The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
1k3dA	[pdb]	0.0910597 2.39618e-05	249^LEU 250^SER 251^GLY 253^GLY 254^LYS 255^THR	4.1.1.49	carboxy-lyase activity lyase activity ATP binding calcium ion binding catalytic activity nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm	gluconeogenesis
1xkvA	[pdb]	0.296008 8.27035e-05	233^LEU 234^SER 235^GLY 237^GLY 238^LYS 239^THR	4.1.1.49	calcium ion binding metal ion binding carboxy-lyase activity lyase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm	gluconeogenesis
2ax4B	[pdb]	0.393307 0.000131497	60^LEU 61^SER 62^GLY 64^GLY 65^LYS 66^THR	2.7.7.4, 2.7.1.25		nucleotidyltransferase activity sulfate adenylyltransferase (ATP) activity transferase activity kinase activity ATP binding catalytic activity nucleotide binding adenylylsulfate kinase activity transferase activity transferring phosphorus-containing groups protein binding	skeletal system development sulfate assimilation blood coagulation
1ii2B	[pdb]	0.456972 0.000171973	222^LEU 223^SER 224^GLY 226^GLY 227^LYS 228^THR	0.0.0.0	carboxy-lyase activity lyase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	gluconeogenesis	glycosome
1yggA	[pdb]	0.48688 0.000189453	249^LEU 250^SER 251^GLY 253^GLY 254^LYS 255^THR		carboxy-lyase activity lyase activity kinase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity carboxy-lyase activity lyase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm cytoplasm	gluconeogenesis gluconeogenesis
1yvyB	[pdb]	0.724231 0.000273442	1243^LEU 1244^SER 1245^GLY 1247^GLY 1248^LYS 1249^THR	4.1.1.49	carboxy-lyase activity lyase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm	gluconeogenesis
2f48A	[pdb]	1.19304 0.000343041	79^LEU 80^SER 81^GLY 175^GLY 203^LYS 204^THR	0.0.0.0	6-phosphofructokinase complex	glycolysis	transferase activity diphosphate-fructose-6-phosphate 1-phosphotransferase activity ATP binding 6-phosphofructokinase activity nucleotide binding kinase activity
2g04A	[pdb]	1.27993 0.00039651	203^THR 205^LYS 206^GLY 208^GLY 209^SER 210^LEU	0.0.0.0		isomerase activity catalytic activity	metabolic process
3cr8C	[pdb]	1.28853 0.000401989	377^LEU 378^SER 379^GLY 381^GLY 382^LYS 384^THR	0.0.0.0		nucleotidyltransferase activity transferase activity kinase activity sulfate adenylyltransferase (ATP) activity adenylylsulfate kinase activity transferase activity transferring phosphorus-containing groups ATP binding	sulfate assimilation
1f9oA	[pdb]	1.37978 0.000481454	140^LEU 261^THR 262^LYS 264^GLY 342^SER 345^GLY	3.2.1.4		cellulose catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process	hydrolase activity acting on glycosyl bonds hydrolase activity cellulase activity hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity
2px0E	[pdb]	1.49529 0.000689682	183^SER 185^GLY 187^GLY 188^LYS 189^THR 290^LEU		GTP binding nucleotide binding 7S RNA binding protein binding	plasma membrane membrane signal recognition particle	protein transport transport SRP-dependent cotranslational protein targeting to membrane flagellum organization
2duoB	[pdb]	1.49828 0.000710175	91^THR 97^LYS 130^GLY 258^GLY 262^LEU 263^SER		Golgi membrane integral to membrane membrane Golgi apparatus	protein transport transport	sugar binding calcium ion binding
1r9dB	[pdb]	1.50867 0.000732064	330^THR 331^LYS 334^GLY 335^GLY 770^SER 771^LEU	0.0.0.0	cytoplasm	formate C-acetyltransferase activity catalytic activity	metabolic process glucose metabolic process
3c9fA	[pdb]	1.52705 0.000777743	53^GLY 318^THR 320^LYS 321^GLY 325^SER 327^LEU	0.0.0.0			hydrolase activity
1jjuA	[pdb]	1.52841 0.00080207	31^GLU 32^ALA 63^ASP 64^VAL 68^TRP 225^ASP	0.0.0.0	heme binding electron carrier activity iron ion binding oxidoreductase activity oxidoreductase activity acting on the CH-NH2 group of donors	oxidation reduction electron transport chain transport	periplasmic space
2dr3D	[pdb]	1.54106 0.000828087	28^LEU 29^SER 30^GLY 35^GLY 36^LYS 37^THR			ATP binding nucleotide binding nucleoside-triphosphatase activity damaged DNA binding	DNA repair
1iv8A	[pdb]	1.55633 0.000884291	455^SER 457^LEU 563^GLY 679^THR 680^LYS 681^GLY	0.0.0.0		carbohydrate metabolic process	cation binding catalytic activity
1ls1A	[pdb]	1.56484 0.000946575	108^GLY 109^SER 110^GLY 111^LYS 112^THR 218^LEU		GTP binding RNA binding nucleotide binding nucleoside-triphosphatase activity 7S RNA binding protein binding	SRP-dependent cotranslational protein targeting to membrane	ribonucleoprotein complex signal recognition particle endoplasmic reticulum targeting signal recognition particle
2g8yB	[pdb]	1.57944 0.00101588	115^LEU 251^SER 252^GLY 253^GLY 254^LYS 255^THR		cytoplasm	oxidation reduction metabolic process	oxidoreductase activity
2vdcE	[pdb]	1.60533 0.00113121	1300^LEU 1301^SER 1302^GLY 1334^GLY 1335^LYS 1354^THR	1.4.1.13		cellular amino acid biosynthetic process glutamine metabolic process glutamate biosynthetic process metabolic process nitrogen compound metabolic process oxidation reduction oxidation reduction cellular amino acid biosynthetic process glutamate biosynthetic process	iron ion binding glutamate synthase (NADPH) activity oxidoreductase activity glutamate synthase activity catalytic activity 3 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding glutamate synthase (NADPH) activity FAD binding oxidoreductase activity acting on the CH-NH2 group of donors NAD or NADP as acceptor electron carrier activity
1w36D	[pdb]	1.61167 0.00117262	170^SER 171^GLY 176^GLY 177^LYS 178^THR 354^LEU	3.1.11.5	exodeoxyribonuclease V complex exodeoxyribonuclease V complex	hydrolase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity nucleotide binding exodeoxyribonuclease V activity nucleoside-triphosphatase activity hydrolase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity nucleotide binding exodeoxyribonuclease V activity ATP-dependent DNA helicase activity DNA binding hydrolase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity nucleotide binding exodeoxyribonuclease V activity protein binding	response to DNA damage stimulus DNA repair response to DNA damage stimulus DNA repair response to DNA damage stimulus DNA repair
2inrA	[pdb]	1.61544 0.00121606	217^GLY 218^GLY 242^LYS 258^THR 481^SER 482^LEU		DNA topological change DNA metabolic process	chromosome	isomerase activity DNA topoisomerase activity DNA binding ATP binding DNA topoisomerase (ATP-hydrolyzing) activity
1sxjB	[pdb]	1.62035 0.00121629	48^VAL 49^SER 54^VAL 55^GLU 56^ALA 161^MSE		cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation chromatin silencing at telomere postreplication repair mismatch repair nucleotide-excision repair base-excision repair lagging strand elongation leading strand elongation meiotic mismatch repair regulation of DNA replication response to DNA damage stimulus DNA repair DNA replication chromatin silencing at silent mating-type cassette mitotic sister chromatid cohesion cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation cell cycle checkpoint cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation cell cycle DNA replication sister chromatid cohesion mismatch repair leading strand elongation cell division cell cycle DNA replication mismatch repair DNA repair leading strand elongation mitotic cell cycle	nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex replication fork nucleus PCNA complex nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex nucleus Elg1 RFC-like complex Ctf18 RFC-like complex Rad17 RFC-like complex DNA replication factor C complex nucleus DNA replication factor C complex intracellular	protein binding ATP binding DNA binding nucleotide binding ATPase activity DNA clamp loader activity nucleoside-triphosphatase activity DNA polymerase processivity factor activity DNA binding protein binding protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity protein binding ATP binding DNA binding nucleotide binding DNA clamp loader activity nucleoside-triphosphatase activity
1r0zA	[pdb]	1.62354 0.00126198	459^SER 461^GLY 463^GLY 464^LYS 465^THR 619^LEU	3.6.3.49	chloride ion binding ATP binding chloride channel activity ion channel activity nucleotide binding ATPase activity coupled to transmembrane movement of substances nucleoside-triphosphatase activity ATPase activity channel-conductance-controlling ATPase activity hydrolase activity	ion transport transport interleukin-8 production interleukin-6 production cholesterol transport cholesterol biosynthetic process transepithelial chloride transport lung development vasodilation response to drug response to peptide hormone stimulus response to estrogen stimulus	membrane integral to membrane cytoplasmic vesicle membrane chloride channel complex
