The LabelHash Server

Top 100 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID	LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
1anjA	[pdb]	0.119404 2.58583e-05	51^ASP 101^ASP 102^SER 166^ARG 331^HIS 412^HIS	3.1.3.1	metabolic process	metal ion binding hydrolase activity zinc ion binding magnesium ion binding alkaline phosphatase activity phosphatase activity catalytic activity protein binding	periplasmic space
1k7hB	[pdb]	0.230743 8.6123e-05	37^ASP 85^ASP 86^SER 162^ARG 319^HIS 432^HIS	0.0.0.0		magnesium ion binding zinc ion binding hydrolase activity alkaline phosphatase activity phosphatase activity catalytic activity	metabolic process
2iucA	[pdb]	0.238548 9.0322e-05	43^ASP 83^ASP 84^SER 148^ARG 263^HIS 337^HIS	0.0.0.0		metabolic process	phosphatase activity catalytic activity
2r3sB	[pdb]	1.02299 0.000187452	119^GLY 277^ARG 287^SER 292^ALA 296^ASN 298^ASP	0.0.0.0
2vvlE	[pdb]	1.08977 0.000273155	48^GLY 336^SER 456^ASN 458^ASP 465^SER 468^ASP	0.0.0.0	oxidation reduction	oxidoreductase activity amine oxidase activity electron carrier activity	peroxisome
2j5gF	[pdb]	1.1229 0.000364673	112^SER 122^SER 123^GLU 141^ASP 156^HIS 168^GLY	0.0.0.0		catalytic activity	metabolic process
1xzwB	[pdb]	1.13255 0.000386591	633^GLY 640^ASP 669^ARG 824^HIS 864^SER 865^GLU	3.1.3.2		extracellular region	hydrolase activity acid phosphatase activity metal ion binding iron ion binding zinc ion binding
2vigE	[pdb]	1.14967 0.000436048	103^GLU 117^SER 277^SER 284^GLN 352^ALA 381^HIS	1.3.99.2	acyl-CoA binding oxidoreductase activity butyryl-CoA dehydrogenase activity acyl-CoA dehydrogenase activity FAD binding oxidoreductase activity acting on the CH-CH group of donors electron carrier activity	mitochondrial matrix mitochondrion	response to glucocorticoid stimulus oxidation reduction fatty acid metabolic process lipid metabolic process fatty acid beta-oxidation metabolic process response to starvation
1zs2A	[pdb]	1.16374 0.000493547	145^GLY 392^HIS 394^ASP 445^CYS 448^SER 511^ALA	2.4.1.4	carbohydrate metabolic process	extracellular region	transferase activity transferring glycosyl groups transferase activity amylosucrase activity cation binding catalytic activity
1xfdD	[pdb]	1.16496 0.00052534	214^SER 279^GLY 289^SER 290^ASP 316^ALA 319^ASN		cell death proteolysis	dipeptidyl-peptidase activity serine-type peptidase activity	membrane integral to membrane
2datA	[pdb]	1.16588 0.000525371	91^ALA 98^GLY 100^GLN 104^ASP 105^SER 110^SER		SWI/SNF complex nucleus nucleoplasm	hydrolase activity ATP binding helicase activity nucleotide binding transcription coactivator activity hydrolase activity acting on acid anhydrides in phosphorus-containing anhydrides DNA binding nucleic acid binding protein binding DNA-dependent ATPase activity transcription activator activity	regulation of transcription DNA-dependent transcription regulation of transcription from RNA polymerase II promoter regulation of transcription negative regulation of cell proliferation chromatin remodeling positive regulation of specific transcription from RNA polymerase II promoter negative regulation of specific transcription from RNA polymerase II promoter
2nvpA	[pdb]	1.1774 0.000559782	64^ARG 219^SER 220^ASP 300^ASP 350^HIS 394^GLY	0.0.0.0			catalytic activity
1f7tD	[pdb]	1.18789 0.000635283	58^GLU 61^SER 63^ALA 73^SER 100^HIS 113^GLN	2.7.8.7	cytoplasm	lipid biosynthetic process fatty acid biosynthetic process macromolecule biosynthetic process	metal ion binding transferase activity magnesium ion binding holo-[acyl-carrier-protein] synthase activity
1vs1D	[pdb]	1.22493 0.000867966	44^GLY 77^ARG 250^ALA 252^SER 253^ASP 257^GLN	0.0.0.0		aromatic amino acid family biosynthetic process biosynthetic process metabolic process	transferase activity 3-deoxy-7-phosphoheptulonate synthase activity aldehyde-lyase activity catalytic activity
3cokA	[pdb]	1.22499 0.00086797	122^GLY 127^HIS 135^ASP 190^GLU 191^SER 252^ARG	2.7.11.21		protein amino acid phosphorylation	transferase activity kinase activity ATP binding protein serine/threonine kinase activity nucleotide binding protein binding protein tyrosine kinase activity protein kinase activity
1j32B	[pdb]	1.22793 0.000868123	22^ALA 335^SER 340^SER 341^GLU 346^HIS 376^GLY	0.0.0.0		biosynthetic process	transferase activity transaminase activity L-aspartate:2-oxoglutarate aminotransferase activity pyridoxal phosphate binding 1-aminocyclopropane-1-carboxylate synthase activity transferase activity transferring nitrogenous groups catalytic activity
1ii2B	[pdb]	1.22946 0.000920015	208^ALA 214^GLY 231^SER 233^ASP 237^ASN 435^ARG	0.0.0.0	carboxy-lyase activity lyase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	gluconeogenesis	glycosome
2rkbB	[pdb]	1.23006 0.000920048	15^HIS 39^GLU 46^SER 78^ALA 150^GLY 276^CYS		biological adhesion metabolic process cellular amino acid metabolic process	cellular_component	molecular_function lyase activity pyridoxal phosphate binding catalytic activity
3czdA	[pdb]	1.2354 0.000974944	314^SER 467^ASP 469^SER 480^ALA 483^GLY 510^ASN	3.5.1.2	glutaminase activity hydrolase activity	glutamine catabolic process glutamine metabolic process	mitochondrion mitochondrial matrix
2nsmA	[pdb]	1.23851 0.000975124	333^ASN 350^SER 355^ASP 358^ARG 371^ALA 394^HIS	3.4.17.3	extracellular region extracellular space	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity carboxypeptidase activity metallocarboxypeptidase activity	proteolysis
3eglC	[pdb]	1.24016 0.000975219	8^ASP 10^SER 27^ASN 29^HIS 69^SER 241^ASP
1zcoA	[pdb]	1.24193 0.000975322	29^GLY 62^ARG 235^ALA 237^SER 238^ASP 242^GLN	0.0.0.0		3-deoxy-7-phosphoheptulonate synthase activity transferase activity aldehyde-lyase activity catalytic activity	aromatic amino acid family biosynthetic process biosynthetic process metabolic process
2qfjB	[pdb]	1.24461 0.00103298	219^ASP 221^SER 222^ASP 227^SER 249^HIS 251^GLY	0.0.0.0	RNA binding DNA binding nucleic acid binding nucleotide binding protein binding	RNA splicing apoptosis mRNA processing regulation of transcription DNA-dependent transcription regulation of transcription	nucleus ribonucleoprotein complex cyclin-dependent protein kinase activating kinase holoenzyme complex
1yggA	[pdb]	1.25019 0.00109384	235^ALA 241^GLY 258^SER 260^ASP 264^GLN 456^ARG		carboxy-lyase activity lyase activity kinase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity carboxy-lyase activity lyase activity ATP binding nucleotide binding phosphoenolpyruvate carboxykinase (ATP) activity purine nucleotide binding phosphoenolpyruvate carboxykinase activity	cytoplasm cytoplasm	gluconeogenesis gluconeogenesis
1ivyB	[pdb]	1.26527 0.00122544	62^SER 149^GLU 150^SER 368^ASN 374^ALA 428^GLY	3.4.16.5	hydrolase activity peptidase activity carboxypeptidase activity enzyme activator activity serine-type carboxypeptidase activity protein binding	intracellular protein transport proteolysis	lysosome endoplasmic reticulum mitochondrion
2b0hA	[pdb]	1.27447 0.00129639	1861^ALA 1918^HIS 1953^CYS 1958^SER 1959^GLU 1963^HIS		cell projection membrane plasma membrane cytoskeleton cytoplasm focal adhesion actin cytoskeleton ruffle	cortical actin cytoskeleton organization cell-substrate junction assembly cell adhesion cytoskeletal anchoring at plasma membrane	protein binding binding structural constituent of cytoskeleton structural molecule activity actin binding
2gp6A	[pdb]	1.27563 0.00129648	169^ALA 172^SER 175^GLU 194^CYS 311^HIS 409^ASN	2.3.1.41	cytoplasm	lipid biosynthetic process fatty acid biosynthetic process biosynthetic process metabolic process	transferase activity acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity catalytic activity
