The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
1dieA	[pdb]	0.110969 0.000110277	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding isomerase activity magnesium ion binding xylose isomerase activity
1xylA	[pdb]	0.167472 0.000162331	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding isomerase activity magnesium ion binding xylose isomerase activity
1qt1A	[pdb]	0.168031 0.000162336	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cobalt ion binding metal ion binding isomerase activity xylose isomerase activity magnesium ion binding	cytoplasm
5ximD	[pdb]	0.192197 0.000195666	26^PHE 54^HIS 57^ASP 94^PHE 137^TRP 183^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding isomerase activity magnesium ion binding xylose isomerase activity
3cwhA	[pdb]	0.284944 0.000300413	26^PHE 54^HIS 57^ASP 94^PHE 137^TRP 183^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding isomerase activity magnesium ion binding xylose isomerase activity
1bxbA	[pdb]	0.304503 0.000325359	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding isomerase activity magnesium ion binding xylose isomerase activity
1bxcD	[pdb]	0.309036 0.000325396	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding isomerase activity magnesium ion binding xylose isomerase activity
1a0cA	[pdb]	0.547587 0.000518658	59^PHE 100^HIS 103^ASP 144^PHE 187^TRP 233^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cobalt ion binding metal ion binding isomerase activity xylose isomerase activity magnesium ion binding	cytoplasm
1a0eA	[pdb]	0.645132 0.000576323	59^PHE 100^HIS 103^ASP 144^PHE 187^TRP 233^LYS	5.3.1.5	carbohydrate metabolic process D-xylose metabolic process pentose-phosphate shunt	cytoplasm	xylose isomerase activity magnesium ion binding cobalt ion binding metal ion binding isomerase activity
1a0dD	[pdb]	0.677859 0.000592701	58^PHE 98^HIS 101^ASP 142^PHE 185^TRP 231^LYS	5.3.1.5	D-xylose metabolic process pentose-phosphate shunt carbohydrate metabolic process	cytoplasm	metal ion binding manganese ion binding isomerase activity xylose isomerase activity magnesium ion binding
2i56D	[pdb]	1.28234 0.000708761	66^PHE 101^HIS 105^ASP 131^PHE 179^TRP 221^LYS	0.0.0.0			isomerase activity
2gthA	[pdb]	1.54075 0.00081053	43^PHE 66^HIS 81^TRP 94^PHE 100^LYS 155^ASP	2.7.7.48	integral to membrane membrane cytoplasm viral replication complex integral to membrane membrane cytoplasm viral replication complex perinuclear region of cytoplasm perinuclear region of cytoplasm	metal ion binding hydrolase activity nucleotidyltransferase activity transferase activity zinc ion binding cysteine-type peptidase activity peptidase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity RNA-directed RNA polymerase activity RNA binding nucleotide binding exoribonuclease activity producing 5'-phosphomonoesters methyltransferase activity cysteine-type endopeptidase activity catalytic activity metal ion binding hydrolase activity zinc ion binding cysteine-type peptidase activity peptidase activity RNA binding RNA-directed RNA polymerase activity catalytic activity	transcription RNA-dependent viral protein processing viral genome replication viral reproduction proteolysis transcription viral protein processing viral genome replication viral reproduction proteolysis
1olpA	[pdb]	1.62168 0.000892377	1^TRP 71^ASP 128^PHE 136^HIS 159^LYS 175^PHE	0.0.0.0			phospholipase C activity hydrolase activity acting on ester bonds zinc ion binding
3b6rB	[pdb]	1.69076 0.00100562	194^PHE 218^TRP 223^LYS 233^ASP 234^HIS 334^PHE	2.7.3.2	creatine metabolic process cellular chloride ion homeostasis brain development	cytoplasm cytosol mitochondrion	transferase activity kinase activity ATP binding nucleotide binding creatine kinase activity transferase activity transferring phosphorus-containing groups catalytic activity protein binding
1khoA	[pdb]	1.77879 0.00126315	1^TRP 71^ASP 128^PHE 136^HIS 159^LYS 175^PHE	3.1.4.3	extracellular region	hemolysis by symbiont of host erythrocytes cytolysis pathogenesis	metal ion binding hydrolase activity zinc ion binding calcium ion binding phosphatidylcholine phospholipase C activity hydrolase activity acting on ester bonds phospholipase C activity
2bkqD	[pdb]	1.79295 0.00132006	29^ASP 30^HIS 36^PHE 116^PHE 198^LYS 202^TRP			hydrolase activity cysteine-type peptidase activity peptidase activity protein binding	ubiquitin-dependent protein catabolic process proteolysis modification-dependent protein catabolic process
1i0eB	[pdb]	1.80207 0.00135063	194^PHE 218^TRP 223^LYS 233^ASP 234^HIS 334^PHE	2.7.3.2	creatine metabolic process phosphocreatine biosynthetic process	cytoplasm cytosol	transferase activity kinase activity ATP binding nucleotide binding creatine kinase activity transferase activity transferring phosphorus-containing groups catalytic activity
1lxmA	[pdb]	1.81042 0.00138258	631^ASP 649^HIS 703^LYS 752^PHE 755^TRP 843^PHE	4.2.2.1	carbohydrate metabolic process	extracellular region	lyase activity hyaluronate lyase activity carbohydrate binding carbon-oxygen lyase activity acting on polysaccharides catalytic activity
1p7bB	[pdb]	1.84404 0.00156183	158^PHE 161^HIS 191^LYS 222^PHE 274^TRP 305^ASP	0.0.0.0	ion channel activity inward rectifier potassium channel activity	membrane	potassium ion transport
1dboA	[pdb]	1.85295 0.00160124	83^PHE 201^ASP 202^HIS 204^PHE 467^TRP 476^LYS	4.2.2.19			lyase activity chondroitin B lyase activity
1qh4B	[pdb]	1.85845 0.00164206	194^PHE 218^TRP 223^LYS 233^ASP 234^HIS 334^PHE	2.7.3.2		cytoplasm mitochondrion	transferase activity kinase activity ATP binding nucleotide binding creatine kinase activity transferase activity transferring phosphorus-containing groups catalytic activity
2bjqA	[pdb]	1.86515 0.0016845	51^ASP 192^PHE 224^HIS 229^PHE 246^TRP 327^LYS	0.0.0.0
3bc9A	[pdb]	1.86723 0.00168459	275^PHE 302^LYS 304^TRP 350^ASP 354^HIS 359^PHE			carbohydrate metabolic process	cation binding catalytic activity
1tl2A	[pdb]	1.88139 0.00177428	43^PHE 108^LYS 134^TRP 141^PHE 152^HIS 182^ASP		extracellular region	innate immune response immune response	sugar binding
1qk1B	[pdb]	1.88303 0.00177436	189^PHE 213^TRP 218^LYS 228^ASP 229^HIS 329^PHE	2.7.3.2	creatine metabolic process	mitochondrial inner membrane membrane mitochondrion	transferase activity kinase activity ATP binding nucleotide binding creatine kinase activity transferase activity transferring phosphorus-containing groups catalytic activity
2h84B	[pdb]	1.8949 0.00186963	3068^PHE 3075^LYS 3096^TRP 3115^ASP 3116^HIS 3138^PHE	0.0.0.0		flavonoid biosynthetic process biosynthetic process metabolic process	naringenin-chalcone synthase activity phosphopantetheine binding transferase activity oxidoreductase activity acyltransferase activity binding catalytic activity acyl carrier activity
2zkmX	[pdb]	1.90014 0.00186989	23^PHE 27^ASP 89^PHE 113^HIS 124^LYS 126^TRP	3.1.4.11		lipid catabolic process signal transduction activation of phospholipase C activity phospholipid metabolic process intracellular signaling cascade lipid metabolic process	metal ion binding hydrolase activity calcium ion binding signal transducer activity phosphoinositide phospholipase C activity phospholipase C activity phosphoric diester hydrolase activity
2inpA	[pdb]	1.92827 0.00207567	85^ILE 156^HOH 219^ASN 339^HOH 493^HOH 495^HOH	0.0.0.0		cellular aromatic compound metabolic process cellular aromatic compound metabolic process cellular aromatic compound metabolic process oxidation reduction oxidation reduction	transition metal ion binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen NADH or NADPH as one donor and incorporation of one atom of oxygen oxidoreductase activity transition metal ion binding oxidoreductase activity monooxygenase activity
2gjrA	[pdb]	1.93519 0.00213134	155^PHE 185^LYS 189^TRP 236^ASP 240^HIS 245^PHE	3.2.1.98	extracellular region	metabolic process carbohydrate metabolic process	metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity glucan 1,4-alpha-maltohexaosidase activity cation binding calcium ion binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
3bbcF	[pdb]	1.93776 0.00213149	8^PHE 39^LYS 51^HIS 54^ASP 108^PHE 133^TRP	2.7.4.6	nucleus cytoplasm lamellipodium ruffle	regulation of transcription regulation of transcription DNA-dependent nucleoside triphosphate biosynthetic process negative regulation of cell proliferation negative regulation of cell cycle nucleotide metabolic process cell cycle transcription CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process positive regulation of epithelial cell proliferation regulation of epidermis development positive regulation of keratinocyte differentiation negative regulation of apoptosis cell adhesion	transcription factor activity ATP binding nucleoside diphosphate kinase activity metal ion binding transferase activity kinase activity DNA binding magnesium ion binding nucleotide binding protein binding