2hb6A	[pdb]	1.62421 0.00126201	86^THR 121^LEU 122^SER 393^GLY 394^LYS 397^GLY	3.4.11.1	intracellular	metal ion binding hydrolase activity zinc ion binding peptidase activity aminopeptidase activity identical protein binding protein binding	proteolysis
1r86A	[pdb]	1.62793 0.00126219	280^THR 325^LEU 327^SER 353^GLY 355^GLY 356^LYS	3.2.1.8	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity endo-1,4-beta-xylanase activity cation binding hydrolase activity hydrolyzing O-glycosyl compounds catalytic activity	xylan catabolic process metabolic process carbohydrate metabolic process
2i9sA	[pdb]	1.64751 0.00141489	9^LEU 15^GLY 16^LYS 17^THR 68^GLY 69^SER		cellular_component	mesoderm development	molecular_function
2pg0A	[pdb]	1.66844 0.00159202	175^LYS 176^THR 186^GLY 188^SER 189^LEU 235^GLY	0.0.0.0		FAD binding oxidoreductase activity acting on the CH-CH group of donors oxidoreductase activity electron carrier activity acyl-CoA dehydrogenase activity	metabolic process oxidation reduction
3e22C	[pdb]	1.67449 0.00165475	109^LYS 111^ASN 112^ARG 148^GLY 151^THR 152^LEU		GTP binding nucleotide binding structural molecule activity GTPase activity GTP binding nucleotide binding structural molecule activity GTPase activity	microtubule protein complex microtubule protein complex	protein polymerization microtubule-based movement microtubule-based process intracellular signaling cascade protein polymerization microtubule-based movement microtubule-based process
3d8bA	[pdb]	1.67911 0.00165505	446^GLY 447^LYS 448^THR 567^LEU 604^SER 605^GLY			ATP metabolic process	hydrolase activity magnesium ion binding metal ion binding ATP binding nucleotide binding nucleoside-triphosphatase activity
2zuyA	[pdb]	1.68178 0.00172096	398^SER 399^LEU 410^GLY 451^THR 453^LYS 454^GLY		calcium ion binding lyase activity metal ion binding	cell wall organization	extracellular region
2nynC	[pdb]	1.68451 0.00172115	109^LYS 110^THR 111^GLY 163^GLY 164^SER 171^LEU	0.0.0.0		biosynthetic process	lyase activity histidine ammonia-lyase activity ammonia ligase activity catalytic activity
1zl9A	[pdb]	1.70085 0.00186472	81^GLY 82^LYS 83^THR 152^GLY 154^SER 155^LEU	2.5.1.18	biological_process	cellular_component	transferase activity glutathione transferase activity
1g3rA	[pdb]	1.71871 0.00210998	9^SER 12^GLY 15^GLY 16^LYS 17^THR 139^LEU	0.0.0.0		cobalamin biosynthetic process cell division	cobyrinic acid a,c-diamide synthase activity
2qz4A	[pdb]	1.72915 0.00220103	354^GLY 355^LYS 356^THR 479^LEU 517^SER 518^GLY		metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity ATP binding nucleotide binding unfolded protein binding metalloendopeptidase activity nucleoside-triphosphatase activity	mitochondrial membrane integral to membrane membrane mitochondrion	nervous system development proteolysis protein catabolic process anterograde axon cargo transport mitochondrion organization cell death
1zkqA	[pdb]	1.73544 0.00229645	49^SER 50^GLY 52^LEU 370^THR 373^LYS 375^GLY	1.8.1.9	mitochondrion cytoplasm	response to oxygen radical oxidation reduction hemopoiesis heart development cell redox homeostasis	thioredoxin-disulfide reductase activity oxidoreductase activity selenium binding protein binding NADP or NADPH binding FAD binding electron carrier activity
3cf0C	[pdb]	1.73629 0.00229653	523^GLY 524^LYS 525^THR 647^LEU 683^SER 684^GLY		endoplasmic reticulum cytosol cytoplasm nucleus microsome	protein binding lipid binding ATP binding nucleotide binding nucleoside-triphosphatase activity hydrolase activity binding	retrograde protein transport ER to cytosol transport ubiquitin-dependent protein catabolic process activation of caspase activity double-strand break repair modification-dependent protein catabolic process
1nhcF	[pdb]	1.74266 0.00239442	350^LEU 351^SER 352^GLY 353^GLY 354^LYS 355^THR	3.2.1.15	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity polygalacturonase activity	metabolic process cell wall organization carbohydrate metabolic process
2q9tA	[pdb]	1.74891 0.00249483	108^LEU 109^SER 229^GLY 230^LYS 236^THR 238^GLY
1w36B	[pdb]	1.75159 0.00249512	24^ALA 26^DA 28^DC 29^DA 30^DG 443^ALA	3.1.11.5	exodeoxyribonuclease V complex exodeoxyribonuclease V complex	hydrolase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity nucleotide binding exodeoxyribonuclease V activity nucleoside-triphosphatase activity hydrolase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity nucleotide binding exodeoxyribonuclease V activity ATP-dependent DNA helicase activity DNA binding hydrolase activity ATP binding exonuclease activity endonuclease activity nuclease activity helicase activity nucleotide binding exodeoxyribonuclease V activity protein binding	response to DNA damage stimulus DNA repair response to DNA damage stimulus DNA repair response to DNA damage stimulus DNA repair
1xmiC	[pdb]	1.75574 0.00260046	459^SER 461^GLY 463^GLY 464^LYS 465^THR 619^LEU	3.6.3.49	chloride channel complex apical plasma membrane basolateral plasma membrane membrane integral to membrane cytoplasmic vesicle membrane	hydrolase activity protein binding PDZ domain binding channel-conductance-controlling ATPase activity chloride ion binding ATP binding chloride channel activity ion channel activity nucleotide binding ATP-binding and phosphorylation-dependent chloride channel activity ATPase activity coupled to transmembrane movement of substances nucleoside-triphosphatase activity ATPase activity	vasodilation cholesterol biosynthetic process cholesterol transport ion transport transport respiratory gaseous exchange response to estrogen stimulus response to peptide hormone stimulus response to drug lung development transepithelial chloride transport
2porA	[pdb]	1.75573 0.00260046	63^LEU 64^SER 65^GLY 68^GLY 69^LYS 122^THR		cell outer membrane integral to membrane membrane plasma membrane	ion transport transport	transporter activity
1zjjA	[pdb]	1.76133 0.00271129	43^SER 45^LYS 46^THR 70^GLY 93^GLY 126^LEU	0.0.0.0		metabolic process	phosphatase activity hydrolase activity catalytic activity
1cc5A	[pdb]	1.76429 0.00271164	57^LEU 58^SER 59^GLY 66^LYS 67^GLY 68^THR	0.0.0.0		electron transport chain transport	metal ion binding iron ion binding heme binding electron carrier activity
2gblD	[pdb]	1.76997 0.00282802	45^SER 46^GLY 51^GLY 52^LYS 53^THR 207^LEU	2.7.11.1		entrainment of circadian clock negative regulation of circadian rhythm rhythmic process regulation of transcription DNA-dependent transcription regulation of transcription regulation of circadian rhythm circadian rhythm	metal ion binding transferase activity kinase activity ATP binding protein serine/threonine kinase activity DNA binding magnesium ion binding nucleotide binding identical protein binding protein binding protein serine/threonine/tyrosine kinase activity
1espA	[pdb]	1.772 0.00282827	8^GLY 10^GLY 11^LYS 17^THR 19^SER 20^LEU	3.4.24.28	calcium ion binding metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity metalloendopeptidase activity	extracellular region	proteolysis
1y9kB	[pdb]	1.77283 0.00282837	87^THR 89^LYS 90^GLY 92^GLY 94^SER 151^LEU	0.0.0.0		metabolic process	transferase activity acyltransferase activity N-acetyltransferase activity
2pzeA	[pdb]	1.77292 0.00282838	459^SER 461^GLY 463^GLY 464^LYS 465^THR 619^LEU	3.6.3.49	chloride channel complex apical plasma membrane basolateral plasma membrane membrane integral to membrane cytoplasmic vesicle membrane	hydrolase activity protein binding PDZ domain binding channel-conductance-controlling ATPase activity chloride ion binding ATP binding chloride channel activity ion channel activity nucleotide binding ATP-binding and phosphorylation-dependent chloride channel activity ATPase activity coupled to transmembrane movement of substances nucleoside-triphosphatase activity ATPase activity	vasodilation cholesterol biosynthetic process cholesterol transport ion transport transport respiratory gaseous exchange response to estrogen stimulus response to peptide hormone stimulus response to drug lung development transepithelial chloride transport
2pw0B	[pdb]	1.77405 0.00282852	48^LEU 52^GLY 53^SER 65^GLY 71^THR 73^LYS	0.0.0.0
2vl7A	[pdb]	1.77407 0.00282852	31^LEU 38^GLY 39^LYS 40^THR 326^SER 327^GLY	0.0.0.0		hydrolase activity acting on acid anhydrides in phosphorus-containing anhydrides ATP-dependent helicase activity ATP binding ATP-dependent DNA helicase activity DNA binding nucleic acid binding	nucleobase nucleoside nucleotide and nucleic acid metabolic process
2dflA	[pdb]	1.77733 0.00295033	117^GLY 118^SER 119^GLY 120^LYS 121^THR 287^LEU			ATP binding DNA binding nucleotide binding nucleoside-triphosphatase activity DNA-dependent ATPase activity protein binding damaged DNA binding	response to DNA damage stimulus DNA recombination DNA repair DNA metabolic process
