase activity methyltransferase activity
1fz5B	[pdb]	1.97798 0.00574235	187^HOH 196^HOH 199^HOH 211^HOH 275^ASN 276^LEU	1.14.13.25		iron ion binding monooxygenase activity methane monooxygenase activity transition metal ion binding metal ion binding oxidoreductase activity oxidoreductase activity monooxygenase activity methane monooxygenase activity oxidoreductase activity monooxygenase activity methane monooxygenase activity transition metal ion binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen NADH or NADPH as one donor and incorporation of one atom of oxygen	one-carbon metabolic process cellular aromatic compound metabolic process oxidation reduction oxidation reduction one-carbon metabolic process methane metabolic process oxidation reduction one-carbon metabolic process cellular aromatic compound metabolic process
2dw7D	[pdb]	1.9782 0.00574239	181^VAL 215^ASN 237^TRP 238^TYR 240^GLU 319^CYS	0.0.0.0		catalytic activity	metabolic process
2qjkO	[pdb]	1.98303 0.00593844	97^ASN 124^VAL 134^CYS 147^TRP 156^TYR 169^GLU	1.10.2.2	2 iron 2 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity ubiquinol-cytochrome-c reductase activity electron carrier activity iron ion binding metal ion binding iron ion binding oxidoreductase activity electron carrier activity metal ion binding iron ion binding heme binding electron carrier activity heme binding electron carrier activity iron ion binding oxidoreductase activity acting on diphenols and related substances as donors	oxidation reduction electron transport chain transport electron transport chain transport respiratory electron transport chain electron transport chain transport	plasma membrane integral to membrane membrane plasma membrane integral to membrane membrane mitochondrial respiratory chain plasma membrane integral to membrane membrane mitochondrial respiratory chain respiratory chain respiratory chain
1elpA	[pdb]	1.9837 0.00593857	7^GLU 8^ASP 37^VAL 65^TYR 68^TRP 78^CYS	0.0.0.0			structural constituent of eye lens
2fsxA	[pdb]	1.98491 0.00593882	25^VAL 29^CYS 53^TRP 64^PHE 67^GLU 70^ASP	0.0.0.0
1k3bA	[pdb]	1.98636 0.00593911	40^VAL 77^TRP 78^PHE 95^ASN 96^GLU 112^CYS	3.4.14.1	chloride ion binding hydrolase activity cysteine-type peptidase activity peptidase activity cysteine-type endopeptidase activity	immune response proteolysis	lysosome
3dgvC	[pdb]	1.98779 0.0059394	12^TYR 16^ASN 17^GLU 73^TRP 79^CYS 111^VAL		extracellular region	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity carboxypeptidase activity metallocarboxypeptidase activity	proteolysis
2ivfA	[pdb]	1.9882 0.00593949	79^LYS 92^GLY 95^ALA 106^VAL 134^GLY 674^VAL	0.0.0.0	iron-sulfur cluster binding electron carrier activity metal ion binding molybdenum ion binding oxidoreductase activity binding heme binding	oxidation reduction oxidation reduction	periplasmic space
3ct9B	[pdb]	1.98938 0.00593972	206^TRP 210^TYR 246^VAL 258^ASP 262^GLU 269^CYS	0.0.0.0		metal ion binding hydrolase activity zinc ion binding protein dimerization activity metallopeptidase activity	proteolysis
2r5iM	[pdb]	1.98967 0.00593978	161^CYS 196^GLU 199^ASP 333^VAL 447^PHE 448^TRP			structural molecule activity structural molecule activity	virion viral capsid virion viral capsid
3dztA	[pdb]	1.99088 0.00614119	211^VAL 232^CYS 245^TRP 248^TYR 253^GLU 258^ASP	0.0.0.0	extracellular region	odorant binding	transport
1vl8B	[pdb]	1.99211 0.00614145	126^CYS 135^GLU 137^ASP 178^TRP 181^TYR 185^VAL	0.0.0.0		metabolic process oxidation reduction	oxidoreductase activity binding catalytic activity
1s4vB	[pdb]	2.00229 0.00635093	121^GLU 122^ASN 135^VAL 178^TYR 179^TRP 208^CYS	0.0.0.0	cytoplasmic vesicle endoplasmic reticulum	hydrolase activity cysteine-type peptidase activity peptidase activity cysteine-type endopeptidase activity	proteolysis
1cjaB	[pdb]	2.00268 0.00635101	102^ASN 106^GLU 108^PHE 113^CYS 200^VAL 315^TRP	2.7.11.1		cytoplasm	kinase activity phosphotransferase activity alcohol group as acceptor phosphotransferase activity alcohol group as acceptor transferase activity kinase activity ATP binding protein serine/threonine kinase activity nucleotide binding
2pbeA	[pdb]	2.00859 0.0065659	159^PHE 160^TRP 167^VAL 180^ASP 184^GLU 246^CYS	0.0.0.0			transferase activity
2b49A	[pdb]	2.01042 0.00656631	741^VAL 779^CYS 809^TRP 821^PHE 823^GLU 826^ASN	3.1.3.48	binding hydrolase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity phosphatase activity cytoskeletal protein binding protein binding	plasma membrane membrane cytoskeleton cytoplasm extrinsic to membrane	protein amino acid dephosphorylation dephosphorylation negative regulation of membrane protein ectodomain proteolysis
1f13B	[pdb]	2.01612 0.00678757	216^GLU 218^ASN 370^TRP 374^CYS 435^VAL 560^TYR	2.3.2.13	blood coagulation peptide cross-linking	cytoplasm extracellular region	metal ion binding transferase activity acyltransferase activity calcium ion binding protein-glutamine gamma-glutamyltransferase activity
2hxzB	[pdb]	2.0166 0.00678768	121^GLU 122^ASP 136^VAL 179^TYR 180^TRP 206^CYS	3.4.22.27	hydrolase activity cysteine-type peptidase activity peptidase activity cysteine-type endopeptidase activity	immune response proteolysis	intracellular membrane-bounded organelle cytoplasm lysosome extracellular region membrane
1wrfA	[pdb]	2.01975 0.00701483	21^CYS 38^GLU 87^ASP 90^TYR 92^TRP 108^VAL	0.0.0.0			extracellular region
1fytA	[pdb]	2.02026 0.00701495	104^TYR 107^THR 121^ASN 161^SER 179^PRO 181^LYS	0.0.0.0	host cell surface receptor binding MHC class II receptor activity receptor activity protein binding	lysosome virion membrane apical plasma membrane viral envelope virion integral to membrane membrane plasma membrane integral to plasma membrane membrane MHC class II protein complex integral to membrane plasma membrane membrane plasma membrane membrane MHC class II protein complex integral to membrane	viral envelope fusion with host membrane immune response antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation immune response immune response antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation
1we5A	[pdb]	2.02044 0.00701499	283^GLU 287^ASN 307^CYS 320^TRP 325^PHE 410^VAL			hydrolase activity acting on glycosyl bonds hydrolase activity hydrolase activity hydrolyzing O-glycosyl compounds protein binding	metabolic process carbohydrate metabolic process
2v2uA	[pdb]	2.02294 0.00701558	7^GLU 8^ASP 37^VAL 65^TYR 68^TRP 78^CYS	0.0.0.0		camera-type eye development eye development	structural constituent of eye lens
2o3cC	[pdb]	2.02441 0.00701593	86^CYS 111^TYR 112^TRP 131^GLU 134^ASN 150^VAL	0.0.0.0	DNA repair heart contraction negative regulation of apoptosis heart looping	endonuclease activity nuclease activity DNA binding oxidoreductase activity	intracellular
1c72D	[pdb]	2.02486 0.00701603	86^CYS 91^VAL 100^GLU 101^ASN 146^TRP 147^PHE	2.5.1.18	cytoplasm	metabolic process	transferase activity glutathione transferase activity
1a7qH	[pdb]	2.02547 0.00701617	202^VAL 222^CYS 298^GLU 300^ASP 305^TYR 306^TRP				antigen binding
2d44A	[pdb]	2.03023 0.00725031	176^CYS 208^TYR 215^TRP 218^VAL 229^ASP 230^GLU	0.0.0.0		hydrolase activity acting on glycosyl bonds hydrolase activity alpha-N-arabinofuranosidase activity	metabolic process L-arabinose metabolic process arabinan metabolic process
3bcnA	[pdb]	2.03165 0.00725066	116^GLU 121^ASN 160^VAL 168^TYR 169^TRP 196^CYS	0.0.0.0		peptidase activity hydrolase activity cysteine-type peptidase activity cysteine-type endopeptidase activity	proteolysis
1p15B	[pdb]	2.03443 0.00749101	607^GLU 608^ASP 635^CYS 638^TYR 639^TRP 722^VAL	3.1.3.48	hydrolase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity phosphatase activity	insulin receptor signaling pathway protein amino acid phosphorylation dephosphorylation protein amino acid dephosphorylation	membrane integral to membrane
2rbdB	[pdb]	2.035 0.00749115	22^TRP 24^TYR 60^ASP 61^GLU 117^CYS 129^VAL	0.0.0.0
3d66B	[pdb]	2.0393 0.0074922	101^TYR 105^ASN 106^GLU 163^TRP 169^CYS 201^VAL	3.4.17.20	extracellular region extracellular space	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity carboxypeptidase activity metallocarboxypeptidase activity	proteolysis fibrinolysis