2gjxF	[pdb]	1.94417 0.00218884	294^LEU 298^TYR 303^THR 319^LEU 354^PHE 370^TYR	3.2.1.52	hydrolase activity acting on glycosyl bonds hydrolase activity beta-N-acetylhexosaminidase activity protein heterodimerization activity cation binding catalytic activity protein binding hydrolase activity acting on glycosyl bonds hydrolase activity beta-N-acetylhexosaminidase activity protein heterodimerization activity protein homodimerization activity cation binding catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolyzing O-glycosyl compounds	lysosome membrane lysosome membrane acrosomal vesicle	metabolic process carbohydrate metabolic process neuromuscular process controlling balance neuromuscular process controlling posture myelination glycosaminoglycan metabolic process sexual reproduction lipid storage adult walking behavior locomotory behavior sensory perception of sound lysosome organization ganglioside catabolic process skeletal system development metabolic process carbohydrate metabolic process neuromuscular process neuromuscular process controlling balance oogenesis cellular protein metabolic process myelination regulation of cellular metabolic process glycosaminoglycan metabolic process sexual reproduction lipid storage oligosaccharide catabolic process phospholipid biosynthetic process male courtship behavior locomotory behavior sensory perception of sound penetration of zona pellucida single fertilization lysosome organization cellular calcium ion homeostasis ganglioside catabolic process glycosphingolipid metabolic process skeletal system development
3bh4A	[pdb]	1.94437 0.00218886	152^PHE 181^LYS 185^TRP 232^ASP 236^HIS 241^PHE	3.2.1.1	extracellular region	metabolic process carbohydrate metabolic process	metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity calcium ion binding alpha-amylase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1pn0B	[pdb]	1.94857 0.00224695	476^LYS 499^HIS 502^ASP 515^PHE 606^TRP 640^PHE	1.14.13.7	cytoplasm	oxidation reduction aromatic compound catabolic process metabolic process	oxidoreductase activity monooxygenase activity phenol 2-monooxygenase activity
1ndlC	[pdb]	1.97355 0.00242995	9^PHE 40^LYS 52^HIS 55^ASP 109^PHE 134^TRP	2.7.4.6	CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process nucleotide metabolic process protein amino acid autophosphorylation peptidyl-serine phosphorylation epithelial cell migration open tracheal system open tracheal system development mitosis microtubule-based process protein amino acid phosphorylation nucleoside diphosphate phosphorylation	kinase activity magnesium ion binding ATP binding nucleoside diphosphate kinase activity metal ion binding transferase activity nucleotide binding microtubule binding GTP binding	nuclear microtubule cytoplasm microtubule cytoskeleton
1j99A	[pdb]	1.98728 0.00256074	13^PHE 125^ASP 144^LYS 146^TRP 150^PHE 257^HIS	2.8.2.14	bile acid catabolic process steroid metabolic process lipid metabolic process digestion	cytoplasm cytosol	transferase activity bile-salt sulfotransferase activity sulfotransferase activity
1iznA	[pdb]	1.99032 0.00256095	20^GLN 62^CYS 79^TYR 81^PRO 177^LEU 210^ILE	0.0.0.0	Z disc membrane lamellipodium cortical cytoskeleton cytoskeleton cytoplasm F-actin capping protein complex cytoplasm F-actin capping protein complex	actin binding actin binding	actin filament capping cell projection organization lamellipodium assembly actin filament capping barbed-end actin filament capping actin cytoskeleton organization barbed-end actin filament capping actin cytoskeleton organization
2ov1A	[pdb]	1.9986 0.0026292	61^PHE 81^ASP 83^HIS 108^PHE 112^TRP 117^LYS	0.0.0.0	binding metal ion binding	metal ion transport	outer membrane-bounded periplasmic space
1zmwB	[pdb]	2.00032 0.00269885	156^PHE 170^PHE 282^LYS 303^TRP 308^HIS 311^ASP	2.7.11.1	ATP binding protein serine/threonine kinase activity magnesium ion binding metal ion binding transferase activity kinase activity nucleotide binding protein kinase activity	establishment or maintenance of epithelial cell apical/basal polarity protein kinase cascade protein amino acid phosphorylation cell differentiation multicellular organismal development	nucleus basal cortex membrane plasma membrane
1pq4A	[pdb]	2.00723 0.0027698	61^PHE 81^ASP 83^HIS 108^PHE 112^TRP 117^LYS	0.0.0.0	binding metal ion binding	metal ion transport	outer membrane-bounded periplasmic space
1e3zA	[pdb]	2.02295 0.00291568	151^PHE 180^LYS 184^TRP 231^ASP 235^HIS 240^PHE	3.2.1.1	extracellular region	metabolic process carbohydrate metabolic process metabolic process carbohydrate metabolic process	metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity calcium ion binding alpha-amylase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity calcium ion binding alpha-amylase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
2d3lA	[pdb]	2.02386 0.00291575	155^PHE 185^LYS 189^TRP 236^ASP 240^HIS 245^PHE	3.2.1.98	extracellular region	metabolic process carbohydrate metabolic process	metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity glucan 1,4-alpha-maltohexaosidase activity cation binding calcium ion binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1wb4B	[pdb]	2.04435 0.0030698	879^LYS 953^PHE 1018^ASP 1058^HIS 1060^TRP 1074^PHE	3.2.1.8		hydrolase activity acting on glycosyl bonds hydrolase activity endo-1,4-beta-xylanase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity protein binding	xylan catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process
1hvxA	[pdb]	2.04964 0.00314941	154^PHE 183^LYS 187^TRP 234^ASP 238^HIS 243^PHE	3.2.1.1		metabolic process carbohydrate metabolic process	metal ion binding hydrolase activity acting on glycosyl bonds hydrolase activity calcium ion binding alpha-amylase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1k8kC	[pdb]	2.05372 0.00323093	149^LYS 151^VAL 164^HOH 169^HOH 185^HOH 234^HOH	0.0.0.0	actin binding ATP binding actin binding nucleotide binding protein binding actin binding protein binding actin binding ATP binding actin binding nucleotide binding protein binding actin binding actin binding	cell projection cytoskeleton cytoplasm cell projection cytoskeleton cytoplasm cytoskeleton cytoplasm cell projection cytoskeleton cytoplasm cell projection cytoskeleton cytoplasm cell projection cytoskeleton cytoplasm cell projection cytoskeleton cytoplasm lamellipodium	regulation of actin filament polymerization regulation of actin filament polymerization regulation of actin filament polymerization regulation of actin filament polymerization regulation of actin filament polymerization actin filament polymerization
3ecqA	[pdb]	2.05965 0.00331464	608^ASP 807^PHE 822^LYS 835^HIS 840^TRP 864^PHE	0.0.0.0		cell adhesion	extracellular region membrane cell surface
2qxvA	[pdb]	2.06419 0.00331503	234^HIS 249^LYS 256^ASP 262^TRP 291^PHE 348^PHE		chromatin modification regulation of transcription DNA-dependent transcription negative regulation of striated muscle cell differentiation histone methylation transcription chromatin modification regulation of transcription DNA-dependent histone methylation genetic imprinting regulation of transcription regulation of transcription	nucleus pronucleus nucleus pronucleus sex chromatin	transferase activity methyltransferase activity histone-lysine N-methyltransferase activity histone methyltransferase activity protein binding chromatin binding DNA binding protein binding chromatin binding
1u7vB	[pdb]	2.07094 0.00339985	339^PHE 404^ASP 405^HIS 408^PHE 509^TRP 519^LYS		regulation of binding paraxial mesoderm morphogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription DNA-dependent cell fate commitment anterior/posterior pattern formation intracellular signaling cascade transforming growth factor beta receptor signaling pathway mesoderm formation regulation of transcription DNA-dependent transcription signal transduction negative regulation of transcription DNA-dependent regulation of transcription DNA-dependent transcription BMP signaling pathway transforming growth factor beta receptor signaling pathway regulation of binding neuron fate commitment positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription DNA-dependent anterior/posterior pattern formation negative regulation of cell proliferation regulation of transcription from RNA polymerase II promoter kidney development gastrulation with mouth forming second branching involved in ureteric bud morphogenesis regulation of transforming growth factor-beta2 production response to hypoxia negative regulation of transcription DNA-dependent negative regulation of cell growth regulation of transforming growth factor beta receptor signaling pathway SMAD protein complex assembly regulation of transforming growth factor beta receptor signaling pathway positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation regulation of cell proliferation regulation of transcription positive regulation of transcription palate development positive regulation of SMAD protein nuclear translocation SMAD protein signal transduction SMAD protein complex assembly zygotic determination of dorsal/ventral axis gastrulation positive regulation of epithelial to mesenchymal transition primary microRNA processing positive regulation of gene-specific transcription regulation of transcription positive regulation of transcription palate development response to cholesterol	transcription factor binding transcription activator activity protein binding double-stranded DNA binding transcription factor activity protein binding transcription factor activity transcription activator activity DNA binding protein homodimerization activity SMAD binding sequence-specific DNA binding collagen binding promoter binding transforming growth factor beta receptor common-partner cytoplasmic mediator activity identical protein binding R-SMAD binding DNA binding transforming growth factor beta receptor binding promoter binding transforming growth factor beta receptor pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding co-SMAD binding R-SMAD binding	transcription factor complex cytoplasm nucleus cytosol nucleoplasm intracellular transcription factor complex cytoplasm nucleus cytosol nucleoplasm intracellular activin responsive factor complex activin responsive factor complex