1p5jA	[pdb]	1.28683 0.00144839	8^HIS 32^ASP 39^SER 71^ALA 144^GLY 270^CYS	4.3.1.17	cytoplasm cellular_component	gluconeogenesis L-serine metabolic process metabolic process cellular amino acid metabolic process L-serine catabolic process pyruvate biosynthetic process	lyase activity L-serine ammonia-lyase activity pyridoxal phosphate binding catalytic activity protein homodimerization activity
1nfbA	[pdb]	1.29299 0.00152986	48^GLN 50^ASP 53^SER 466^HIS 473^ALA 475^SER	1.1.1.205	cytosol	metal ion binding potassium ion binding oxidoreductase activity IMP dehydrogenase activity catalytic activity protein binding	oxidation reduction GMP biosynthetic process purine nucleotide biosynthetic process metabolic process lymphocyte proliferation
1ficB	[pdb]	1.2947 0.00153001	150^GLY 154^GLN 161^ALA 164^SER 183^GLU 219^SER		blood coagulation protein polymerization platelet activation signal transduction response to calcium ion	calcium ion binding protein binding bridging receptor binding eukaryotic cell surface binding	extracellular region platelet alpha granule lumen plasma membrane fibrinogen complex platelet alpha granule external side of plasma membrane extracellular space
1gcaA	[pdb]	1.30207 0.00161537	112^SER 114^GLU 119^GLN 155^ALA 234^GLY 292^ARG		calcium ion binding sugar:hydrogen symporter activity	carbohydrate transport chemotaxis transport	periplasmic space
1gq7B	[pdb]	1.30519 0.00161565	121^HIS 144^ASP 147^SER 148^ASP 192^SER 248^GLY	3.5.3.22		metal ion binding manganese ion binding hydrolase activity proclavaminate amidinohydrolase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds in linear amidines agmatinase activity	polyamine biosynthetic process
3bz6A	[pdb]	1.30859 0.00170455	123^SER 124^GLU 130^ASN 133^HIS 137^ASP 167^ARG
1nhcF	[pdb]	1.30982 0.00170467	219^SER 250^SER 251^ASP 260^GLY 282^GLN 318^ASP	3.2.1.15	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity polygalacturonase activity	metabolic process cell wall organization carbohydrate metabolic process
1xwyA	[pdb]	1.31205 0.00170488	38^ASN 65^ASP 66^SER 90^GLY 98^ARG 109^ALA			cytoplasm	hydrolase activity nuclease activity magnesium ion binding endodeoxyribonuclease activity producing 5'-phosphomonoesters
1jb0L	[pdb]	1.31338 0.00179758	47^GLY 94^ALA 106^SER 114^SER 115^GLU 119^GLN		catalytic activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding chlorophyll binding iron ion binding magnesium ion binding electron carrier activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding chlorophyll binding iron ion binding magnesium ion binding electron carrier activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding iron ion binding electron carrier activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding chlorophyll binding iron ion binding magnesium ion binding electron carrier activity catalytic activity iron-sulfur cluster binding electron carrier activity 4 iron 4 sulfur cluster binding metal ion binding iron ion binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding chlorophyll binding iron ion binding magnesium ion binding electron carrier activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding iron ion binding electron carrier activity 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding chlorophyll binding iron ion binding magnesium ion binding electron carrier activity	photosynthesis photosynthesis photosynthesis photosynthesis photosynthesis photosynthesis photosynthesis electron transport chain protein-chromophore linkage photosynthesis transport photosynthesis electron transport chain protein-chromophore linkage photosynthesis transport oxidation reduction photosynthesis electron transport chain photosynthesis transport oxidation reduction electron transport chain protein-chromophore linkage photosynthesis transport oxidation reduction photosynthesis oxidation reduction photosynthesis electron transport chain transport photosynthesis photosynthesis electron transport chain protein-chromophore linkage photosynthesis transport oxidation reduction photosynthesis photosynthesis photosynthesis photosynthesis electron transport chain photosynthesis transport oxidation reduction photosynthesis electron transport chain protein-chromophore linkage photosynthesis transport	photosystem I photosystem I reaction center thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane membrane thylakoid photosystem I photosystem I reaction center plastid thylakoid membrane integral to membrane membrane thylakoid photosystem I photosystem I photosystem I reaction center thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I photosystem I photosystem I reaction center thylakoid membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane membrane thylakoid photosystem I photosystem I reaction center plastid thylakoid membrane membrane thylakoid photosystem I photosystem I photosystem I reaction center thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I photosystem I reaction center photosystem I photosystem I reaction center thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I photosystem I reaction center thylakoid membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I thylakoid membrane integral to membrane membrane thylakoid photosystem I
2rb7A	[pdb]	1.31834 0.00179805	19^SER 22^SER 31^ALA 72^HIS 74^ASP 145^GLY	0.0.0.0		metal ion binding hydrolase activity zinc ion binding protein dimerization activity metallopeptidase activity	proteolysis
2fgiB	[pdb]	1.32314 0.00189313	610^GLY 621^HIS 625^ALA 682^ASP 685^SER 736^CYS	2.7.10.1	membrane fraction integral to membrane membrane plasma membrane integral to plasma membrane	protein amino acid phosphorylation cell growth fibroblast growth factor receptor signaling pathway skeletal system development MAPKKK cascade	protein binding fibroblast growth factor receptor activity heparin binding ATP binding protein tyrosine kinase activity transferase activity kinase activity receptor activity nucleotide binding transmembrane receptor protein tyrosine kinase activity protein kinase activity
3bczB	[pdb]	1.32567 0.00189337	7^CYS 11^SER 13^ALA 128^GLU 131^HIS 136^HIS				cytosol nucleus
1yqxB	[pdb]	1.33096 0.00199061	51^HIS 53^ASP 56^SER 60^ASP 126^SER 278^GLY	0.0.0.0		metal ion binding oxidoreductase activity zinc ion binding binding catalytic activity	oxidation reduction metabolic process
9gacA	[pdb]	1.33722 0.00209218	68^CYS 71^ASP 157^ALA 165^SER 195^ASN 198^GLY	3.5.1.26		hydrolase activity N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	periplasmic space
1snuB	[pdb]	1.33753 0.00209221	469^GLY 480^HIS 484^ALA 540^ASP 543^SER 594^CYS	2.7.10.2	metal ion binding transferase activity kinase activity zinc ion binding ATP binding protein tyrosine kinase activity nucleotide binding non-membrane spanning protein tyrosine kinase activity protein binding protein kinase activity	plasma membrane membrane cytosol	signal transduction cellular defense response intracellular signaling cascade protein amino acid phosphorylation
2cv9A	[pdb]	1.33803 0.00209227	11^ALA 46^ASP 49^SER 54^ARG 66^HIS 70^HIS	0.0.0.0			hydrolase activity
1mqbA	[pdb]	1.34129 0.00209261	726^GLY 737^HIS 741^ALA 799^ASP 802^SER 853^CYS	2.7.10.1	membrane integral to membrane integral to plasma membrane	multicellular organismal development signal transduction transmembrane receptor protein tyrosine kinase signaling pathway protein amino acid phosphorylation ephrin receptor signaling pathway neuron differentiation	transferase activity kinase activity ATP binding receptor activity protein tyrosine kinase activity nucleotide binding transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein kinase activity