1bl9A	[pdb]	1.7775 0.00295036	299^LYS 301^THR 302^GLY 305^LEU 319^SER 321^GLY	1.7.2.1, 1.7.99.1	metal ion binding oxidoreductase activity iron ion binding nitrite reductase (NO-forming) activity hydroxylamine reductase activity heme binding electron carrier activity	oxidation reduction electron transport chain transport	periplasmic space
1figL	[pdb]	1.77791 0.00295041	125^ALA 127^GLY 128^SER 129^ALA 182^THR 183^ASP	0.0.0.0
2pxxA	[pdb]	1.77801 0.00295042	66^GLY 68^GLY 70^SER 72^LEU 130^LYS 132^THR	3.4.24.71	cell-cell signaling peptide hormone processing heart development cardioblast differentiation brain development metabolic process proteolysis	cytoplasmic vesicle membrane Golgi membrane integral to membrane membrane Golgi apparatus	metalloendopeptidase activity metal ion binding hydrolase activity transferase activity zinc ion binding metallopeptidase activity peptidase activity methyltransferase activity catalytic activity
1eepA	[pdb]	1.78282 0.00295104	268^SER 357^THR 360^LYS 361^GLY 362^GLY 363^LEU	1.1.1.205		metal ion binding potassium ion binding oxidoreductase activity IMP dehydrogenase activity catalytic activity	oxidation reduction GMP biosynthetic process purine nucleotide biosynthetic process metabolic process
1hdcB	[pdb]	1.78456 0.00307857	4^LEU 5^SER 6^GLY 7^LYS 8^THR 30^GLY	1.1.1.53		oxidation reduction steroid metabolic process lipid metabolic process metabolic process	oxidoreductase activity 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity binding catalytic activity
1rk6A	[pdb]	1.7896 0.00307924	12^LEU 13^SER 14^GLY 16^THR 56^GLY 57^LYS	0.0.0.0			hydrolase activity N-acyl-D-amino-acid deacylase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds in linear amides hydrolase activity acting on carbon-nitrogen (but not peptide) bonds zinc ion binding
2rgoA	[pdb]	1.79197 0.00321296	256^LYS 257^GLY 301^THR 348^LEU 353^SER 354^GLY	0.0.0.0	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate metabolic process oxidation reduction	oxidoreductase activity glycerol-3-phosphate dehydrogenase activity
3enkA	[pdb]	1.79341 0.00321317	133^GLY 146^LEU 147^SER 153^GLY 155^THR 156^LYS	0.0.0.0		cellular metabolic process metabolic process galactose metabolic process	isomerase activity UDP-glucose 4-epimerase activity coenzyme binding binding catalytic activity
1pznB	[pdb]	1.80326 0.00335427	141^GLY 142^SER 143^GLY 144^LYS 145^THR 315^LEU		ATP binding DNA binding nucleotide binding sequence-specific DNA binding nucleoside-triphosphatase activity DNA-dependent ATPase activity protein binding damaged DNA binding	intracellular	response to DNA damage stimulus DNA recombination DNA repair DNA metabolic process
1pieA	[pdb]	1.80521 0.00350069	59^GLY 61^THR 127^LYS 128^GLY 141^SER 142^LEU	2.7.1.6	cytoplasm	galactose metabolic process carbohydrate metabolic process carbohydrate phosphorylation phosphorylation metabolic process	transferase activity kinase activity ATP binding nucleotide binding galactokinase activity phosphotransferase activity alcohol group as acceptor
2wafA	[pdb]	1.80592 0.0035008	342^GLY 360^GLY 362^LYS 371^THR 374^SER 375^LEU		penicillin binding	plasma membrane integral to membrane membrane	response to antibiotic peptidoglycan biosynthetic process regulation of cell shape cell wall organization peptidoglycan-based cell wall biogenesis
1gyhA	[pdb]	1.81416 0.00365149	254^GLY 266^LYS 267^THR 276^GLY 277^SER 278^LEU	0.0.0.0		carbohydrate metabolic process metabolic process	hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity acting on glycosyl bonds hydrolase activity arabinan endo-1,5-alpha-L-arabinosidase activity
2v7yA	[pdb]	1.81755 0.00365201	366^LEU 367^SER 369^GLY 378^THR 379^LYS 412^GLY			ATP binding nucleotide binding unfolded protein binding	response to stress protein folding
3ecpA	[pdb]	1.8179 0.00365206	42^SER 43^GLY 333^LYS 334^THR 337^GLY 356^LEU			metal ion binding hydrolase activity endonuclease activity nuclease activity DNA binding magnesium ion binding transposase activity nucleic acid binding	transposition DNA recombination transposition DNA-mediated
1gpwA	[pdb]	1.81847 0.00365215	178^HIS 179^PRO 201^ARG 202^GLY 203^GLY 222^LEU		cellular amino acid biosynthetic process glutamine metabolic process histidine biosynthetic process cellular amino acid biosynthetic process histidine biosynthetic process metabolic process	cytoplasm cytoplasm imidazoleglycerol-phosphate synthase complex	transferase activity transferase activity transferring pentosyl groups catalytic activity imidazoleglycerol-phosphate synthase activity lyase activity catalytic activity imidazoleglycerol-phosphate synthase activity
2e6kB	[pdb]	1.81886 0.00365221	371^GLY 373^SER 382^THR 383^LYS 400^LEU 426^GLY	0.0.0.0		metabolic process	transferase activity transketolase activity catalytic activity
1uaaA	[pdb]	1.81926 0.00365227	25^GLY 26^SER 27^GLY 28^LYS 29^THR 273^LEU		DNA replication DNA repair DNA unwinding during replication	cytoplasm	hydrolase activity ATP binding helicase activity DNA binding nucleotide binding ATP-dependent DNA helicase activity
3g8yA	[pdb]	1.82424 0.00380589	149^THR 150^LYS 152^GLY 155^GLY 173^SER 176^LEU	0.0.0.0
2pbrB	[pdb]	1.8253 0.00380606	10^GLY 11^SER 12^GLY 13^LYS 14^THR 129^LEU	2.7.4.9		nucleotide biosynthetic process dTDP biosynthetic process dTTP biosynthetic process	transferase activity kinase activity ATP binding nucleotide binding thymidylate kinase activity
3fdiA	[pdb]	1.82934 0.00396635	13^GLY 14^SER 15^GLY 121^LEU 127^LYS 128^THR	0.0.0.0
1igrA	[pdb]	1.83025 0.00396651	380^GLY 384^LEU 389^SER 414^GLY 415^LYS 438^THR	2.7.10.1	brain development protein amino acid phosphorylation immune response positive regulation of DNA replication positive regulation of cell migration phosphoinositide-mediated signaling phosphoinositide 3-kinase cascade protein amino acid autophosphorylation insulin-like growth factor receptor signaling pathway protein tetramerization anti-apoptosis insulin receptor signaling pathway positive regulation of cell proliferation signal transduction transmembrane receptor protein tyrosine kinase signaling pathway mammary gland development male sex determination organ morphogenesis	identical protein binding protein binding insulin binding insulin-like growth factor I binding insulin receptor binding insulin-like growth factor receptor activity insulin-like growth factor binding protein tyrosine kinase activity phosphoinositide 3-kinase binding insulin receptor substrate binding transferase activity kinase activity ATP binding receptor activity nucleotide binding transmembrane receptor protein tyrosine kinase activity protein kinase activity	membrane microsome integral to plasma membrane integral to membrane
3b6uB	[pdb]	1.8306 0.00396657	80^LEU 83^SER 87^GLY 222^THR 239^GLY 240^LYS		ATP binding motor activity nucleotide binding plus-end-directed microtubule motor activity microtubule motor activity protein binding	anterograde axon cargo transport determination of left/right symmetry microtubule-based movement	microtubule plus-end kinesin complex microtubule associated complex
3bv0A	[pdb]	1.83099 0.00396663	66^THR 123^SER 124^GLY 282^GLY 283^LYS 292^LEU	2.6.1.62		biotin biosynthetic process	transferase activity transaminase activity adenosylmethionine-8-amino-7-oxononanoate transaminase activity pyridoxal phosphate binding catalytic activity
2a5zC	[pdb]	1.8326 0.0039669	69^SER 70^LEU 106^GLY 141^THR 229^GLY 231^LYS	0.0.0.0
2qyoB	[pdb]	1.83272 0.00396692	205^GLY 206^THR 209^LYS 234^GLY 235^SER 238^LEU	0.0.0.0			protein dimerization activity O-methyltransferase activity methyltransferase activity
3b85A	[pdb]	1.84161 0.00430885	144^GLY 145^SER 146^GLY 147^LYS 148^THR 301^LEU	0.0.0.0			ATP binding RNA binding ATP binding RNA binding
2w5rA	[pdb]	1.84173 0.00430887	278^LEU 279^SER 281^GLY 286^THR 511^LYS 517^GLY		cell wall organization metabolic process	plasma membrane integral to membrane membrane extracellular region	transferase activity sulfuric ester hydrolase activity catalytic activity
1sjpB	[pdb]	1.84878 0.00431016	293^THR 295^GLY 311^LEU 312^SER 315^GLY 316^LYS	0.0.0.0	ATP binding nucleotide binding protein binding unfolded protein binding	cellular protein metabolic process protein refolding protein folding	cytoplasm
2egxC	[pdb]	1.84908 0.00449134	110^GLY 113^LYS 114^THR 133^GLY 160^LEU 161^SER	0.0.0.0	cellular amino acid biosynthetic process arginine biosynthetic process proline biosynthetic process	cytoplasm	transferase activity kinase activity ATP binding nucleotide binding glutamate 5-kinase activity acetylglutamate kinase activity
1vquA	[pdb]	1.8494 0.0044914	211^THR 234^GLY 235^LYS 261^LEU 262^SER 264^GLY	2.4.2.18		aromatic amino acid family biosynthetic process cellular amino acid biosynthetic process tryptophan biosynthetic process metabolic process	transferase activity transferring glycosyl groups transferase activity anthranilate phosphoribosyltransferase activity