2fgtA	[pdb]	2.0733 0.00340005	155^PHE 306^LYS 314^TRP 317^HIS 331^PHE 336^ASP			metal ion binding calcium ion binding	plasma membrane integral to membrane membrane
1t2aB	[pdb]	2.07469 0.00348547	35^ASP 118^PHE 207^PHE 246^LYS 249^TRP 251^HIS	4.2.1.47	GDP-mannose 4,6-dehydratase activity lyase activity coenzyme binding binding catalytic activity	cytoplasm intracellular	leukocyte adhesion 'de novo' GDP-L-fucose biosynthetic process carbohydrate metabolic process cellular metabolic process GDP-mannose metabolic process metabolic process
1bhnE	[pdb]	2.07492 0.00348549	8^PHE 39^LYS 51^HIS 54^ASP 108^PHE 133^TRP	2.7.4.6	metal ion binding transferase activity kinase activity ATP binding magnesium ion binding nucleotide binding nucleoside diphosphate kinase activity protein binding	nucleotide metabolic process CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process endocytosis nervous system development cell differentiation	plasma membrane cytoplasm membrane nucleus mitochondrion
2ggzB	[pdb]	2.08067 0.00348599	25^PHE 55^HIS 57^ASP 63^PHE 91^LYS 94^TRP			calcium ion binding calcium sensitive guanylate cyclase activator activity	signal transduction visual perception
2f1zB	[pdb]	2.08518 0.00357379	158^PHE 206^ASP 210^HIS 477^TRP 480^PHE 490^LYS	3.1.2.15	modification-dependent protein catabolic process protein deubiquitination interspecies interaction between organisms ubiquitin-dependent protein catabolic process	nucleus cytoplasm	ubiquitin-specific protease activity protein C-terminus binding protein binding hydrolase activity cysteine-type peptidase activity peptidase activity ubiquitin thiolesterase activity cysteine-type endopeptidase activity
3cihA	[pdb]	2.08768 0.00357401	304^PHE 561^PHE 659^LYS 660^TRP 671^ASP 673^HIS	0.0.0.0			catalytic activity
2ilyA	[pdb]	2.10671 0.00385086	198^PHE 215^ASP 228^LYS 368^TRP 373^PHE 389^HIS	3.4.22.29, 3.4.22.28, 2.7.7.48, 3.6.1.15	host cell cytoplasm cytoplasm cytoplasmic vesicle viral capsid virion membrane	hydrolase activity nucleotidyltransferase activity transferase activity cysteine-type peptidase activity peptidase activity ATP binding structural molecule activity helicase activity RNA-directed RNA polymerase activity RNA binding nucleotide binding nucleoside-triphosphatase activity cysteine-type endopeptidase activity catalytic activity RNA helicase activity	interspecies interaction between organisms RNA-protein covalent cross-linking transcription RNA-dependent proteolysis transcription viral genome replication viral reproduction
1yrqK	[pdb]	2.11453 0.00394772	119^PHE 127^TRP 278^LYS 400^PHE 538^HIS 541^ASP	1.12.2.1	4 iron 4 sulfur cluster binding 3 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding cytochrome-c3 hydrogenase activity ferredoxin hydrogenase activity NADH dehydrogenase (ubiquinone) activity metal ion binding oxidoreductase activity nickel ion binding cytochrome-c3 hydrogenase activity ferredoxin hydrogenase activity quinone binding	oxidation reduction oxidation reduction	periplasmic space ferredoxin hydrogenase complex periplasmic space
1ii7A	[pdb]	2.12173 0.00404678	3^PHE 25^PHE 52^HIS 86^ASP 209^LYS 229^TRP			metal ion binding manganese ion binding hydrolase activity exonuclease activity nuclease activity endonuclease activity identical protein binding	response to DNA damage stimulus DNA repair DNA metabolic process
2g62A	[pdb]	2.12544 0.00404715	215^PHE 237^HIS 240^ASP 253^PHE 284^TRP 286^LYS		nucleolus nucleus soluble fraction protein phosphatase type 2A complex calcium channel complex	protein amino acid dephosphorylation positive regulation of phosphoprotein phosphatase activity positive regulation of protein amino acid dephosphorylation regulation of phosphoprotein phosphatase activity negative regulation of phosphoprotein phosphatase activity negative regulation of protein amino acid dephosphorylation	protein tyrosine phosphatase activator activity phosphatase activator activity ATP binding protein homodimerization activity ATPase activity protein phosphatase type 2A regulator activity receptor binding protein phosphatase 2A binding protein heterodimerization activity
1k3dA	[pdb]	2.13376 0.00414747	163^PHE 226^LYS 232^HIS 269^ASP 273^TRP 279^PHE	4.1.1.49	carboxy-lyase activity lyase activity ATP binding calcium ion binding catalytic activity nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm	gluconeogenesis
1delB	[pdb]	2.15189 0.00445819	20^PHE 37^LYS 152^TRP 156^PHE 180^HIS 183^ASP	2.7.4.13			transferase activity kinase activity (deoxy)nucleoside-phosphate kinase activity nucleotide binding ATP binding
2p0aB	[pdb]	2.15591 0.00445863	230^PHE 286^PHE 314^TRP 315^LYS 355^HIS 361^ASP		ATP binding calcium ion binding nucleotide binding catalytic activity protein binding	neurotransmitter secretion	synaptic vesicle membrane synapse cytoplasmic vesicle cell junction membrane synaptic vesicle
1pk8G	[pdb]	2.15607 0.00445864	251^PHE 307^PHE 335^TRP 336^LYS 376^HIS 382^ASP		neurotransmitter secretion	protein binding actin binding ATP binding catalytic activity	synaptic vesicle Golgi apparatus synapse cell junction
1yhsA	[pdb]	2.15632 0.00445867	100^PHE 169^LYS 195^ASP 219^HIS 226^TRP 281^PHE	2.7.11.1	ATP binding manganese ion binding protein serine/threonine kinase activity metal ion binding transferase activity kinase activity nucleotide binding protein kinase activity protein binding	cytoplasm plasma membrane nucleus membrane	negative regulation of apoptosis cell proliferation protein amino acid phosphorylation multicellular organismal development
1tvpA	[pdb]	2.15961 0.00456665	33^TRP 38^PHE 51^PHE 98^ASP 100^HIS 261^LYS	0.0.0.0	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity cellulase activity cation binding carbohydrate binding calcium ion binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity	metabolic process cell adhesion carbohydrate metabolic process
2hv7A	[pdb]	2.16069 0.00456677	215^PHE 237^HIS 240^ASP 253^PHE 284^TRP 286^LYS		nucleolus nucleus soluble fraction protein phosphatase type 2A complex calcium channel complex	protein amino acid dephosphorylation positive regulation of phosphoprotein phosphatase activity positive regulation of protein amino acid dephosphorylation regulation of phosphoprotein phosphatase activity negative regulation of phosphoprotein phosphatase activity negative regulation of protein amino acid dephosphorylation	protein tyrosine phosphatase activator activity phosphatase activator activity ATP binding protein homodimerization activity ATPase activity protein phosphatase type 2A regulator activity receptor binding protein phosphatase 2A binding protein heterodimerization activity
1olmA	[pdb]	2.17061 0.00467788	92^ASP 174^PHE 190^PHE 193^LYS 224^TRP 231^HIS		cytoplasm nucleus intracellular cytosol	positive regulation of transcription DNA-dependent regulation of cholesterol biosynthetic process transport regulation of transcription DNA-dependent transcription positive regulation of cholesterol biosynthetic process regulation of transcription	transcription activator activity phospholipid binding vitamin E binding lipid binding transporter activity enzyme activator activity
2fhxB	[pdb]	2.1778 0.00479114	53^PHE 120^ASP 180^PHE 257^LYS 263^HIS 266^TRP	0.0.0.0		antibiotic catabolic process	hydrolase activity beta-lactamase activity zinc ion binding
1yggA	[pdb]	2.17944 0.00479133	163^PHE 226^LYS 232^HIS 269^ASP 273^TRP 279^PHE		carboxy-lyase activity lyase activity kinase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity carboxy-lyase activity lyase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm cytoplasm	gluconeogenesis gluconeogenesis
1yrzB	[pdb]	2.18502 0.00490687	2014^HIS 2016^ASP 2035^TRP 2066^LYS 2100^PHE 2497^PHE	0.0.0.0		hydrolase activity acting on glycosyl bonds hydrolase activity xylan 1,4-beta-xylosidase activity hydrolase activity hydrolyzing O-glycosyl compounds	metabolic process carbohydrate metabolic process
1i5pA	[pdb]	2.18764 0.00502331	177^PHE 231^PHE 239^HIS 240^ASP 293^TRP 515^LYS	0.0.0.0		receptor binding	sporulation resulting in formation of a cellular spore pathogenesis defense response