1wlsA	[pdb]	1.35026 0.00230848	153^SER 156^ARG 164^GLU 167^ASN 267^GLY 294^ALA	0.0.0.0		asparaginase activity	cellular amino acid metabolic process
2a9mM	[pdb]	1.35047 0.00230851	32^GLY 39^PHE 42^SER 58^LEU 79^THR 107^ALA
1uyoX	[pdb]	1.35661 0.00242335	803^ARG 809^SER 810^ASP 814^HIS 861^ALA 1081^GLY	0.0.0.0	outer membrane	proteolysis	serine-type endopeptidase activity
1pweD	[pdb]	1.36219 0.00242402	8^HIS 32^ASP 39^SER 44^GLY 71^ALA 270^CYS	4.3.1.17, 4.3.1.19	cytoplasm	gluconeogenesis metabolic process cellular amino acid metabolic process response to nutrient levels response to cobalamin response to amino acid stimulus	lyase activity L-threonine ammonia-lyase activity L-serine ammonia-lyase activity pyridoxal phosphate binding catalytic activity protein dimerization activity
1qibA	[pdb]	1.36546 0.00254313	100^ARG 165^ALA 177^ASP 178^SER 201^HIS 205^HIS	3.4.24.24	intracellular membrane-bounded organelle proteinaceous extracellular matrix extracellular region extracellular space sarcomere plasma membrane	intramembranous ossification skeletal system morphogenesis face morphogenesis bone trabecula formation collagen catabolic process proteolysis metabolic process blood vessel maturation response to hypoxia	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity calcium ion binding metalloendopeptidase activity protein binding
2v3rA	[pdb]	1.36808 0.00254345	264^ASN 269^GLY 378^ASP 379^SER 392^ALA 398^SER	3.2.1.91	cellulose catabolic process metabolic process carbohydrate metabolic process polysaccharide catabolic process	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity cellulose 1,4-beta-cellobiosidase activity cellulose binding hydrolase activity hydrolyzing O-glycosyl compounds
2qvpA	[pdb]	1.36936 0.00254361	126^ASN 128^GLY 225^ASP 229^GLU 230^SER 235^SER	0.0.0.0		hydrolase activity acting on ester bonds zinc ion binding hydrolase activity metal ion binding	metabolic process
1s3rB	[pdb]	1.37041 0.00266712	426^ASP 485^GLY 509^ARG 512^SER 521^GLN 523^GLU	0.0.0.0		cholesterol binding	pathogenesis
1ztpB	[pdb]	1.37244 0.00266738	89^ASN 122^HIS 126^SER 177^ASP 182^ARG 206^ASP	0.0.0.0
1eepA	[pdb]	1.37468 0.00266767	51^ASP 57^GLN 69^GLY 293^GLU 294^SER 349^SER	1.1.1.205		metal ion binding potassium ion binding oxidoreductase activity IMP dehydrogenase activity catalytic activity	oxidation reduction GMP biosynthetic process purine nucleotide biosynthetic process metabolic process
2vdcE	[pdb]	1.37502 0.00266771	24^ALA 30^GLU 351^GLU 367^ILE 368^HIS 1237^ASN	1.4.1.13		cellular amino acid biosynthetic process glutamine metabolic process glutamate biosynthetic process metabolic process nitrogen compound metabolic process oxidation reduction oxidation reduction cellular amino acid biosynthetic process glutamate biosynthetic process	iron ion binding glutamate synthase (NADPH) activity oxidoreductase activity glutamate synthase activity catalytic activity 3 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding 4 iron 4 sulfur cluster binding iron-sulfur cluster binding metal ion binding oxidoreductase activity iron ion binding glutamate synthase (NADPH) activity FAD binding oxidoreductase activity acting on the CH-NH2 group of donors NAD or NADP as acceptor electron carrier activity
2ch1D	[pdb]	1.37948 0.00279643	127^ASP 153^ASP 156^SER 160^GLN 312^HIS 356^ARG	0.0.0.0		metabolic process	pyridoxal phosphate binding catalytic activity
1ryeB	[pdb]	1.38187 0.00279675	33^GLY 52^ALA 56^HIS 157^ARG 326^SER 330^ASP	1.1.99.28	oxidation reduction metabolic process	oxidoreductase activity glucose-fructose oxidoreductase activity electron carrier activity binding catalytic activity	periplasmic space
1ggqB	[pdb]	1.38278 0.00279687	46^SER 51^ASP 52^SER 117^ASN 119^GLY 187^ALA			cell outer membrane membrane plasma membrane	defense response
2ri9A	[pdb]	1.38281 0.00279687	1051^ALA 1072^HIS 1126^ARG 1464^ASN 1466^GLU 1467^SER	3.2.1.113	extracellular region membrane	hydrolase activity acting on glycosyl bonds hydrolase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding	metabolic process
1jbiA	[pdb]	1.38366 0.00279699	50^ALA 55^GLY 76^SER 79^ASP 81^ASN 85^SER	0.0.0.0		proteinaceous extracellular matrix extracellular region	sensory perception of sound
1r0mA	[pdb]	1.38667 0.00293043	221^GLN 227^ASP 246^GLU 247^SER 250^SER 263^GLY	0.0.0.0		catalytic activity	metabolic process
1tuoA	[pdb]	1.38844 0.00293068	184^SER 207^ARG 211^GLU 214^HIS 219^GLY 249^ASP	0.0.0.0		carbohydrate metabolic process	intramolecular transferase activity phosphotransferases
1qlrB	[pdb]	1.39096 0.00293103	35^SER 50^GLU 70^SER 96^ALA 100^HIS 105^HIS	0.0.0.0
2pmzQ	[pdb]	1.39213 0.0030693	333^ASP 335^LYS 444^ASP 483^ARG 497^VAL 629^GLU	2.7.7.6	nucleus nucleus RNA polymerase complex	transcription transcription transcription DNA-dependent transcription transcription transcription DNA-dependent transcription transcription DNA-dependent transcription transcription transcription DNA-dependent transcription regulation of transcription transcription DNA-dependent cellular metabolic process transcription transcription transcription DNA-dependent transcription DNA-dependent transcription	zinc ion binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity ribonucleoside binding DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity DNA binding metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity protein dimerization activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity RNA binding DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity protein dimerization activity DNA binding metal ion binding nucleotidyltransferase activity transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity DNA-directed RNA polymerase activity catalytic activity nucleotide binding transferase activity zinc ion binding DNA-directed RNA polymerase activity DNA binding metal ion binding nucleotidyltransferase activity DNA-directed RNA polymerase activity DNA binding nucleotidyltransferase activity transferase activity
2a1lA	[pdb]	1.39593 0.00306985	14^SER 17^GLU 22^GLN 187^CYS 192^ALA 225^HIS		Golgi apparatus cytoplasm intracellular	lipid binding phosphatidylinositol transporter activity	transport in utero embryonic development
1p7zD	[pdb]	1.39847 0.00321359	54^SER 57^ALA 72^ARG 136^GLY 378^ASN 380^ASP	1.11.1.6	cytosol cytoplasm	metal ion binding oxidoreductase activity iron ion binding peroxidase activity catalase activity heme binding	oxidation reduction hydrogen peroxide catabolic process response to oxidative stress
2dnnA	[pdb]	1.39862 0.00321361	263^HIS 275^ASN 292^ARG 303^GLU 305^SER 307^ALA			RNA binding nucleic acid binding nucleotide binding protein binding	nucleus
2reiA	[pdb]	1.40091 0.00321395	745^GLY 756^HIS 760^ALA 818^ASP 821^SER 872^CYS	0.0.0.0	membrane integral to membrane	phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein amino acid phosphorylation	protein binding protein tyrosine kinase activity transferase activity kinase activity ATP binding receptor activity nucleotide binding transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein kinase activity
1eakC	[pdb]	1.40294 0.00321426	127^ARG 192^ALA 204^ASP 205^SER 403^HIS 407^HIS	3.4.24.24	collagen catabolic process proteolysis metabolic process blood vessel maturation response to hypoxia intramembranous ossification skeletal system morphogenesis face morphogenesis bone trabecula formation	intracellular membrane-bounded organelle proteinaceous extracellular matrix extracellular region extracellular space sarcomere plasma membrane	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity calcium ion binding metalloendopeptidase activity protein binding