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

1zviA

[pdb]

0.186666
0.000111301

415^CYS 567^VAL 587^TRP 588^TYR 592^GLU 597^ASP

1.14.13.39

aging
regulation of heart contraction
response to heat
response to organic nitrogen
response to organic cyclic substance
response to vitamin E
response to estrogen stimulus
response to ethanol
negative regulation of blood pressure
negative regulation of heart contraction
positive regulation of vasodilation
negative regulation of insulin secretion
regulation of sensory perception of pain
oxidation reduction
nitric oxide biosynthetic process
arginine catabolic process
response to hypoxia

enzyme binding
protein homodimerization activity
protein binding
metal ion binding
oxidoreductase activity
calmodulin binding
iron ion binding
nitric-oxide synthase activity
NADP or NADPH binding
FAD binding
heme binding
FMN binding
electron carrier activity
cadmium ion binding
amino acid binding

nucleus
cytoplasm
mitochondrial outer membrane
cytosol
dendrite
nuclear membrane
azurophil granule
dendritic spine
synapse
cell projection
membrane
plasma membrane
mitochondrion
sarcolemma
perinuclear region of cytoplasm
photoreceptor inner segment

3e6nA

[pdb]

0.201589
0.000129253

194^CYS 346^VAL 366^TRP 367^TYR 371^GLU 376^ASP

1.14.13.39

cytosol
perinuclear region of cytoplasm
cortical cytoskeleton
cytoplasm
peroxisome
nucleus

defense response to bacterium
superoxide metabolic process
inflammatory response
oxidation reduction
regulation of cell proliferation
nitric oxide biosynthetic process
response to hypoxia
ovulation from ovarian follicle
defense response to Gram-negative bacterium
retinoic acid receptor signaling pathway
regulation of blood pressure
regulation of heart contraction
protein kinase cascade
G-protein signaling
coupled to cGMP nucleotide second messenger
signal transduction
blood vessel remodeling
endothelial cell proliferation
arginine catabolic process

protein binding
calmodulin binding
metal ion binding
oxidoreductase activity
zinc ion binding
iron ion binding
nitric-oxide synthase activity
protein homodimerization activity
NADP or NADPH binding
FAD binding
heme binding
FMN binding
electron carrier activity
cAMP-dependent protein kinase regulator activity
tetrahydrobiopterin binding
arginine binding

1d1xB

[pdb]

0.23573
0.000177126

186^CYS 338^VAL 358^TRP 359^TYR 363^GLU 368^ASN

1.14.13.39

Golgi apparatus
membrane
plasma membrane
cytoskeleton
cytoplasm
caveola

metal ion binding
oxidoreductase activity
zinc ion binding
calmodulin binding
calcium ion binding
iron ion binding
nitric-oxide synthase activity
NADP or NADPH binding
FAD binding
heme binding
FMN binding
electron carrier activity

mitochondrion organization
arginine catabolic process
oxidation reduction
blood coagulation
nitric oxide biosynthetic process
positive regulation of guanylate cyclase activity
anti-apoptosis
angiogenesis
ovulation from ovarian follicle
blood vessel remodeling
regulation of sodium ion transport
negative regulation of muscle hyperplasia
smooth muscle hyperplasia
lung development
lipopolysaccharide-mediated signaling pathway
negative regulation of potassium ion transport
positive regulation of angiogenesis
regulation of blood vessel size
negative regulation of hydrolase activity
negative regulation of calcium ion transport