2olvB	[pdb]	1.85036 0.00449158	397^GLY 398^SER 400^LEU 583^LYS 584^THR 585^GLY	0.0.0.0	peptidoglycan biosynthetic process regulation of cell shape cell wall organization peptidoglycan-based cell wall biogenesis peptidoglycan-based cell wall biogenesis	peptidoglycan-based cell wall	transferase activity acyltransferase activity penicillin binding catalytic activity penicillin binding
1njfD	[pdb]	1.85492 0.00449245	44^SER 45^GLY 50^GLY 51^LYS 52^THR 175^LEU	2.7.7.7	DNA polymerase III complex nucleus	DNA replication	nucleotidyltransferase activity transferase activity ATP binding DNA-directed DNA polymerase activity nucleotide binding nucleoside-triphosphatase activity DNA binding protein binding
1oxsC	[pdb]	1.85825 0.00468175	37^LEU 41^GLY 43^GLY 44^LYS 45^THR 198^SER	0.0.0.0	ATP-binding cassette (ABC) transporter complex	nucleoside-triphosphatase activity ATPase activity hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances ATP binding transporter activity nucleotide binding	transport
2v9kA	[pdb]	1.85956 0.00468201	492^GLY 497^THR 498^LYS 502^GLY 503^SER 504^LEU			isomerase activity	tRNA processing
1kc3A	[pdb]	1.86034 0.00468217	7^GLY 8^LYS 9^THR 29^LEU 33^SER 38^GLY	1.1.1.133		oxidation reduction lipopolysaccharide biosynthetic process extracellular polysaccharide biosynthetic process metabolic process	oxidoreductase activity dTDP-4-dehydrorhamnose reductase activity binding catalytic activity
1yy9A	[pdb]	1.86146 0.00468239	379^GLY 404^GLY 406^THR 407^LYS 413^SER 414^LEU	2.7.10.1	endocytic vesicle basolateral plasma membrane intracellular endoplasmic reticulum cytoplasm membrane AP-2 adaptor complex endosome nucleus plasma membrane extracellular region integral to membrane extracellular space Shc-EGFR complex	protein amino acid phosphorylation protein amino acid autophosphorylation response to UV-A positive regulation of cyclin-dependent protein kinase activity during G1/S positive regulation of epithelial cell proliferation positive regulation of MAP kinase activity signal transduction protein insertion into membrane regulation of peptidyl-tyrosine phosphorylation activation of phospholipase A2 activity by calcium-mediated signaling positive regulation of cell migration cell-cell adhesion activation of phospholipase C activity epidermal growth factor receptor signaling pathway positive regulation of nitric oxide biosynthetic process response to stress ossification positive regulation of phosphorylation negative regulation of cell cycle cell cycle cell proliferation positive regulation of cell proliferation cell surface receptor linked signal transduction transmembrane receptor protein tyrosine kinase signaling pathway regulation of nitric-oxide synthase activity cell morphogenesis salivary gland morphogenesis regulation of cell proliferation	receptor activity protein kinase activity identical protein binding protein binding protein heterodimerization activity MAP/ERK kinase kinase activity epidermal growth factor receptor activity actin filament binding protein tyrosine kinase activity nitric-oxide synthase regulator activity double-stranded DNA binding transferase activity kinase activity ATP binding receptor activity nucleotide binding transmembrane receptor protein tyrosine kinase activity transmembrane receptor activity signal transducer activity protein phosphatase binding
2hr7A	[pdb]	1.86643 0.00487977	390^GLY 393^LEU 399^SER 424^GLY 425^LYS 448^THR	2.7.10.1	insulin receptor activity protein binding protein tyrosine kinase activity SH2 domain binding phosphoinositide 3-kinase binding insulin binding insulin receptor substrate binding PTB domain binding transferase activity kinase activity ATP binding receptor activity nucleotide binding transmembrane receptor protein tyrosine kinase activity protein kinase activity 3-phosphoinositide-dependent protein kinase binding protein phosphatase binding receptor signaling protein tyrosine kinase activity GTP binding insulin-like growth factor receptor binding insulin-like growth factor I binding insulin-like growth factor II binding	insulin receptor complex membrane integral to membrane endosome membrane plasma membrane cytosol endosome integral to plasma membrane caveola microsome	positive regulation of protein amino acid phosphorylation positive regulation of cell proliferation activation of protein kinase activity activation of protein kinase B activity cellular response to insulin stimulus positive regulation of MAPKKK cascade positive regulation of glycogen biosynthetic process positive regulation of mitosis positive regulation of glucose import positive regulation of protein kinase B signaling cascade protein heterotetramerization insulin receptor signaling pathway protein amino acid autophosphorylation carbohydrate metabolic process transmembrane receptor protein tyrosine kinase signaling pathway protein amino acid phosphorylation male sex determination peptidyl-tyrosine phosphorylation organ morphogenesis G-protein coupled receptor protein signaling pathway positive regulation of developmental growth regulation of embryonic development glucose homeostasis heart morphogenesis positive regulation of glycolysis positive regulation of DNA replication positive regulation of cell migration positive regulation of nitric oxide biosynthetic process transformation of host cell by virus activation of MAPK activity regulation of gene-specific transcription positive regulation of respiratory burst
2wadC	[pdb]	1.86649 0.00487978	342^GLY 360^GLY 362^LYS 371^THR 374^SER 375^LEU	0.0.0.0	penicillin binding	plasma membrane integral to membrane membrane	response to antibiotic peptidoglycan biosynthetic process regulation of cell shape cell wall organization peptidoglycan-based cell wall biogenesis
2ccgB	[pdb]	1.86812 0.00488012	12^GLY 13^SER 14^GLY 15^LYS 16^THR 131^LEU	2.7.4.9		dTDP biosynthetic process dTTP biosynthetic process nucleotide biosynthetic process	thymidylate kinase activity ATP binding transferase activity kinase activity nucleotide binding
2h58A	[pdb]	1.87015 0.00488053	512^LEU 515^SER 519^GLY 654^THR 668^GLY 669^LYS		ATP binding motor activity nucleotide binding microtubule motor activity	microtubule kinesin complex microtubule associated complex Golgi apparatus	visual perception microtubule-based movement Golgi organization microtubule-based process
1k7hB	[pdb]	1.87054 0.00488061	40^SER 41^LEU 75^LYS 76^THR 358^GLY 434^GLY	0.0.0.0		magnesium ion binding zinc ion binding hydrolase activity alkaline phosphatase activity phosphatase activity catalytic activity	metabolic process
1pyyA	[pdb]	1.87123 0.00508504	664^GLY 666^GLY 667^THR 668^LYS 689^LEU 690^SER		cell division response to antibiotic peptidoglycan biosynthetic process regulation of cell shape cell cycle cell wall organization peptidoglycan-based cell wall biogenesis	penicillin binding	plasma membrane integral to membrane membrane
1kb0A	[pdb]	1.87225 0.00508526	114^LYS 115^GLY 163^SER 164^LEU 183^GLY 438^THR		metal ion binding oxidoreductase activity calcium ion binding iron ion binding heme binding oxidoreductase activity acting on CH-OH group of donors electron carrier activity	oxidation reduction	periplasmic space outer membrane-bounded periplasmic space membrane
2icsA	[pdb]	1.87329 0.00508548	53^SER 55^GLY 308^THR 309^LYS 321^GLY 323^LEU	0.0.0.0			hydrolase activity acting on carbon-nitrogen (but not peptide) bonds hydrolase activity
2vq8A	[pdb]	1.87462 0.00508576	61^LYS 62^THR 65^GLY 68^GLY 77^SER 110^LEU
1czfA	[pdb]	1.87993 0.0052993	66^LEU 69^GLY 71^LYS 93^SER 94^GLY 98^THR	3.2.1.15	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity polygalacturonase activity	metabolic process cell wall organization carbohydrate metabolic process
2uyyC	[pdb]	1.88165 0.00529968	393^LEU 394^SER 397^GLY 421^GLY 422^LYS 423^THR		coenzyme binding oxidoreductase activity binding phosphogluconate dehydrogenase (decarboxylating) activity catalytic activity DNA binding	metabolic process pentose-phosphate shunt	nucleus
1wndB	[pdb]	1.88323 0.00530002	248^GLY 249^GLY 250^LYS 281^THR 449^LEU 450^SER	1.2.1.19		oxidation reduction putrescine catabolic process metabolic process	oxidoreductase activity aminobutyraldehyde dehydrogenase activity NAD or NADH binding oxidoreductase activity acting on the CH-NH group of donors NAD or NADP as acceptor
2gk6B	[pdb]	1.88604 0.00551717	492^GLY 498^LYS 499^THR 638^SER 659^LEU 661^GLY		cytoplasmic mRNA processing body cytoplasm chromatin	hydrolase activity nucleotide binding ATP-dependent RNA helicase activity RNA binding protein binding helicase activity metal ion binding zinc ion binding ATP binding DNA binding chromatin binding	regulation of translational termination nuclear-transcribed mRNA catabolic process nonsense-mediated decay RNA processing cell cycle mRNA export from nucleus DNA repair DNA replication