1uokA	[pdb]	2.18772 0.00502332	203^PHE 265^LYS 279^PHE 283^HIS 285^ASP 311^TRP	3.2.1.10	cytoplasm	hydrolase activity acting on glycosyl bonds hydrolase activity oligo-1,6-glucosidase activity cation binding catalytic activity	metabolic process carbohydrate metabolic process
2pvcB	[pdb]	2.18801 0.00502336	196^PHE 250^HIS 253^ASP 301^PHE 359^TRP 362^LYS		DNA methylation genetic imprinting spermatogenesis in utero embryonic development	cytosol nucleus cytoplasm nuclear heterochromatin condensed nuclear chromosome	zinc ion binding enzyme activator activity protein binding transcription repressor activity enzyme binding metal ion binding
2z95C	[pdb]	2.19065 0.00502367	15^ASP 92^PHE 179^PHE 181^HIS 218^LYS 221^TRP	0.0.0.0	cellular metabolic process GDP-mannose metabolic process metabolic process	coenzyme binding GDP-mannose 4,6-dehydratase activity binding catalytic activity	intracellular
2rf7B	[pdb]	2.1926 0.0050239	123^TRP 126^LYS 140^ASP 144^HIS 196^PHE 218^PHE	1.7.2.2	metal ion binding oxidoreductase activity calcium ion binding iron ion binding nitrite reductase (cytochrome ammonia-forming) activity heme binding	oxidation reduction electron transport chain transport nitrogen compound metabolic process	periplasmic space
3d3aA	[pdb]	2.19697 0.00514183	186^PHE 266^ASP 267^HIS 316^PHE 428^TRP 481^LYS	0.0.0.0	beta-galactosidase complex	cell adhesion carbohydrate metabolic process	hydrolase activity hydrolyzing O-glycosyl compounds cation binding beta-galactosidase activity catalytic activity
1efhB	[pdb]	2.20046 0.00514225	13^PHE 125^ASP 144^LYS 146^TRP 150^PHE 257^HIS	2.8.2.14	bile acid catabolic process steroid metabolic process lipid metabolic process digestion	cytoplasm cytosol	transferase activity bile-salt sulfotransferase activity sulfotransferase activity
2vduB	[pdb]	2.20437 0.00526269	219^THR 221^VAL 236^PRO 238^PHE 270^LYS 278^THR		nucleus nucleus	tRNA binding RNA binding tRNA (guanine-N7-)-methyltransferase activity protein binding transferase activity methyltransferase activity tRNA (guanine-N7-)-methyltransferase activity protein binding	tRNA processing ribosome biogenesis tRNA methylation tRNA processing ribosome biogenesis tRNA methylation tRNA modification
2inyA	[pdb]	2.21024 0.00538598	619^LYS 641^TRP 687^PHE 695^ASP 865^PHE 889^HIS			structural molecule activity	virion viral capsid
2qz7A	[pdb]	2.21503 0.00538658	29^LYS 30^TRP 112^HIS 120^PHE 156^PHE 176^ASP	0.0.0.0			response to stress
2rcuA	[pdb]	2.21743 0.0055121	213^ASP 218^PHE 354^LYS 374^TRP 388^PHE 496^HIS	2.3.1.21	mitochondrial inner membrane membrane mitochondrion	transferase activity acyltransferase activity carnitine O-palmitoyltransferase activity	transport fatty acid metabolic process lipid metabolic process long-chain fatty acid transport fatty acid beta-oxidation
1gyhA	[pdb]	2.22019 0.00551246	38^ASP 183^PHE 203^LYS 235^PHE 238^TRP 291^HIS	0.0.0.0		carbohydrate metabolic process metabolic process	hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity acting on glycosyl bonds hydrolase activity arabinan endo-1,5-alpha-L-arabinosidase activity
1u8wB	[pdb]	2.22512 0.00564102	5^PHE 36^LYS 48^HIS 51^ASP 105^PHE 130^TRP	2.7.4.6	apoplast chloroplast plasma membrane vacuole	metal ion binding transferase activity kinase activity ATP binding magnesium ion binding nucleotide binding nucleoside diphosphate kinase activity	response to cadmium ion response to salt stress nucleotide metabolic process CTP biosynthetic process UTP biosynthetic process GTP biosynthetic process
2cwnA	[pdb]	2.22752 0.00564134	147^TRP 154^LYS 227^PHE 294^PHE 298^HIS 301^ASP	2.2.1.2	cytoplasm	pentose-phosphate shunt metabolic process carbohydrate metabolic process	transferase activity transaldolase activity catalytic activity protein binding
1wubA	[pdb]	2.23147 0.00564186	63^ASP 65^HIS 71^PHE 82^PHE 140^LYS 146^TRP	0.0.0.0
2g3hA	[pdb]	2.23233 0.00577267	32^PHE 89^TRP 91^LYS 136^ASP 137^HIS 143^PHE	0.0.0.0		heme binding oxygen binding iron ion binding protein binding oxygen transporter activity	oxygen transport transport
2qruA	[pdb]	2.23406 0.0057729	41^LYS 73^ASP 74^HIS 83^PHE 124^PHE 163^TRP	0.0.0.0
1nwtA	[pdb]	2.24505 0.00590648	207^ASP 219^HIS 265^PHE 287^PHE 321^LYS 325^TRP	0.0.0.0	chitin catabolic process carbohydrate metabolic process	extracellular region extracellular space proteinaceous extracellular matrix	sugar binding extracellular matrix structural constituent cation binding chitinase activity hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
1f05B	[pdb]	2.24665 0.0059067	147^TRP 154^LYS 227^PHE 294^PHE 298^HIS 301^ASP	2.2.1.2	cytoplasm cytosol	pentose-phosphate shunt carbohydrate metabolic process metabolic process	transferase activity transaldolase activity catalytic activity protein binding
3b8cB	[pdb]	2.24764 0.00604039	96^PHE 269^LYS 667^TRP 671^PHE 748^ASP 751^HIS	3.6.3.6	membrane plasma membrane integral to membrane	protein binding metal ion binding hydrolase activity hydrogen ion transmembrane transporter activity ATP binding magnesium ion binding nucleotide binding hydrogen-exporting ATPase activity phosphorylative mechanism ATPase activity hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances ATPase activity coupled to transmembrane movement of ions phosphorylative mechanism catalytic activity	proton transport ion transport transport metabolic process cation transport ATP biosynthetic process
2j47A	[pdb]	2.2571 0.00617817	349^HIS 421^PHE 427^ASP 465^PHE 498^TRP 503^LYS	3.2.1.52		hydrolase activity acting on glycosyl bonds hydrolase activity beta-N-acetylhexosaminidase activity	metabolic process
2cmuA	[pdb]	2.25905 0.00617845	20^PHE 105^PHE 108^TRP 111^LYS 204^HIS 206^ASP	0.0.0.0
2vfiB	[pdb]	2.27304 0.00646246	11^TRP 12^LYS 42^PHE 49^ASP 50^HIS 69^PHE	5.3.1.1		isomerase activity triose-phosphate isomerase activity catalytic activity	lipid biosynthetic process fatty acid biosynthetic process pentose-phosphate shunt glycolysis gluconeogenesis metabolic process
3e58A	[pdb]	2.27856 0.00660898	14^PHE 36^ASP 37^HIS 42^PHE 49^LYS 52^TRP	0.0.0.0		hydrolase activity phosphoglycolate phosphatase activity catalytic activity	metabolic process
2z73A	[pdb]	2.27991 0.00660918	12^TRP 20^HIS 83^PHE 99^LYS 105^PHE 189^ASP		membrane integral to membrane	photoreceptor activity G-protein coupled receptor activity receptor activity signal transducer activity	response to stimulus protein-chromophore linkage phototransduction visual perception G-protein coupled receptor protein signaling pathway signal transduction
1xx1C	[pdb]	2.28296 0.00660964	8^TRP 12^HIS 34^ASP 88^PHE 145^PHE 226^LYS	3.1.4.41	extracellular region	hemolysis by symbiont of host erythrocytes cytolysis pathogenesis lipid metabolic process	metal ion binding hydrolase activity magnesium ion binding sphingomyelin phosphodiesterase D activity phosphoric diester hydrolase activity
1c3bB	[pdb]	2.28686 0.00675921	10^ASP 13^HIS 41^PHE 43^TRP 328^PHE 342^LYS	3.5.2.6	hydrolase activity beta-lactamase activity protein binding	periplasmic space outer membrane-bounded periplasmic space	response to antibiotic antibiotic catabolic process
1lwhB	[pdb]	2.28679 0.0067592	679^ASP 682^HIS 689^TRP 726^PHE 734^LYS 775^PHE	2.4.1.25	carbohydrate metabolic process	cytoplasm	metal ion binding transferase activity transferring glycosyl groups transferase activity calcium ion binding 4-alpha-glucanotransferase activity cation binding catalytic activity
1h3gA	[pdb]	2.28769 0.00675934	13^PHE 21^LYS 77^PHE 187^ASP 188^HIS 298^TRP	0.0.0.0		hydrolase activity acting on glycosyl bonds hydrolase activity cyclomaltodextrinase activity cation binding catalytic activity	metabolic process carbohydrate metabolic process
2i3sE	[pdb]	2.2879 0.00675937	40^PHE 241^HIS 264^LYS 272^ASP 278^TRP 289^PHE	0.0.0.0	cell cycle sister chromatid biorientation mitotic cell cycle spindle assembly checkpoint protein amino acid phosphorylation cell cycle checkpoint cell cycle mitotic cell cycle spindle assembly checkpoint	nucleus condensed nuclear chromosome centromeric region condensed nuclear chromosome kinetochore kinetochore nucleus mitotic checkpoint complex condensed nuclear chromosome kinetochore	transferase activity kinase activity ATP binding protein serine/threonine kinase activity nucleotide binding protein binding protein kinase activity protein binding
2vexA	[pdb]	2.29333 0.00691256	60^HIS 65^ASP 95^PHE 100^TRP 103^LYS 256^PHE	3.1.3.48	endoplasmic reticulum membrane membrane endoplasmic reticulum	protein tyrosine phosphatase activity zinc ion binding hydrolase activity phosphoprotein phosphatase activity phosphatase activity protein binding	signal transduction dephosphorylation protein amino acid dephosphorylation negative regulation of insulin receptor signaling pathway insulin receptor signaling pathway
3cweA	[pdb]	2.30408 0.00706833	560^HIS 565^ASP 595^PHE 600^TRP 603^LYS 756^PHE	3.1.3.48	endoplasmic reticulum membrane membrane endoplasmic reticulum	negative regulation of insulin receptor signaling pathway insulin receptor signaling pathway signal transduction dephosphorylation protein amino acid dephosphorylation	protein tyrosine phosphatase activity zinc ion binding hydrolase activity phosphoprotein phosphatase activity phosphatase activity protein binding