2jnkA	[pdb]	1.40439 0.00321447	5^ASN 7^GLY 44^ALA 64^SER 66^GLU 71^ARG	3.2.1.35	extracellular region	hydrolase activity acting on glycosyl bonds hydrolase activity hyalurononglucosaminidase activity	pathogenesis metabolic process cell adhesion polysaccharide catabolic process
2r5rA	[pdb]	1.40475 0.00321453	24^ASP 60^ASN 63^GLY 90^ARG 97^GLU 98^SER	3.5.4.16			GTP cyclohydrolase I activity hydrolase activity
1lcpB	[pdb]	1.40603 0.00336359	81^ASN 83^HIS 388^GLU 390^SER 395^ASP 481^ARG	3.4.11.1, 3.4.11.5	cytoplasm intracellular mitochondrion	metal ion binding manganese ion binding hydrolase activity zinc ion binding peptidase activity aminopeptidase activity magnesium ion binding metalloexopeptidase activity	protein metabolic process proteolysis
1p31B	[pdb]	1.41695 0.00351697	85^SER 127^HIS 175^ASP 177^SER 197^ASP 348^HIS	6.3.2.8	binding ligase activity ATP binding nucleotide binding UDP-N-acetylmuramate-L-alanine ligase activity catalytic activity	cell division peptidoglycan biosynthetic process regulation of cell shape cell cycle cell wall organization peptidoglycan-based cell wall biogenesis biosynthetic process metabolic process	cytoplasm
1m1oB	[pdb]	1.41845 0.00351721	17^SER 56^GLN 117^GLU 118^SER 122^ALA 147^GLY	2.3.1.9	cytoplasm	poly-hydroxybutyrate biosynthetic process metabolic process	transferase activity acyltransferase activity acetyl-CoA C-acetyltransferase activity catalytic activity
3ez1B	[pdb]	1.42094 0.00367228	93^ASN 96^SER 98^GLU 135^ARG 248^ALA 259^GLY	0.0.0.0			transferase activity transaminase activity pyridoxal phosphate binding catalytic activity
2v3fB	[pdb]	1.42186 0.00367242	25^SER 82^GLY 110^SER 111^GLU 117^ASN 164^ALA	3.2.1.45	hydrolase activity acting on glycosyl bonds hydrolase activity glucosylceramidase activity cation binding catalytic activity protein binding	lysosomal membrane membrane lysosome	metabolic process lysosome organization sphingolipid metabolic process lipid metabolic process carbohydrate metabolic process
1cfeA	[pdb]	1.42203 0.00367245	11^HIS 32^ARG 53^GLU 67^ALA 96^GLN 120^SER			defense response to fungus response to biotic stimulus defense response xenobiotic metabolic process	extracellular region
2cduA	[pdb]	1.42429 0.00367282	246^ARG 279^ALA 282^ASP 283^SER 287^HIS 302^ASN	0.0.0.0	cell redox homeostasis	cytoplasm	electron carrier activity FAD binding oxidoreductase activity
3dntB	[pdb]	1.42895 0.00383432	63^ASN 253^GLU 260^GLY 312^ALA 316^SER 326^ARG				protein binding
2eceA	[pdb]	1.42923 0.00383436	260^HIS 267^GLY 327^ASP 329^SER 331^ASP 426^SER	0.0.0.0			selenium binding
1cn1B	[pdb]	1.43161 0.00383477	44^ASP 164^SER 201^SER 203^ASP 205^HIS 209^GLY	0.0.0.0			protein binding metal ion binding manganese ion binding sugar binding calcium ion binding binding
3fm3B	[pdb]	1.43152 0.00383475	21^GLY 46^GLN 52^ALA 91^ARG 135^SER 136^ASP	3.4.11.18		cellular process proteolysis	cobalt ion binding metal ion binding hydrolase activity peptidase activity aminopeptidase activity metalloexopeptidase activity
3ck2A	[pdb]	1.43873 0.00400312	11^ASP 39^SER 40^GLU 45^SER 57^ASN 81^HIS	0.0.0.0			hydrolase activity
3cmnA	[pdb]	1.43978 0.00400331	288^ALA 295^GLY 348^GLN 377^SER 380^GLU 390^ARG	0.0.0.0
1uyrA	[pdb]	1.44066 0.00400346	1993^GLY 2019^ASN 2098^ASP 2100^SER 2110^SER 2112^GLU	6.4.1.2, 6.3.4.14	cytoplasm endoplasmic reticulum membrane mitochondrion	lipid biosynthetic process fatty acid biosynthetic process nuclear envelope organization protein import into nucleus metabolic process	metal ion binding manganese ion binding ligase activity ATP binding catalytic activity nucleotide binding biotin carboxylase activity acetyl-CoA carboxylase activity biotin binding
1fqvI	[pdb]	1.44084 0.00417742	179^ARG 197^HIS 199^ASP 224^SER 409^ALA 423^GLY		cytosol nucleoplasm SCF ubiquitin ligase complex	protein binding protein binding	ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle ubiquitin-dependent protein catabolic process G1/S transition of mitotic cell cycle cell proliferation negative regulation of survival gene product expression modification-dependent protein catabolic process regulation of cell cycle modification-dependent protein catabolic process
3b4uB	[pdb]	1.44239 0.0041777	9^ALA 29^HIS 36^ASN 39^ASP 40^SER 73^SER	0.0.0.0
2okxA	[pdb]	1.4448 0.00417814	147^GLN 149^GLY 448^SER 483^ASP 570^SER 572^GLU	0.0.0.0			catalytic activity
2owoA	[pdb]	1.44691 0.00417853	75^HIS 122^SER 134^ALA 139^GLY 169^GLU 224^CYS	6.5.1.2	intracellular	ligase activity DNA ligase (NAD+) activity sequence-specific DNA binding DNA binding magnesium ion binding zinc ion binding metal ion binding	response to DNA damage stimulus DNA repair DNA replication DNA metabolic process
1f89B	[pdb]	1.44753 0.00417864	353^GLU 411^ASN 426^HIS 471^ASP 493^SER 538^SER		hydrolase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds	mitochondrion cytoplasm	nitrogen compound metabolic process
3ce9D	[pdb]	1.44854 0.00436003	171^ASP 174^SER 201^SER 254^HIS 266^HIS 273^ALA	0.0.0.0		oxidation reduction aromatic amino acid family biosynthetic process	oxidoreductase activity acting on CH-OH group of donors metal ion binding 3-dehydroquinate synthase activity
2vdxA	[pdb]	1.44946 0.00436021	51^ALA 86^GLY 91^HIS 122^SER 130^GLU 131^SER	0.0.0.0	extracellular space extracellular region	glucocorticoid metabolic process transport	lipid binding steroid binding serine-type endopeptidase inhibitor activity
1f1uA	[pdb]	1.45297 0.00436088	155^HIS 179^GLU 194^HIS 251^SER 272^ASP 292^ARG	0.0.0.0			oxidoreductase activity acting on single donors with incorporation of molecular oxygen incorporation of two atoms of oxygen
1hovA	[pdb]	1.45368 0.00436101	19^ARG 84^ALA 96^ASP 97^SER 120^HIS 124^HIS	3.4.24.24	collagen catabolic process proteolysis metabolic process blood vessel maturation response to hypoxia intramembranous ossification skeletal system morphogenesis face morphogenesis bone trabecula formation	intracellular membrane-bounded organelle proteinaceous extracellular matrix extracellular region extracellular space sarcomere plasma membrane	metal ion binding hydrolase activity zinc ion binding metallopeptidase activity peptidase activity calcium ion binding metalloendopeptidase activity protein binding
3ctzA	[pdb]	1.45821 0.00455093	34^SER 40^SER 41^GLU 201^ALA 496^ASN 500^GLY	3.4.11.9	aminopeptidase activity metal ion binding manganese ion binding hydrolase activity metallopeptidase activity peptidase activity metalloexopeptidase activity	cytoplasm	proteolysis cellular process
2pmbB	[pdb]	1.46199 0.00474915	43^SER 100^GLU 104^SER 141^ALA 215^GLY 232^ASN	0.0.0.0
2c0oA	[pdb]	1.46578 0.00474994	347^GLY 358^HIS 363^ALA 418^ASP 421^SER 472^CYS	2.7.10.2	interspecies interaction between organisms mesoderm development protein amino acid phosphorylation	membrane cytoplasm	transferase activity kinase activity ATP binding protein tyrosine kinase activity nucleotide binding non-membrane spanning protein tyrosine kinase activity protein binding protein kinase activity
2qtkB	[pdb]	1.4658 0.00474994	22^ARG 65^GLY 77^SER 78^GLU 88^ALA 159^ASN	0.0.0.0	membrane integral to membrane	porin activity	transport
2jbwA	[pdb]	1.47408 0.00495827	187^GLY 238^SER 243^SER 244^ASP 276^HIS 283^ASP			alkaloid metabolic process	hydrolase activity
1gvhA	[pdb]	1.4772 0.00517533	294^HIS 321^HIS 332^ARG 338^ASP 339^SER 344^ASP	1.14.12.17	cytoplasm	metal ion binding oxidoreductase activity iron ion binding oxygen transporter activity nitric oxide dioxygenase activity heme binding oxygen binding electron carrier activity	oxidation reduction oxygen transport response to toxin transport