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

1k3dA

[pdb]

0.0910597
2.39618e-05

249^LEU 250^SER 251^GLY 253^GLY 254^LYS 255^THR

4.1.1.49

carboxy-lyase activity
lyase activity
ATP binding
calcium ion binding
catalytic activity
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm

gluconeogenesis

1xkvA

[pdb]

0.296008
8.27035e-05

233^LEU 234^SER 235^GLY 237^GLY 238^LYS 239^THR

4.1.1.49

calcium ion binding
metal ion binding
carboxy-lyase activity
lyase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm

gluconeogenesis

2ax4B

[pdb]

0.393307
0.000131497

60^LEU 61^SER 62^GLY 64^GLY 65^LYS 66^THR

2.7.7.4, 2.7.1.25

nucleotidyltransferase activity
sulfate adenylyltransferase (ATP) activity
transferase activity
kinase activity
ATP binding
catalytic activity
nucleotide binding
adenylylsulfate kinase activity
transferase activity
transferring phosphorus-containing groups
protein binding

skeletal system development
sulfate assimilation
blood coagulation

1ii2B

[pdb]

0.456972
0.000171973

222^LEU 223^SER 224^GLY 226^GLY 227^LYS 228^THR

0.0.0.0

carboxy-lyase activity
lyase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

gluconeogenesis

glycosome

1yggA

[pdb]

0.48688
0.000189453

249^LEU 250^SER 251^GLY 253^GLY 254^LYS 255^THR

carboxy-lyase activity
lyase activity
kinase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity
carboxy-lyase activity
lyase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm
cytoplasm

gluconeogenesis
gluconeogenesis

1yvyB

[pdb]

0.724231
0.000273442

1243^LEU 1244^SER 1245^GLY 1247^GLY 1248^LYS 1249^THR

4.1.1.49

carboxy-lyase activity
lyase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm

gluconeogenesis

2f48A

[pdb]

1.19304
0.000343041

79^LEU 80^SER 81^GLY 175^GLY 203^LYS 204^THR

0.0.0.0

6-phosphofructokinase complex

glycolysis

transferase activity
diphosphate-fructose-6-phosphate 1-phosphotransferase activity
ATP binding
6-phosphofructokinase activity
nucleotide binding
kinase activity

2g04A

[pdb]

1.27993
0.00039651

203^THR 205^LYS 206^GLY 208^GLY 209^SER 210^LEU

0.0.0.0

isomerase activity
catalytic activity

metabolic process

3cr8C

[pdb]

1.28853
0.000401989

377^LEU 378^SER 379^GLY 381^GLY 382^LYS 384^THR

0.0.0.0

nucleotidyltransferase activity
transferase activity
kinase activity
sulfate adenylyltransferase (ATP) activity
adenylylsulfate kinase activity
transferase activity
transferring phosphorus-containing groups
ATP binding

sulfate assimilation

1f9oA

[pdb]

1.37978
0.000481454

140^LEU 261^THR 262^LYS 264^GLY 342^SER 345^GLY

3.2.1.4

cellulose catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

hydrolase activity
acting on glycosyl bonds
hydrolase activity
cellulase activity
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

2px0E

[pdb]

1.49529
0.000689682

183^SER 185^GLY 187^GLY 188^LYS 189^THR 290^LEU

GTP binding
nucleotide binding
7S RNA binding
protein binding

plasma membrane
membrane
signal recognition particle

protein transport
transport
SRP-dependent cotranslational protein targeting to membrane
flagellum organization

2duoB

[pdb]

1.49828
0.000710175

91^THR 97^LYS 130^GLY 258^GLY 262^LEU 263^SER

Golgi membrane
integral to membrane
membrane
Golgi apparatus

protein transport
transport

sugar binding
calcium ion binding

1r9dB

[pdb]

1.50867
0.000732064

330^THR 331^LYS 334^GLY 335^GLY 770^SER 771^LEU

0.0.0.0

cytoplasm

formate C-acetyltransferase activity
catalytic activity

metabolic process
glucose metabolic process

3c9fA

[pdb]

1.52705
0.000777743

53^GLY 318^THR 320^LYS 321^GLY 325^SER 327^LEU

0.0.0.0

hydrolase activity

1jjuA

[pdb]

1.52841
0.00080207

31^GLU 32^ALA 63^ASP 64^VAL 68^TRP 225^ASP

0.0.0.0

heme binding
electron carrier activity
iron ion binding
oxidoreductase activity
oxidoreductase activity
acting on the CH-NH2 group of donors

oxidation reduction
electron transport chain
transport

periplasmic space

2dr3D

[pdb]

1.54106
0.000828087

28^LEU 29^SER 30^GLY 35^GLY 36^LYS 37^THR

ATP binding
nucleotide binding
nucleoside-triphosphatase activity
damaged DNA binding

DNA repair

1iv8A

[pdb]

1.55633
0.000884291

455^SER 457^LEU 563^GLY 679^THR 680^LYS 681^GLY

0.0.0.0

carbohydrate metabolic process

cation binding
catalytic activity

1ls1A

[pdb]

1.56484
0.000946575

108^GLY 109^SER 110^GLY 111^LYS 112^THR 218^LEU

GTP binding
RNA binding
nucleotide binding
nucleoside-triphosphatase activity
7S RNA binding
protein binding

SRP-dependent cotranslational protein targeting to membrane

ribonucleoprotein complex
signal recognition particle
endoplasmic reticulum targeting
signal recognition particle

2g8yB

[pdb]

1.57944
0.00101588

115^LEU 251^SER 252^GLY 253^GLY 254^LYS 255^THR

cytoplasm

oxidation reduction
metabolic process

oxidoreductase activity

2vdcE

[pdb]

1.60533
0.00113121

1300^LEU 1301^SER 1302^GLY 1334^GLY 1335^LYS 1354^THR

1.4.1.13

cellular amino acid biosynthetic process
glutamine metabolic process
glutamate biosynthetic process
metabolic process
nitrogen compound metabolic process
oxidation reduction
oxidation reduction
cellular amino acid biosynthetic process
glutamate biosynthetic process

iron ion binding
glutamate synthase (NADPH) activity
oxidoreductase activity
glutamate synthase activity
catalytic activity
3 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
glutamate synthase (NADPH) activity
FAD binding
oxidoreductase activity
acting on the CH-NH2 group of donors
NAD or NADP as acceptor
electron carrier activity

1w36D

[pdb]

1.61167
0.00117262

170^SER 171^GLY 176^GLY 177^LYS 178^THR 354^LEU

3.1.11.5

exodeoxyribonuclease V complex
exodeoxyribonuclease V complex

hydrolase activity
ATP binding
exonuclease activity
endonuclease activity
nuclease activity
helicase activity
nucleotide binding
exodeoxyribonuclease V activity
nucleoside-triphosphatase activity
hydrolase activity
ATP binding
exonuclease activity
endonuclease activity
nuclease activity
helicase activity
nucleotide binding
exodeoxyribonuclease V activity
ATP-dependent DNA helicase activity
DNA binding
hydrolase activity
ATP binding
exonuclease activity
endonuclease activity
nuclease activity
helicase activity
nucleotide binding
exodeoxyribonuclease V activity
protein binding

response to DNA damage stimulus
DNA repair
response to DNA damage stimulus
DNA repair
response to DNA damage stimulus
DNA repair

2inrA

[pdb]

1.61544
0.00121606

217^GLY 218^GLY 242^LYS 258^THR 481^SER 482^LEU

DNA topological change
DNA metabolic process

chromosome

isomerase activity
DNA topoisomerase activity
DNA binding
ATP binding
DNA topoisomerase (ATP-hydrolyzing) activity

1sxjB

[pdb]

1.62035
0.00121629

48^VAL 49^SER 54^VAL 55^GLU 56^ALA 161^MSE

cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
chromatin silencing at telomere
postreplication repair
mismatch repair
nucleotide-excision repair
base-excision repair
lagging strand elongation
leading strand elongation
meiotic mismatch repair
regulation of DNA replication
response to DNA damage stimulus
DNA repair
DNA replication
chromatin silencing at silent mating-type cassette
mitotic sister chromatid cohesion
cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
cell cycle checkpoint
cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
cell cycle
DNA replication
sister chromatid cohesion
mismatch repair
leading strand elongation
cell division
cell cycle
DNA replication
mismatch repair
DNA repair
leading strand elongation
mitotic cell cycle

nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
replication fork
nucleus
PCNA complex
nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
nucleus
Elg1 RFC-like complex
Ctf18 RFC-like complex
Rad17 RFC-like complex
DNA replication factor C complex
nucleus
DNA replication factor C complex
intracellular

protein binding
ATP binding
DNA binding
nucleotide binding
ATPase activity
DNA clamp loader activity
nucleoside-triphosphatase activity
DNA polymerase processivity factor activity
DNA binding
protein binding
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity
protein binding
ATP binding
DNA binding
nucleotide binding
DNA clamp loader activity
nucleoside-triphosphatase activity

1r0zA

[pdb]

1.62354
0.00126198

459^SER 461^GLY 463^GLY 464^LYS 465^THR 619^LEU

3.6.3.49

chloride ion binding
ATP binding
chloride channel activity
ion channel activity
nucleotide binding
ATPase activity
coupled to transmembrane movement of substances
nucleoside-triphosphatase activity
ATPase activity
channel-conductance-controlling ATPase activity
hydrolase activity

ion transport
transport
interleukin-8 production
interleukin-6 production
cholesterol transport
cholesterol biosynthetic process
transepithelial chloride transport
lung development
vasodilation
response to drug
response to peptide hormone stimulus
response to estrogen stimulus

membrane
integral to membrane
cytoplasmic vesicle membrane
chloride channel complex

2hb6A

[pdb]

1.62421
0.00126201

86^THR 121^LEU 122^SER 393^GLY 394^LYS 397^GLY

3.4.11.1

intracellular

metal ion binding
hydrolase activity
zinc ion binding
peptidase activity
aminopeptidase activity
identical protein binding
protein binding

proteolysis

1r86A

[pdb]

1.62793
0.00126219

280^THR 325^LEU 327^SER 353^GLY 355^GLY 356^LYS

3.2.1.8

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
endo-1,4-beta-xylanase activity
cation binding
hydrolase activity
hydrolyzing O-glycosyl compounds
catalytic activity

xylan catabolic process
metabolic process
carbohydrate metabolic process

2i9sA

[pdb]

1.64751
0.00141489

9^LEU 15^GLY 16^LYS 17^THR 68^GLY 69^SER

cellular_component

mesoderm development

molecular_function

2pg0A

[pdb]