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

1dieA

[pdb]

0.110969
0.000110277

25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
isomerase activity
magnesium ion binding
xylose isomerase activity

1xylA

[pdb]

0.167472
0.000162331

25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
isomerase activity
magnesium ion binding
xylose isomerase activity

1qt1A

[pdb]

0.168031
0.000162336

25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cobalt ion binding
metal ion binding
isomerase activity
xylose isomerase activity
magnesium ion binding

cytoplasm

5ximD

[pdb]

0.192197
0.000195666

26^PHE 54^HIS 57^ASP 94^PHE 137^TRP 183^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
isomerase activity
magnesium ion binding
xylose isomerase activity

3cwhA

[pdb]

0.284944
0.000300413

26^PHE 54^HIS 57^ASP 94^PHE 137^TRP 183^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
isomerase activity
magnesium ion binding
xylose isomerase activity

1bxbA

[pdb]

0.304503
0.000325359

25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
isomerase activity
magnesium ion binding
xylose isomerase activity

1bxcD

[pdb]

0.309036
0.000325396

25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
isomerase activity
magnesium ion binding
xylose isomerase activity

1a0cA

[pdb]

0.547587
0.000518658

59^PHE 100^HIS 103^ASP 144^PHE 187^TRP 233^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cobalt ion binding
metal ion binding
isomerase activity
xylose isomerase activity
magnesium ion binding

cytoplasm

1a0eA

[pdb]

0.645132
0.000576323

59^PHE 100^HIS 103^ASP 144^PHE 187^TRP 233^LYS

5.3.1.5

carbohydrate metabolic process
D-xylose metabolic process
pentose-phosphate shunt

cytoplasm

xylose isomerase activity
magnesium ion binding
cobalt ion binding
metal ion binding
isomerase activity

1a0dD

[pdb]

0.677859
0.000592701

58^PHE 98^HIS 101^ASP 142^PHE 185^TRP 231^LYS

5.3.1.5

D-xylose metabolic process
pentose-phosphate shunt
carbohydrate metabolic process

cytoplasm

metal ion binding
manganese ion binding
isomerase activity
xylose isomerase activity
magnesium ion binding

2i56D

[pdb]

1.28234
0.000708761

66^PHE 101^HIS 105^ASP 131^PHE 179^TRP 221^LYS

0.0.0.0

isomerase activity

2gthA

[pdb]

1.54075
0.00081053

43^PHE 66^HIS 81^TRP 94^PHE 100^LYS 155^ASP

2.7.7.48

integral to membrane
membrane
cytoplasm
viral replication complex
integral to membrane
membrane
cytoplasm
viral replication complex
perinuclear region of cytoplasm
perinuclear region of cytoplasm

metal ion binding
hydrolase activity
nucleotidyltransferase activity
transferase activity
zinc ion binding
cysteine-type peptidase activity
peptidase activity
ATP binding
exonuclease activity
endonuclease activity
nuclease activity
helicase activity
RNA-directed RNA polymerase activity
RNA binding
nucleotide binding
exoribonuclease activity
producing 5'-phosphomonoesters
methyltransferase activity
cysteine-type endopeptidase activity
catalytic activity
metal ion binding
hydrolase activity
zinc ion binding
cysteine-type peptidase activity
peptidase activity
RNA binding
RNA-directed RNA polymerase activity
catalytic activity

transcription
RNA-dependent
viral protein processing
viral genome replication
viral reproduction
proteolysis
transcription
viral protein processing
viral genome replication
viral reproduction
proteolysis

1olpA

[pdb]

1.62168
0.000892377

1^TRP 71^ASP 128^PHE 136^HIS 159^LYS 175^PHE

0.0.0.0

phospholipase C activity
hydrolase activity
acting on ester bonds
zinc ion binding

3b6rB

[pdb]

1.69076
0.00100562

194^PHE 218^TRP 223^LYS 233^ASP 234^HIS 334^PHE

2.7.3.2

creatine metabolic process
cellular chloride ion homeostasis
brain development

cytoplasm
cytosol
mitochondrion

transferase activity
kinase activity
ATP binding
nucleotide binding
creatine kinase activity
transferase activity
transferring phosphorus-containing groups
catalytic activity
protein binding

1khoA

[pdb]

1.77879
0.00126315

1^TRP 71^ASP 128^PHE 136^HIS 159^LYS 175^PHE

3.1.4.3

extracellular region

hemolysis by symbiont of host erythrocytes
cytolysis
pathogenesis

metal ion binding
hydrolase activity
zinc ion binding
calcium ion binding
phosphatidylcholine phospholipase C activity
hydrolase activity
acting on ester bonds
phospholipase C activity

2bkqD

[pdb]

1.79295
0.00132006

29^ASP 30^HIS 36^PHE 116^PHE 198^LYS 202^TRP

hydrolase activity
cysteine-type peptidase activity
peptidase activity
protein binding

ubiquitin-dependent protein catabolic process
proteolysis
modification-dependent protein catabolic process

1i0eB

[pdb]

1.80207
0.00135063

194^PHE 218^TRP 223^LYS 233^ASP 234^HIS 334^PHE

2.7.3.2

creatine metabolic process
phosphocreatine biosynthetic process

cytoplasm
cytosol

transferase activity
kinase activity
ATP binding
nucleotide binding
creatine kinase activity
transferase activity
transferring phosphorus-containing groups
catalytic activity

1lxmA

[pdb]

1.81042
0.00138258

631^ASP 649^HIS 703^LYS 752^PHE 755^TRP 843^PHE

4.2.2.1

carbohydrate metabolic process

extracellular region

lyase activity
hyaluronate lyase activity
carbohydrate binding
carbon-oxygen lyase activity
acting on polysaccharides
catalytic activity

1p7bB

[pdb]

1.84404
0.00156183

158^PHE 161^HIS 191^LYS 222^PHE 274^TRP 305^ASP

0.0.0.0

ion channel activity
inward rectifier potassium channel activity

membrane

potassium ion transport

1dboA

[pdb]

1.85295
0.00160124

83^PHE 201^ASP 202^HIS 204^PHE 467^TRP 476^LYS

4.2.2.19

lyase activity
chondroitin B lyase activity

1qh4B

[pdb]

1.85845
0.00164206

194^PHE 218^TRP 223^LYS 233^ASP 234^HIS 334^PHE

2.7.3.2

cytoplasm
mitochondrion

transferase activity
kinase activity
ATP binding
nucleotide binding
creatine kinase activity
transferase activity
transferring phosphorus-containing groups
catalytic activity

2bjqA

[pdb]

1.86515
0.0016845

51^ASP 192^PHE 224^HIS 229^PHE 246^TRP 327^LYS

0.0.0.0

3bc9A

[pdb]

1.86723
0.00168459

275^PHE 302^LYS 304^TRP 350^ASP 354^HIS 359^PHE

carbohydrate metabolic process

cation binding
catalytic activity

1tl2A

[pdb]

1.88139
0.00177428

43^PHE 108^LYS 134^TRP 141^PHE 152^HIS 182^ASP

extracellular region

innate immune response
immune response

sugar binding

1qk1B

[pdb]

1.88303
0.00177436

189^PHE 213^TRP 218^LYS 228^ASP 229^HIS 329^PHE

2.7.3.2

creatine metabolic process

mitochondrial inner membrane
membrane
mitochondrion

transferase activity
kinase activity
ATP binding
nucleotide binding
creatine kinase activity
transferase activity
transferring phosphorus-containing groups
catalytic activity

2h84B

[pdb]

1.8949
0.00186963

3068^PHE 3075^LYS 3096^TRP 3115^ASP 3116^HIS 3138^PHE

0.0.0.0

flavonoid biosynthetic process
biosynthetic process
metabolic process

naringenin-chalcone synthase activity
phosphopantetheine binding
transferase activity
oxidoreductase activity
acyltransferase activity
binding
catalytic activity
acyl carrier activity

2zkmX

[pdb]

1.90014
0.00186989

23^PHE 27^ASP 89^PHE 113^HIS 124^LYS 126^TRP

3.1.4.11

lipid catabolic process
signal transduction
activation of phospholipase C activity
phospholipid metabolic process
intracellular signaling cascade
lipid metabolic process

metal ion binding
hydrolase activity
calcium ion binding
signal transducer activity
phosphoinositide phospholipase C activity
phospholipase C activity
phosphoric diester hydrolase activity

2inpA

[pdb]

1.92827
0.00207567

85^ILE 156^HOH 219^ASN 339^HOH 493^HOH 495^HOH

0.0.0.0

cellular aromatic compound metabolic process
cellular aromatic compound metabolic process
cellular aromatic compound metabolic process
oxidation reduction
oxidation reduction

transition metal ion binding
oxidoreductase activity
acting on paired donors
with incorporation or reduction of molecular oxygen
NADH or NADPH as one donor
and incorporation of one atom of oxygen
oxidoreductase activity
transition metal ion binding
oxidoreductase activity
monooxygenase activity

2gjrA

[pdb]

1.93519
0.00213134

155^PHE 185^LYS 189^TRP 236^ASP 240^HIS 245^PHE

3.2.1.98

extracellular region

metabolic process
carbohydrate metabolic process

metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
glucan 1,4-alpha-maltohexaosidase activity
cation binding
calcium ion binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

3bbcF

[pdb]

1.93776
0.00213149

8^PHE 39^LYS 51^HIS 54^ASP 108^PHE 133^TRP

2.7.4.6

nucleus
cytoplasm
lamellipodium
ruffle

regulation of transcription
regulation of transcription
DNA-dependent
nucleoside triphosphate biosynthetic process
negative regulation of cell proliferation
negative regulation of cell cycle
nucleotide metabolic process
cell cycle
transcription
CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process
positive regulation of epithelial cell proliferation
regulation of epidermis development
positive regulation of keratinocyte differentiation
negative regulation of apoptosis
cell adhesion

transcription factor activity
ATP binding
nucleoside diphosphate kinase activity
metal ion binding
transferase activity
kinase activity
DNA binding
magnesium ion binding
nucleotide binding
protein binding

2gjxF

[pdb]

1.94417
0.00218884

294^LEU 298^TYR 303^THR 319^LEU 354^PHE 370^TYR

3.2.1.52

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
cation binding
catalytic activity
protein binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
protein homodimerization activity
cation binding
catalytic activity
hydrolase activity
hydrolyzing O-glycosyl compounds
hydrolase activity
hydrolyzing O-glycosyl compounds

lysosome
membrane
lysosome
membrane
acrosomal vesicle

metabolic process
carbohydrate metabolic process
neuromuscular process controlling balance
neuromuscular process controlling posture
myelination
glycosaminoglycan metabolic process
sexual reproduction
lipid storage
adult walking behavior
locomotory behavior
sensory perception of sound
lysosome organization
ganglioside catabolic process
skeletal system development
metabolic process
carbohydrate metabolic process
neuromuscular process
neuromuscular process controlling balance
oogenesis
cellular protein metabolic process
myelination
regulation of cellular metabolic process
glycosaminoglycan metabolic process
sexual reproduction
lipid storage
oligosaccharide catabolic process
phospholipid biosynthetic process
male courtship behavior
locomotory behavior
sensory perception of sound
penetration of zona pellucida
single fertilization
lysosome organization
cellular calcium ion homeostasis
ganglioside catabolic process
glycosphingolipid metabolic process
skeletal system development