3ej8A

[pdb]

0.264228
0.000216297

200^CYS 352^VAL 372^TRP 373^TYR 377^GLU 382^ASP

1.14.13.39

defense response to bacterium
superoxide metabolic process
oxidation reduction
nitric oxide biosynthetic process
regulation of insulin secretion
arginine catabolic process
defense response to Gram-negative bacterium
innate immune response in mucosa
positive regulation of killing of cells of another organism
regulation of cellular respiration
positive regulation of leukocyte mediated cytotoxicity
response to hypoxia
endothelial cell proliferation
blood vessel remodeling
signal transduction
G-protein signaling
coupled to cGMP nucleotide second messenger
protein kinase cascade
regulation of heart contraction
regulation of blood pressure
regulation of cell proliferation
retinoic acid receptor signaling pathway

nucleus
cytoplasm
cytosol
intracellular
peroxisome
cortical cytoskeleton
perinuclear region of cytoplasm

protein binding
metal ion binding
oxidoreductase activity
zinc ion binding
calmodulin binding
calcium ion binding
iron ion binding
nitric-oxide synthase activity
NADP or NADPH binding
FAD binding
heme binding
FMN binding
electron carrier activity
tetrahydrobiopterin binding
protein homodimerization activity
arginine binding
cAMP-dependent protein kinase regulator activity

1m9jB

[pdb]

0.265419
0.000216309

184^CYS 336^VAL 356^TRP 357^TYR 361^GLU 366^ASN

1.14.13.39

Golgi apparatus
membrane
plasma membrane
cytoskeleton
cytoplasm
cytosol
Golgi membrane
apical part of cell
nucleus
caveola
soluble fraction

oxidation reduction
nitric oxide biosynthetic process
negative regulation of calcium ion transport
negative regulation of hydrolase activity
negative regulation of smooth muscle cell proliferation
negative regulation of potassium ion transport
lung development
learning
signal transduction
regulation of sodium ion transport
ovulation from ovarian follicle
angiogenesis
mitochondrion organization
positive regulation of guanylate cyclase activity
anti-apoptosis
positive regulation of angiogenesis
arginine catabolic process
endothelial cell migration
regulation of systemic arterial blood pressure by endothelin
response to fluid shear stress
regulation of blood vessel size
smooth muscle hyperplasia
negative regulation of muscle hyperplasia
negative regulation of cell proliferation
blood vessel remodeling
negative regulation of platelet activation
regulation of blood pressure
response to heat
positive regulation of vasodilation
lipopolysaccharide-mediated signaling pathway

protein binding
metal ion binding
oxidoreductase activity
zinc ion binding
calmodulin binding
iron ion binding
nitric-oxide synthase activity
NADP or NADPH binding
FAD binding
heme binding
FMN binding
electron carrier activity
actin monomer binding
cadmium ion binding
tetrahydrobiopterin binding
arginine binding
calcium ion binding

1zsoA

[pdb]

1.2631
0.000437108

11^GLU 91^ASN 117^VAL 135^TRP 145^CYS 149^TYR

0.0.0.0

2yxmA

[pdb]

1.28303
0.000446027

29^VAL 41^TRP 42^TYR 75^ASP 77^GLU 87^CYS

cell adhesion
striated muscle contraction

protein binding
actin binding
structural constituent of muscle
titin binding

striated muscle thick filament
myofibril

1m80B

[pdb]

1.49812
0.000663965

104^TRP 127^CYS 242^VAL 336^TYR 341^GLU 344^ASP

2.7.3.3

arginine kinase activity
transferase activity
kinase activity
ATP binding
nucleotide binding
transferase activity
transferring phosphorus-containing groups
catalytic activity

cytoplasm

phosphorylation

1bdgA

[pdb]

1.51149
0.000693902

261^TRP 264^PHE 269^GLU 271^ASP 297^VAL 392^CYS

2.7.1.1

glycolysis
carbohydrate metabolic process

transferase activity
kinase activity
ATP binding
nucleotide binding
hexokinase activity
phosphotransferase activity
alcohol group as acceptor

1yb0A

[pdb]

1.53459
0.00074554

105^GLU 107^ASN 126^VAL 137^CYS 147^TRP 150^PHE

0.0.0.0

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan catabolic process

1gv4B

[pdb]

1.58041
0.000896952

425^GLU 440^CYS 458^VAL 467^ASN 475^TYR 476^TRP

0.0.0.0

apoptotic chromosome condensation
neuron apoptosis
oxidation reduction
apoptosis
apoptotic mitochondrial changes
DNA fragmentation involved in apoptosis
cell redox homeostasis

electron carrier activity
oxidoreductase activity
DNA binding
electron-transferring-flavoprotein dehydrogenase activity
FAD binding

mitochondrial intermembrane space
nucleus
mitochondrion
cytosol
microsome
mitochondrial outer membrane
cytoplasm
soluble fraction

1m6iA

[pdb]

1.58202
0.000896994

426^GLU 441^CYS 459^VAL 468^ASN 476^TYR 477^TRP

0.0.0.0

mitochondrial intermembrane space
nucleus
mitochondrion
cytoplasm
microsome
soluble fraction

oxidation reduction
apoptosis
DNA fragmentation involved in apoptosis
DNA damage response
signal transduction resulting in induction of apoptosis
cell redox homeostasis
apoptotic chromosome condensation

oxidoreductase activity
DNA binding
electron carrier activity
FAD binding
protein binding

1qf9A

[pdb]

1.62171
0.00103762

9^VAL 23^CYS 30^PHE 32^TRP 186^GLU 187^ASN

2.7.4.14

pyrimidine nucleotide biosynthetic process
nucleobase
nucleoside
nucleotide and nucleic acid metabolic process

transferase activity
kinase activity
ATP binding
nucleotide binding
cytidylate kinase activity
nucleobase
nucleoside
nucleotide kinase activity
nucleotide kinase activity
phosphotransferase activity
phosphate group as acceptor