1.66844
0.00159202

175^LYS 176^THR 186^GLY 188^SER 189^LEU 235^GLY

0.0.0.0

FAD binding
oxidoreductase activity
acting on the CH-CH group of donors
oxidoreductase activity
electron carrier activity
acyl-CoA dehydrogenase activity

metabolic process
oxidation reduction

3e22C

[pdb]

1.67449
0.00165475

109^LYS 111^ASN 112^ARG 148^GLY 151^THR 152^LEU

GTP binding
nucleotide binding
structural molecule activity
GTPase activity
GTP binding
nucleotide binding
structural molecule activity
GTPase activity

microtubule
protein complex
microtubule
protein complex

protein polymerization
microtubule-based movement
microtubule-based process
intracellular signaling cascade
protein polymerization
microtubule-based movement
microtubule-based process

3d8bA

[pdb]

1.67911
0.00165505

446^GLY 447^LYS 448^THR 567^LEU 604^SER 605^GLY

ATP metabolic process

hydrolase activity
magnesium ion binding
metal ion binding
ATP binding
nucleotide binding
nucleoside-triphosphatase activity

2zuyA

[pdb]

1.68178
0.00172096

398^SER 399^LEU 410^GLY 451^THR 453^LYS 454^GLY

calcium ion binding
lyase activity
metal ion binding

cell wall organization

extracellular region

2nynC

[pdb]

1.68451
0.00172115

109^LYS 110^THR 111^GLY 163^GLY 164^SER 171^LEU

0.0.0.0

biosynthetic process

lyase activity
histidine ammonia-lyase activity
ammonia ligase activity
catalytic activity

1zl9A

[pdb]

1.70085
0.00186472

81^GLY 82^LYS 83^THR 152^GLY 154^SER 155^LEU

2.5.1.18

biological_process

cellular_component

transferase activity
glutathione transferase activity

1g3rA

[pdb]

1.71871
0.00210998

9^SER 12^GLY 15^GLY 16^LYS 17^THR 139^LEU

0.0.0.0

cobalamin biosynthetic process
cell division

cobyrinic acid a,c-diamide synthase activity

2qz4A

[pdb]

1.72915
0.00220103

354^GLY 355^LYS 356^THR 479^LEU 517^SER 518^GLY

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
ATP binding
nucleotide binding
unfolded protein binding
metalloendopeptidase activity
nucleoside-triphosphatase activity

mitochondrial membrane
integral to membrane
membrane
mitochondrion

nervous system development
proteolysis
protein catabolic process
anterograde axon cargo transport
mitochondrion organization
cell death

1zkqA

[pdb]

1.73544
0.00229645

49^SER 50^GLY 52^LEU 370^THR 373^LYS 375^GLY

1.8.1.9

mitochondrion
cytoplasm

response to oxygen radical
oxidation reduction
hemopoiesis
heart development
cell redox homeostasis

thioredoxin-disulfide reductase activity
oxidoreductase activity
selenium binding
protein binding
NADP or NADPH binding
FAD binding
electron carrier activity

3cf0C

[pdb]

1.73629
0.00229653

523^GLY 524^LYS 525^THR 647^LEU 683^SER 684^GLY

endoplasmic reticulum
cytosol
cytoplasm
nucleus
microsome

protein binding
lipid binding
ATP binding
nucleotide binding
nucleoside-triphosphatase activity
hydrolase activity
binding

retrograde protein transport
ER to cytosol
transport
ubiquitin-dependent protein catabolic process
activation of caspase activity
double-strand break repair
modification-dependent protein catabolic process

1nhcF

[pdb]

1.74266
0.00239442

350^LEU 351^SER 352^GLY 353^GLY 354^LYS 355^THR

3.2.1.15

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
polygalacturonase activity

metabolic process
cell wall organization
carbohydrate metabolic process

2q9tA

[pdb]

1.74891
0.00249483

108^LEU 109^SER 229^GLY 230^LYS 236^THR 238^GLY

1w36B

[pdb]

1.75159
0.00249512

24^ALA 26^DA 28^DC 29^DA 30^DG 443^ALA

3.1.11.5

exodeoxyribonuclease V complex
exodeoxyribonuclease V complex

hydrolase activity
ATP binding
exonuclease activity
endonuclease activity
nuclease activity
helicase activity
nucleotide binding
exodeoxyribonuclease V activity
nucleoside-triphosphatase activity
hydrolase activity
ATP binding
exonuclease activity
endonuclease activity
nuclease activity
helicase activity
nucleotide binding
exodeoxyribonuclease V activity
ATP-dependent DNA helicase activity
DNA binding
hydrolase activity
ATP binding
exonuclease activity
endonuclease activity
nuclease activity
helicase activity
nucleotide binding
exodeoxyribonuclease V activity
protein binding

response to DNA damage stimulus
DNA repair
response to DNA damage stimulus
DNA repair
response to DNA damage stimulus
DNA repair

1xmiC

[pdb]

1.75574
0.00260046

459^SER 461^GLY 463^GLY 464^LYS 465^THR 619^LEU

3.6.3.49

chloride channel complex
apical plasma membrane
basolateral plasma membrane
membrane
integral to membrane
cytoplasmic vesicle membrane

hydrolase activity
protein binding
PDZ domain binding
channel-conductance-controlling ATPase activity
chloride ion binding
ATP binding
chloride channel activity
ion channel activity
nucleotide binding
ATP-binding and phosphorylation-dependent chloride channel activity
ATPase activity
coupled to transmembrane movement of substances
nucleoside-triphosphatase activity
ATPase activity

vasodilation
cholesterol biosynthetic process
cholesterol transport
ion transport
transport
respiratory gaseous exchange
response to estrogen stimulus
response to peptide hormone stimulus
response to drug
lung development
transepithelial chloride transport

2porA

[pdb]

1.75573
0.00260046

63^LEU 64^SER 65^GLY 68^GLY 69^LYS 122^THR

cell outer membrane
integral to membrane
membrane
plasma membrane

ion transport
transport

transporter activity

1zjjA

[pdb]

1.76133
0.00271129

43^SER 45^LYS 46^THR 70^GLY 93^GLY 126^LEU

0.0.0.0

metabolic process

phosphatase activity
hydrolase activity
catalytic activity

1cc5A

[pdb]

1.76429
0.00271164

57^LEU 58^SER 59^GLY 66^LYS 67^GLY 68^THR

0.0.0.0

electron transport chain
transport

metal ion binding
iron ion binding
heme binding
electron carrier activity

2gblD

[pdb]

1.76997
0.00282802

45^SER 46^GLY 51^GLY 52^LYS 53^THR 207^LEU

2.7.11.1

entrainment of circadian clock
negative regulation of circadian rhythm
rhythmic process
regulation of transcription
DNA-dependent
transcription
regulation of transcription
regulation of circadian rhythm
circadian rhythm

metal ion binding
transferase activity
kinase activity
ATP binding
protein serine/threonine kinase activity
DNA binding
magnesium ion binding
nucleotide binding
identical protein binding
protein binding
protein serine/threonine/tyrosine kinase activity

1espA

[pdb]

1.772
0.00282827

8^GLY 10^GLY 11^LYS 17^THR 19^SER 20^LEU

3.4.24.28

calcium ion binding
metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
metalloendopeptidase activity

extracellular region

proteolysis

1y9kB

[pdb]

1.77283
0.00282837

87^THR 89^LYS 90^GLY 92^GLY 94^SER 151^LEU

0.0.0.0

metabolic process

transferase activity
acyltransferase activity
N-acetyltransferase activity

2pzeA

[pdb]

1.77292
0.00282838

459^SER 461^GLY 463^GLY 464^LYS 465^THR 619^LEU

3.6.3.49

chloride channel complex
apical plasma membrane
basolateral plasma membrane
membrane
integral to membrane
cytoplasmic vesicle membrane

hydrolase activity
protein binding
PDZ domain binding
channel-conductance-controlling ATPase activity
chloride ion binding
ATP binding
chloride channel activity
ion channel activity
nucleotide binding
ATP-binding and phosphorylation-dependent chloride channel activity
ATPase activity
coupled to transmembrane movement of substances
nucleoside-triphosphatase activity
ATPase activity

vasodilation
cholesterol biosynthetic process
cholesterol transport
ion transport
transport
respiratory gaseous exchange
response to estrogen stimulus
response to peptide hormone stimulus
response to drug
lung development
transepithelial chloride transport

2pw0B

[pdb]

1.77405
0.00282852

48^LEU 52^GLY 53^SER 65^GLY 71^THR 73^LYS

0.0.0.0

2vl7A

[pdb]

1.77407
0.00282852

31^LEU 38^GLY 39^LYS 40^THR 326^SER 327^GLY

0.0.0.0

hydrolase activity
acting on acid anhydrides
in phosphorus-containing anhydrides
ATP-dependent helicase activity
ATP binding
ATP-dependent DNA helicase activity
DNA binding
nucleic acid binding

nucleobase
nucleoside
nucleotide and nucleic acid metabolic process

2dflA

[pdb]

1.77733
0.00295033

117^GLY 118^SER 119^GLY 120^LYS 121^THR 287^LEU

ATP binding
DNA binding
nucleotide binding
nucleoside-triphosphatase activity
DNA-dependent ATPase activity
protein binding
damaged DNA binding

response to DNA damage stimulus
DNA recombination
DNA repair
DNA metabolic process

1bl9A

[pdb]

1.7775
0.00295036

299^LYS 301^THR 302^GLY 305^LEU 319^SER 321^GLY

1.7.2.1, 1.7.99.1

metal ion binding
oxidoreductase activity
iron ion binding
nitrite reductase (NO-forming) activity
hydroxylamine reductase activity
heme binding
electron carrier activity

oxidation reduction
electron transport chain
transport

periplasmic space

1figL

[pdb]