3bh4A

[pdb]

1.94437
0.00218886

152^PHE 181^LYS 185^TRP 232^ASP 236^HIS 241^PHE

3.2.1.1

extracellular region

metabolic process
carbohydrate metabolic process

metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
calcium ion binding
alpha-amylase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1pn0B

[pdb]

1.94857
0.00224695

476^LYS 499^HIS 502^ASP 515^PHE 606^TRP 640^PHE

1.14.13.7

cytoplasm

oxidation reduction
aromatic compound catabolic process
metabolic process

oxidoreductase activity
monooxygenase activity
phenol 2-monooxygenase activity

1ndlC

[pdb]

1.97355
0.00242995

9^PHE 40^LYS 52^HIS 55^ASP 109^PHE 134^TRP

2.7.4.6

CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process
nucleotide metabolic process
protein amino acid autophosphorylation
peptidyl-serine phosphorylation
epithelial cell migration
open tracheal system
open tracheal system development
mitosis
microtubule-based process
protein amino acid phosphorylation
nucleoside diphosphate phosphorylation

kinase activity
magnesium ion binding
ATP binding
nucleoside diphosphate kinase activity
metal ion binding
transferase activity
nucleotide binding
microtubule binding
GTP binding

nuclear microtubule
cytoplasm
microtubule
cytoskeleton

1j99A

[pdb]

1.98728
0.00256074

13^PHE 125^ASP 144^LYS 146^TRP 150^PHE 257^HIS

2.8.2.14

bile acid catabolic process
steroid metabolic process
lipid metabolic process
digestion

cytoplasm
cytosol

transferase activity
bile-salt sulfotransferase activity
sulfotransferase activity

1iznA

[pdb]

1.99032
0.00256095

20^GLN 62^CYS 79^TYR 81^PRO 177^LEU 210^ILE

0.0.0.0

Z disc
membrane
lamellipodium
cortical cytoskeleton
cytoskeleton
cytoplasm
F-actin capping protein complex
cytoplasm
F-actin capping protein complex

actin binding
actin binding

actin filament capping
cell projection organization
lamellipodium assembly
actin filament capping
barbed-end actin filament capping
actin cytoskeleton organization
barbed-end actin filament capping
actin cytoskeleton organization

2ov1A

[pdb]

1.9986
0.0026292

61^PHE 81^ASP 83^HIS 108^PHE 112^TRP 117^LYS

0.0.0.0

binding
metal ion binding

metal ion transport

outer membrane-bounded periplasmic space

1zmwB

[pdb]

2.00032
0.00269885

156^PHE 170^PHE 282^LYS 303^TRP 308^HIS 311^ASP

2.7.11.1

ATP binding
protein serine/threonine kinase activity
magnesium ion binding
metal ion binding
transferase activity
kinase activity
nucleotide binding
protein kinase activity

establishment or maintenance of epithelial cell apical/basal polarity
protein kinase cascade
protein amino acid phosphorylation
cell differentiation
multicellular organismal development

nucleus
basal cortex
membrane
plasma membrane

1pq4A

[pdb]

2.00723
0.0027698

61^PHE 81^ASP 83^HIS 108^PHE 112^TRP 117^LYS

0.0.0.0

binding
metal ion binding

metal ion transport

outer membrane-bounded periplasmic space

1e3zA

[pdb]

2.02295
0.00291568

151^PHE 180^LYS 184^TRP 231^ASP 235^HIS 240^PHE

3.2.1.1

extracellular region

metabolic process
carbohydrate metabolic process
metabolic process
carbohydrate metabolic process

metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
calcium ion binding
alpha-amylase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity
metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
calcium ion binding
alpha-amylase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

2d3lA

[pdb]

2.02386
0.00291575

155^PHE 185^LYS 189^TRP 236^ASP 240^HIS 245^PHE

3.2.1.98

extracellular region

metabolic process
carbohydrate metabolic process

metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
glucan 1,4-alpha-maltohexaosidase activity
cation binding
calcium ion binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1wb4B

[pdb]

2.04435
0.0030698

879^LYS 953^PHE 1018^ASP 1058^HIS 1060^TRP 1074^PHE

3.2.1.8

hydrolase activity
acting on glycosyl bonds
hydrolase activity
endo-1,4-beta-xylanase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity
protein binding

xylan catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

1hvxA

[pdb]

2.04964
0.00314941

154^PHE 183^LYS 187^TRP 234^ASP 238^HIS 243^PHE

3.2.1.1

metabolic process
carbohydrate metabolic process

metal ion binding
hydrolase activity
acting on glycosyl bonds
hydrolase activity
calcium ion binding
alpha-amylase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1k8kC

[pdb]

2.05372
0.00323093

149^LYS 151^VAL 164^HOH 169^HOH 185^HOH 234^HOH

0.0.0.0

actin binding
ATP binding
actin binding
nucleotide binding
protein binding
actin binding
protein binding
actin binding
ATP binding
actin binding
nucleotide binding
protein binding
actin binding
actin binding

cell projection
cytoskeleton
cytoplasm
cell projection
cytoskeleton
cytoplasm
cytoskeleton
cytoplasm
cell projection
cytoskeleton
cytoplasm
cell projection
cytoskeleton
cytoplasm
cell projection
cytoskeleton
cytoplasm
cell projection
cytoskeleton
cytoplasm
lamellipodium

regulation of actin filament polymerization
regulation of actin filament polymerization
regulation of actin filament polymerization
regulation of actin filament polymerization
regulation of actin filament polymerization
actin filament polymerization

3ecqA

[pdb]

2.05965
0.00331464

608^ASP 807^PHE 822^LYS 835^HIS 840^TRP 864^PHE

0.0.0.0

cell adhesion

extracellular region
membrane
cell surface

2qxvA

[pdb]

2.06419
0.00331503

234^HIS 249^LYS 256^ASP 262^TRP 291^PHE 348^PHE

chromatin modification
regulation of transcription
DNA-dependent
transcription
negative regulation of striated muscle cell differentiation
histone methylation
transcription
chromatin modification
regulation of transcription
DNA-dependent
histone methylation
genetic imprinting
regulation of transcription
regulation of transcription

nucleus
pronucleus
nucleus
pronucleus
sex chromatin

transferase activity
methyltransferase activity
histone-lysine N-methyltransferase activity
histone methyltransferase activity
protein binding
chromatin binding
DNA binding
protein binding
chromatin binding

1u7vB

[pdb]

2.07094
0.00339985

339^PHE 404^ASP 405^HIS 408^PHE 509^TRP 519^LYS

regulation of binding
paraxial mesoderm morphogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription
DNA-dependent
cell fate commitment
anterior/posterior pattern formation
intracellular signaling cascade
transforming growth factor beta receptor signaling pathway
mesoderm formation
regulation of transcription
DNA-dependent
transcription
signal transduction
negative regulation of transcription
DNA-dependent
regulation of transcription
DNA-dependent
transcription
BMP signaling pathway
transforming growth factor beta receptor signaling pathway
regulation of binding
neuron fate commitment
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription
DNA-dependent
anterior/posterior pattern formation
negative regulation of cell proliferation
regulation of transcription from RNA polymerase II promoter
kidney development
gastrulation with mouth forming second
branching involved in ureteric bud morphogenesis
regulation of transforming growth factor-beta2 production
response to hypoxia
negative regulation of transcription
DNA-dependent
negative regulation of cell growth
regulation of transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
regulation of transforming growth factor beta receptor signaling pathway
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of cell proliferation
regulation of transcription
positive regulation of transcription
palate development
positive regulation of SMAD protein nuclear translocation
SMAD protein signal transduction
SMAD protein complex assembly
zygotic determination of dorsal/ventral axis
gastrulation
positive regulation of epithelial to mesenchymal transition
primary microRNA processing
positive regulation of gene-specific transcription
regulation of transcription
positive regulation of transcription
palate development
response to cholesterol

transcription factor binding
transcription activator activity
protein binding
double-stranded DNA binding
transcription factor activity
protein binding
transcription factor activity
transcription activator activity
DNA binding
protein homodimerization activity
SMAD binding
sequence-specific DNA binding
collagen binding
promoter binding
transforming growth factor beta receptor
common-partner cytoplasmic mediator activity
identical protein binding
R-SMAD binding
DNA binding
transforming growth factor beta receptor binding
promoter binding
transforming growth factor beta receptor
pathway-specific cytoplasmic mediator activity
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
co-SMAD binding
R-SMAD binding

transcription factor complex
cytoplasm
nucleus
cytosol
nucleoplasm
intracellular
transcription factor complex
cytoplasm
nucleus
cytosol
nucleoplasm
intracellular
activin responsive factor complex
activin responsive factor complex

2fgtA

[pdb]

2.0733
0.00340005

155^PHE 306^LYS 314^TRP 317^HIS 331^PHE 336^ASP

metal ion binding
calcium ion binding

plasma membrane
integral to membrane
membrane

1t2aB

[pdb]

2.07469
0.00348547

35^ASP 118^PHE 207^PHE 246^LYS 249^TRP 251^HIS

4.2.1.47

GDP-mannose 4,6-dehydratase activity
lyase activity
coenzyme binding
binding
catalytic activity

cytoplasm
intracellular

leukocyte adhesion
'de novo' GDP-L-fucose biosynthetic process
carbohydrate metabolic process
cellular metabolic process
GDP-mannose metabolic process
metabolic process

1bhnE

[pdb]