1arcA

[pdb]

1.62798
0.00106898

9^ASP 25^VAL 36^CYS 73^TRP 75^TYR 154^GLU

3.4.21.50

extracellular region

hydrolase activity
serine-type peptidase activity
peptidase activity
serine-type endopeptidase activity
catalytic activity

proteolysis

1j0tA

[pdb]

1.63252
0.00110167

20^VAL 27^CYS 49^TRP 50^PHE 60^GLU 61^ASP

extracellular region

hormone activity
neuropeptide hormone activity

neuropeptide signaling pathway

2bo6B

[pdb]

1.63922
0.00113589

233^CYS 324^VAL 335^ASP 337^GLU 341^PHE 344^TRP

0.0.0.0

1yvjA

[pdb]

1.66418
0.00124819

946^VAL 993^TRP 994^TYR 997^GLU 1001^ASP 1077^CYS

2.7.10.2

endomembrane system
membrane
cytoskeleton

enzyme linked receptor protein signaling pathway
protein kinase cascade
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
protein amino acid phosphorylation

transferase activity
kinase activity
ATP binding
protein tyrosine kinase activity
nucleotide binding
non-membrane spanning protein tyrosine kinase activity
protein binding
Janus kinase activity
protein kinase activity

1ia6A

[pdb]

1.70064
0.00146453

76^TRP 79^TYR 83^GLU 86^ASP 321^CYS 422^VAL

0.0.0.0

carbohydrate metabolic process
polysaccharide catabolic process

hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

2iqfA

[pdb]

1.70243
0.00151296

89^GLU 117^TYR 124^TRP 300^ASN 356^VAL 361^CYS

1.11.1.6

cytoplasm

oxidation reduction
response to oxidative stress
oxidation reduction
hydrogen peroxide catabolic process
response to oxidative stress
hydrogen peroxide catabolic process

oxidoreductase activity
peroxidase activity
catalase activity
heme binding
iron ion binding
metal ion binding
oxidoreductase activity
iron ion binding
peroxidase activity
catalase activity
heme binding
metal ion binding

1bbpD

[pdb]

1.71369
0.00156408

30^VAL 35^ASN 38^GLU 45^TRP 60^TYR 175^CYS

0.0.0.0

extracellular region

pigment binding
binding
transporter activity

protein-chromophore linkage
transport

1fg9D

[pdb]

1.71875
0.0016172

21^GLU 30^TYR 31^TRP 68^CYS 83^VAL 107^ASP

membrane
integral to membrane
integral to plasma membrane
extracellular region
extracellular space

receptor activity
interferon-gamma receptor activity
cytokine binding
cytokine activity
interferon-gamma receptor binding

response to virus
signal transduction
positive regulation of smooth muscle cell apoptosis
cell cycle arrest
protein import into nucleus
translocation
tyrosine phosphorylation of Stat1 protein
positive regulation of interleukin-12 production
response to virus
regulation of cell growth
cell surface receptor linked signal transduction
cell motion
immune response
regulation of immune response
positive regulation of interleukin-1 beta secretion
positive regulation of isotype switching to IgG isotypes
positive regulation of transcription
DNA-dependent
regulation of transcription
positive regulation of interleukin-6 biosynthetic process
positive regulation of MHC class II biosynthetic process
positive regulation of interleukin-12 biosynthetic process
positive regulation of chemokine biosynthetic process
defense response to bacterium
negative regulation of myelination
endoplasmic reticulum unfolded protein response
neutrophil chemotaxis
antigen processing and presentation
inflammatory cell apoptosis
neutrophil apoptosis
positive regulation of membrane protein ectodomain proteolysis
positive regulation of killing of cells of another organism
regulation of insulin secretion
positive regulation of nitric oxide biosynthetic process
negative regulation of smooth muscle cell proliferation
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
positive regulation of fructose 1,6-bisphosphate metabolic process
positive regulation of peptidyl-serine phosphorylation of STAT protein
regulation of growth
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of vitamin D biosynthetic process
positive regulation of calcidiol 1-monooxygenase activity

2r6hD

[pdb]

1.74073
0.00179206

283^TYR 313^TRP 377^ASP 379^GLU 383^CYS 392^VAL

0.0.0.0

2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
sodium ion binding
oxidoreductase activity
iron ion binding
oxidoreductase activity
acting on NADH or NADPH
quinone or similar compound as acceptor
electron carrier activity

oxidation reduction
sodium ion transport
ion transport
transport

plasma membrane
membrane
integral to membrane
Gram-negative-bacterium-type cell wall

1vkwA

[pdb]

1.74614
0.00185424

121^PHE 123^GLU 125^ASP 137^VAL 152^TRP 162^CYS

0.0.0.0

oxidoreductase activity

1nw7A

[pdb]

1.76935
0.00205441

57^ASP 64^CYS 93^GLU 161^TRP 162^PHE 236^VAL

2.1.1.72

DNA restriction-modification system
methylation
DNA methylation

transferase activity
methyltransferase activity
site-specific DNA-methyltransferase (adenine-specific) activity
N-methyltransferase activity
DNA binding
nucleic acid binding

2ivfC

[pdb]

1.77873
0.0021274

118^TRP 119^TYR 125^ASN 126^GLU 162^VAL 165^CYS

0.0.0.0

iron-sulfur cluster binding
electron carrier activity
metal ion binding
molybdenum ion binding
oxidoreductase activity
binding
heme binding

oxidation reduction
oxidation reduction

periplasmic space

1e8iA

[pdb]

1.78557
0.00220347

122^VAL 140^GLU 173^CYS 178^ASN 191^TYR 192^TRP

0.0.0.0

integral to membrane
membrane
integral to plasma membrane
external side of plasma membrane

sugar binding
transmembrane receptor activity
binding
calcium ion binding

2rgkC

[pdb]

1.79185
0.00228288

154^CYS 203^VAL 217^ASN 218^GLU 220^PHE 224^TRP

isomerase activity
mannose-6-phosphate isomerase activity
catalytic activity

mannose metabolic process

2ditA

[pdb]