PDB ID

LRMSD /
p-value

Matching Residues

Gene Ontology annotations

Biological Process

Cellular Component

Molecular Function

1anjA

[pdb]

0.119404
2.58583e-05

51^ASP 101^ASP 102^SER 166^ARG 331^HIS 412^HIS

3.1.3.1

metabolic process

metal ion binding
hydrolase activity
zinc ion binding
magnesium ion binding
alkaline phosphatase activity
phosphatase activity
catalytic activity
protein binding

periplasmic space

1k7hB

[pdb]

0.230743
8.6123e-05

37^ASP 85^ASP 86^SER 162^ARG 319^HIS 432^HIS

0.0.0.0

magnesium ion binding
zinc ion binding
hydrolase activity
alkaline phosphatase activity
phosphatase activity
catalytic activity

metabolic process

2iucA

[pdb]

0.238548
9.0322e-05

43^ASP 83^ASP 84^SER 148^ARG 263^HIS 337^HIS

0.0.0.0

metabolic process

phosphatase activity
catalytic activity

2r3sB

[pdb]

1.02299
0.000187452

119^GLY 277^ARG 287^SER 292^ALA 296^ASN 298^ASP

0.0.0.0

2vvlE

[pdb]

1.08977
0.000273155

48^GLY 336^SER 456^ASN 458^ASP 465^SER 468^ASP

0.0.0.0

oxidation reduction

oxidoreductase activity
amine oxidase activity
electron carrier activity

peroxisome

2j5gF

[pdb]

1.1229
0.000364673

112^SER 122^SER 123^GLU 141^ASP 156^HIS 168^GLY

0.0.0.0

catalytic activity

metabolic process

1xzwB

[pdb]

1.13255
0.000386591

633^GLY 640^ASP 669^ARG 824^HIS 864^SER 865^GLU

3.1.3.2

extracellular region

hydrolase activity
acid phosphatase activity
metal ion binding
iron ion binding
zinc ion binding

2vigE

[pdb]

1.14967
0.000436048

103^GLU 117^SER 277^SER 284^GLN 352^ALA 381^HIS

1.3.99.2

acyl-CoA binding
oxidoreductase activity
butyryl-CoA dehydrogenase activity
acyl-CoA dehydrogenase activity
FAD binding
oxidoreductase activity
acting on the CH-CH group of donors
electron carrier activity

mitochondrial matrix
mitochondrion

response to glucocorticoid stimulus
oxidation reduction
fatty acid metabolic process
lipid metabolic process
fatty acid beta-oxidation
metabolic process
response to starvation

1zs2A

[pdb]

1.16374
0.000493547

145^GLY 392^HIS 394^ASP 445^CYS 448^SER 511^ALA

2.4.1.4

carbohydrate metabolic process

extracellular region

transferase activity
transferring glycosyl groups
transferase activity
amylosucrase activity
cation binding
catalytic activity

1xfdD

[pdb]

1.16496
0.00052534

214^SER 279^GLY 289^SER 290^ASP 316^ALA 319^ASN

cell death
proteolysis

dipeptidyl-peptidase activity
serine-type peptidase activity

membrane
integral to membrane

2datA

[pdb]

1.16588
0.000525371

91^ALA 98^GLY 100^GLN 104^ASP 105^SER 110^SER

SWI/SNF complex
nucleus
nucleoplasm

hydrolase activity
ATP binding
helicase activity
nucleotide binding
transcription coactivator activity
hydrolase activity
acting on acid anhydrides
in phosphorus-containing anhydrides
DNA binding
nucleic acid binding
protein binding
DNA-dependent ATPase activity
transcription activator activity

regulation of transcription
DNA-dependent
transcription
regulation of transcription from RNA polymerase II promoter
regulation of transcription
negative regulation of cell proliferation
chromatin remodeling
positive regulation of specific transcription from RNA polymerase II promoter
negative regulation of specific transcription from RNA polymerase II promoter

2nvpA

[pdb]

1.1774
0.000559782

64^ARG 219^SER 220^ASP 300^ASP 350^HIS 394^GLY

0.0.0.0

catalytic activity

1f7tD

[pdb]

1.18789
0.000635283

58^GLU 61^SER 63^ALA 73^SER 100^HIS 113^GLN

2.7.8.7

cytoplasm

lipid biosynthetic process
fatty acid biosynthetic process
macromolecule biosynthetic process

metal ion binding
transferase activity
magnesium ion binding
holo-[acyl-carrier-protein] synthase activity

1vs1D

[pdb]

1.22493
0.000867966

44^GLY 77^ARG 250^ALA 252^SER 253^ASP 257^GLN

0.0.0.0

aromatic amino acid family biosynthetic process
biosynthetic process
metabolic process

transferase activity
3-deoxy-7-phosphoheptulonate synthase activity
aldehyde-lyase activity
catalytic activity

3cokA

[pdb]

1.22499
0.00086797

122^GLY 127^HIS 135^ASP 190^GLU 191^SER 252^ARG

2.7.11.21

protein amino acid phosphorylation

transferase activity
kinase activity
ATP binding
protein serine/threonine kinase activity
nucleotide binding
protein binding
protein tyrosine kinase activity
protein kinase activity

1j32B

[pdb]

1.22793
0.000868123

22^ALA 335^SER 340^SER 341^GLU 346^HIS 376^GLY

0.0.0.0

biosynthetic process

transferase activity
transaminase activity
L-aspartate:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
1-aminocyclopropane-1-carboxylate synthase activity
transferase activity
transferring nitrogenous groups
catalytic activity

1ii2B

[pdb]

1.22946
0.000920015

208^ALA 214^GLY 231^SER 233^ASP 237^ASN 435^ARG

0.0.0.0

carboxy-lyase activity
lyase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

gluconeogenesis

glycosome

2rkbB

[pdb]

1.23006
0.000920048

15^HIS 39^GLU 46^SER 78^ALA 150^GLY 276^CYS

biological adhesion
metabolic process
cellular amino acid metabolic process

cellular_component

molecular_function
lyase activity
pyridoxal phosphate binding
catalytic activity

3czdA

[pdb]

1.2354
0.000974944

314^SER 467^ASP 469^SER 480^ALA 483^GLY 510^ASN

3.5.1.2

glutaminase activity
hydrolase activity

glutamine catabolic process
glutamine metabolic process

mitochondrion
mitochondrial matrix

2nsmA

[pdb]

1.23851
0.000975124

333^ASN 350^SER 355^ASP 358^ARG 371^ALA 394^HIS

3.4.17.3

extracellular region
extracellular space

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
carboxypeptidase activity
metallocarboxypeptidase activity

proteolysis

3eglC

[pdb]