2.07492
0.00348549

8^PHE 39^LYS 51^HIS 54^ASP 108^PHE 133^TRP

2.7.4.6

metal ion binding
transferase activity
kinase activity
ATP binding
magnesium ion binding
nucleotide binding
nucleoside diphosphate kinase activity
protein binding

nucleotide metabolic process
CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process
endocytosis
nervous system development
cell differentiation

plasma membrane
cytoplasm
membrane
nucleus
mitochondrion

2ggzB

[pdb]

2.08067
0.00348599

25^PHE 55^HIS 57^ASP 63^PHE 91^LYS 94^TRP

calcium ion binding
calcium sensitive guanylate cyclase activator activity

signal transduction
visual perception

2f1zB

[pdb]

2.08518
0.00357379

158^PHE 206^ASP 210^HIS 477^TRP 480^PHE 490^LYS

3.1.2.15

modification-dependent protein catabolic process
protein deubiquitination
interspecies interaction between organisms
ubiquitin-dependent protein catabolic process

nucleus
cytoplasm

ubiquitin-specific protease activity
protein C-terminus binding
protein binding
hydrolase activity
cysteine-type peptidase activity
peptidase activity
ubiquitin thiolesterase activity
cysteine-type endopeptidase activity

3cihA

[pdb]

2.08768
0.00357401

304^PHE 561^PHE 659^LYS 660^TRP 671^ASP 673^HIS

0.0.0.0

catalytic activity

2ilyA

[pdb]

2.10671
0.00385086

198^PHE 215^ASP 228^LYS 368^TRP 373^PHE 389^HIS

3.4.22.29, 3.4.22.28, 2.7.7.48, 3.6.1.15

host cell cytoplasm
cytoplasm
cytoplasmic vesicle
viral capsid
virion
membrane

hydrolase activity
nucleotidyltransferase activity
transferase activity
cysteine-type peptidase activity
peptidase activity
ATP binding
structural molecule activity
helicase activity
RNA-directed RNA polymerase activity
RNA binding
nucleotide binding
nucleoside-triphosphatase activity
cysteine-type endopeptidase activity
catalytic activity
RNA helicase activity

interspecies interaction between organisms
RNA-protein covalent cross-linking
transcription
RNA-dependent
proteolysis
transcription
viral genome replication
viral reproduction

1yrqK

[pdb]

2.11453
0.00394772

119^PHE 127^TRP 278^LYS 400^PHE 538^HIS 541^ASP

1.12.2.1

4 iron
4 sulfur cluster binding
3 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
cytochrome-c3 hydrogenase activity
ferredoxin hydrogenase activity
NADH dehydrogenase (ubiquinone) activity
metal ion binding
oxidoreductase activity
nickel ion binding
cytochrome-c3 hydrogenase activity
ferredoxin hydrogenase activity
quinone binding

oxidation reduction
oxidation reduction

periplasmic space
ferredoxin hydrogenase complex
periplasmic space

1ii7A

[pdb]

2.12173
0.00404678

3^PHE 25^PHE 52^HIS 86^ASP 209^LYS 229^TRP

metal ion binding
manganese ion binding
hydrolase activity
exonuclease activity
nuclease activity
endonuclease activity
identical protein binding

response to DNA damage stimulus
DNA repair
DNA metabolic process

2g62A

[pdb]

2.12544
0.00404715

215^PHE 237^HIS 240^ASP 253^PHE 284^TRP 286^LYS

nucleolus
nucleus
soluble fraction
protein phosphatase type 2A complex
calcium channel complex

protein amino acid dephosphorylation
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein amino acid dephosphorylation
regulation of phosphoprotein phosphatase activity
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein amino acid dephosphorylation

protein tyrosine phosphatase activator activity
phosphatase activator activity
ATP binding
protein homodimerization activity
ATPase activity
protein phosphatase type 2A regulator activity
receptor binding
protein phosphatase 2A binding
protein heterodimerization activity

1k3dA

[pdb]

2.13376
0.00414747

163^PHE 226^LYS 232^HIS 269^ASP 273^TRP 279^PHE

4.1.1.49

carboxy-lyase activity
lyase activity
ATP binding
calcium ion binding
catalytic activity
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm

gluconeogenesis

1delB

[pdb]

2.15189
0.00445819

20^PHE 37^LYS 152^TRP 156^PHE 180^HIS 183^ASP

2.7.4.13

transferase activity
kinase activity
(deoxy)nucleoside-phosphate kinase activity
nucleotide binding
ATP binding

2p0aB

[pdb]

2.15591
0.00445863

230^PHE 286^PHE 314^TRP 315^LYS 355^HIS 361^ASP

ATP binding
calcium ion binding
nucleotide binding
catalytic activity
protein binding

neurotransmitter secretion

synaptic vesicle membrane
synapse
cytoplasmic vesicle
cell junction
membrane
synaptic vesicle

1pk8G

[pdb]

2.15607
0.00445864

251^PHE 307^PHE 335^TRP 336^LYS 376^HIS 382^ASP

neurotransmitter secretion

protein binding
actin binding
ATP binding
catalytic activity

synaptic vesicle
Golgi apparatus
synapse
cell junction

1yhsA

[pdb]

2.15632
0.00445867

100^PHE 169^LYS 195^ASP 219^HIS 226^TRP 281^PHE

2.7.11.1

ATP binding
manganese ion binding
protein serine/threonine kinase activity
metal ion binding
transferase activity
kinase activity
nucleotide binding
protein kinase activity
protein binding

cytoplasm
plasma membrane
nucleus
membrane

negative regulation of apoptosis
cell proliferation
protein amino acid phosphorylation
multicellular organismal development

1tvpA

[pdb]

2.15961
0.00456665

33^TRP 38^PHE 51^PHE 98^ASP 100^HIS 261^LYS

0.0.0.0

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
cellulase activity
cation binding
carbohydrate binding
calcium ion binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

metabolic process
cell adhesion
carbohydrate metabolic process

2hv7A

[pdb]

2.16069
0.00456677

215^PHE 237^HIS 240^ASP 253^PHE 284^TRP 286^LYS

nucleolus
nucleus
soluble fraction
protein phosphatase type 2A complex
calcium channel complex

protein amino acid dephosphorylation
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein amino acid dephosphorylation
regulation of phosphoprotein phosphatase activity
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein amino acid dephosphorylation

protein tyrosine phosphatase activator activity
phosphatase activator activity
ATP binding
protein homodimerization activity
ATPase activity
protein phosphatase type 2A regulator activity
receptor binding
protein phosphatase 2A binding
protein heterodimerization activity

1olmA

[pdb]

2.17061
0.00467788

92^ASP 174^PHE 190^PHE 193^LYS 224^TRP 231^HIS

cytoplasm
nucleus
intracellular
cytosol

positive regulation of transcription
DNA-dependent
regulation of cholesterol biosynthetic process
transport
regulation of transcription
DNA-dependent
transcription
positive regulation of cholesterol biosynthetic process
regulation of transcription

transcription activator activity
phospholipid binding
vitamin E binding
lipid binding
transporter activity
enzyme activator activity

2fhxB

[pdb]

2.1778
0.00479114

53^PHE 120^ASP 180^PHE 257^LYS 263^HIS 266^TRP

0.0.0.0

antibiotic catabolic process

hydrolase activity
beta-lactamase activity
zinc ion binding

1yggA

[pdb]

2.17944
0.00479133

163^PHE 226^LYS 232^HIS 269^ASP 273^TRP 279^PHE

carboxy-lyase activity
lyase activity
kinase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity
carboxy-lyase activity
lyase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm
cytoplasm

gluconeogenesis
gluconeogenesis

1yrzB

[pdb]

2.18502
0.00490687

2014^HIS 2016^ASP 2035^TRP 2066^LYS 2100^PHE 2497^PHE

0.0.0.0

hydrolase activity
acting on glycosyl bonds
hydrolase activity
xylan 1,4-beta-xylosidase activity
hydrolase activity
hydrolyzing O-glycosyl compounds

metabolic process
carbohydrate metabolic process

1i5pA

[pdb]

2.18764
0.00502331

177^PHE 231^PHE 239^HIS 240^ASP 293^TRP 515^LYS

0.0.0.0

receptor binding

sporulation resulting in formation of a cellular spore
pathogenesis
defense response

1uokA

[pdb]

2.18772
0.00502332

203^PHE 265^LYS 279^PHE 283^HIS 285^ASP 311^TRP

3.2.1.10

cytoplasm

hydrolase activity
acting on glycosyl bonds
hydrolase activity
oligo-1,6-glucosidase activity
cation binding
catalytic activity

metabolic process
carbohydrate metabolic process

2pvcB

[pdb]

2.18801
0.00502336

196^PHE 250^HIS 253^ASP 301^PHE 359^TRP 362^LYS

DNA methylation
genetic imprinting
spermatogenesis
in utero embryonic development

cytosol
nucleus
cytoplasm
nuclear heterochromatin
condensed nuclear chromosome

zinc ion binding
enzyme activator activity
protein binding
transcription repressor activity
enzyme binding
metal ion binding

2z95C

[pdb]

2.19065
0.00502367

15^ASP 92^PHE 179^PHE 181^HIS 218^LYS 221^TRP

0.0.0.0

cellular metabolic process
GDP-mannose metabolic process
metabolic process

coenzyme binding
GDP-mannose 4,6-dehydratase activity
binding
catalytic activity

intracellular

2rf7B

[pdb]

2.1926
0.0050239

123^TRP 126^LYS 140^ASP 144^HIS 196^PHE 218^PHE

1.7.2.2

metal ion binding
oxidoreductase activity
calcium ion binding
iron ion binding
nitrite reductase (cytochrome
ammonia-forming) activity
heme binding

oxidation reduction
electron transport chain
transport
nitrogen compound metabolic process

periplasmic space

3d3aA

[pdb]