1.7992
0.00236588

37^ASN 38^GLU 47^CYS 66^VAL 88^TRP 89^PHE

RNA binding
RNA polymerase II transcription factor activity
transcription elongation regulator activity
nucleic acid binding
nucleotide binding
protein binding

nucleolus
nucleus

regulation of transcription
regulation of transcription
DNA-dependent
transcription
viral genome replication
regulation of transcription from RNA polymerase II promoter

2afaD

[pdb]

1.8057
0.00245244

156^CYS 205^VAL 219^ASN 220^GLU 222^PHE 226^TRP

0.0.0.0

isomerase activity
mannose-6-phosphate isomerase activity
catalytic activity

mannose metabolic process

1dnpB

[pdb]

1.81018
0.00254256

6^TRP 34^TYR 76^GLU 78^ASP 91^CYS 116^VAL

4.1.99.3

lyase activity
DNA binding
nucleotide binding
deoxyribodipyrimidine photo-lyase activity
DNA photolyase activity
protein binding

protein-chromophore linkage
response to DNA damage stimulus
DNA repair

1umrB

[pdb]

1.81865
0.00263498

20^ASN 21^GLU 30^TRP 31^PHE 42^VAL 121^CYS

0.0.0.0

extracellular region
extracellular region

sugar binding
binding
sugar binding
binding

1d2fB

[pdb]

1.82256
0.00263534

147^TRP 148^PHE 169^CYS 178^VAL 182^ASP 183^GLU

4.4.1.8

lyase activity
cystathionine beta-lyase activity
pyridoxal phosphate binding
transferase activity
transferring nitrogenous groups
catalytic activity

regulation of transcription
DNA-dependent
transcription
biosynthetic process
cellular amino acid biosynthetic process
methionine biosynthetic process
regulation of transcription

1zoxA

[pdb]

1.82267
0.00263536

9^GLU 22^CYS 62^VAL 88^TYR 89^TRP 106^ASN

0.0.0.0

immune response
osteoclast differentiation

plasma membrane
integral to membrane
membrane

receptor activity
protein binding

1vjzA

[pdb]

1.82531
0.00272921

8^TRP 82^CYS 182^ASN 194^VAL 259^GLU 289^PHE

0.0.0.0

carbohydrate metabolic process

cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

3ebgA

[pdb]

1.82673
0.00272935

512^TRP 513^PHE 566^GLU 579^VAL 617^CYS 680^ASN

0.0.0.0

aminopeptidase activity
metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity

cytoplasm

proteolysis

1z72A

[pdb]

1.83215
0.00282747

68^CYS 143^VAL 180^TRP 183^PHE 187^GLU 189^ASN

0.0.0.0

2yu9J

[pdb]

1.83315
0.00282757

18^LYS 21^ILE 31^CYS 32^ALA 46^VAL 54^ARG

metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
magnesium ion binding
protein binding
ribonucleoside binding
metal ion binding
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
protein binding
protein binding
protein binding
protein binding
metal ion binding
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
protein binding
metal ion binding
zinc ion binding
DNA-directed RNA polymerase activity
transcription regulator activity
DNA binding
nucleic acid binding
protein binding
DNA-directed RNA polymerase activity
DNA binding
protein binding
metal ion binding
zinc ion binding
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
DNA-directed RNA polymerase activity
DNA binding
metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
magnesium ion binding
DNA binding
DNA-directed RNA polymerase activity
protein binding

nucleus
mitochondrion
DNA-directed RNA polymerase II
core complex
DNA-directed RNA polymerase III complex
nucleus
DNA-directed RNA polymerase I complex
DNA-directed RNA polymerase III complex
DNA-directed RNA polymerase II
core complex
nucleoplasm
nucleolus
nucleolus
nucleus
DNA-directed RNA polymerase I complex
DNA-directed RNA polymerase II
core complex
nucleoplasm
nucleus
DNA-directed RNA polymerase II
core complex
nucleus
DNA-directed RNA polymerase I complex
DNA-directed RNA polymerase III complex
DNA-directed RNA polymerase II
core complex
nucleoplasm
nucleus
DNA-directed RNA polymerase II
core complex
nucleoplasm
nucleus
DNA-directed RNA polymerase II
core complex
cytoplasm
nucleus
DNA-directed RNA polymerase I complex
DNA-directed RNA polymerase III complex
DNA-directed RNA polymerase II
core complex
nucleoplasm
RNA polymerase complex
nucleus
mitochondrion
DNA-directed RNA polymerase II
core complex
nucleus
DNA-directed RNA polymerase I complex
DNA-directed RNA polymerase III complex
DNA-directed RNA polymerase II
core complex
nucleoplasm

transcription
transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription
RNA elongation from RNA polymerase II promoter
transcription
transcription from RNA polymerase II promoter
regulation of transcription
response to DNA damage stimulus
transcription
DNA repair
response to drug
transcription from RNA polymerase II promoter
transcription-coupled nucleotide-excision repair
regulation of transcription
transcription
transcription from RNA polymerase II promoter
transcription
transcription from RNA polymerase II promoter
transcription
transcription from RNA polymerase II promoter
transcription
transcription from RNA polymerase II promoter
transcription
DNA-dependent
transcription
transcription from RNA polymerase II promoter
transcription
transcription from RNA polymerase II promoter

2e6pA

[pdb]

1.83547
0.00282781

32^CYS 43^TRP 44^TYR 58^VAL 76^ASP 79^GLU

cardiac myofibril assembly
cytoskeleton organization

cytoskeletal adaptor activity

perinuclear region of cytoplasm
M band
Z disc
intercalated disc

1f97A

[pdb]

1.8367
0.00282794

49^CYS 61^TRP 63^PHE 86^VAL 103^ASN 105^GLU

interspecies interaction between organisms
epithelial cell differentiation
cell adhesion

plasma membrane
cell junction
integral to membrane
membrane
tight junction

protein binding

2qqkH

[pdb]