1.24016
0.000975219

8^ASP 10^SER 27^ASN 29^HIS 69^SER 241^ASP

1zcoA

[pdb]

1.24193
0.000975322

29^GLY 62^ARG 235^ALA 237^SER 238^ASP 242^GLN

0.0.0.0

3-deoxy-7-phosphoheptulonate synthase activity
transferase activity
aldehyde-lyase activity
catalytic activity

aromatic amino acid family biosynthetic process
biosynthetic process
metabolic process

2qfjB

[pdb]

1.24461
0.00103298

219^ASP 221^SER 222^ASP 227^SER 249^HIS 251^GLY

0.0.0.0

RNA binding
DNA binding
nucleic acid binding
nucleotide binding
protein binding

RNA splicing
apoptosis
mRNA processing
regulation of transcription
DNA-dependent
transcription
regulation of transcription

nucleus
ribonucleoprotein complex
cyclin-dependent protein kinase activating kinase holoenzyme complex

1yggA

[pdb]

1.25019
0.00109384

235^ALA 241^GLY 258^SER 260^ASP 264^GLN 456^ARG

carboxy-lyase activity
lyase activity
kinase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity
carboxy-lyase activity
lyase activity
ATP binding
nucleotide binding
phosphoenolpyruvate carboxykinase (ATP) activity
purine nucleotide binding
phosphoenolpyruvate carboxykinase activity

cytoplasm
cytoplasm

gluconeogenesis
gluconeogenesis

1ivyB

[pdb]

1.26527
0.00122544

62^SER 149^GLU 150^SER 368^ASN 374^ALA 428^GLY

3.4.16.5

hydrolase activity
peptidase activity
carboxypeptidase activity
enzyme activator activity
serine-type carboxypeptidase activity
protein binding

intracellular protein transport
proteolysis

lysosome
endoplasmic reticulum
mitochondrion

2b0hA

[pdb]

1.27447
0.00129639

1861^ALA 1918^HIS 1953^CYS 1958^SER 1959^GLU 1963^HIS

cell projection
membrane
plasma membrane
cytoskeleton
cytoplasm
focal adhesion
actin cytoskeleton
ruffle

cortical actin cytoskeleton organization
cell-substrate junction assembly
cell adhesion
cytoskeletal anchoring at plasma membrane

protein binding
binding
structural constituent of cytoskeleton
structural molecule activity
actin binding

2gp6A

[pdb]

1.27563
0.00129648

169^ALA 172^SER 175^GLU 194^CYS 311^HIS 409^ASN

2.3.1.41

cytoplasm

lipid biosynthetic process
fatty acid biosynthetic process
biosynthetic process
metabolic process

transferase activity
acyltransferase activity
3-oxoacyl-[acyl-carrier-protein] synthase activity
catalytic activity

1p5jA

[pdb]

1.28683
0.00144839

8^HIS 32^ASP 39^SER 71^ALA 144^GLY 270^CYS

4.3.1.17

cytoplasm
cellular_component

gluconeogenesis
L-serine metabolic process
metabolic process
cellular amino acid metabolic process
L-serine catabolic process
pyruvate biosynthetic process

lyase activity
L-serine ammonia-lyase activity
pyridoxal phosphate binding
catalytic activity
protein homodimerization activity

1nfbA

[pdb]

1.29299
0.00152986

48^GLN 50^ASP 53^SER 466^HIS 473^ALA 475^SER

1.1.1.205

cytosol

metal ion binding
potassium ion binding
oxidoreductase activity
IMP dehydrogenase activity
catalytic activity
protein binding

oxidation reduction
GMP biosynthetic process
purine nucleotide biosynthetic process
metabolic process
lymphocyte proliferation

1ficB

[pdb]

1.2947
0.00153001

150^GLY 154^GLN 161^ALA 164^SER 183^GLU 219^SER

blood coagulation
protein polymerization
platelet activation
signal transduction
response to calcium ion

calcium ion binding
protein binding
bridging
receptor binding
eukaryotic cell surface binding

extracellular region
platelet alpha granule lumen
plasma membrane
fibrinogen complex
platelet alpha granule
external side of plasma membrane
extracellular space

1gcaA

[pdb]

1.30207
0.00161537

112^SER 114^GLU 119^GLN 155^ALA 234^GLY 292^ARG

calcium ion binding
sugar:hydrogen symporter activity

carbohydrate transport
chemotaxis
transport

periplasmic space

1gq7B

[pdb]

1.30519
0.00161565

121^HIS 144^ASP 147^SER 148^ASP 192^SER 248^GLY

3.5.3.22

metal ion binding
manganese ion binding
hydrolase activity
proclavaminate amidinohydrolase activity
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds
in linear amidines
agmatinase activity

polyamine biosynthetic process

3bz6A

[pdb]

1.30859
0.00170455

123^SER 124^GLU 130^ASN 133^HIS 137^ASP 167^ARG

1nhcF

[pdb]

1.30982
0.00170467

219^SER 250^SER 251^ASP 260^GLY 282^GLN 318^ASP

3.2.1.15

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
polygalacturonase activity

metabolic process
cell wall organization
carbohydrate metabolic process

1xwyA

[pdb]

1.31205
0.00170488

38^ASN 65^ASP 66^SER 90^GLY 98^ARG 109^ALA

cytoplasm

hydrolase activity
nuclease activity
magnesium ion binding
endodeoxyribonuclease activity
producing 5'-phosphomonoesters

1jb0L

[pdb]

1.31338
0.00179758

47^GLY 94^ALA 106^SER 114^SER 115^GLU 119^GLN

catalytic activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
chlorophyll binding
iron ion binding
magnesium ion binding
electron carrier activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
chlorophyll binding
iron ion binding
magnesium ion binding
electron carrier activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
iron ion binding
electron carrier activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
chlorophyll binding
iron ion binding
magnesium ion binding
electron carrier activity
catalytic activity
iron-sulfur cluster binding
electron carrier activity
4 iron
4 sulfur cluster binding
metal ion binding
iron ion binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
chlorophyll binding
iron ion binding
magnesium ion binding
electron carrier activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
iron ion binding
electron carrier activity
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
chlorophyll binding
iron ion binding
magnesium ion binding
electron carrier activity

photosynthesis
photosynthesis
photosynthesis
photosynthesis
photosynthesis
photosynthesis
photosynthesis
electron transport chain
protein-chromophore linkage
photosynthesis
transport
photosynthesis
electron transport chain
protein-chromophore linkage
photosynthesis
transport
oxidation reduction
photosynthesis
electron transport chain
photosynthesis
transport
oxidation reduction
electron transport chain
protein-chromophore linkage
photosynthesis
transport
oxidation reduction
photosynthesis
oxidation reduction
photosynthesis
electron transport chain
transport
photosynthesis
photosynthesis
electron transport chain
protein-chromophore linkage
photosynthesis
transport
oxidation reduction
photosynthesis
photosynthesis
photosynthesis
photosynthesis
electron transport chain
photosynthesis
transport
oxidation reduction
photosynthesis
electron transport chain
protein-chromophore linkage
photosynthesis
transport

photosystem I
photosystem I reaction center
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
membrane
thylakoid
photosystem I
photosystem I reaction center
plastid
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
photosystem I
photosystem I reaction center
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
photosystem I
photosystem I reaction center
thylakoid membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
membrane
thylakoid
photosystem I
photosystem I reaction center
plastid
thylakoid membrane
membrane
thylakoid
photosystem I
photosystem I
photosystem I reaction center
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
photosystem I reaction center
photosystem I
photosystem I reaction center
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
photosystem I reaction center
thylakoid membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I
thylakoid membrane
integral to membrane
membrane
thylakoid
photosystem I

2rb7A

[pdb]

1.31834
0.00179805

19^SER 22^SER 31^ALA 72^HIS 74^ASP 145^GLY

0.0.0.0

metal ion binding
hydrolase activity
zinc ion binding
protein dimerization activity
metallopeptidase activity

proteolysis

2fgiB

[pdb]