2.19697
0.00514183

186^PHE 266^ASP 267^HIS 316^PHE 428^TRP 481^LYS

0.0.0.0

beta-galactosidase complex

cell adhesion
carbohydrate metabolic process

hydrolase activity
hydrolyzing O-glycosyl compounds
cation binding
beta-galactosidase activity
catalytic activity

1efhB

[pdb]

2.20046
0.00514225

13^PHE 125^ASP 144^LYS 146^TRP 150^PHE 257^HIS

2.8.2.14

bile acid catabolic process
steroid metabolic process
lipid metabolic process
digestion

cytoplasm
cytosol

transferase activity
bile-salt sulfotransferase activity
sulfotransferase activity

2vduB

[pdb]

2.20437
0.00526269

219^THR 221^VAL 236^PRO 238^PHE 270^LYS 278^THR

nucleus
nucleus

tRNA binding
RNA binding
tRNA (guanine-N7-)-methyltransferase activity
protein binding
transferase activity
methyltransferase activity
tRNA (guanine-N7-)-methyltransferase activity
protein binding

tRNA processing
ribosome biogenesis
tRNA methylation
tRNA processing
ribosome biogenesis
tRNA methylation
tRNA modification

2inyA

[pdb]

2.21024
0.00538598

619^LYS 641^TRP 687^PHE 695^ASP 865^PHE 889^HIS

structural molecule activity

virion
viral capsid

2qz7A

[pdb]

2.21503
0.00538658

29^LYS 30^TRP 112^HIS 120^PHE 156^PHE 176^ASP

0.0.0.0

response to stress

2rcuA

[pdb]

2.21743
0.0055121

213^ASP 218^PHE 354^LYS 374^TRP 388^PHE 496^HIS

2.3.1.21

mitochondrial inner membrane
membrane
mitochondrion

transferase activity
acyltransferase activity
carnitine O-palmitoyltransferase activity

transport
fatty acid metabolic process
lipid metabolic process
long-chain fatty acid transport
fatty acid beta-oxidation

1gyhA

[pdb]

2.22019
0.00551246

38^ASP 183^PHE 203^LYS 235^PHE 238^TRP 291^HIS

0.0.0.0

carbohydrate metabolic process
metabolic process

hydrolase activity
hydrolyzing O-glycosyl compounds
hydrolase activity
acting on glycosyl bonds
hydrolase activity
arabinan endo-1,5-alpha-L-arabinosidase activity

1u8wB

[pdb]

2.22512
0.00564102

5^PHE 36^LYS 48^HIS 51^ASP 105^PHE 130^TRP

2.7.4.6

apoplast
chloroplast
plasma membrane
vacuole

metal ion binding
transferase activity
kinase activity
ATP binding
magnesium ion binding
nucleotide binding
nucleoside diphosphate kinase activity

response to cadmium ion
response to salt stress
nucleotide metabolic process
CTP biosynthetic process
UTP biosynthetic process
GTP biosynthetic process

2cwnA

[pdb]

2.22752
0.00564134

147^TRP 154^LYS 227^PHE 294^PHE 298^HIS 301^ASP

2.2.1.2

cytoplasm

pentose-phosphate shunt
metabolic process
carbohydrate metabolic process

transferase activity
transaldolase activity
catalytic activity
protein binding

1wubA

[pdb]

2.23147
0.00564186

63^ASP 65^HIS 71^PHE 82^PHE 140^LYS 146^TRP

0.0.0.0

2g3hA

[pdb]

2.23233
0.00577267

32^PHE 89^TRP 91^LYS 136^ASP 137^HIS 143^PHE

0.0.0.0

heme binding
oxygen binding
iron ion binding
protein binding
oxygen transporter activity

oxygen transport
transport

2qruA

[pdb]

2.23406
0.0057729

41^LYS 73^ASP 74^HIS 83^PHE 124^PHE 163^TRP

0.0.0.0

1nwtA

[pdb]

2.24505
0.00590648

207^ASP 219^HIS 265^PHE 287^PHE 321^LYS 325^TRP

0.0.0.0

chitin catabolic process
carbohydrate metabolic process

extracellular region
extracellular space
proteinaceous extracellular matrix

sugar binding
extracellular matrix structural constituent
cation binding
chitinase activity
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

1f05B

[pdb]

2.24665
0.0059067

147^TRP 154^LYS 227^PHE 294^PHE 298^HIS 301^ASP

2.2.1.2

cytoplasm
cytosol

pentose-phosphate shunt
carbohydrate metabolic process
metabolic process

transferase activity
transaldolase activity
catalytic activity
protein binding

3b8cB

[pdb]

2.24764
0.00604039

96^PHE 269^LYS 667^TRP 671^PHE 748^ASP 751^HIS

3.6.3.6

membrane
plasma membrane
integral to membrane

protein binding
metal ion binding
hydrolase activity
hydrogen ion transmembrane transporter activity
ATP binding
magnesium ion binding
nucleotide binding
hydrogen-exporting ATPase activity
phosphorylative mechanism
ATPase activity
hydrolase activity
acting on acid anhydrides
catalyzing transmembrane movement of substances
ATPase activity
coupled to transmembrane movement of ions
phosphorylative mechanism
catalytic activity

proton transport
ion transport
transport
metabolic process
cation transport
ATP biosynthetic process

2j47A

[pdb]

2.2571
0.00617817

349^HIS 421^PHE 427^ASP 465^PHE 498^TRP 503^LYS

3.2.1.52

hydrolase activity
acting on glycosyl bonds
hydrolase activity
beta-N-acetylhexosaminidase activity

metabolic process

2cmuA

[pdb]

2.25905
0.00617845

20^PHE 105^PHE 108^TRP 111^LYS 204^HIS 206^ASP

0.0.0.0

2vfiB

[pdb]

2.27304
0.00646246

11^TRP 12^LYS 42^PHE 49^ASP 50^HIS 69^PHE

5.3.1.1

isomerase activity
triose-phosphate isomerase activity
catalytic activity

lipid biosynthetic process
fatty acid biosynthetic process
pentose-phosphate shunt
glycolysis
gluconeogenesis
metabolic process

3e58A

[pdb]

2.27856
0.00660898

14^PHE 36^ASP 37^HIS 42^PHE 49^LYS 52^TRP

0.0.0.0

hydrolase activity
phosphoglycolate phosphatase activity
catalytic activity

metabolic process

2z73A

[pdb]

2.27991
0.00660918

12^TRP 20^HIS 83^PHE 99^LYS 105^PHE 189^ASP

membrane
integral to membrane

photoreceptor activity
G-protein coupled receptor activity
receptor activity
signal transducer activity

response to stimulus
protein-chromophore linkage
phototransduction
visual perception
G-protein coupled receptor protein signaling pathway
signal transduction

1xx1C

[pdb]

2.28296
0.00660964

8^TRP 12^HIS 34^ASP 88^PHE 145^PHE 226^LYS

3.1.4.41

extracellular region

hemolysis by symbiont of host erythrocytes
cytolysis
pathogenesis
lipid metabolic process

metal ion binding
hydrolase activity
magnesium ion binding
sphingomyelin phosphodiesterase D activity
phosphoric diester hydrolase activity

1c3bB

[pdb]

2.28686
0.00675921

10^ASP 13^HIS 41^PHE 43^TRP 328^PHE 342^LYS

3.5.2.6

hydrolase activity
beta-lactamase activity
protein binding

periplasmic space
outer membrane-bounded periplasmic space

response to antibiotic
antibiotic catabolic process

1lwhB

[pdb]

2.28679
0.0067592

679^ASP 682^HIS 689^TRP 726^PHE 734^LYS 775^PHE

2.4.1.25

carbohydrate metabolic process

cytoplasm

metal ion binding
transferase activity
transferring glycosyl groups
transferase activity
calcium ion binding
4-alpha-glucanotransferase activity
cation binding
catalytic activity

1h3gA

[pdb]

2.28769
0.00675934

13^PHE 21^LYS 77^PHE 187^ASP 188^HIS 298^TRP

0.0.0.0

hydrolase activity
acting on glycosyl bonds
hydrolase activity
cyclomaltodextrinase activity
cation binding
catalytic activity

metabolic process
carbohydrate metabolic process

2i3sE

[pdb]

2.2879
0.00675937

40^PHE 241^HIS 264^LYS 272^ASP 278^TRP 289^PHE

0.0.0.0

cell cycle
sister chromatid biorientation
mitotic cell cycle spindle assembly checkpoint
protein amino acid phosphorylation
cell cycle checkpoint
cell cycle
mitotic cell cycle spindle assembly checkpoint

nucleus
condensed nuclear chromosome
centromeric region
condensed nuclear chromosome kinetochore
kinetochore
nucleus
mitotic checkpoint complex
condensed nuclear chromosome kinetochore

transferase activity
kinase activity
ATP binding
protein serine/threonine kinase activity
nucleotide binding
protein binding
protein kinase activity
protein binding

2vexA

[pdb]

2.29333
0.00691256

60^HIS 65^ASP 95^PHE 100^TRP 103^LYS 256^PHE

3.1.3.48

endoplasmic reticulum membrane
membrane
endoplasmic reticulum

protein tyrosine phosphatase activity
zinc ion binding
hydrolase activity
phosphoprotein phosphatase activity
phosphatase activity
protein binding

signal transduction
dephosphorylation
protein amino acid dephosphorylation
negative regulation of insulin receptor signaling pathway
insulin receptor signaling pathway

3cweA

[pdb]

2.30408
0.00706833

560^HIS 565^ASP 595^PHE 600^TRP 603^LYS 756^PHE

3.1.3.48

endoplasmic reticulum membrane
membrane
endoplasmic reticulum

negative regulation of insulin receptor signaling pathway
insulin receptor signaling pathway
signal transduction
dephosphorylation
protein amino acid dephosphorylation

protein tyrosine phosphatase activity
zinc ion binding
hydrolase activity
phosphoprotein phosphatase activity
phosphatase activity
protein binding