1.84034
0.00293002

2^ILE 22^THR 95^LEU 96^PRO 102^THR 103^LYS

cell differentiation
nervous system development
multicellular organismal development
axon guidance
cell adhesion
immune response
immune response

membrane
integral to membrane
plasma membrane
membrane fraction
extracellular region
membrane fraction
extracellular region

receptor activity
vascular endothelial growth factor receptor activity
antigen binding
protein binding
antigen binding
protein binding

1mhzD

[pdb]

1.8459
0.00303659

187^VAL 196^ASP 199^GLU 211^CYS 275^PHE 276^TRP

1.14.13.25

oxidation reduction
one-carbon metabolic process
methane metabolic process
oxidation reduction
one-carbon metabolic process
cellular aromatic compound metabolic process
oxidation reduction
one-carbon metabolic process
cellular aromatic compound metabolic process

oxidoreductase activity
monooxygenase activity
methane monooxygenase activity
monooxygenase activity
metal ion binding
oxidoreductase activity
iron ion binding
methane monooxygenase activity
transition metal ion binding
oxidoreductase activity
monooxygenase activity
methane monooxygenase activity
transition metal ion binding
oxidoreductase activity
acting on paired donors
with incorporation or reduction of molecular oxygen
NADH or NADPH as one donor
and incorporation of one atom of oxygen

2ywmD

[pdb]

1.8686
0.00338406

151^CYS 159^TRP 161^PHE 194^VAL 208^GLU 209^ASN

0.0.0.0

1jwoA

[pdb]

1.87838
0.00350959

122^TRP 123^PHE 148^GLU 155^ASP 159^CYS 193^VAL

2.7.10.2

cytoplasm
nucleus

protein amino acid phosphorylation
positive regulation of cell proliferation
cell proliferation
mesoderm development
signal transduction

transferase activity
kinase activity
ATP binding
protein tyrosine kinase activity
nucleotide binding
non-membrane spanning protein tyrosine kinase activity
protein binding
protein kinase activity

2pa5A

[pdb]

1.87942
0.00350972

380^GLU 381^ASN 390^VAL 415^TYR 416^TRP 515^CYS

3.1.3.48

cytoplasm

hydrolase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
phosphatase activity
protein binding

protein amino acid dephosphorylation
dephosphorylation

1kirB

[pdb]

1.88225
0.00363921

2^VAL 22^GLY 98^ILE 100^SER 105^MET 106^ASN

defense response to bacterium
cytolysis
metabolic process
cell wall macromolecule catabolic process

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
catalytic activity
lysozyme activity

1qgc4

[pdb]

1.88739
0.0036399

220^VAL 240^CYS 318^GLU 319^ASP 325^PHE 328^TRP

cytoplasmic vesicle
viral capsid
virion
membrane
cytoplasm
icosahedral viral capsid
cytoplasm
cytoplasmic vesicle
viral capsid
virion
membrane
cytoplasm
cytoplasmic vesicle
viral capsid
virion
membrane
icosahedral viral capsid
host cell cytoplasm
host cell cytoplasm

hydrolase activity
nucleotidyltransferase activity
transferase activity
cysteine-type peptidase activity
peptidase activity
ATP binding
structural molecule activity
helicase activity
RNA-directed RNA polymerase activity
RNA binding
nucleotide binding
cysteine-type endopeptidase activity
catalytic activity
RNA helicase activity
hydrolase activity
nucleotidyltransferase activity
transferase activity
cysteine-type peptidase activity
peptidase activity
structural molecule activity
RNA-directed RNA polymerase activity
RNA binding
nucleotide binding
cysteine-type endopeptidase activity
catalytic activity
hydrolase activity
nucleotidyltransferase activity
transferase activity
cysteine-type peptidase activity
peptidase activity
structural molecule activity
RNA-directed RNA polymerase activity
RNA binding
nucleotide binding
cysteine-type endopeptidase activity

transcription
RNA-dependent
viral protein processing
viral genome replication
viral reproduction
proteolysis
transcription
transcription
RNA-dependent
viral genome replication
proteolysis
transcription
transcription
RNA-dependent
viral protein processing
viral reproduction

1bvkE

[pdb]

1.89485
0.00377249

2^VAL 22^GLY 98^ILE 100^SER 105^MET 106^ASN

defense response to bacterium
cytolysis
metabolic process
cell wall macromolecule catabolic process

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
catalytic activity
lysozyme activity

1c5dH

[pdb]

1.89792
0.00390702

2^VAL 22^CYS 98^GLU 99^ASP 104^PHE 107^TRP

antigen binding
antigen binding

2oo6A

[pdb]

1.90752
0.00404755

119^VAL 124^CYS 211^ASP 213^GLU 240^PHE 241^TRP

0.0.0.0

catalytic activity

metabolic process

2p0vA

[pdb]

1.9105
0.00404799

55^GLU 79^CYS 88^VAL 116^TRP 118^TYR 125^ASP

0.0.0.0

catalytic activity

1ukcA

[pdb]

1.91231
0.00419259

241^TRP 335^ASP 338^GLU 400^PHE 407^VAL 526^CYS

0.0.0.0

hydrolase activity

2preA

[pdb]

1.91352
0.00419277

116^GLU 117^ASN 129^VAL 168^TYR 169^TRP 196^CYS

0.0.0.0

hydrolase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activity
peptidase activity

proteolysis

1s2kA

[pdb]

1.91391
0.00419283

39^TRP 93^VAL 130^ASN 132^GLU 133^PHE 165^CYS

3.4.23.32

hydrolase activity
peptidase activity
aspartic-type endopeptidase activity

proteolysis

1eemA

[pdb]

1.9145
0.00419292

32^CYS 123^VAL 178^TRP 181^PHE 185^GLU 190^ASN

2.5.1.18

L-ascorbic acid biosynthetic process
biological_process
metabolic process

cytoplasm

glutathione transferase activity
monodehydroascorbate reductase (NADH) activity
transferase activity

1rrsA

[pdb]

1.9176
0.00419339

20^TRP 21^PHE 187^ASN 188^GLU 198^CYS 210^VAL

0.0.0.0

hydrolase activity
acting on glycosyl bonds
hydrolase activity
4 iron
4 sulfur cluster binding
DNA N-glycosylase activity
endonuclease activity
catalytic activity
DNA binding

intracellular

metabolic process
DNA repair
base-excision repair

2fo5D

[pdb]