1.77791
0.00295041

125^ALA 127^GLY 128^SER 129^ALA 182^THR 183^ASP

0.0.0.0

2pxxA

[pdb]

1.77801
0.00295042

66^GLY 68^GLY 70^SER 72^LEU 130^LYS 132^THR

3.4.24.71

cell-cell signaling
peptide hormone processing
heart development
cardioblast differentiation
brain development
metabolic process
proteolysis

cytoplasmic vesicle membrane
Golgi membrane
integral to membrane
membrane
Golgi apparatus

metalloendopeptidase activity
metal ion binding
hydrolase activity
transferase activity
zinc ion binding
metallopeptidase activity
peptidase activity
methyltransferase activity
catalytic activity

1eepA

[pdb]

1.78282
0.00295104

268^SER 357^THR 360^LYS 361^GLY 362^GLY 363^LEU

1.1.1.205

metal ion binding
potassium ion binding
oxidoreductase activity
IMP dehydrogenase activity
catalytic activity

oxidation reduction
GMP biosynthetic process
purine nucleotide biosynthetic process
metabolic process

1hdcB

[pdb]

1.78456
0.00307857

4^LEU 5^SER 6^GLY 7^LYS 8^THR 30^GLY

1.1.1.53

oxidation reduction
steroid metabolic process
lipid metabolic process
metabolic process

oxidoreductase activity
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity
binding
catalytic activity

1rk6A

[pdb]

1.7896
0.00307924

12^LEU 13^SER 14^GLY 16^THR 56^GLY 57^LYS

0.0.0.0

hydrolase activity
N-acyl-D-amino-acid deacylase activity
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds
in linear amides
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds
zinc ion binding

2rgoA

[pdb]

1.79197
0.00321296

256^LYS 257^GLY 301^THR 348^LEU 353^SER 354^GLY

0.0.0.0

glycerol-3-phosphate dehydrogenase complex

glycerol-3-phosphate metabolic process
oxidation reduction

oxidoreductase activity
glycerol-3-phosphate dehydrogenase activity

3enkA

[pdb]

1.79341
0.00321317

133^GLY 146^LEU 147^SER 153^GLY 155^THR 156^LYS

0.0.0.0

cellular metabolic process
metabolic process
galactose metabolic process

isomerase activity
UDP-glucose 4-epimerase activity
coenzyme binding
binding
catalytic activity

1pznB

[pdb]

1.80326
0.00335427

141^GLY 142^SER 143^GLY 144^LYS 145^THR 315^LEU

ATP binding
DNA binding
nucleotide binding
sequence-specific DNA binding
nucleoside-triphosphatase activity
DNA-dependent ATPase activity
protein binding
damaged DNA binding

intracellular

response to DNA damage stimulus
DNA recombination
DNA repair
DNA metabolic process

1pieA

[pdb]

1.80521
0.00350069

59^GLY 61^THR 127^LYS 128^GLY 141^SER 142^LEU

2.7.1.6

cytoplasm

galactose metabolic process
carbohydrate metabolic process
carbohydrate phosphorylation
phosphorylation
metabolic process

transferase activity
kinase activity
ATP binding
nucleotide binding
galactokinase activity
phosphotransferase activity
alcohol group as acceptor

2wafA

[pdb]

1.80592
0.0035008

342^GLY 360^GLY 362^LYS 371^THR 374^SER 375^LEU

penicillin binding

plasma membrane
integral to membrane
membrane

response to antibiotic
peptidoglycan biosynthetic process
regulation of cell shape
cell wall organization
peptidoglycan-based cell wall biogenesis

1gyhA

[pdb]

1.81416
0.00365149

254^GLY 266^LYS 267^THR 276^GLY 277^SER 278^LEU

0.0.0.0

carbohydrate metabolic process
metabolic process

hydrolase activity
hydrolyzing O-glycosyl compounds
hydrolase activity
acting on glycosyl bonds
hydrolase activity
arabinan endo-1,5-alpha-L-arabinosidase activity

2v7yA

[pdb]

1.81755
0.00365201

366^LEU 367^SER 369^GLY 378^THR 379^LYS 412^GLY

ATP binding
nucleotide binding
unfolded protein binding

response to stress
protein folding

3ecpA

[pdb]

1.8179
0.00365206

42^SER 43^GLY 333^LYS 334^THR 337^GLY 356^LEU

metal ion binding
hydrolase activity
endonuclease activity
nuclease activity
DNA binding
magnesium ion binding
transposase activity
nucleic acid binding

transposition
DNA recombination
transposition
DNA-mediated

1gpwA

[pdb]

1.81847
0.00365215

178^HIS 179^PRO 201^ARG 202^GLY 203^GLY 222^LEU

cellular amino acid biosynthetic process
glutamine metabolic process
histidine biosynthetic process
cellular amino acid biosynthetic process
histidine biosynthetic process
metabolic process

cytoplasm
cytoplasm
imidazoleglycerol-phosphate synthase complex

transferase activity
transferase activity
transferring pentosyl groups
catalytic activity
imidazoleglycerol-phosphate synthase activity
lyase activity
catalytic activity
imidazoleglycerol-phosphate synthase activity

2e6kB

[pdb]

1.81886
0.00365221

371^GLY 373^SER 382^THR 383^LYS 400^LEU 426^GLY

0.0.0.0

metabolic process

transferase activity
transketolase activity
catalytic activity

1uaaA

[pdb]

1.81926
0.00365227

25^GLY 26^SER 27^GLY 28^LYS 29^THR 273^LEU

DNA replication
DNA repair
DNA unwinding during replication

cytoplasm

hydrolase activity
ATP binding
helicase activity
DNA binding
nucleotide binding
ATP-dependent DNA helicase activity

3g8yA

[pdb]

1.82424
0.00380589

149^THR 150^LYS 152^GLY 155^GLY 173^SER 176^LEU

0.0.0.0

2pbrB

[pdb]

1.8253
0.00380606

10^GLY 11^SER 12^GLY 13^LYS 14^THR 129^LEU

2.7.4.9

nucleotide biosynthetic process
dTDP biosynthetic process
dTTP biosynthetic process

transferase activity
kinase activity
ATP binding
nucleotide binding
thymidylate kinase activity

3fdiA

[pdb]

1.82934
0.00396635

13^GLY 14^SER 15^GLY 121^LEU 127^LYS 128^THR

0.0.0.0

1igrA

[pdb]

1.83025
0.00396651

380^GLY 384^LEU 389^SER 414^GLY 415^LYS 438^THR

2.7.10.1

brain development
protein amino acid phosphorylation
immune response
positive regulation of DNA replication
positive regulation of cell migration
phosphoinositide-mediated signaling
phosphoinositide 3-kinase cascade
protein amino acid autophosphorylation
insulin-like growth factor receptor signaling pathway
protein tetramerization
anti-apoptosis
insulin receptor signaling pathway
positive regulation of cell proliferation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
mammary gland development
male sex determination
organ morphogenesis

identical protein binding
protein binding
insulin binding
insulin-like growth factor I binding
insulin receptor binding
insulin-like growth factor receptor activity
insulin-like growth factor binding
protein tyrosine kinase activity
phosphoinositide 3-kinase binding
insulin receptor substrate binding
transferase activity
kinase activity
ATP binding
receptor activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
protein kinase activity

membrane
microsome
integral to plasma membrane
integral to membrane

3b6uB

[pdb]

1.8306
0.00396657

80^LEU 83^SER 87^GLY 222^THR 239^GLY 240^LYS

ATP binding
motor activity
nucleotide binding
plus-end-directed microtubule motor activity
microtubule motor activity
protein binding

anterograde axon cargo transport
determination of left/right symmetry
microtubule-based movement

microtubule
plus-end kinesin complex
microtubule associated complex

3bv0A

[pdb]

1.83099
0.00396663

66^THR 123^SER 124^GLY 282^GLY 283^LYS 292^LEU

2.6.1.62

biotin biosynthetic process

transferase activity
transaminase activity
adenosylmethionine-8-amino-7-oxononanoate transaminase activity
pyridoxal phosphate binding
catalytic activity

2a5zC

[pdb]

1.8326
0.0039669

69^SER 70^LEU 106^GLY 141^THR 229^GLY 231^LYS

0.0.0.0

2qyoB

[pdb]

1.83272
0.00396692

205^GLY 206^THR 209^LYS 234^GLY 235^SER 238^LEU

0.0.0.0

protein dimerization activity
O-methyltransferase activity
methyltransferase activity

3b85A

[pdb]

1.84161
0.00430885

144^GLY 145^SER 146^GLY 147^LYS 148^THR 301^LEU

0.0.0.0

ATP binding
RNA binding
ATP binding
RNA binding

2w5rA

[pdb]

1.84173
0.00430887

278^LEU 279^SER 281^GLY 286^THR 511^LYS 517^GLY

cell wall organization
metabolic process

plasma membrane
integral to membrane
membrane
extracellular region

transferase activity
sulfuric ester hydrolase activity
catalytic activity

1sjpB

[pdb]

1.84878
0.00431016

293^THR 295^GLY 311^LEU 312^SER 315^GLY 316^LYS

0.0.0.0

ATP binding
nucleotide binding
protein binding
unfolded protein binding

cellular protein metabolic process
protein refolding
protein folding

cytoplasm

2egxC

[pdb]

1.84908
0.00449134

110^GLY 113^LYS 114^THR 133^GLY 160^LEU 161^SER

0.0.0.0

cellular amino acid biosynthetic process
arginine biosynthetic process
proline biosynthetic process

cytoplasm

transferase activity
kinase activity
ATP binding
nucleotide binding
glutamate 5-kinase activity
acetylglutamate kinase activity

1vquA

[pdb]