1.32314
0.00189313

610^GLY 621^HIS 625^ALA 682^ASP 685^SER 736^CYS

2.7.10.1

membrane fraction
integral to membrane
membrane
plasma membrane
integral to plasma membrane

protein amino acid phosphorylation
cell growth
fibroblast growth factor receptor signaling pathway
skeletal system development
MAPKKK cascade

protein binding
fibroblast growth factor receptor activity
heparin binding
ATP binding
protein tyrosine kinase activity
transferase activity
kinase activity
receptor activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
protein kinase activity

3bczB

[pdb]

1.32567
0.00189337

7^CYS 11^SER 13^ALA 128^GLU 131^HIS 136^HIS

cytosol
nucleus

1yqxB

[pdb]

1.33096
0.00199061

51^HIS 53^ASP 56^SER 60^ASP 126^SER 278^GLY

0.0.0.0

metal ion binding
oxidoreductase activity
zinc ion binding
binding
catalytic activity

oxidation reduction
metabolic process

9gacA

[pdb]

1.33722
0.00209218

68^CYS 71^ASP 157^ALA 165^SER 195^ASN 198^GLY

3.5.1.26

hydrolase activity
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity

periplasmic space

1snuB

[pdb]

1.33753
0.00209221

469^GLY 480^HIS 484^ALA 540^ASP 543^SER 594^CYS

2.7.10.2

metal ion binding
transferase activity
kinase activity
zinc ion binding
ATP binding
protein tyrosine kinase activity
nucleotide binding
non-membrane spanning protein tyrosine kinase activity
protein binding
protein kinase activity

plasma membrane
membrane
cytosol

signal transduction
cellular defense response
intracellular signaling cascade
protein amino acid phosphorylation

2cv9A

[pdb]

1.33803
0.00209227

11^ALA 46^ASP 49^SER 54^ARG 66^HIS 70^HIS

0.0.0.0

hydrolase activity

1mqbA

[pdb]

1.34129
0.00209261

726^GLY 737^HIS 741^ALA 799^ASP 802^SER 853^CYS

2.7.10.1

membrane
integral to membrane
integral to plasma membrane

multicellular organismal development
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
protein amino acid phosphorylation
ephrin receptor signaling pathway
neuron differentiation

transferase activity
kinase activity
ATP binding
receptor activity
protein tyrosine kinase activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein kinase activity

1wlsA

[pdb]

1.35026
0.00230848

153^SER 156^ARG 164^GLU 167^ASN 267^GLY 294^ALA

0.0.0.0

asparaginase activity

cellular amino acid metabolic process

2a9mM

[pdb]

1.35047
0.00230851

32^GLY 39^PHE 42^SER 58^LEU 79^THR 107^ALA

1uyoX

[pdb]

1.35661
0.00242335

803^ARG 809^SER 810^ASP 814^HIS 861^ALA 1081^GLY

0.0.0.0

outer membrane

proteolysis

serine-type endopeptidase activity

1pweD

[pdb]

1.36219
0.00242402

8^HIS 32^ASP 39^SER 44^GLY 71^ALA 270^CYS

4.3.1.17, 4.3.1.19

cytoplasm

gluconeogenesis
metabolic process
cellular amino acid metabolic process
response to nutrient levels
response to cobalamin
response to amino acid stimulus

lyase activity
L-threonine ammonia-lyase activity
L-serine ammonia-lyase activity
pyridoxal phosphate binding
catalytic activity
protein dimerization activity

1qibA

[pdb]

1.36546
0.00254313

100^ARG 165^ALA 177^ASP 178^SER 201^HIS 205^HIS

3.4.24.24

intracellular membrane-bounded organelle
proteinaceous extracellular matrix
extracellular region
extracellular space
sarcomere
plasma membrane

intramembranous ossification
skeletal system morphogenesis
face morphogenesis
bone trabecula formation
collagen catabolic process
proteolysis
metabolic process
blood vessel maturation
response to hypoxia

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
calcium ion binding
metalloendopeptidase activity
protein binding

2v3rA

[pdb]

1.36808
0.00254345

264^ASN 269^GLY 378^ASP 379^SER 392^ALA 398^SER

3.2.1.91

cellulose catabolic process
metabolic process
carbohydrate metabolic process
polysaccharide catabolic process

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
cellulose 1,4-beta-cellobiosidase activity
cellulose binding
hydrolase activity
hydrolyzing O-glycosyl compounds

2qvpA

[pdb]

1.36936
0.00254361

126^ASN 128^GLY 225^ASP 229^GLU 230^SER 235^SER

0.0.0.0

hydrolase activity
acting on ester bonds
zinc ion binding
hydrolase activity
metal ion binding

metabolic process

1s3rB

[pdb]

1.37041
0.00266712

426^ASP 485^GLY 509^ARG 512^SER 521^GLN 523^GLU

0.0.0.0

cholesterol binding

pathogenesis

1ztpB

[pdb]

1.37244
0.00266738

89^ASN 122^HIS 126^SER 177^ASP 182^ARG 206^ASP

0.0.0.0

1eepA

[pdb]

1.37468
0.00266767

51^ASP 57^GLN 69^GLY 293^GLU 294^SER 349^SER

1.1.1.205

metal ion binding
potassium ion binding
oxidoreductase activity
IMP dehydrogenase activity
catalytic activity

oxidation reduction
GMP biosynthetic process
purine nucleotide biosynthetic process
metabolic process

2vdcE

[pdb]

1.37502
0.00266771

24^ALA 30^GLU 351^GLU 367^ILE 368^HIS 1237^ASN

1.4.1.13

cellular amino acid biosynthetic process
glutamine metabolic process
glutamate biosynthetic process
metabolic process
nitrogen compound metabolic process
oxidation reduction
oxidation reduction
cellular amino acid biosynthetic process
glutamate biosynthetic process

iron ion binding
glutamate synthase (NADPH) activity
oxidoreductase activity
glutamate synthase activity
catalytic activity
3 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
4 iron
4 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
oxidoreductase activity
iron ion binding
glutamate synthase (NADPH) activity
FAD binding
oxidoreductase activity
acting on the CH-NH2 group of donors
NAD or NADP as acceptor
electron carrier activity

2ch1D

[pdb]

1.37948
0.00279643

127^ASP 153^ASP 156^SER 160^GLN 312^HIS 356^ARG

0.0.0.0

metabolic process

pyridoxal phosphate binding
catalytic activity

1ryeB

[pdb]

1.38187
0.00279675

33^GLY 52^ALA 56^HIS 157^ARG 326^SER 330^ASP

1.1.99.28

oxidation reduction
metabolic process

oxidoreductase activity
glucose-fructose oxidoreductase activity
electron carrier activity
binding
catalytic activity

periplasmic space

1ggqB

[pdb]

1.38278
0.00279687

46^SER 51^ASP 52^SER 117^ASN 119^GLY 187^ALA

cell outer membrane
membrane
plasma membrane

defense response

2ri9A

[pdb]

1.38281
0.00279687

1051^ALA 1072^HIS 1126^ARG 1464^ASN 1466^GLU 1467^SER

3.2.1.113

extracellular region
membrane

hydrolase activity
acting on glycosyl bonds
hydrolase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
calcium ion binding

metabolic process

1jbiA

[pdb]

1.38366
0.00279699

50^ALA 55^GLY 76^SER 79^ASP 81^ASN 85^SER

0.0.0.0

proteinaceous extracellular matrix
extracellular region

sensory perception of sound

1r0mA

[pdb]

1.38667
0.00293043

221^GLN 227^ASP 246^GLU 247^SER 250^SER 263^GLY

0.0.0.0

catalytic activity

metabolic process

1tuoA

[pdb]

1.38844
0.00293068

184^SER 207^ARG 211^GLU 214^HIS 219^GLY 249^ASP

0.0.0.0

carbohydrate metabolic process

intramolecular transferase activity
phosphotransferases

1qlrB

[pdb]

1.39096
0.00293103

35^SER 50^GLU 70^SER 96^ALA 100^HIS 105^HIS

0.0.0.0

2pmzQ

[pdb]