1.9287
0.00449968

126^GLU 128^ASP 140^VAL 183^TYR 184^TRP 213^CYS

0.0.0.0

hydrolase activity
peptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activity

proteolysis

2z64A

[pdb]

1.93282
0.00466077

555^GLU 576^ASN 582^CYS 587^PHE 590^TRP 617^VAL

extracellular region
extracellular space
lipopolysaccharide receptor complex
membrane
integral to membrane
intrinsic to membrane
perinuclear region of cytoplasm
integral to plasma membrane

immune response
inflammatory response
detection of lipopolysaccharide
activation of innate immune response
positive regulation of platelet activation
detection of lipopolysaccharide
positive regulation of interleukin-6 production
positive regulation of stress-activated MAPK cascade
positive regulation of interferon-beta biosynthetic process
defense response to Gram-negative bacterium
positive regulation of ERK1 and ERK2 cascade
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
mast cell activation
activation of NF-kappaB-inducing kinase activity
macrophage activation
positive regulation of interleukin-6 biosynthetic process
positive regulation of interleukin-13 biosynthetic process
positive regulation of interleukin-1 biosynthetic process
innate immune response
immune response
inflammatory response
positive regulation of JNK cascade
positive regulation of I-kappaB kinase/NF-kappaB cascade
positive regulation of tumor necrosis factor production
interferon-gamma production
response to lipopolysaccharide
response to bacterium
production of nitric oxide during acute inflammatory response
signal transduction
positive regulation of interleukin-8 biosynthetic process
positive regulation of tumor necrosis factor biosynthetic process

protein binding
lipopolysaccharide receptor activity
lipopolysaccharide receptor activity
receptor activity
protein binding
transmembrane receptor activity

2dgaA

[pdb]

1.93716
0.0046615

186^TRP 187^PHE 191^GLU 262^ASP 326^CYS 403^VAL

0.0.0.0

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-glucosidase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

metabolic process
carbohydrate metabolic process

2ai0M

[pdb]

1.94036
0.00482803

25^SER 30^ARG 39^GLN 58^THR 94^TYR 101^TRP

0.0.0.0

1z8hB

[pdb]

1.9418
0.00482827

35^CYS 81^VAL 196^GLU 197^ASN 204^TRP 205^PHE

0.0.0.0

hydrolase activity
acting on ester bonds
hydrolase activity

lipid metabolic process

1dbiA

[pdb]

1.94355
0.00482858

137^CYS 145^GLU 149^ASN 159^VAL 176^TYR 200^TRP

extracellular region

metal ion binding
hydrolase activity
serine-type peptidase activity
peptidase activity
calcium ion binding
serine-type endopeptidase activity

proteolysis

2cagA

[pdb]

1.9512
0.00500156

87^GLU 115^PHE 122^TRP 298^ASN 354^VAL 359^CYS

1.11.1.6

cytoplasm

metal ion binding
oxidoreductase activity
iron ion binding
peroxidase activity
catalase activity
heme binding

oxidation reduction
hydrogen peroxide catabolic process
response to oxidative stress

1pg7X

[pdb]

1.95297
0.00500187

2^VAL 22^CYS 95^GLU 96^ASP 102^TYR 103^TRP

antigen binding

2q4aB

[pdb]

1.95457
0.00517952

156^TYR 157^GLU 161^ASP 247^TRP 282^VAL 293^CYS

metal ion binding
oxidoreductase activity
iron ion binding
electron carrier activity

nucleus

oxidation reduction

1tuoA

[pdb]

1.95613
0.00517981

253^ASP 293^VAL 315^PHE 317^TRP 327^CYS 345^GLU

0.0.0.0

carbohydrate metabolic process

intramolecular transferase activity
phosphotransferases

1k9aE

[pdb]

1.96164
0.005364

82^TRP 83^PHE 108^GLU 115^ASP 119^CYS 153^VAL

2.7.10.2

cell-cell junction
plasma membrane
cytoplasm
membrane

negative regulation of cell proliferation
protein amino acid phosphorylation

transferase activity
kinase activity
ATP binding
protein tyrosine kinase activity
nucleotide binding
non-membrane spanning protein tyrosine kinase activity
protein binding
protein kinase activity

2eefA

[pdb]

1.9654
0.00536471

54^VAL 80^CYS 118^GLU 120^ASN 124^TYR 125^TRP

glycogen metabolic process
carbohydrate metabolic process

2vtcB

[pdb]

1.97047
0.00555179

4^VAL 37^TRP 38^TYR 40^GLU 43^ASP 59^CYS

3.2.1.4

calcium ion binding
cellulase activity
hydrolase activity
hydrolase activity
acting on glycosyl bonds
metal ion binding

extracellular region

polysaccharide catabolic process
carbohydrate metabolic process
metabolic process
cellulose catabolic process

1bapA

[pdb]

1.97177
0.00555204

14^GLU 17^PHE 21^TRP 64^CYS 235^ASP 258^VAL

0.0.0.0

carbohydrate transport
transport

periplasmic space

sugar:hydrogen symporter activity

2h00B

[pdb]

1.97579
0.00574192

53^GLU 54^ASP 143^PHE 207^TRP 210^CYS 233^VAL

transferase activity
methyltransferase activity

1fz5B

[pdb]

1.97798
0.00574235

187^HOH 196^HOH 199^HOH 211^HOH 275^ASN 276^LEU

1.14.13.25

iron ion binding
monooxygenase activity
methane monooxygenase activity
transition metal ion binding
metal ion binding
oxidoreductase activity
oxidoreductase activity
monooxygenase activity
methane monooxygenase activity
oxidoreductase activity
monooxygenase activity
methane monooxygenase activity
transition metal ion binding
oxidoreductase activity
acting on paired donors
with incorporation or reduction of molecular oxygen
NADH or NADPH as one donor
and incorporation of one atom of oxygen

one-carbon metabolic process
cellular aromatic compound metabolic process
oxidation reduction
oxidation reduction
one-carbon metabolic process
methane metabolic process
oxidation reduction
one-carbon metabolic process
cellular aromatic compound metabolic process

2dw7D

[pdb]