1.8494
0.0044914

211^THR 234^GLY 235^LYS 261^LEU 262^SER 264^GLY

2.4.2.18

aromatic amino acid family biosynthetic process
cellular amino acid biosynthetic process
tryptophan biosynthetic process
metabolic process

transferase activity
transferring glycosyl groups
transferase activity
anthranilate phosphoribosyltransferase activity

2olvB

[pdb]

1.85036
0.00449158

397^GLY 398^SER 400^LEU 583^LYS 584^THR 585^GLY

0.0.0.0

peptidoglycan biosynthetic process
regulation of cell shape
cell wall organization
peptidoglycan-based cell wall biogenesis
peptidoglycan-based cell wall biogenesis

peptidoglycan-based cell wall

transferase activity
acyltransferase activity
penicillin binding
catalytic activity
penicillin binding

1njfD

[pdb]

1.85492
0.00449245

44^SER 45^GLY 50^GLY 51^LYS 52^THR 175^LEU

2.7.7.7

DNA polymerase III complex
nucleus

DNA replication

nucleotidyltransferase activity
transferase activity
ATP binding
DNA-directed DNA polymerase activity
nucleotide binding
nucleoside-triphosphatase activity
DNA binding
protein binding

1oxsC

[pdb]

1.85825
0.00468175

37^LEU 41^GLY 43^GLY 44^LYS 45^THR 198^SER

0.0.0.0

ATP-binding cassette (ABC) transporter complex

nucleoside-triphosphatase activity
ATPase activity
hydrolase activity
acting on acid anhydrides
catalyzing transmembrane movement of substances
ATP binding
transporter activity
nucleotide binding

transport

2v9kA

[pdb]

1.85956
0.00468201

492^GLY 497^THR 498^LYS 502^GLY 503^SER 504^LEU

isomerase activity

tRNA processing

1kc3A

[pdb]

1.86034
0.00468217

7^GLY 8^LYS 9^THR 29^LEU 33^SER 38^GLY

1.1.1.133

oxidation reduction
lipopolysaccharide biosynthetic process
extracellular polysaccharide biosynthetic process
metabolic process

oxidoreductase activity
dTDP-4-dehydrorhamnose reductase activity
binding
catalytic activity

1yy9A

[pdb]

1.86146
0.00468239

379^GLY 404^GLY 406^THR 407^LYS 413^SER 414^LEU

2.7.10.1

endocytic vesicle
basolateral plasma membrane
intracellular
endoplasmic reticulum
cytoplasm
membrane
AP-2 adaptor complex
endosome
nucleus
plasma membrane
extracellular region
integral to membrane
extracellular space
Shc-EGFR complex

protein amino acid phosphorylation
protein amino acid autophosphorylation
response to UV-A
positive regulation of cyclin-dependent protein kinase activity during G1/S
positive regulation of epithelial cell proliferation
positive regulation of MAP kinase activity
signal transduction
protein insertion into membrane
regulation of peptidyl-tyrosine phosphorylation
activation of phospholipase A2 activity by calcium-mediated signaling
positive regulation of cell migration
cell-cell adhesion
activation of phospholipase C activity
epidermal growth factor receptor signaling pathway
positive regulation of nitric oxide biosynthetic process
response to stress
ossification
positive regulation of phosphorylation
negative regulation of cell cycle
cell cycle
cell proliferation
positive regulation of cell proliferation
cell surface receptor linked signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of nitric-oxide synthase activity
cell morphogenesis
salivary gland morphogenesis
regulation of cell proliferation

receptor activity
protein kinase activity
identical protein binding
protein binding
protein heterodimerization activity
MAP/ERK kinase kinase activity
epidermal growth factor receptor activity
actin filament binding
protein tyrosine kinase activity
nitric-oxide synthase regulator activity
double-stranded DNA binding
transferase activity
kinase activity
ATP binding
receptor activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor activity
signal transducer activity
protein phosphatase binding

2hr7A

[pdb]

1.86643
0.00487977

390^GLY 393^LEU 399^SER 424^GLY 425^LYS 448^THR

2.7.10.1

insulin receptor activity
protein binding
protein tyrosine kinase activity
SH2 domain binding
phosphoinositide 3-kinase binding
insulin binding
insulin receptor substrate binding
PTB domain binding
transferase activity
kinase activity
ATP binding
receptor activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
protein kinase activity
3-phosphoinositide-dependent protein kinase binding
protein phosphatase binding
receptor signaling protein tyrosine kinase activity
GTP binding
insulin-like growth factor receptor binding
insulin-like growth factor I binding
insulin-like growth factor II binding

insulin receptor complex
membrane
integral to membrane
endosome membrane
plasma membrane
cytosol
endosome
integral to plasma membrane
caveola
microsome

positive regulation of protein amino acid phosphorylation
positive regulation of cell proliferation
activation of protein kinase activity
activation of protein kinase B activity
cellular response to insulin stimulus
positive regulation of MAPKKK cascade
positive regulation of glycogen biosynthetic process
positive regulation of mitosis
positive regulation of glucose import
positive regulation of protein kinase B signaling cascade
protein heterotetramerization
insulin receptor signaling pathway
protein amino acid autophosphorylation
carbohydrate metabolic process
transmembrane receptor protein tyrosine kinase signaling pathway
protein amino acid phosphorylation
male sex determination
peptidyl-tyrosine phosphorylation
organ morphogenesis
G-protein coupled receptor protein signaling pathway
positive regulation of developmental growth
regulation of embryonic development
glucose homeostasis
heart morphogenesis
positive regulation of glycolysis
positive regulation of DNA replication
positive regulation of cell migration
positive regulation of nitric oxide biosynthetic process
transformation of host cell by virus
activation of MAPK activity
regulation of gene-specific transcription
positive regulation of respiratory burst

2wadC

[pdb]

1.86649
0.00487978

342^GLY 360^GLY 362^LYS 371^THR 374^SER 375^LEU

0.0.0.0

penicillin binding

plasma membrane
integral to membrane
membrane

response to antibiotic
peptidoglycan biosynthetic process
regulation of cell shape
cell wall organization
peptidoglycan-based cell wall biogenesis

2ccgB

[pdb]

1.86812
0.00488012

12^GLY 13^SER 14^GLY 15^LYS 16^THR 131^LEU

2.7.4.9

dTDP biosynthetic process
dTTP biosynthetic process
nucleotide biosynthetic process

thymidylate kinase activity
ATP binding
transferase activity
kinase activity
nucleotide binding

2h58A

[pdb]

1.87015
0.00488053

512^LEU 515^SER 519^GLY 654^THR 668^GLY 669^LYS

ATP binding
motor activity
nucleotide binding
microtubule motor activity

microtubule
kinesin complex
microtubule associated complex
Golgi apparatus

visual perception
microtubule-based movement
Golgi organization
microtubule-based process

1k7hB

[pdb]

1.87054
0.00488061

40^SER 41^LEU 75^LYS 76^THR 358^GLY 434^GLY

0.0.0.0

magnesium ion binding
zinc ion binding
hydrolase activity
alkaline phosphatase activity
phosphatase activity
catalytic activity

metabolic process

1pyyA

[pdb]

1.87123
0.00508504

664^GLY 666^GLY 667^THR 668^LYS 689^LEU 690^SER

cell division
response to antibiotic
peptidoglycan biosynthetic process
regulation of cell shape
cell cycle
cell wall organization
peptidoglycan-based cell wall biogenesis

penicillin binding

plasma membrane
integral to membrane
membrane

1kb0A

[pdb]

1.87225
0.00508526

114^LYS 115^GLY 163^SER 164^LEU 183^GLY 438^THR

metal ion binding
oxidoreductase activity
calcium ion binding
iron ion binding
heme binding
oxidoreductase activity
acting on CH-OH group of donors
electron carrier activity

oxidation reduction

periplasmic space
outer membrane-bounded periplasmic space
membrane

2icsA

[pdb]

1.87329
0.00508548

53^SER 55^GLY 308^THR 309^LYS 321^GLY 323^LEU

0.0.0.0

hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity

2vq8A

[pdb]

1.87462
0.00508576

61^LYS 62^THR 65^GLY 68^GLY 77^SER 110^LEU

1czfA

[pdb]

1.87993
0.0052993

66^LEU 69^GLY 71^LYS 93^SER 94^GLY 98^THR

3.2.1.15

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
polygalacturonase activity

metabolic process
cell wall organization
carbohydrate metabolic process

2uyyC

[pdb]

1.88165
0.00529968

393^LEU 394^SER 397^GLY 421^GLY 422^LYS 423^THR

coenzyme binding
oxidoreductase activity
binding
phosphogluconate dehydrogenase (decarboxylating) activity
catalytic activity
DNA binding

metabolic process
pentose-phosphate shunt

nucleus

1wndB

[pdb]

1.88323
0.00530002

248^GLY 249^GLY 250^LYS 281^THR 449^LEU 450^SER

1.2.1.19

oxidation reduction
putrescine catabolic process
metabolic process

oxidoreductase activity
aminobutyraldehyde dehydrogenase activity
NAD or NADH binding
oxidoreductase activity
acting on the CH-NH group of donors
NAD or NADP as acceptor

2gk6B

[pdb]

1.88604
0.00551717

492^GLY 498^LYS 499^THR 638^SER 659^LEU 661^GLY

cytoplasmic mRNA processing body
cytoplasm
chromatin

hydrolase activity
nucleotide binding
ATP-dependent RNA helicase activity
RNA binding
protein binding
helicase activity
metal ion binding
zinc ion binding
ATP binding
DNA binding
chromatin binding

regulation of translational termination
nuclear-transcribed mRNA catabolic process
nonsense-mediated decay
RNA processing
cell cycle
mRNA export from nucleus
DNA repair
DNA replication