1.39213
0.0030693

333^ASP 335^LYS 444^ASP 483^ARG 497^VAL 629^GLU

2.7.7.6

nucleus
nucleus
RNA polymerase complex

transcription
transcription
transcription
DNA-dependent
transcription
transcription
transcription
DNA-dependent
transcription
transcription
DNA-dependent
transcription
transcription
transcription
DNA-dependent
transcription
regulation of transcription
transcription
DNA-dependent
cellular metabolic process
transcription
transcription
transcription
DNA-dependent
transcription
DNA-dependent
transcription

zinc ion binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
ribonucleoside binding
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
DNA binding
metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
RNA binding
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
protein dimerization activity
DNA binding
metal ion binding
nucleotidyltransferase activity
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity
DNA-directed RNA polymerase activity
catalytic activity
nucleotide binding
transferase activity
zinc ion binding
DNA-directed RNA polymerase activity
DNA binding
metal ion binding
nucleotidyltransferase activity
DNA-directed RNA polymerase activity
DNA binding
nucleotidyltransferase activity
transferase activity

2a1lA

[pdb]

1.39593
0.00306985

14^SER 17^GLU 22^GLN 187^CYS 192^ALA 225^HIS

Golgi apparatus
cytoplasm
intracellular

lipid binding
phosphatidylinositol transporter activity

transport
in utero embryonic development

1p7zD

[pdb]

1.39847
0.00321359

54^SER 57^ALA 72^ARG 136^GLY 378^ASN 380^ASP

1.11.1.6

cytosol
cytoplasm

metal ion binding
oxidoreductase activity
iron ion binding
peroxidase activity
catalase activity
heme binding

oxidation reduction
hydrogen peroxide catabolic process
response to oxidative stress

2dnnA

[pdb]

1.39862
0.00321361

263^HIS 275^ASN 292^ARG 303^GLU 305^SER 307^ALA

RNA binding
nucleic acid binding
nucleotide binding
protein binding

nucleus

2reiA

[pdb]

1.40091
0.00321395

745^GLY 756^HIS 760^ALA 818^ASP 821^SER 872^CYS

0.0.0.0

membrane
integral to membrane

phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
protein amino acid phosphorylation

protein binding
protein tyrosine kinase activity
transferase activity
kinase activity
ATP binding
receptor activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein kinase activity

1eakC

[pdb]

1.40294
0.00321426

127^ARG 192^ALA 204^ASP 205^SER 403^HIS 407^HIS

3.4.24.24

collagen catabolic process
proteolysis
metabolic process
blood vessel maturation
response to hypoxia
intramembranous ossification
skeletal system morphogenesis
face morphogenesis
bone trabecula formation

intracellular membrane-bounded organelle
proteinaceous extracellular matrix
extracellular region
extracellular space
sarcomere
plasma membrane

metal ion binding
hydrolase activity
zinc ion binding
metallopeptidase activity
peptidase activity
calcium ion binding
metalloendopeptidase activity
protein binding

2jnkA

[pdb]

1.40439
0.00321447

5^ASN 7^GLY 44^ALA 64^SER 66^GLU 71^ARG

3.2.1.35

extracellular region

hydrolase activity
acting on glycosyl bonds
hydrolase activity
hyalurononglucosaminidase activity

pathogenesis
metabolic process
cell adhesion
polysaccharide catabolic process

2r5rA

[pdb]

1.40475
0.00321453

24^ASP 60^ASN 63^GLY 90^ARG 97^GLU 98^SER

3.5.4.16

GTP cyclohydrolase I activity
hydrolase activity

1lcpB

[pdb]

1.40603
0.00336359

81^ASN 83^HIS 388^GLU 390^SER 395^ASP 481^ARG

3.4.11.1, 3.4.11.5

cytoplasm
intracellular
mitochondrion

metal ion binding
manganese ion binding
hydrolase activity
zinc ion binding
peptidase activity
aminopeptidase activity
magnesium ion binding
metalloexopeptidase activity

protein metabolic process
proteolysis

1p31B

[pdb]

1.41695
0.00351697

85^SER 127^HIS 175^ASP 177^SER 197^ASP 348^HIS

6.3.2.8

binding
ligase activity
ATP binding
nucleotide binding
UDP-N-acetylmuramate-L-alanine ligase activity
catalytic activity

cell division
peptidoglycan biosynthetic process
regulation of cell shape
cell cycle
cell wall organization
peptidoglycan-based cell wall biogenesis
biosynthetic process
metabolic process

cytoplasm

1m1oB

[pdb]

1.41845
0.00351721

17^SER 56^GLN 117^GLU 118^SER 122^ALA 147^GLY

2.3.1.9

cytoplasm

poly-hydroxybutyrate biosynthetic process
metabolic process

transferase activity
acyltransferase activity
acetyl-CoA C-acetyltransferase activity
catalytic activity

3ez1B

[pdb]

1.42094
0.00367228

93^ASN 96^SER 98^GLU 135^ARG 248^ALA 259^GLY

0.0.0.0

transferase activity
transaminase activity
pyridoxal phosphate binding
catalytic activity

2v3fB

[pdb]

1.42186
0.00367242

25^SER 82^GLY 110^SER 111^GLU 117^ASN 164^ALA

3.2.1.45

hydrolase activity
acting on glycosyl bonds
hydrolase activity
glucosylceramidase activity
cation binding
catalytic activity
protein binding

lysosomal membrane
membrane
lysosome

metabolic process
lysosome organization
sphingolipid metabolic process
lipid metabolic process
carbohydrate metabolic process

1cfeA

[pdb]

1.42203
0.00367245

11^HIS 32^ARG 53^GLU 67^ALA 96^GLN 120^SER

defense response to fungus
response to biotic stimulus
defense response
xenobiotic metabolic process

extracellular region

2cduA

[pdb]

1.42429
0.00367282

246^ARG 279^ALA 282^ASP 283^SER 287^HIS 302^ASN

0.0.0.0

cell redox homeostasis

cytoplasm

electron carrier activity
FAD binding
oxidoreductase activity

3dntB

[pdb]

1.42895
0.00383432

63^ASN 253^GLU 260^GLY 312^ALA 316^SER 326^ARG

protein binding

2eceA

[pdb]

1.42923
0.00383436

260^HIS 267^GLY 327^ASP 329^SER 331^ASP 426^SER

0.0.0.0

selenium binding

1cn1B

[pdb]

1.43161
0.00383477

44^ASP 164^SER 201^SER 203^ASP 205^HIS 209^GLY

0.0.0.0

protein binding
metal ion binding
manganese ion binding
sugar binding
calcium ion binding
binding

3fm3B

[pdb]

1.43152
0.00383475

21^GLY 46^GLN 52^ALA 91^ARG 135^SER 136^ASP

3.4.11.18

cellular process
proteolysis

cobalt ion binding
metal ion binding
hydrolase activity
peptidase activity
aminopeptidase activity
metalloexopeptidase activity

3ck2A

[pdb]

1.43873
0.00400312

11^ASP 39^SER 40^GLU 45^SER 57^ASN 81^HIS

0.0.0.0

hydrolase activity

3cmnA

[pdb]

1.43978
0.00400331

288^ALA 295^GLY 348^GLN 377^SER 380^GLU 390^ARG

0.0.0.0

1uyrA

[pdb]

1.44066
0.00400346

1993^GLY 2019^ASN 2098^ASP 2100^SER 2110^SER 2112^GLU

6.4.1.2, 6.3.4.14

cytoplasm
endoplasmic reticulum membrane
mitochondrion

lipid biosynthetic process
fatty acid biosynthetic process
nuclear envelope organization
protein import into nucleus
metabolic process

metal ion binding
manganese ion binding
ligase activity
ATP binding
catalytic activity
nucleotide binding
biotin carboxylase activity
acetyl-CoA carboxylase activity
biotin binding

1fqvI

[pdb]

1.44084
0.00417742

179^ARG 197^HIS 199^ASP 224^SER 409^ALA 423^GLY

cytosol
nucleoplasm
SCF ubiquitin ligase complex

protein binding
protein binding

ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
ubiquitin-dependent protein catabolic process
G1/S transition of mitotic cell cycle
cell proliferation
negative regulation of survival gene product expression
modification-dependent protein catabolic process
regulation of cell cycle
modification-dependent protein catabolic process