1.9782
0.00574239

181^VAL 215^ASN 237^TRP 238^TYR 240^GLU 319^CYS

0.0.0.0

catalytic activity

metabolic process

2qjkO

[pdb]

1.98303
0.00593844

97^ASN 124^VAL 134^CYS 147^TRP 156^TYR 169^GLU

1.10.2.2

2 iron
2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
ubiquinol-cytochrome-c reductase activity
electron carrier activity
iron ion binding
metal ion binding
iron ion binding
oxidoreductase activity
electron carrier activity
metal ion binding
iron ion binding
heme binding
electron carrier activity
heme binding
electron carrier activity
iron ion binding
oxidoreductase activity
acting on diphenols and related substances as donors

oxidation reduction
electron transport chain
transport
electron transport chain
transport
respiratory electron transport chain
electron transport chain
transport

plasma membrane
integral to membrane
membrane
plasma membrane
integral to membrane
membrane
mitochondrial respiratory chain
plasma membrane
integral to membrane
membrane
mitochondrial respiratory chain
respiratory chain
respiratory chain

1elpA

[pdb]

1.9837
0.00593857

7^GLU 8^ASP 37^VAL 65^TYR 68^TRP 78^CYS

0.0.0.0

structural constituent of eye lens

2fsxA

[pdb]

1.98491
0.00593882

25^VAL 29^CYS 53^TRP 64^PHE 67^GLU 70^ASP

0.0.0.0

1k3bA

[pdb]

1.98636
0.00593911

40^VAL 77^TRP 78^PHE 95^ASN 96^GLU 112^CYS

3.4.14.1

chloride ion binding
hydrolase activity
cysteine-type peptidase activity
peptidase activity
cysteine-type endopeptidase activity

immune response
proteolysis

lysosome

3dgvC

[pdb]

1.98779
0.0059394

12^TYR 16^ASN 17^GLU 73^TRP 79^CYS 111^VAL

extracellular region

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
carboxypeptidase activity
metallocarboxypeptidase activity

proteolysis

2ivfA

[pdb]

1.9882
0.00593949

79^LYS 92^GLY 95^ALA 106^VAL 134^GLY 674^VAL

0.0.0.0

iron-sulfur cluster binding
electron carrier activity
metal ion binding
molybdenum ion binding
oxidoreductase activity
binding
heme binding

oxidation reduction
oxidation reduction

periplasmic space

3ct9B

[pdb]

1.98938
0.00593972

206^TRP 210^TYR 246^VAL 258^ASP 262^GLU 269^CYS

0.0.0.0

metal ion binding
hydrolase activity
zinc ion binding
protein dimerization activity
metallopeptidase activity

proteolysis

2r5iM

[pdb]

1.98967
0.00593978

161^CYS 196^GLU 199^ASP 333^VAL 447^PHE 448^TRP

structural molecule activity
structural molecule activity

virion
viral capsid
virion
viral capsid

3dztA

[pdb]

1.99088
0.00614119

211^VAL 232^CYS 245^TRP 248^TYR 253^GLU 258^ASP

0.0.0.0

extracellular region

odorant binding

transport

1vl8B

[pdb]

1.99211
0.00614145

126^CYS 135^GLU 137^ASP 178^TRP 181^TYR 185^VAL

0.0.0.0

metabolic process
oxidation reduction

oxidoreductase activity
binding
catalytic activity

1s4vB

[pdb]

2.00229
0.00635093

121^GLU 122^ASN 135^VAL 178^TYR 179^TRP 208^CYS

0.0.0.0

cytoplasmic vesicle
endoplasmic reticulum

hydrolase activity
cysteine-type peptidase activity
peptidase activity
cysteine-type endopeptidase activity

proteolysis

1cjaB

[pdb]

2.00268
0.00635101

102^ASN 106^GLU 108^PHE 113^CYS 200^VAL 315^TRP

2.7.11.1

cytoplasm

kinase activity
phosphotransferase activity
alcohol group as acceptor
phosphotransferase activity
alcohol group as acceptor
transferase activity
kinase activity
ATP binding
protein serine/threonine kinase activity
nucleotide binding

2pbeA

[pdb]

2.00859
0.0065659

159^PHE 160^TRP 167^VAL 180^ASP 184^GLU 246^CYS

0.0.0.0

transferase activity

2b49A

[pdb]

2.01042
0.00656631

741^VAL 779^CYS 809^TRP 821^PHE 823^GLU 826^ASN

3.1.3.48

binding
hydrolase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
phosphatase activity
cytoskeletal protein binding
protein binding

plasma membrane
membrane
cytoskeleton
cytoplasm
extrinsic to membrane

protein amino acid dephosphorylation
dephosphorylation
negative regulation of membrane protein ectodomain proteolysis

1f13B

[pdb]

2.01612
0.00678757

216^GLU 218^ASN 370^TRP 374^CYS 435^VAL 560^TYR

2.3.2.13

blood coagulation
peptide cross-linking

cytoplasm
extracellular region

metal ion binding
transferase activity
acyltransferase activity
calcium ion binding
protein-glutamine gamma-glutamyltransferase activity

2hxzB

[pdb]

2.0166
0.00678768

121^GLU 122^ASP 136^VAL 179^TYR 180^TRP 206^CYS

3.4.22.27

hydrolase activity
cysteine-type peptidase activity
peptidase activity
cysteine-type endopeptidase activity

immune response
proteolysis

intracellular membrane-bounded organelle
cytoplasm
lysosome
extracellular region
membrane

1wrfA

[pdb]

2.01975
0.00701483

21^CYS 38^GLU 87^ASP 90^TYR 92^TRP 108^VAL

0.0.0.0

extracellular region

1fytA

[pdb]

2.02026
0.00701495

104^TYR 107^THR 121^ASN 161^SER 179^PRO 181^LYS

0.0.0.0

host cell surface receptor binding
MHC class II receptor activity
receptor activity
protein binding

lysosome
virion membrane
apical plasma membrane
viral envelope
virion
integral to membrane
membrane
plasma membrane
integral to plasma membrane
membrane
MHC class II protein complex
integral to membrane
plasma membrane
membrane
plasma membrane
membrane
MHC class II protein complex
integral to membrane

viral envelope fusion with host membrane
immune response
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation
immune response
immune response
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation